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中国健康人外周血中具有CD4^+CD25^(nt/hi)CD127^(lo)特征的调节性T细胞频率 被引量:22
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作者 王盈 周磊明 +9 位作者 宫菊丽 周明奎 沈方伟 郑晓虹 张玮 庄鸣华 卢伟 钟平 潘启超 康来仪 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2007年第9期816-818,共3页
目的:初步确定健康人外周血中具有CD4+CD25nt/hiCD127lo特征的调节性T细胞(Treg)频率,为临床相关疾病的研究及Treg的分选提供参考。方法:采集312名8~60岁(5个年龄组)、不同性别健康人的静脉血,经三重免疫荧光染色,用流式细胞术分析CD4+C... 目的:初步确定健康人外周血中具有CD4+CD25nt/hiCD127lo特征的调节性T细胞(Treg)频率,为临床相关疾病的研究及Treg的分选提供参考。方法:采集312名8~60岁(5个年龄组)、不同性别健康人的静脉血,经三重免疫荧光染色,用流式细胞术分析CD4+CD25nt/hiCD127loTreg细胞频率,并观察细胞内Foxp3转录因子的表达。结果:健康人CD4+CD25nt/hiCD127loTreg细胞在外周血中约占CD4+T细胞的(6.55±0.11)%,各年龄组之间有差异(P=0.015),组内性别之间也存在统计学意义(P<0.05);CD25nt/hiCD127lo细胞特异性地表达Foxp3转录因子。结论:初步确定了中国健康人外周血中具有CD4+CD25nt/hiCD127lo表达特征的细胞频率,为Treg细胞的临床研究奠定了基础;CD25nt/hiCD127lo作为CD4+CD25+Treg细胞表面的特征性标志,可在分选时排除其他细胞干扰,获得较完整的Treg细胞。 展开更多
关键词 中国健康人 CD4^+CD25^+调节性T细胞 CD127 FOXP3
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中国健康人血清游离表皮生长因子受体外显子18-22序列分析 被引量:2
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作者 郭野 秦绪珍 +1 位作者 崔巍 李龙芸 《现代检验医学杂志》 CAS 2009年第1期7-10,共4页
目的分析中国健康人血清游离DNA中表皮生长因子受体(EGFR)外显子18~22基因序列是否存在突变,为监测EGFR酪氨酸激酶选择性抑制剂(EGFR TKIs)的临床疗效提供正常参考数据。方法采用高灵敏度DNA提取方法结合高保真巢式PCR和基因测序... 目的分析中国健康人血清游离DNA中表皮生长因子受体(EGFR)外显子18~22基因序列是否存在突变,为监测EGFR酪氨酸激酶选择性抑制剂(EGFR TKIs)的临床疗效提供正常参考数据。方法采用高灵敏度DNA提取方法结合高保真巢式PCR和基因测序技术对42例中国健康人外周血血清游离DNA中EGFR TKIs作用靶点所在结构域即EGFR外显子18-22的基因序列和氨基酸序列进行分析。结果从外周血血清游离DNA中均扩增出EGFR外显子18~22的基因片段,片段大小(分别为400,374,404,408和419bp)与预期设计片段完全相符。健康人外周血游离DNA中存在EGFR基因突变,突变频率出现最多的是EGFR外显子20,41名健康人样本中有7例样本出现1处相同位点的沉默点突变(4838499G→A),其氨基酸序列(Glu)没有发生改变;EGFR外显子18也出现点突变,34名健康人样本中有1名健康者样本出现3处点突变,其中2处点突变(4830989 G→C;4831025 G→C)导致氨基酸序列发生改变(Glu→Gln;Ala-Pro),另外1处点突变(4831000 A→C)为沉默突变,其氨基酸序列(Thr)没有发生变化;EGFR外显子19、外显子21~22没有出现基因突变。结论通过巢式PCR结合基因测序可以分析外周血游离DNA中EGFR基因序列,健康人外周血游离EGFR外显予18和20存在基因点突变,其中外显子18的点突变导致了氨基酸序列改变。 展开更多
关键词 中国健康人 血清 表皮生长因子受体 游离DNA 序列
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HPLC法测定中国健康人血浆中依帕司他浓度及药动学研究 被引量:1
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作者 谢一凡 陈聪颖 +5 位作者 荣征星 赵咏桔 吴兰风 陈泽乃 陆阳 陈红专 《上海第二医科大学学报》 CSCD 2003年第6期502-504,共3页
目的建立血浆中依帕司他的HPLC测定方法,研究依帕司他胶囊在中国健康男性的药动学特性。方法HPLC测定以地西泮作内标,测定20名健康志愿受试者口服50 mg依帕司他胶囊后血药浓度-时间过程。用非房室模型参数估算法计算药动学参数。 结果... 目的建立血浆中依帕司他的HPLC测定方法,研究依帕司他胶囊在中国健康男性的药动学特性。方法HPLC测定以地西泮作内标,测定20名健康志愿受试者口服50 mg依帕司他胶囊后血药浓度-时间过程。用非房室模型参数估算法计算药动学参数。 结果方法回收率大于90%,日内、日间变异系数均低于5%,线性范围20.2~8080 ng/ml(r=0.9996,n=5),最低检测浓度2ng/ml,符合生物样品的分析要求。 结论本研究建立的HPLC测定方法专属性较好,血浆中杂质不干扰样品的测定,适合于依帕司他的临床药动学研究。 展开更多
关键词 HPLC法 测定 中国健康人 血浆 依帕司他 浓度 药动学
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HPLC法测定中国健康人血浆中甲巯咪唑浓度及药动学研究
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作者 谢一凡 陈聪颖 《中国药理通讯》 2003年第1期78-78,共1页
关键词 HPLC法 测定 中国健康人 血浆 甲巯咪唑浓度 药动学研究
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低剂量替格瑞洛在中国健康人群中抗血小板有效性与安全性分析 被引量:4
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作者 奥斯曼江·阿斯木 徐汝明 +3 位作者 张云雁 赵仙先 顾颖 马丽萍 《临床军医杂志》 CAS 2017年第6期575-578,共4页
目的探讨低剂量替格瑞洛在中国健康人群中抗血小板的有效性与安全性。方法随机选取20例健康受试者,其中,10例接受标准剂量替格瑞洛(标准剂量组),10例接受低剂量替格瑞洛(低剂量组)。所有受试者第1天接受负荷剂量,用药后0、0.5、1、2、4... 目的探讨低剂量替格瑞洛在中国健康人群中抗血小板的有效性与安全性。方法随机选取20例健康受试者,其中,10例接受标准剂量替格瑞洛(标准剂量组),10例接受低剂量替格瑞洛(低剂量组)。所有受试者第1天接受负荷剂量,用药后0、0.5、1、2、4、8 h采血;第2天(24 h)、第3天(48 h)、第4天(72 h)接受维持剂量,用药前采血。应用Verify NowP2Y12系统进行血小板功能检测并观察两组受试者主要不良反应。结果用药后0、0.5、1、2、4、8、24、48及72 h,两组P2Y12反应单位(PRU)值与血小板聚集率差异无统计学意义(P>0.05)。用药后0.5 h,标准剂量组与低剂量组血小板聚集率分别为58.5%与53.9%;用药后2~4 h,标准剂量组与低剂量组血小板聚集率达到峰值,分别为98.7%与97.1%,且在8、24、48 h均维持在较高水平。受试者对替格瑞洛均耐受,无严重不良反应发生。标准剂量组出现2例轻微出血事件,低剂量组出现1例轻微出血事件,两组差异无统计学意义(P>0.05)。结论在中国健康人群中,低剂量与标准剂量替格瑞洛均有着较快、较强的血小板抑制作用,且不增加出血风险。 展开更多
关键词 中国健康人 替格瑞洛 低剂量 标准剂量
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匹伐他汀钙片在健康人体内单、多剂量的药动学
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作者 张维 宋颖 +6 位作者 贾艳艳 李雪晴 陈敏纯 刘美佑 宋薇 周伦 文爱东 《中国新药与临床杂志》 CAS CSCD 北大核心 2013年第2期135-139,共5页
