This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early...This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early pregnancy across species. Ultrastructural, biochemical and more general morphological data reveal that strikingly common phenomena occur in this plasma membrane during early pregnancy despite the diversity of placental types-from epitheliochorial to hemochorial, which ultimately form in different species. To encapsulate the concept that common morphological and molecular alterations occur across species, that they are found basolaterally as well as apically, and that moreover they are an ongoing process during much of early pregnancy, not just an event at the time attachment, the term 'plasma membrane transformation' is suggested which also emphasises that alterations in this plasma membrane during early pregnancy are key to uterine receptivity.展开更多
妊娠期肝内胆汁淤积症（intrahepatie cholestasis of pregnancy，ICP）是妊娠特有的并发症，其严重危害是突然胎死宫内，具体机制尚未明了，可能是急性缺氧的结果，与子宫-胎盘-胎儿单位功能及其血流调节有关。胎盘小叶血管无神经分布...妊娠期肝内胆汁淤积症（intrahepatie cholestasis of pregnancy，ICP）是妊娠特有的并发症，其严重危害是突然胎死宫内，具体机制尚未明了，可能是急性缺氧的结果，与子宫-胎盘-胎儿单位功能及其血流调节有关。胎盘小叶血管无神经分布，子宫-胎盘-胎儿单位血管床血流调控依赖于局部产生和循环中的血管舒张因子。促肾上腺皮质激素释放激素（corticotropin-releasing hormone，CRH）是近年研究较多的血管活性物质，主要由胎盘组织分泌，是妊娠期特殊标志物，对子宫-胎盘-胎儿单位血管具有强效的浓度依赖性舒张作用。展开更多
文摘This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early pregnancy across species. Ultrastructural, biochemical and more general morphological data reveal that strikingly common phenomena occur in this plasma membrane during early pregnancy despite the diversity of placental types-from epitheliochorial to hemochorial, which ultimately form in different species. To encapsulate the concept that common morphological and molecular alterations occur across species, that they are found basolaterally as well as apically, and that moreover they are an ongoing process during much of early pregnancy, not just an event at the time attachment, the term 'plasma membrane transformation' is suggested which also emphasises that alterations in this plasma membrane during early pregnancy are key to uterine receptivity.
文摘妊娠期肝内胆汁淤积症（intrahepatie cholestasis of pregnancy，ICP）是妊娠特有的并发症，其严重危害是突然胎死宫内，具体机制尚未明了，可能是急性缺氧的结果，与子宫-胎盘-胎儿单位功能及其血流调节有关。胎盘小叶血管无神经分布，子宫-胎盘-胎儿单位血管床血流调控依赖于局部产生和循环中的血管舒张因子。促肾上腺皮质激素释放激素（corticotropin-releasing hormone，CRH）是近年研究较多的血管活性物质，主要由胎盘组织分泌，是妊娠期特殊标志物，对子宫-胎盘-胎儿单位血管具有强效的浓度依赖性舒张作用。
