Objective ： Evaluate the application values of ^99mTc-2 β [ N, N＇-bis （ 2-mercaptoethyl ） ethylenediamiino ] methyl, 3 β -（4-chlorophenyl） tropane （ TRODAT-1 ） dopamine transporter （DAT） SPECT imaging in c...Objective ： Evaluate the application values of ^99mTc-2 β [ N, N＇-bis （ 2-mercaptoethyl ） ethylenediamiino ] methyl, 3 β -（4-chlorophenyl） tropane （ TRODAT-1 ） dopamine transporter （DAT） SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods：Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of ^99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striaturn and cerebellum [ （ STR-BKG）/BKG ]. Results ： There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children （ P = 0. 562） and in normal controls （ P = 0. 573 ） ; dopamine transporter in brain of patients with autism increased more significantly than that in normal controls （ P = 0. 017）. Conclusion ： Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.展开更多
文摘Objective ： Evaluate the application values of ^99mTc-2 β [ N, N＇-bis （ 2-mercaptoethyl ） ethylenediamiino ] methyl, 3 β -（4-chlorophenyl） tropane （ TRODAT-1 ） dopamine transporter （DAT） SPECT imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. Methods：Ten autistic children and ten healthy controls were examined with ^99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of ^99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratios between striaturn and cerebellum [ （ STR-BKG）/BKG ]. Results ： There was no difference in semiquantitative dopamine transporter between bilateral striatum in autistic children （ P = 0. 562） and in normal controls （ P = 0. 573 ） ; dopamine transporter in brain of patients with autism increased more significantly than that in normal controls （ P = 0. 017）. Conclusion ： Dopaminergic nervous system is dysfunction in human brain with children autism, and DAT ^99mTc-TRODAT-1 SPECT imaging on human brain will help the imaging diagnosis of children autism.