目的研究匹伐他汀钙片在中国健康人体内的单、多剂量药动学。方法 30名健康志愿者随机分为3组,分别单剂量口服匹伐他汀钙片l、2、4 mg进行单剂量药动学研究,2 mg剂量组继续给药7 d,进行多剂量药动学研究。血药浓度用液相色谱-串联质谱(L... 目的研究匹伐他汀钙片在中国健康人体内的单、多剂量药动学。方法 30名健康志愿者随机分为3组,分别单剂量口服匹伐他汀钙片l、2、4 mg进行单剂量药动学研究,2 mg剂量组继续给药7 d,进行多剂量药动学研究。血药浓度用液相色谱-串联质谱(LC-MS/MS)法测定。结果健康受试者单剂量给药匹伐他汀钙片l、2、4 mg后,主要的药动学参数分别为tmax分别为(0.61±0.11)、(0.62±0.21)、(0.62±0.11)h,ρmax分别为(23.79±3.54)、(59.66±43.08)、(91.44±33.26) μg·L-1,AUC0-48 h分别为(59.81±12.34)、(126.8±97.90)、(216.8±34.75)μg·h·L-1,tl/2分别为(12.14±1.51)、(10.43±2.24)、(12.33±0.85)h;多剂量给药达稳态时,主要的药动学参数为tmax(0.83±0.14)h,ρmax(51.45±39.93) μg·L-1,AUCss(131.80±110.7)μg·h·L-1,t1/2(11.74±3.22)h,CL(19.92±10.54)L.h-1,ρav(5.49±4.61) μg·L-1,DF(9.43±1.21)%。结论匹伐他汀在连续多次给药后,体内无蓄积现象,血药浓度4 d已达稳态。在1~4 mg剂量范围内匹伐他汀的ρmax、AUC0-48 h和AUC0-∞均与剂量呈线性关系。 展开更多
关键词 药动学参数 多剂量给药 匹伐他汀 中国健康人 钙片 体内 单剂量口服 单剂量给药
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Social isolation and health-promoting behaviors among older adults living with different health statuses:A cross-sectional study 被引量:7
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作者 Fan Wu Yu Sheng 《International Journal of Nursing Sciences》 CSCD 2021年第3期304-309,I0005,共7页
Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health statuses.Methods:Totally 485 older adults were recruited.Th... Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health statuses.Methods:Totally 485 older adults were recruited.They were divided into three groups based on their health status:healthy group(n=72),group with one disease(n=183)and group with multimorbidity(n=230).Lubben Social Network Scale-6 and Health-Promoting Lifestyle Profile II were used to measure their social isolation and health-promoting behaviors,respectively.Results:Among the aged with one disease or multimorbidity,30.6%(56/183)and 31.7%(73/230)were socially isolated,respectively,based on the score of the Lubben Social Network Scale-6.The three groups differed significantly in health-promoting behaviors and scores on several subscales.The group with multimorbidity exhibited more social isolation and fewer health-promoting behaviors than other groups.Social isolation was among the factors adversely affecting health-promoting behaviors in older adults.Conclusions:Health care providers should help older adults with multimorbidity preserve the remaining abilities to improve health-promoting behaviors.Meanwhile,it is important to support healthy older adults to increase self-responsibility to achieve healthy aging. 展开更多
关键词 Aged China Healthy aging Health status MULTIMORBIDITY Healthy lifestyle Social isolation
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Impacts of Climate Change on Human Health and Adaptation Strategies in South China 被引量:2
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作者 DU Yao-Dong WANG Xian-Wei +3 位作者 YANG Xiao-Feng MA Wen-Jun AI Hui WU Xiao-Xuan 《Advances in Climate Change Research》 SCIE 2013年第4期208-214,共7页
This study reviews the impacts of climate change on human health and presents corresponding adaptation strategies in South China. The daily mean surface air temperatures above or below 26.4~C increase the death risk f... This study reviews the impacts of climate change on human health and presents corresponding adaptation strategies in South China. The daily mean surface air temperatures above or below 26.4~C increase the death risk for people in Guangzhou, especially the elderly are vulnerable to variations in temperature. Heat waves can cause insomnia, fatigue, clinical exacerbation, or death from heatstroke etc., while cold spells show increases in patients with fractures. During a cold spell period, the rates of both on-site emergency rescues and non-implementable rescues increase, and the risk of non-accidental deaths and respiratory disease deaths significantly rise as well. Both time series of hazy days and ozone concentrations have significant positive correlations with the number of patients with cardiovascular diseases. Both malaria and dengue fever reach higher altitudes and mountainous areas due to climate warming. Climate change is likely to bring stronger heat waves in the future, thereby increasing heat wave-related illnesses and deaths, particularly in the metropolitan areas of the Pearl River Delta. The projected increase of consecutive