Aim: To determine if photodynamic therapy (PDT) outcomes are related to lesion size in patients with subfoveal predominantly classic choroidal neovascularisat ion (CNV) secondary to age related macular degeneration (A...Aim: To determine if photodynamic therapy (PDT) outcomes are related to lesion size in patients with subfoveal predominantly classic choroidal neovascularisat ion (CNV) secondary to age related macular degeneration (AMD). Methods: Accordin g to greatest linear dimension (GLD) of the entire lesion determined with fluore scein angiography (FA) patients were divided into two groups. In the first group GLD was < 3000 μm and in the second one GLD was 3000-5000 μm. All eyes were treated with standard PDT with the verteporfin protocol. The primary outcome was the proportion of eyes in both groups that did not show significant leakage in FA at the end of follow up. Secondary outcomes were changes in GLD and in best corrected visual acuity (BCVA). Resul ts: 64 patients (mean (SD) age, 76.7 (7.7) years; range 58-95 years) were recru ited to participate in the study. All participants in the study completed the fo llow up time (mean 16.6 months). 24 patients (75%) in the group of smaller lesi ons (n=32) compared with 15 patients (46.8%) in the group of larger lesions (n= 32) did not show significant leakage in FA at the end of follow up (p=0.02). A G LD increase >1000 μm was recorded in nine eyes (28.1%) in the group of smaller lesions and in 16 eyes (50%) in the group of larger lesions (p=0.07). 22 eyes (68.7%) in the group of smaller lesions compared with 19 eyes (59.3%) in the g roup of larger lesions lost less than three lines of vision (p=0.06). Relevant s ide effects related to verteporfin therapy were not recorded, except for four pa tients (6.2%) with infusion related back pain. Conclusions: These results sugge st that lesion size at baseline may be a prognosis factor in PDT in patients wit h subfoveal predominantly classic CNV secondary to AMD. There are no relevant si de effects or safety concerns derived from verteporfin therapy.展开更多
例1患者，男，22岁。双侧耳后肿物10年余，左侧颊部肿物1年余，伴有瘙痒。体检：肿物质软，边界不清，皮肤表面略发紫，无明显溃破现象。追问病史：患者父亲，曾有类似表现，未经治疗，数年后自行消退。 MR平扫示左侧颌面部、两侧耳后...例1患者，男，22岁。双侧耳后肿物10年余，左侧颊部肿物1年余，伴有瘙痒。体检：肿物质软，边界不清，皮肤表面略发紫，无明显溃破现象。追问病史：患者父亲，曾有类似表现，未经治疗，数年后自行消退。 MR平扫示左侧颌面部、两侧耳后、右侧后枕部皮下及右侧腮腺内均可见不规则形、梭形、类圆形团块状异常信号影，大小不一，最大约7．0 cm ×4．2 cm ×4．3 cm，最小约3．7 cm ×1．3 cm ×0．9 cm，边界欠清，T1 WI呈低信号，T2 WI呈等略高信号，T2 stir呈高信号，病灶内信号均匀，无囊变、坏死，周围软组织受推挤，信号未见明显异常，两侧颈动脉鞘、颌下及颈后三角区淋巴结广泛肿大，部分融合，冠状面呈串珠状改变，信号同前；增强扫描：动脉期病灶呈不均匀异常强化，延迟扫描病灶强化程度逐渐加重，增大的淋巴结异常强化。 MR诊断：颅面部嗜酸性淋巴肉芽肿。实验室检查：骨髓象显示淋巴组织增生、淋巴滤泡形成，内含活跃的生发中心，滤泡间见大量增生毛细血管、内皮细胞扁平状，血管周围见大量嗜酸性粒细胞浸润。多肿块穿刺：均可见大量淋巴细胞，较多组织细胞及嗜酸性粒细胞。病理诊断：颅面部嗜酸性淋巴肉芽肿。展开更多
