目的:研究肝脏局灶性结节性增生(FNH)和肝腺瘤(HA)的实时剪切波超声弹性成像(SWE)声像图特点,探讨SWE在FNH和HA鉴别诊断中的临床应用价值。方法:选取34个FNH及12个HA的肝脏占位性病变,行SWE检查,获取病变的杨氏模量平均值、病变与邻近...目的:研究肝脏局灶性结节性增生(FNH)和肝腺瘤(HA)的实时剪切波超声弹性成像(SWE)声像图特点,探讨SWE在FNH和HA鉴别诊断中的临床应用价值。方法:选取34个FNH及12个HA的肝脏占位性病变,行SWE检查,获取病变的杨氏模量平均值、病变与邻近肝组织杨氏模量平均值的比值(杨氏模量比值),所有病变均以病理检查结果为金标准,对SWE鉴别诊断FNH和HA的准确性进行评价。结果:FNH组杨氏模量平均值为(40.56±13.37)k Pa,HA组为(14.33±7.81)k Pa;FNH组杨氏模量比值为(6.42±2.13),HA组为(2.45±1.61);FNH组与HA组比较,差异均有统计学意义(P均<0.001)。通过ROC曲线确定FNH和HA杨氏模量平均值的临界点为14.45 k Pa,其敏感度97.1%、特异性93.3%,曲线下面积为96.1%;杨氏模量比值的临界点为6.32,其敏感度98.2%、特异性67.4%,曲线下面积为97.2%。结论:SWE在FNH及HA鉴别诊断中具有重要临床价值。展开更多
目的:探讨二维剪切波弹性成像(2D-SWE)在HIV感染者肝纤维化评估中的临床应用价值。方法:前瞻性选取2023年10月~2024年10月157例在本院艾滋病门诊接受正规治疗的HIV感染者和70例年龄、性别相匹配的同期健康正常人作为研究对象。均进行2D-...目的:探讨二维剪切波弹性成像(2D-SWE)在HIV感染者肝纤维化评估中的临床应用价值。方法:前瞻性选取2023年10月~2024年10月157例在本院艾滋病门诊接受正规治疗的HIV感染者和70例年龄、性别相匹配的同期健康正常人作为研究对象。均进行2D-SWE检查及血常规、肝功能等相应的血清学检查,对两组之间所有测量参数进行差异性、相关性的统计学分析。结果:1) 长、短病程组的骨密度按照对照组、短病程组、长病程组的顺序逐渐降低(F = 25.161, P P P Objective: To investigate the clinical value of two-dimensional shear wave elastography (2D-SWE) in the evaluation of liver fibrosis in HIV-Infected patients. Methods: From October 2023 to October 2024, 157 HIV-Infected patients who received formal treatment in the AIDS clinic of our hospital and 70 age and gender-matched healthy people in the same period were prospectively selected as the research objects. 2D-SWE examination, blood routine, liver function, and other corresponding serological tests were performed on all patients. The differences and correlations of all measured parameters between the two groups were statistically analyzed. Results: 1) The BMD of the long and short course groups gradually decreased in the order of the control group, the short course group, and the long course group (F = 25.161, P P P < 0.05). 4) The repeatability test showed good operability and repeatability. 5) Pearson correlation analysis showed that Young’s modulus was positively correlated with the course of disease, ALT, AST, APRI, urine creatinine, triglyceride, and BMI. 6) ROC curve analysis showed that the area under the curve, sensitivity, and specificity of Young’s modulus value were higher than those of APRI and FIB-4. Conclusions: 2D-SWE can quantitatively assess liver fibrosis in HIV-Infected patients at an early stage. Compared with APRI and FIB-4, 2D-SWE can detect changes in liver fibrosis earlier and provide an objective reference for clinical practice.展开更多
文摘目的:研究肝脏局灶性结节性增生(FNH)和肝腺瘤(HA)的实时剪切波超声弹性成像(SWE)声像图特点,探讨SWE在FNH和HA鉴别诊断中的临床应用价值。方法:选取34个FNH及12个HA的肝脏占位性病变,行SWE检查,获取病变的杨氏模量平均值、病变与邻近肝组织杨氏模量平均值的比值(杨氏模量比值),所有病变均以病理检查结果为金标准,对SWE鉴别诊断FNH和HA的准确性进行评价。结果:FNH组杨氏模量平均值为(40.56±13.37)k Pa,HA组为(14.33±7.81)k Pa;FNH组杨氏模量比值为(6.42±2.13),HA组为(2.45±1.61);FNH组与HA组比较,差异均有统计学意义(P均<0.001)。通过ROC曲线确定FNH和HA杨氏模量平均值的临界点为14.45 k Pa,其敏感度97.1%、特异性93.3%,曲线下面积为96.1%;杨氏模量比值的临界点为6.32,其敏感度98.2%、特异性67.4%,曲线下面积为97.2%。结论:SWE在FNH及HA鉴别诊断中具有重要临床价值。
文摘目的:探讨二维剪切波弹性成像(2D-SWE)在HIV感染者肝纤维化评估中的临床应用价值。方法:前瞻性选取2023年10月~2024年10月157例在本院艾滋病门诊接受正规治疗的HIV感染者和70例年龄、性别相匹配的同期健康正常人作为研究对象。均进行2D-SWE检查及血常规、肝功能等相应的血清学检查,对两组之间所有测量参数进行差异性、相关性的统计学分析。结果:1) 长、短病程组的骨密度按照对照组、短病程组、长病程组的顺序逐渐降低(F = 25.161, P P P Objective: To investigate the clinical value of two-dimensional shear wave elastography (2D-SWE) in the evaluation of liver fibrosis in HIV-Infected patients. Methods: From October 2023 to October 2024, 157 HIV-Infected patients who received formal treatment in the AIDS clinic of our hospital and 70 age and gender-matched healthy people in the same period were prospectively selected as the research objects. 2D-SWE examination, blood routine, liver function, and other corresponding serological tests were performed on all patients. The differences and correlations of all measured parameters between the two groups were statistically analyzed. Results: 1) The BMD of the long and short course groups gradually decreased in the order of the control group, the short course group, and the long course group (F = 25.161, P P P < 0.05). 4) The repeatability test showed good operability and repeatability. 5) Pearson correlation analysis showed that Young’s modulus was positively correlated with the course of disease, ALT, AST, APRI, urine creatinine, triglyceride, and BMI. 6) ROC curve analysis showed that the area under the curve, sensitivity, and specificity of Young’s modulus value were higher than those of APRI and FIB-4. Conclusions: 2D-SWE can quantitatively assess liver fibrosis in HIV-Infected patients at an early stage. Compared with APRI and FIB-4, 2D-SWE can detect changes in liver fibrosis earlier and provide an objective reference for clinical practice.