cold days in Guangdong province and parts of northern Guangxi province will affect residents' health in the future. The rising temperature exaggerates ozone pollution, but it is not clear whether climate change is aggravating or mitigating haze pollution. The transmission potential of malaria in South China will increase by 39%-140% and the transmission season will extend by 1 2 months with an air temperature increase of 1-2~C. By 2050, most areas in Hainan province are projected to convert from non-endemic dengue into endemic dengue areas. The aging population will cause more vulnerable people. To mitigate the adverse impacts of climate change on human health, sound and scientific adaptation strategies must be adopted in advance, such as strengthening the surveillance of epidemic diseases in potential transmission areas, conducting timely weather forecasting for human health, evaluating health vulnerability to climate change, improving environmental and health education, and strengthening hazard management and the cooperation between meteorological and health departments. 展开更多
关键词 climate change human health impact assessment adaptation strategy
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Structure analysis and performance measurement of Chinese health de-livery system
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作者 欧崇阳 张鹭鹭 +2 位作者 田伟 卢杨 马玉琴 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第6期364-369,共6页
Objective:Although evidence has already demonstrated that the performance of Health Deliv- ery System(HDS) varies widely across nations,relatively little is known about the factors that give rise to these variations a... Objective:Although evidence has already demonstrated that the performance of Health Deliv- ery System(HDS) varies widely across nations,relatively little is known about the factors that give rise to these variations and the key point to improve the performance besides adjusting system structure.By setup of HDS performance measurement system on the base of association of financial,social,and environmental characteristics,we construct system dynamic model of HDS to simulate the invention policies.Methods: Performance measures were collected from HDS in 31 regions of China and combined with secondary data sources.Multivariate,linear,nonlinear regression and factor analysis models were used to estimate associ- ations between system characteristics and the performance.Results:Performance varied significantly with the size,financial resources and organizational structure of HDS.Performance measurement system of health delivery system was developed to give the rank of all Chinese regions.Conclusion:Performance measurement system of HDS is the basic of HDS modeling by system dynamic. 展开更多
关键词 health delivery system performance measurement population health
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Population-based Cohort Study in Outcome of Phased Progression of Atherosclerosis in China (PERSUADE): objective, rationale and design 被引量:2
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作者 Dong-Kai SHAN Yong ZHOU +4 位作者 You-Xin WANG Xiang GAO Wei WANG Jun-Jie YANG Yun-Dai CHEN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第8期491-495,共5页
The coronary artery calcification score and pericardial fat volume have recently been reported to be strongly associated with the severity and presence of coronary atherosclerosis. However, no studies have explored th... The coronary artery calcification score and pericardial fat volume have recently been reported to be strongly associated with the severity and presence of coronary atherosclerosis. However, no studies have explored the outcome of phased progression of atherosclerosis by non-contrast computed tomography in asymptomatic people in China. The population-based cohort study in outcome of phased progression of atherosclerosis in China (PERSUADE), an observational, longitudinal and prospective cohort study in a target population of healthy sub- jects based in Jidong Oilfield (China), prospectively analyzes the outcome of phased progression of atherosclerosis by non-contrast computed tomography in healthy population. The results of this study are expected to be of value for utilizing noninvasive imaging combine with tradi- tional cardiovascular risk factors to create a risk stratification and find pertinent biomarkers associated with the outcome of phased progres- sion of atherosclerosis in healthy people, thereby could help to establish a more personalized treatment of clinical practice. 展开更多