目的探讨高危型人乳头状病毒(HR-HPV)检测及阴道镜检查在意义不明确的宫颈不典型鳞状上皮细胞(ASCUS)中的诊断价值。方法对116例宫颈薄层液基细胞学诊断为ASCUS的患者进行HR-HPV检测和阴道镜宫颈活组织病理检查。结果 116例患者中,经阴...目的探讨高危型人乳头状病毒(HR-HPV)检测及阴道镜检查在意义不明确的宫颈不典型鳞状上皮细胞(ASCUS)中的诊断价值。方法对116例宫颈薄层液基细胞学诊断为ASCUS的患者进行HR-HPV检测和阴道镜宫颈活组织病理检查。结果 116例患者中,经阴道镜宫颈活组织病理检查证实炎症反应86例(74.14%),宫颈内瘤样变(CIN)30例(25.86%)。HR-HPV检测阳性72例,其中检出CIN 22例(CIN I 6例,CIN II 8例,CIN III 8例),CIN检出率30.56%;HR-HPV阴性44例,其中检出CIN 8例,CIN检出率18.18%,均为CIN I病变。结论应用HR-HPV检测可对ASCUS进行分流;阴道镜检查是处理ASCUS、减少宫颈上皮病变漏诊的较好方法。展开更多
目的：探讨乳腺不典型炎性病变超声特征。方法：选择我院2011年1月～2015年1月之间收治经穿刺活组织或手术治疗并经病理检查证实为不典型炎性病变的192例患者为观察对象，其中，乳腺慢性炎症（ CI ）患者40例、肉芽肿性乳腺炎（ GLM）患...目的：探讨乳腺不典型炎性病变超声特征。方法：选择我院2011年1月～2015年1月之间收治经穿刺活组织或手术治疗并经病理检查证实为不典型炎性病变的192例患者为观察对象，其中，乳腺慢性炎症（ CI ）患者40例、肉芽肿性乳腺炎（ GLM）患者56例、乳腺导管扩张症（ MDE）患者96例，所有观察对象均接受超声检查，回顾分析患者声像学表现，总结超声特征。结果：3组观察对象平均年龄、病灶最大平均直径对比具有明显的统计学差异（P＜0．05），病灶纵横比对比无明显的统计学差异（P＞0．05）。3组乳腺炎性疾病患者超声检查结果，显示为病灶内血流信号、合并囊性成分以及均匀回声有差异（P＜0．05），其他检查指标相比无明显的统计学差异（P＞0．05）。结论：乳腺不典型炎性病变声学表现有一定特征，超声医生应提高对该类病症的认识，提高超声诊断率。展开更多
文摘Aim: To determine if photodynamic therapy (PDT) outcomes are related to lesion size in patients with subfoveal predominantly classic choroidal neovascularisat ion (CNV) secondary to age related macular degeneration (AMD). Methods: Accordin g to greatest linear dimension (GLD) of the entire lesion determined with fluore scein angiography (FA) patients were divided into two groups. In the first group GLD was < 3000 μm and in the second one GLD was 3000-5000 μm. All eyes were treated with standard PDT with the verteporfin protocol. The primary outcome was the proportion of eyes in both groups that did not show significant leakage in FA at the end of follow up. Secondary outcomes were changes in GLD and in best corrected visual acuity (BCVA). Resul ts: 64 patients (mean (SD) age, 76.7 (7.7) years; range 58-95 years) were recru ited to participate in the study. All participants in the study completed the fo llow up time (mean 16.6 months). 24 patients (75%) in the group of smaller lesi ons (n=32) compared with 15 patients (46.8%) in the group of larger lesions (n= 32) did not show significant leakage in FA at the end of follow up (p=0.02). A G LD increase >1000 μm was recorded in nine eyes (28.1%) in the group of smaller lesions and in 16 eyes (50%) in the group of larger lesions (p=0.07). 22 eyes (68.7%) in the group of smaller lesions compared with 19 eyes (59.3%) in the g roup of larger lesions lost less than three lines of vision (p=0.06). Relevant s ide effects related to verteporfin therapy were not recorded, except for four pa tients (6.2%) with infusion related back pain. Conclusions: These results sugge st that lesion size at baseline may be a prognosis factor in PDT in patients wit h subfoveal predominantly classic CNV secondary to AMD. There are no relevant si de effects or safety concerns derived from verteporfin therapy.
