The “mainstream” climatology (MSC)—i.e. which includes the Intergovernmental Panel on Climate Change (IPCC) community—considers the present day massive release of greenhouse gases into the atmosphere as the main c...The “mainstream” climatology (MSC)—i.e. which includes the Intergovernmental Panel on Climate Change (IPCC) community—considers the present day massive release of greenhouse gases into the atmosphere as the main cause of the current global warming trend. The main inference from this stance is that the increase in temperature must occur after the release of greenhouse gases originating from the anthropic activities. However, no scientific evidence has been provided for this basic notion. Earth paleoclimatic records document the antecedence of temperature over CO<sub>2</sub> levels. For the past 65 Ma, the temperature parameter has controlled the subsequent increase in CO<sub>2</sub>. This includes the three rapid aberrant shifts and extreme climate transients at 55 Ma, 34 Ma, and 23 Ma REF _Ref159913672 \r \h \* MERGEFORMAT [1]. The simple fact of their existence points to the potential for highly nonlinear responses in climate forcing. Whatever these shifts and transients are, CO<sub>2</sub> remains a second order parameter in their evolution through time. Confronted with the past, a suitable response must therefore be given to the unresolved question of whether the CO<sub>2</sub> trends precede the temperature trends in the current period, or not. The assertion that the current global warming is anthropogenic in origin implicitly presupposes a change of paradigm, with the consequence (the increase in CO<sub>2</sub> levels) that occurred in Earth’s past being positioned as the cause of the warming for its present day climatic evolution. The compulsory assumption regarding the antecedence of CO<sub>2</sub> levels over the temperature trends is associated with the haziness of the methodological framework—i.e. the paradigm—and tightens the research fields on the likely origins of global warming. The possible involvement of an “aberrant” natural event, hidden behind the massive release of greenhouse gases, has not been considered by the MSC.展开更多
Arguments that global warming in the Earth’s atmosphere of the last 70 years is partially or entirely caused by changes in the solar magnetic field are presented in the work. Global warming is probably a consequence ...Arguments that global warming in the Earth’s atmosphere of the last 70 years is partially or entirely caused by changes in the solar magnetic field are presented in the work. Global warming is probably a consequence of ionizing radiation emitted from the Sun mainly in the “rise” phase of solar activity. The ionizing radiation is positively charged particles with high energy. They penetrate deep into the Earth’s atmosphere, creating increased content of ions serving as condensation nuclei. The condensation nuclei increase cloudiness in the lower atmosphere and lower the surface air temperature. When solar activity decreases as observed in the last 70 years, the reverse process occurs— cloud cover decreases, more solar electromagnetic radiation reaches the earth’s surface and increases the temperature. An additional argument for the presence of high-energy radiation that penetrates deeply into the Earth’s atmosphere and even reaches the Earth’s surface is the high statistically significant correlation between the fluxes of such radiation recorded by GOES series satellites in a geostationary orbit (36,000 km above the Earth’s surface) and the human mortality from deadliest diseases.展开更多
We compare observed with predicted distributions of galaxy stellar masses M<sub>* </sub>and galaxy rest-frame ultra-violet luminosities per unit bandwidth L<sub>UV</sub>, in the redsh...We compare observed with predicted distributions of galaxy stellar masses M<sub>* </sub>and galaxy rest-frame ultra-violet luminosities per unit bandwidth L<sub>UV</sub>, in the redshift range z=2 to 13. The comparison is presented as a function of the comoving warm dark matter free-streaming cut-off wavenumber k<sub>fs</sub>. For this comparison the theory is a minimal extension of the Press-Schechter formalism with only two parameters: the star formation efficiency, and a proportionality factor between the star formation rate per galaxy and LUV</sub>. These two parameters are fixed to their values obtained prior to the James Webb Space Telescope (JWST) data. The purpose of this comparison is to identify if, and where, detailed astrophysical evolution is needed to account for the new JWST observations.展开更多