关键词 ATHEROSCLEROSIS Cardiovascular events Chest computed tomography
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The distribution of 10-year cardiovascular risk in Chinese adults: analysis of the China Health Examination Database (CHED) 2008 被引量:1
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作者 Liu-Xin Wu Qiang Zen Dong-Chang Qiang 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2010年第3期131-137,共7页
Objective Global cardiovascular risk assessment has been incorporated into current Chinese guidelines for the management of hypertension and hypercholesterolemia. The aim of our study is to determine the distribution ... Objective Global cardiovascular risk assessment has been incorporated into current Chinese guidelines for the management of hypertension and hypercholesterolemia. The aim of our study is to determine the distribution of 10-year risk for ischemic cardiovascular disease (ICVD) among middle-aged Chinese adults, and to evaluate the usefulness of global risk assessment tools in the primary prevention of ICVD in Chinese population.Methods Simplified prediction tools derived from the USA-PRC Collaborative Study of Cardiovascular Epidemiology cohort were applied to the Chinese Health Examination Database (CHED) 2008. 10-year risk for ICVD was estimated in 461 157 ICVD-free subjects (264 432 male and 196 725 female) aged 35 to 59 years. Results Among the male subjects, 82.4% had a 10-year risk for ICVD of 〈5%, 14.4% of 5% to 12.1% and 3.4 of≥ 12.2%, and in female subjects, 86.7% had a 10-year risk for ICVD of 〈5%, 12.1% of 5% to 12.0% and 1.2% of ≥ 12.1%. All subjects with predicted high level ICVD risk (≥ 12.2% in male or ≥ 12.1% in female) had either remarkably elevated (≥ 160 mmHg) blood pressure, significantly increased (≥ 6.22 mml/L) total serum cholesterol or diabetes.Conclusion Using the currently recommended prediction tools, only very small proportions of middle-aged Chinese men and women who were free of ICVD would be classified into high level risk group. These prediction tools are unlikely to help for the medical intervention decision making in Chinese adult patients with hypertension and/or hypercholesterolemia 展开更多
关键词 cardiovascular disease HYPERTENSION HYPERCHOLESTEROLEMIA PREVENTION Chinese
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Shifting towards a Mediterranean Diet in the US: How Far Do We Have to Go, What Are the Potential Health Benefits and Can We Get There?
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作者 Allison Cappelaere Righter Arlin Wasserman 《Journal of Agricultural Science and Technology(B)》 2015年第8期575-587,共13页
In the public dialogue surrounding the development of the 2015 dietary guidelines for Americans, public health and environmental advocates converged around a simple theme of shifting towards a more plant-forward Medit... In the public dialogue surrounding the development of the 2015 dietary guidelines for Americans, public health and environmental advocates converged around a simple theme of shifting towards a more plant-forward Mediterranean-style diet. A robust body of literature documenting the health benefits of this eating pattern provides compelling reasons to change our dietary habits in ways that also benefit our environment, but we also need to have the right foods available and affordable to support this modest shift. This commentary discusses the gaps in current US dietary intakes compared to recommendations for meat and protein versus plant-based foods and the potential health benefits of shifting towards a more plant-based diet, focusing on the complex role of Mediterranean crops, such as tree nuts and olive oils, needed to support this shift. 展开更多
