The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three ...The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.展开更多
According to our analysis of variations in Chinas＇ industrial growth rate. industrial demand, industrial structure, regional structure and the performance of industrial firms, China ＇s＇ industrial economv is moving...According to our analysis of variations in Chinas＇ industrial growth rate. industrial demand, industrial structure, regional structure and the performance of industrial firms, China ＇s＇ industrial economv is moving towards＇ a ＂new normal＂ of slower growth and structural improvement. This process coincides with the late stage of China＇s industrialization, which international experience suggests is often frauht with twists and challenges. Among these challenges, great attention must be paid to overcapacity industrial restructuring and upgrades, and the ＂reindustrialization＂ of developed countries. As China enters the late stage of its industrialization, particularly during the 13th Five-Year Plan period from 2016 to 2020, the promotion of industrial development is of strategic significance for China to successfully complete industrialization and its economy to adapt to the ＂new normal ＂. In the face of these new challenges regarding industrial development, policymakers must strive to increase the dynamism of growth for industrial economy. In this new era, the momentum of industrial growth derives from the integration of the supply impetus of industrialization and the pull of demand caused by urbanization, while, the comprehensive deepening of refom provides the key source of momentum.展开更多
Singapore's remarkable economic development in the past five decades since independence has attracted much policy attention.This article first provides a brief overview of Singapore's economic development.The ...Singapore's remarkable economic development in the past five decades since independence has attracted much policy attention.This article first provides a brief overview of Singapore's economic development.The second part discusses Singapore's development strategies that are aligned with the Washington Consensus:globalisation,conservative fiscal and monetary policies,investments in education and infrastructure.It also discusses the policies adopted to further enhance the outcomes of such policies.The third part focusses on policies that are inconsistent with the prescriptions of the Washington Consensus:the visible hand of government direction of industry,the important role of state owned enterprises,as well as growth-enhancing social policies.It concludes with the present challenges facing the city-state.展开更多
基金supported by the National Medical Products Administration Commissioned Research Project (No.20211440216)the National Administration of Traditional Chinese Medicine Science and Technology Project (No.GZY-KJS-2024-03)+3 种基金the State Key Laboratory of Drug Regulatory Science Project (No.2023SKLDRS0104)the Basic Research Program Natural Science Fund-Frontier Leading Technology Basic Research Special Project of Jiangsu Province (No.BK20232014)the Programs Foundation for Leading Talents in National Administration of Traditional Chinese Medicine of China“Qihuang scholars”Projectthe Tianjin Administration for Market Regulation Science and Technology Key Projects (No.2022-W35)。
文摘The research and development of new traditional Chinese medicine(TCM)drugs have progressively established a novel system founded on the integration of TCM theory,human experience,and clinical trials(termed the“Three Combinations”).However,considering TCM's distinctive features of“syndrome differentiation and treatment”and“multicomponent formulations and complex mechanisms”,current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system.Moreover,significant obstacles persist in gathering human experience data,evaluating clinical efficacy,and controlling the quality of active ingredients,which impede the innovation process in TCM drug development.Network pharmacology,centered on the“network targets”theory,transcends the limitations of the conventional“single target”reductionist research model.It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions.This approach aligns with the holistic perspective of TCM,offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs.It is internationally recognized as a“next-generation drug research model”.To advance the research of new tools,methods,and standards for TCM evaluation and to overcome fundamental,critical,and cutting-edge technical challenges in TCM regulation,this consensus aims to explore the characteristics,progress,challenges,applicable pathways,and specific applications of network pharmacology as a new theory,method,and tool in TCM drug development.The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.
文摘According to our analysis of variations in Chinas＇ industrial growth rate. industrial demand, industrial structure, regional structure and the performance of industrial firms, China ＇s＇ industrial economv is moving towards＇ a ＂new normal＂ of slower growth and structural improvement. This process coincides with the late stage of China＇s industrialization, which international experience suggests is often frauht with twists and challenges. Among these challenges, great attention must be paid to overcapacity industrial restructuring and upgrades, and the ＂reindustrialization＂ of developed countries. As China enters the late stage of its industrialization, particularly during the 13th Five-Year Plan period from 2016 to 2020, the promotion of industrial development is of strategic significance for China to successfully complete industrialization and its economy to adapt to the ＂new normal ＂. In the face of these new challenges regarding industrial development, policymakers must strive to increase the dynamism of growth for industrial economy. In this new era, the momentum of industrial growth derives from the integration of the supply impetus of industrialization and the pull of demand caused by urbanization, while, the comprehensive deepening of refom provides the key source of momentum.
文摘Singapore's remarkable economic development in the past five decades since independence has attracted much policy attention.This article first provides a brief overview of Singapore's economic development.The second part discusses Singapore's development strategies that are aligned with the Washington Consensus:globalisation,conservative fiscal and monetary policies,investments in education and infrastructure.It also discusses the policies adopted to further enhance the outcomes of such policies.The third part focusses on policies that are inconsistent with the prescriptions of the Washington Consensus:the visible hand of government direction of industry,the important role of state owned enterprises,as well as growth-enhancing social policies.It concludes with the present challenges facing the city-state.