Changes in CO2 and temperature are correlated, but it is difficult to observe which is the cause and which is the effect. The release of CO2 dissolved in the ocean into the atmosphere depends on the atmospheric temper...Changes in CO2 and temperature are correlated, but it is difficult to observe which is the cause and which is the effect. The release of CO2 dissolved in the ocean into the atmosphere depends on the atmospheric temperature. However, examining the relationship between changes in CO2 caused by other phenomena and temperature is difficult. Studies of soil respiration (Rs) since the late 20th century have shown that CO2 emissions from soil respiration (Rs) are overwhelmingly greater than CO2 emissions from fossil fuel combustion. This is also noted in the IPCC carbon budget assessment. In this paper, the dependences of Rs on temperature, time, latitude, precipitation, seasons, etc., were investigated using the latest NASA database. The changes in temperature and Rs correlated well. There is also a good correlation between Rs and CO2 generation. Therefore, an increase in temperature results in an increase in CO2. On the other hand, there is no evidence other than model calculations that an increase in anthropogenic CO2 is mainly linked to a rise in temperature. The idea that global warming is caused by anthropogenic CO2 production is still a hypothesis. For these reasons, the relationship between global warming and anthropogenic CO2 should be reconsidered based on physical evidence without preconceptions. .展开更多
The use of air conditioning and refrigeration systems improved the standard of living. However, the system contributes to global warming by releasing potential global warming refrigerants directly and powering the sys...The use of air conditioning and refrigeration systems improved the standard of living. However, the system contributes to global warming by releasing potential global warming refrigerants directly and powering the system. There is an obligation, like UN Kyoto Protocol, EU MAC Directive and Japan METI Directive to find an alternative low-GWP refrigerant with excellent thermophysical properties. In this paper, the global warming effect of an air-conditioning system is analyzed theoretically using few low-GWP refrigerant mixtures. New refrigerant mixtures are formed based on low GWP, high volumetric capacity, and refrigerating effect. After analyzing, refrigerant blends of R1234yf/R32 (40/60, 50/50, and 60/40 by wt%) and R1234ze/R32 (40/60, 50/50, and 60/40 by wt%) are found promising to replace the widely used R410A. The best performance of the refrigerant blend is found for R1234yf/R32 (40/60). These analyses are crucial for selecting suitable refrigerants for domestic air conditioning systems.展开更多
In this study, we investigated the variations in warming between Japanese cities for 1960-1989, and 1990-2019 using principal component analysis (PCA) and k-means clustering. The precipitation and sunshine hours exhib...In this study, we investigated the variations in warming between Japanese cities for 1960-1989, and 1990-2019 using principal component analysis (PCA) and k-means clustering. The precipitation and sunshine hours exhibited opposite tendencies in the PCA results. It was found that 1960M and 1990M had a correlation (r = 0.51). The 1960M and 1990M are the mean temperature anomalies in Japanese cities for 1960-1989 and 1990-2019, respectively. There was a strong correlation between temperature and precipitation (r = 0.62). There was an inverse correlation between 1960M and sunshine hours (r = −0.25), but a correlation between 1990M and sunshine hours (r = 0.11). Sunshine hours had less effect on the 1960M but more impact on the 1990M. The k-means clustering for 1960M and 1990M can be classified into four types: high 1960M and high 1990M, which indicates that global warming is progressing rapidly (Sapporo, Tokyo, Kyoto, Osaka, Fukuoka, Nagasaki), low 1960M and low 1990M, global warming is progressing slowly (Nemuro, Ishinomaki, Yamagata, Niigata, Fushiki, Nagano, Karuizawa, Mito, Suwa, Iida, Hamada, Miyazaki, Naha), low 1960M and high 1990M, global warming has accelerated since 1990 (Utsunomiya, Kofu, Okayama, Hiroshima), and normal 1960M and normal 1990M, the rate of warming is normal among the 38 cities (Asahikawa, Aomori, Akita, Kanazawa, Maebashi, Matsumoto, Yokohama, Gifu, Nagoya, Hamamatsu, Kochi, Kagoshima). Higher annual temperatures were correlated with higher annual precipitation according to the k-means clustering of temperature and precipitation. Two of the four categories consisted of places with high annual temperatures and high precipitation (Fushiki, Kanazawa, Kochi, Miyazaki, Kagoshima, Naha, Ishigakijima), and places with low annual temperatures and low precipitation (Asahikawa, Nemuro, Sapporo, Karuizawa).展开更多