关键词 NUTRITION public health sustainable Mediterranean diet environment food systems tree nuts olive oil.
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Strategic Analysis on the Harmonious Regional Development of the Chinese Population Health 被引量:1
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作者 Jing ZHOU Hao WU 《International Journal of Technology Management》 2015年第11期71-73,共3页
Since the reform and opening-up policy was implemented in China, the development of China' s medical and health undertakings has been very significant along with the rapid development of economy, and the people' s h... Since the reform and opening-up policy was implemented in China, the development of China' s medical and health undertakings has been very significant along with the rapid development of economy, and the people' s health level is steadily improved and the life expectancy is on the top list in the developing world. However, there are remarkable health differences among urban and rural areas, different regions, and small, medium-sized and large cities. In this paper, on the basis of the healthy social economic decision theory, the characteristics and causes of the regional difference between China' s residents in the health level are systematically analyzed, and then the strategies for the harmonious regional development of the Chinese population health are deeply discussed. 展开更多
关键词 Residents' Health Regional Difference Harmonious Development
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Development Status and Prospect of Healthy Sports Industry
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作者 Jianjun ZHU 《International Journal of Technology Management》 2015年第3期4-6,共3页
Our health sports industry from small to large, continuous development is gradually standardized and mature. As China' s economic development and people' s consumption level of escalation of health sports industry m... Our health sports industry from small to large, continuous development is gradually standardized and mature. As China' s economic development and people' s consumption level of escalation of health sports industry made a historic breakthrough. Our health sports industry in recent years, despite considerable progress, but the constraints of economic, social, and other resources by healthy sports industry slow growth. Health Situation of the sports industry research is to identify bottleneck healthy development of sports industry. It has an important significance to promote the development of the health of the sports industry. 展开更多
关键词 Health Sports Industry Development Status PROSPECTS
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SEROPREVALENCE OF HUMAN HERPESVIRUS-6 IN HEALTHY POPULATION IN TWO PROVINCES OF NORTH CHINA
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作者 乌正赉 沐桂藩 王璐 《Chinese Medical Sciences Journal》 CAS CSCD 1997年第2期111-114,共4页
Background. Human herpesvirus-6 (HHV-6) infection is ubiquitous in selected population with sero-prevalence of 60-80%. Little is known for that in China, except few sporadic studies. To understand prevalence of HHV-6 ... Background. Human herpesvirus-6 (HHV-6) infection is ubiquitous in selected population with sero-prevalence of 60-80%. Little is known for that in China, except few sporadic studies. To understand prevalence of HHV-6 antibody in Chinese population,this seroepidemiological study was conducted.Methods. Sera were collected from 430 healthy persons and donors living in North China,and tested for HHV-6 antibodies using IFA with HHV-6 GS strain passaged on HSB-2 cells as antigen, and titer e-qual or higher than 1:10 was regarded as seropositive.Results. Of the 430 serum samples tested,297 (69.1%) were positive for HHV-6 IgG. Both seropositive rate and GMT in females were significantly higher than those in males,with X2 = 7. 05,P<0. 01 and F = 7.23,P<0. 01,respectively. Statistically significant difference in prevalence of HHV-6 antibody among various age groups was observed in both sexes,with X2=20. 08 and 20. 28,P = 0. 04,respectively,and young children had a higher titer than adults. But, no significant difference in prevalence was observed in blood donors between various age groups or both sexes.Conclusions. This study suggests that HHV-6 infection with seropositive IgG is ubiquitous in North China,and its importance should be further studied. 展开更多
