目的研究咀管紧张素ⅡR的Ⅰ型受体基因(angiotensinⅡR type 1 receptor,AT1R)的多态性位点Al166C与急性心肌梗塞发生风险的关系。方法采用聚合酶链式反应-限制酶片段长度多态性(PCR-RFLP)技术,对96例急性心肌梗塞患者和96例正常对照个...目的研究咀管紧张素ⅡR的Ⅰ型受体基因(angiotensinⅡR type 1 receptor,AT1R)的多态性位点Al166C与急性心肌梗塞发生风险的关系。方法采用聚合酶链式反应-限制酶片段长度多态性(PCR-RFLP)技术,对96例急性心肌梗塞患者和96例正常对照个体进行分型。结果在病例组与对照组间Al166C位点的基因型和等位型频率均无显著差异(P>0.05)。结论AT1R基因的Al166C多态性位点对急性心肌梗塞的发生风险不产生影响。展开更多
Objectives To explore the feasibility, safety and efficacy of transmyocardial stent to treat acute myocardial infarction. Methods 24 Chinese mini swines have been divided into 2 groups randomly：group myocardial infar...Objectives To explore the feasibility, safety and efficacy of transmyocardial stent to treat acute myocardial infarction. Methods 24 Chinese mini swines have been divided into 2 groups randomly：group myocardial infarction （group MI n1 = 14） and group transmyocardial stent（group ST n2 = 10）. In group MI, acute myocardial infarction animal model has been established by the ligation of the left descending coronary artery. In group ST, after the establishment of the model, 3 transmyocardial stents were implanted. 4 weeks later, echocardiography and pathological analysis have been done. Results The density of blood vessel in group ST is 6.47 ± 0.60/HP which is significandy higher than the group MI. At the same time, left ventricular ejection fraction and regional wall motion score index （WMSI） in group ST are ameliorated significandy compared with group MI. Conclusion It is feasible and safe to implant transmyocardial stents in acute myocardial infarction model. Although the channel can＇ t remain patent in long term, the prolonged stimulation can cause moderate-serious inflammatory reaction and proficient angiogenesis.展开更多
Embryonic stem cells and adult stem cells derives from bone marrow, muscule, liver, skin, nerve, adiposes and other tissues or organs are pluripotent. Embryonic stem cells in vitro can differentiate into derivatives o...Embryonic stem cells and adult stem cells derives from bone marrow, muscule, liver, skin, nerve, adiposes and other tissues or organs are pluripotent. Embryonic stem cells in vitro can differentiate into derivatives of all three embryonic germ layers when transferred to an in vitro environment, and have the ability to form any fully differentiated cells of the body. A series of remarkable studies suggested that adult stem cells undergo novel patterns of development named as transdifferentiation. All of them can be induced into cardiomyocytes in a certain condition and used to treat myocardial infarction. In this review, progress in the treatment of myocardial infarction with stem cells transplantation is summarized.展开更多
文摘目的研究咀管紧张素ⅡR的Ⅰ型受体基因(angiotensinⅡR type 1 receptor,AT1R)的多态性位点Al166C与急性心肌梗塞发生风险的关系。方法采用聚合酶链式反应-限制酶片段长度多态性(PCR-RFLP)技术,对96例急性心肌梗塞患者和96例正常对照个体进行分型。结果在病例组与对照组间Al166C位点的基因型和等位型频率均无显著差异(P>0.05)。结论AT1R基因的Al166C多态性位点对急性心肌梗塞的发生风险不产生影响。
文摘Objectives To explore the feasibility, safety and efficacy of transmyocardial stent to treat acute myocardial infarction. Methods 24 Chinese mini swines have been divided into 2 groups randomly：group myocardial infarction （group MI n1 = 14） and group transmyocardial stent（group ST n2 = 10）. In group MI, acute myocardial infarction animal model has been established by the ligation of the left descending coronary artery. In group ST, after the establishment of the model, 3 transmyocardial stents were implanted. 4 weeks later, echocardiography and pathological analysis have been done. Results The density of blood vessel in group ST is 6.47 ± 0.60/HP which is significandy higher than the group MI. At the same time, left ventricular ejection fraction and regional wall motion score index （WMSI） in group ST are ameliorated significandy compared with group MI. Conclusion It is feasible and safe to implant transmyocardial stents in acute myocardial infarction model. Although the channel can＇ t remain patent in long term, the prolonged stimulation can cause moderate-serious inflammatory reaction and proficient angiogenesis.
文摘Embryonic stem cells and adult stem cells derives from bone marrow, muscule, liver, skin, nerve, adiposes and other tissues or organs are pluripotent. Embryonic stem cells in vitro can differentiate into derivatives of all three embryonic germ layers when transferred to an in vitro environment, and have the ability to form any fully differentiated cells of the body. A series of remarkable studies suggested that adult stem cells undergo novel patterns of development named as transdifferentiation. All of them can be induced into cardiomyocytes in a certain condition and used to treat myocardial infarction. In this review, progress in the treatment of myocardial infarction with stem cells transplantation is summarized.