文摘The “mainstream” climatology (MSC)—i.e. which includes the Intergovernmental Panel on Climate Change (IPCC) community—considers the present day massive release of greenhouse gases into the atmosphere as the main cause of the current global warming trend. The main inference from this stance is that the increase in temperature must occur after the release of greenhouse gases originating from the anthropic activities. However, no scientific evidence has been provided for this basic notion. Earth paleoclimatic records document the antecedence of temperature over CO<sub>2</sub> levels. For the past 65 Ma, the temperature parameter has controlled the subsequent increase in CO<sub>2</sub>. This includes the three rapid aberrant shifts and extreme climate transients at 55 Ma, 34 Ma, and 23 Ma REF _Ref159913672 \r \h \* MERGEFORMAT [1]. The simple fact of their existence points to the potential for highly nonlinear responses in climate forcing. Whatever these shifts and transients are, CO<sub>2</sub> remains a second order parameter in their evolution through time. Confronted with the past, a suitable response must therefore be given to the unresolved question of whether the CO<sub>2</sub> trends precede the temperature trends in the current period, or not. The assertion that the current global warming is anthropogenic in origin implicitly presupposes a change of paradigm, with the consequence (the increase in CO<sub>2</sub> levels) that occurred in Earth’s past being positioned as the cause of the warming for its present day climatic evolution. The compulsory assumption regarding the antecedence of CO<sub>2</sub> levels over the temperature trends is associated with the haziness of the methodological framework—i.e. the paradigm—and tightens the research fields on the likely origins of global warming. The possible involvement of an “aberrant” natural event, hidden behind the massive release of greenhouse gases, has not been considered by the MSC.
文摘Arguments that global warming in the Earth’s atmosphere of the last 70 years is partially or entirely caused by changes in the solar magnetic field are presented in the work. Global warming is probably a consequence of ionizing radiation emitted from the Sun mainly in the “rise” phase of solar activity. The ionizing radiation is positively charged particles with high energy. They penetrate deep into the Earth’s atmosphere, creating increased content of ions serving as condensation nuclei. The condensation nuclei increase cloudiness in the lower atmosphere and lower the surface air temperature. When solar activity decreases as observed in the last 70 years, the reverse process occurs— cloud cover decreases, more solar electromagnetic radiation reaches the earth’s surface and increases the temperature. An additional argument for the presence of high-energy radiation that penetrates deeply into the Earth’s atmosphere and even reaches the Earth’s surface is the high statistically significant correlation between the fluxes of such radiation recorded by GOES series satellites in a geostationary orbit (36,000 km above the Earth’s surface) and the human mortality from deadliest diseases.
文摘We compare observed with predicted distributions of galaxy stellar masses M<sub>* </sub>and galaxy rest-frame ultra-violet luminosities per unit bandwidth L<sub>UV</sub>, in the redshift range z=2 to 13. The comparison is presented as a function of the comoving warm dark matter free-streaming cut-off wavenumber k<sub>fs</sub>. For this comparison the theory is a minimal extension of the Press-Schechter formalism with only two parameters: the star formation efficiency, and a proportionality factor between the star formation rate per galaxy and LUV</sub>. These two parameters are fixed to their values obtained prior to the James Webb Space Telescope (JWST) data. The purpose of this comparison is to identify if, and where, detailed astrophysical evolution is needed to account for the new JWST observations.
文摘Changes in CO2 and temperature are correlated, but it is difficult to observe which is the cause and which is the effect. The release of CO2 dissolved in the ocean into the atmosphere depends on the atmospheric temperature. However, examining the relationship between changes in CO2 caused by other phenomena and temperature is difficult. Studies of soil respiration (Rs) since the late 20th century have shown that CO2 emissions from soil respiration (Rs) are overwhelmingly greater than CO2 emissions from fossil fuel combustion. This is also noted in the IPCC carbon budget assessment. In this paper, the dependences of Rs on temperature, time, latitude, precipitation, seasons, etc., were investigated using the latest NASA database. The changes in temperature and Rs correlated well. There is also a good correlation between Rs and CO2 generation. Therefore, an increase in temperature results in an increase in CO2. On the other hand, there is no evidence other than model calculations that an increase in anthropogenic CO2 is mainly linked to a rise in temperature. The idea that global warming is caused by anthropogenic CO2 production is still a hypothesis. For these reasons, the relationship between global warming and anthropogenic CO2 should be reconsidered based on physical evidence without preconceptions. .
