目的:探讨不同左室射血分数(LVEF)水平与心力衰竭人群肾功能障碍的关联。方法:以2006年至2018年期间参与开滦集团健康体检并于2020年12月31日前首次确诊心力衰竭的个体为研究对象,按照LVEF Objective: To investigate the association b...目的:探讨不同左室射血分数(LVEF)水平与心力衰竭人群肾功能障碍的关联。方法:以2006年至2018年期间参与开滦集团健康体检并于2020年12月31日前首次确诊心力衰竭的个体为研究对象,按照LVEF Objective: To investigate the association between different levels of left ventricular ejection fraction (LVEF) and renal dysfunction in patients with heart failure. Methods: Individuals who participated in the Kailuan Group health examinations between 2006 and 2018 and were first diagnosed with heart failure by December 31, 2020, were included as the study population. Participants were categorized into three groups based on LVEF levels: LVEF < 40%, 40% ≤ LVEF < 50%, and LVEF ≥ 50%. LVEF was used as the independent variable, and the presence of renal dysfunction was used as the dependent variable. A binary logistic regression model was constructed to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). Subgroup analyses were performed according to age, sex, and obesity. Additionally, sensitivity analyses were conducted by excluding individuals with a history of hypertension, diabetes, myocardial infarction, or pre-existing chronic kidney disease (CKD) to verify the robustness of the results. Results: A total of 3272 participants were included in this study, of whom 2837 (86.7%) were male, with a mean age of 68.01 ± 10.99 years. Logistic regression analysis showed that, compared with the reference group (LVEF ≥ 50%), the odds ratios (ORs) for renal dysfunction were 1.73 (95% CI: 1.31~2.29) in the 40% ≤ LVEF < 50% group and 2.42 (95% CI: 1.72~3.41) in the LVEF < 40% group. Subgroup analysis revealed that, except for the female subgroup, which showed no statistically significant difference, the results were consistent with the overall analysis across all other subgroups. Conclusion: The risk of renal dysfunction increases progressively with the decline in LVEF among patients with heart failure.展开更多
Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic ...Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic valve implantation (TAVI), based on references and data summaries. Methods: Seventy-eight patients with severe aortic stenosis diagnosed and treated in the Department of Cardiovascular Medicine of the Affiliated Hospital of Qingdao University from March 2019 to October 2022 were selected to detect the CT coronary flow reserve fraction of the anterior descending branches of the patients before and after transcatheter aortic replacement, and according to the pre- and post-surgery CT coronary flow reserve fractions, patients were divided into the variable group (Group I), the large group (Group II), and unchanged group (Group III), to explore the effects of left ventricular ejection fraction and age on each group. Results: Compared to Group III, in Group I, LVEF mainly influenced CT-FFR to become smaller after TAVI and played a positive role;compared to Group III, age mainly influenced CT-FFR to become larger after TAVI and played a negative role. Conclusion: LVEF and age predict changes in anterior descending CT coronary flow reserve fraction after transcatheter aortic implantation.展开更多
文摘目的:探讨不同左室射血分数(LVEF)水平与心力衰竭人群肾功能障碍的关联。方法:以2006年至2018年期间参与开滦集团健康体检并于2020年12月31日前首次确诊心力衰竭的个体为研究对象,按照LVEF Objective: To investigate the association between different levels of left ventricular ejection fraction (LVEF) and renal dysfunction in patients with heart failure. Methods: Individuals who participated in the Kailuan Group health examinations between 2006 and 2018 and were first diagnosed with heart failure by December 31, 2020, were included as the study population. Participants were categorized into three groups based on LVEF levels: LVEF < 40%, 40% ≤ LVEF < 50%, and LVEF ≥ 50%. LVEF was used as the independent variable, and the presence of renal dysfunction was used as the dependent variable. A binary logistic regression model was constructed to calculate odds ratios (ORs) and their 95% confidence intervals (CIs). Subgroup analyses were performed according to age, sex, and obesity. Additionally, sensitivity analyses were conducted by excluding individuals with a history of hypertension, diabetes, myocardial infarction, or pre-existing chronic kidney disease (CKD) to verify the robustness of the results. Results: A total of 3272 participants were included in this study, of whom 2837 (86.7%) were male, with a mean age of 68.01 ± 10.99 years. Logistic regression analysis showed that, compared with the reference group (LVEF ≥ 50%), the odds ratios (ORs) for renal dysfunction were 1.73 (95% CI: 1.31~2.29) in the 40% ≤ LVEF < 50% group and 2.42 (95% CI: 1.72~3.41) in the LVEF < 40% group. Subgroup analysis revealed that, except for the female subgroup, which showed no statistically significant difference, the results were consistent with the overall analysis across all other subgroups. Conclusion: The risk of renal dysfunction increases progressively with the decline in LVEF among patients with heart failure.
文摘Objective: To investigate the correlation between left ventricular ejection fraction (LVEF) and age with changes in anterior descending CT coronary flow reserve fraction (CT-FFR) before and after transcatheter aortic valve implantation (TAVI), based on references and data summaries. Methods: Seventy-eight patients with severe aortic stenosis diagnosed and treated in the Department of Cardiovascular Medicine of the Affiliated Hospital of Qingdao University from March 2019 to October 2022 were selected to detect the CT coronary flow reserve fraction of the anterior descending branches of the patients before and after transcatheter aortic replacement, and according to the pre- and post-surgery CT coronary flow reserve fractions, patients were divided into the variable group (Group I), the large group (Group II), and unchanged group (Group III), to explore the effects of left ventricular ejection fraction and age on each group. Results: Compared to Group III, in Group I, LVEF mainly influenced CT-FFR to become smaller after TAVI and played a positive role;compared to Group III, age mainly influenced CT-FFR to become larger after TAVI and played a negative role. Conclusion: LVEF and age predict changes in anterior descending CT coronary flow reserve fraction after transcatheter aortic implantation.