文摘例1患者，男，22岁。双侧耳后肿物10年余，左侧颊部肿物1年余，伴有瘙痒。体检：肿物质软，边界不清，皮肤表面略发紫，无明显溃破现象。追问病史：患者父亲，曾有类似表现，未经治疗，数年后自行消退。 MR平扫示左侧颌面部、两侧耳后、右侧后枕部皮下及右侧腮腺内均可见不规则形、梭形、类圆形团块状异常信号影，大小不一，最大约7．0 cm ×4．2 cm ×4．3 cm，最小约3．7 cm ×1．3 cm ×0．9 cm，边界欠清，T1 WI呈低信号，T2 WI呈等略高信号，T2 stir呈高信号，病灶内信号均匀，无囊变、坏死，周围软组织受推挤，信号未见明显异常，两侧颈动脉鞘、颌下及颈后三角区淋巴结广泛肿大，部分融合，冠状面呈串珠状改变，信号同前；增强扫描：动脉期病灶呈不均匀异常强化，延迟扫描病灶强化程度逐渐加重，增大的淋巴结异常强化。 MR诊断：颅面部嗜酸性淋巴肉芽肿。实验室检查：骨髓象显示淋巴组织增生、淋巴滤泡形成，内含活跃的生发中心，滤泡间见大量增生毛细血管、内皮细胞扁平状，血管周围见大量嗜酸性粒细胞浸润。多肿块穿刺：均可见大量淋巴细胞，较多组织细胞及嗜酸性粒细胞。病理诊断：颅面部嗜酸性淋巴肉芽肿。
文摘目的探讨高危型人乳头状病毒(HR-HPV)检测及阴道镜检查在意义不明确的宫颈不典型鳞状上皮细胞(ASCUS)中的诊断价值。方法对116例宫颈薄层液基细胞学诊断为ASCUS的患者进行HR-HPV检测和阴道镜宫颈活组织病理检查。结果 116例患者中,经阴道镜宫颈活组织病理检查证实炎症反应86例(74.14%),宫颈内瘤样变(CIN)30例(25.86%)。HR-HPV检测阳性72例,其中检出CIN 22例(CIN I 6例,CIN II 8例,CIN III 8例),CIN检出率30.56%;HR-HPV阴性44例,其中检出CIN 8例,CIN检出率18.18%,均为CIN I病变。结论应用HR-HPV检测可对ASCUS进行分流;阴道镜检查是处理ASCUS、减少宫颈上皮病变漏诊的较好方法。
文摘目的：探讨乳腺不典型炎性病变超声特征。方法：选择我院2011年1月～2015年1月之间收治经穿刺活组织或手术治疗并经病理检查证实为不典型炎性病变的192例患者为观察对象，其中，乳腺慢性炎症（ CI ）患者40例、肉芽肿性乳腺炎（ GLM）患者56例、乳腺导管扩张症（ MDE）患者96例，所有观察对象均接受超声检查，回顾分析患者声像学表现，总结超声特征。结果：3组观察对象平均年龄、病灶最大平均直径对比具有明显的统计学差异（P＜0．05），病灶纵横比对比无明显的统计学差异（P＞0．05）。3组乳腺炎性疾病患者超声检查结果，显示为病灶内血流信号、合并囊性成分以及均匀回声有差异（P＜0．05），其他检查指标相比无明显的统计学差异（P＞0．05）。结论：乳腺不典型炎性病变声学表现有一定特征，超声医生应提高对该类病症的认识，提高超声诊断率。