文摘The use of air conditioning and refrigeration systems improved the standard of living. However, the system contributes to global warming by releasing potential global warming refrigerants directly and powering the system. There is an obligation, like UN Kyoto Protocol, EU MAC Directive and Japan METI Directive to find an alternative low-GWP refrigerant with excellent thermophysical properties. In this paper, the global warming effect of an air-conditioning system is analyzed theoretically using few low-GWP refrigerant mixtures. New refrigerant mixtures are formed based on low GWP, high volumetric capacity, and refrigerating effect. After analyzing, refrigerant blends of R1234yf/R32 (40/60, 50/50, and 60/40 by wt%) and R1234ze/R32 (40/60, 50/50, and 60/40 by wt%) are found promising to replace the widely used R410A. The best performance of the refrigerant blend is found for R1234yf/R32 (40/60). These analyses are crucial for selecting suitable refrigerants for domestic air conditioning systems.
文摘In this study, we investigated the variations in warming between Japanese cities for 1960-1989, and 1990-2019 using principal component analysis (PCA) and k-means clustering. The precipitation and sunshine hours exhibited opposite tendencies in the PCA results. It was found that 1960M and 1990M had a correlation (r = 0.51). The 1960M and 1990M are the mean temperature anomalies in Japanese cities for 1960-1989 and 1990-2019, respectively. There was a strong correlation between temperature and precipitation (r = 0.62). There was an inverse correlation between 1960M and sunshine hours (r = −0.25), but a correlation between 1990M and sunshine hours (r = 0.11). Sunshine hours had less effect on the 1960M but more impact on the 1990M. The k-means clustering for 1960M and 1990M can be classified into four types: high 1960M and high 1990M, which indicates that global warming is progressing rapidly (Sapporo, Tokyo, Kyoto, Osaka, Fukuoka, Nagasaki), low 1960M and low 1990M, global warming is progressing slowly (Nemuro, Ishinomaki, Yamagata, Niigata, Fushiki, Nagano, Karuizawa, Mito, Suwa, Iida, Hamada, Miyazaki, Naha), low 1960M and high 1990M, global warming has accelerated since 1990 (Utsunomiya, Kofu, Okayama, Hiroshima), and normal 1960M and normal 1990M, the rate of warming is normal among the 38 cities (Asahikawa, Aomori, Akita, Kanazawa, Maebashi, Matsumoto, Yokohama, Gifu, Nagoya, Hamamatsu, Kochi, Kagoshima). Higher annual temperatures were correlated with higher annual precipitation according to the k-means clustering of temperature and precipitation. Two of the four categories consisted of places with high annual temperatures and high precipitation (Fushiki, Kanazawa, Kochi, Miyazaki, Kagoshima, Naha, Ishigakijima), and places with low annual temperatures and low precipitation (Asahikawa, Nemuro, Sapporo, Karuizawa).
文摘温抗体型自身免疫性溶血性贫血(warm autoimmune hemolytic anemia,wAIHA)是由自身抗体介导的自身免疫性疾病。随着对wAIHA免疫发病机制的深入理解,针对免疫系统不同靶点的药物研发取得了显著进展,为wAIHA患者的治疗提供了更多选择。以新型CD20单抗、Bruton酪氨酸激酶(Bruton tyrosine kinase,BTK)抑制剂、磷脂酰肌醇3激酶(phosphatidylinositol 3-kinases,PI3K)抑制剂和B淋巴细胞活化因子(B-cell activating factor of the TNF family,BAFF)抑制剂等为代表的抗B细胞靶向治疗,以及以蛋白酶体抑制剂和CD38单抗为代表的抗浆细胞靶向治疗均取得了显著成效。此外,补体抑制剂、新生儿Fc受体(neonatal Fc receptor,FcRn)单抗、脾酪氨酸激酶(spleen tyrosine kinase,SYK)抑制剂、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)抑制剂等也取得了显著进展。本文对近年来wAIHA的免疫靶向治疗进展进行综述,以期为临床实践提供参考。
