目的:探讨微血管密度(M V D)与非小细胞肺癌(N SC LC)侵袭性行为和预后的关系。方法:微波枸椽酸缓冲液抗原修复后采用微波免疫组化染色方法(LSA B)检测778例N SC LC中的M V D与此组病人的性别、年龄、吸烟史、肿瘤大小、组织学类型、分...目的:探讨微血管密度(M V D)与非小细胞肺癌(N SC LC)侵袭性行为和预后的关系。方法:微波枸椽酸缓冲液抗原修复后采用微波免疫组化染色方法(LSA B)检测778例N SC LC中的M V D与此组病人的性别、年龄、吸烟史、肿瘤大小、组织学类型、分化程度和淋巴结有无转移的关系。结果:78例N SC LC标本平均微血管计数为(65.8±14.3)条,实际范围18～112条。有淋巴结转移的微血管为(69.5±15.7)条,无淋巴结转移的微血管为(44.3±14.3)条,M V D与有无转移有非常显著的差异性(P<0.01),与年龄、性别、吸烟史、肿瘤大小以及病理学分级等临床病理学特征无明显关系(P>0.05)。结论:M V D高的病人侵袭性强、转移率高、病人预后差,M V D可作为检测N SC LC病人预后的指标。展开更多
Objective： To research the contributions of p130Cas and PTEN signal molecules to the carcinogenesis of gastric carcinoma and the relationship between them. Methods： Detecting proteins of p130Cas, PTEN and PTEN mRNA ...Objective： To research the contributions of p130Cas and PTEN signal molecules to the carcinogenesis of gastric carcinoma and the relationship between them. Methods： Detecting proteins of p130Cas, PTEN and PTEN mRNA of 76 cases normal gastric mucosa and 112 cases gastric carcinoma by immunohistochemistry EnVision method and molecular hybridization in situ method respectively. Detecting PTEN genetic mutation of 30 cases normal gastric mucosa, 7 cases early gastric cancer and 30 cases progressive gastric cancer by PCR-SSCP. Results： The expression of p130Cas protein of gastric carcinoma increased significantly than that of normal gastric mucosa （P 〈 0.05）. Opposite to above, the expression of PTEN protein of gastric carcinoma group was significantly lower than that of normal gastric rnucosa group （P 〈 0.05）. The expression of PTEN mRNA of gastric carcinoma group decreased obviously than normal gastric mucosa group （P 〈 0.001）. Only one case exon 5 and one case exon 8 of PTEN appeared gene mutation of progressive gastric carcinoma group, the difference has no significance compared with normal gastric mucosa group and early gastric cancer group. Conclusion： The signaling molecules p130Cas and PTEN play an important role in the carcinogenesis of gastric carcinoma, and p130Cas plays the part of promoter, oppositely, maybe PTEN can inhibit it.展开更多
Meningiomas occur in 1%-4% of primary intracranial tumors in the pediatric group, and is increasing in incidence with age. Some authors have reported that meningioma is more prevalent among adult males, but there is n...Meningiomas occur in 1%-4% of primary intracranial tumors in the pediatric group, and is increasing in incidence with age. Some authors have reported that meningioma is more prevalent among adult males, but there is no gender prevalence. The accepted origin of meningiomas is from the arachnoid ceils lining the meninges, or the choroid plexuses. Since Beckwith and Palmer introduced the term ＇rhabdoid tumor＇ in 1978 in reference to a subgroup of childhood malignant renal tumors, many tumors with a rhabdoid morphology have been reported in various sites, including the central nervous system. In 1998 Kepes et al.展开更多
文摘目的:探讨微血管密度(M V D)与非小细胞肺癌(N SC LC)侵袭性行为和预后的关系。方法:微波枸椽酸缓冲液抗原修复后采用微波免疫组化染色方法(LSA B)检测778例N SC LC中的M V D与此组病人的性别、年龄、吸烟史、肿瘤大小、组织学类型、分化程度和淋巴结有无转移的关系。结果:78例N SC LC标本平均微血管计数为(65.8±14.3)条,实际范围18～112条。有淋巴结转移的微血管为(69.5±15.7)条,无淋巴结转移的微血管为(44.3±14.3)条,M V D与有无转移有非常显著的差异性(P<0.01),与年龄、性别、吸烟史、肿瘤大小以及病理学分级等临床病理学特征无明显关系(P>0.05)。结论:M V D高的病人侵袭性强、转移率高、病人预后差,M V D可作为检测N SC LC病人预后的指标。
基金Supported by a grant from Sanitary Science and Technological Development Foundation of Shandong Province (No. 2003HW015)
文摘Objective： To research the contributions of p130Cas and PTEN signal molecules to the carcinogenesis of gastric carcinoma and the relationship between them. Methods： Detecting proteins of p130Cas, PTEN and PTEN mRNA of 76 cases normal gastric mucosa and 112 cases gastric carcinoma by immunohistochemistry EnVision method and molecular hybridization in situ method respectively. Detecting PTEN genetic mutation of 30 cases normal gastric mucosa, 7 cases early gastric cancer and 30 cases progressive gastric cancer by PCR-SSCP. Results： The expression of p130Cas protein of gastric carcinoma increased significantly than that of normal gastric mucosa （P 〈 0.05）. Opposite to above, the expression of PTEN protein of gastric carcinoma group was significantly lower than that of normal gastric rnucosa group （P 〈 0.05）. The expression of PTEN mRNA of gastric carcinoma group decreased obviously than normal gastric mucosa group （P 〈 0.001）. Only one case exon 5 and one case exon 8 of PTEN appeared gene mutation of progressive gastric carcinoma group, the difference has no significance compared with normal gastric mucosa group and early gastric cancer group. Conclusion： The signaling molecules p130Cas and PTEN play an important role in the carcinogenesis of gastric carcinoma, and p130Cas plays the part of promoter, oppositely, maybe PTEN can inhibit it.
文摘Meningiomas occur in 1%-4% of primary intracranial tumors in the pediatric group, and is increasing in incidence with age. Some authors have reported that meningioma is more prevalent among adult males, but there is no gender prevalence. The accepted origin of meningiomas is from the arachnoid ceils lining the meninges, or the choroid plexuses. Since Beckwith and Palmer introduced the term ＇rhabdoid tumor＇ in 1978 in reference to a subgroup of childhood malignant renal tumors, many tumors with a rhabdoid morphology have been reported in various sites, including the central nervous system. In 1998 Kepes et al.