关键词 human herpesvirus-6 SEROEPIDEMIOLOGY indirect fluorescence assay
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Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project 被引量:73
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作者 Chao Han Fangchao Liu +13 位作者 Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu 《Science China(Life Sciences)》 SCIE CAS CSCD 2018年第5期504-514,共11页
Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics o... Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. 展开更多
关键词 cardiovascular health ASCVD cohort China
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Data mining-based study on sub-mentally healthy state among residents in eight provinces and cities in China 被引量:3
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作者 Hongmei Ni Xuming Yang +3 位作者 Chengquan Fang Yingying Guo Mingyue Xu Yumin He 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2014年第4期511-517,共7页
OBJECTIVE: To apply data mining methods to research on the state of sub-mental health among residents in eight provinces and cities in China and to mine latent knowledge about many conditions through data mining and a... OBJECTIVE: To apply data mining methods to research on the state of sub-mental health among residents in eight provinces and cities in China and to mine latent knowledge about many conditions through data mining and analysis of data on 3970 sub-mentally healthy individuals selected from 13385 relevant question naires.METHODS: The strategic tree algorithm was used to identify the main mani festations of the state of sub-mental health. The backpropogation artificial neural network was used to analyze the main mani festations of sub-healthy mental states of three different degrees. A sub-mental health evaluation model was then established to achieve predictive evaluationresults.RESULTS: Using classifications from the Scale of Chinese Sub-healthy State, the main manifestations of sub-mental health selected using the strate gictree were F1101(Do you lack peace of mind?),F1102(Are you easily nervous when something comes up?), and F1002(Do you often sigh?). The relative intensity of manifestations of sub-mental health was highest for F1101, followed by F1102,and then F1002. Through study of the neural network, better differentiation could be made between moderate and severe and between mild and severe states of sub-mental health. The differentiation between mild and moderate sub-mental health states was less apparent. Additionally, the sub-mental health state evaluation model, which could be used to predict states of sub-mental health of different individuals, was established using F1101, F1102, F1002, and the mental self-assessment totals core.CONCLUSION: The main manifestations of the state of sub-mental health can be discovered using data mining methods to research and analyze the latent laws and knowledge hidden in research evidence on the state of sub-mental health. The state of sub-mental health of different individuals can be rapidly predicted using the model established here.This can provide a basis for assessment and intervention for sub-mental health. It can also replace the relatively outdated approaches to research on sub-health in the technical era of information and digitization by combining the study of states of sub-mental health with information techniques and by further quantifying the relevant information. 展开更多
关键词 Questionnaires Mental health Data mining Strategictree Artificial neural network
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