By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers t...By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers to link these marks to cis-regulatory elements. With the help of next generation sequencing technologies, we can now correlate one specific chromatin mark with regulatory elements (e.g. enhancers or promoters) and also build tools, such as hidden Markov models, to gain insight into mark combinations. However, hidden Markov models have limitation for their character of generative models and assume that a current observation depends only on a current hidden state in the chain. Here, we employed two graphical probabilistic models, namely the linear conditional random field model and multivariate hidden Markov model, to mark gene regions with different states based on recurrent and spatially coherent character of these eight marks. Both models revealed chromatin states that may correspond to enhancers and promoters, transcribed regions, transcriptional elongation, and low-signal regions. We also found that the linear conditional random field model was more effective than the hidden Markov model in recognizing regulatory elements, such as promoter-, enhancer-, and transcriptional elongation-associated regions, which gives us a better choice.展开更多
By using a Rosenthal type inequality established in this paper, the complete convergence and almost sure summability on the convergence rates with respect to the strong law of large numbers are discussed for *-mixing...By using a Rosenthal type inequality established in this paper, the complete convergence and almost sure summability on the convergence rates with respect to the strong law of large numbers are discussed for *-mixing random fields.展开更多
This paper discusses complete convergence properties of the sums of -mixing random sequences.As a result,we improve the corresponding results of Wu Qunying(2001). And extended the Baum and Katz complete convergence ...This paper discusses complete convergence properties of the sums of -mixing random sequences.As a result,we improve the corresponding results of Wu Qunying(2001). And extended the Baum and Katz complete convergence to the case of -mixing random sequences by moment inequality and truncating without necessarily adding any extra conditions.展开更多
The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte C...The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.展开更多
In this paper, we will present some strong convergence results for sequences of ψ-mixing random variables. The results for sequences of ψ-mixing random variables generalize the corresponding results for independent ...In this paper, we will present some strong convergence results for sequences of ψ-mixing random variables. The results for sequences of ψ-mixing random variables generalize the corresponding results for independent random variable sequences without any extra conditions.展开更多
We give some theorems of strong law of large numbers and complete convergence for sequences of φ-mixing random variables. In particular, Wittmann＇s strong law of large numbers and Teicher＇s strong law of large nnum...We give some theorems of strong law of large numbers and complete convergence for sequences of φ-mixing random variables. In particular, Wittmann＇s strong law of large numbers and Teicher＇s strong law of large nnumbers for independent random variables are generalized to the case of φ -minxing random variables.展开更多
In this paper,we establish a Rosenthal-type inequality of partial sums for ρ~mixing random variables.As its applications,we get the complete convergence rates in the strong laws for ρ^-mixing random variables.The re...In this paper,we establish a Rosenthal-type inequality of partial sums for ρ~mixing random variables.As its applications,we get the complete convergence rates in the strong laws for ρ^-mixing random variables.The result obtained extends the corresponding result.展开更多
To investigate the strong random nature of the geometric interfaces between soil and rock, a rock-soil slope is considered as a two-phase random medium. A nonlinear translation of a Gaussian field is utilized to simul...To investigate the strong random nature of the geometric interfaces between soil and rock, a rock-soil slope is considered as a two-phase random medium. A nonlinear translation of a Gaussian field is utilized to simulate the two-phase random media, such that the soil(or rock) volume fraction and the inclination of the soil layer can be examined. The finite element method with random media incorporated as the material properties is used to determine the factor of safety of the rock-soil slope. Monte-Carlo simulations are used to estimate the statistical characteristics of the factor of safety. The failure mode of the rock-soil slope is examined by observing the maximum principal plastic strain at incipient slope failure. It is found that the critical surface of a rock-soil slope is fairly irregular, and it significantly differs from that of a pure soil slope. The factor of safety is sensitive to the soil volume faction, but it is predictable. The average factor of safety could be well predicted by the weighted harmonic average between the strength of soil and rock; the prediction model is practical and simple. Parametric studies on the inclination of the soil layer demonstrate that the most instable scenario occurs when the slope angle is consistent with the inclination of the soil layer.展开更多
The probability distribution function of n random elements subjected to the flexible boundary condition is derived. The probability density is a descending curve and converges to a delta function as n tends to infinit...The probability distribution function of n random elements subjected to the flexible boundary condition is derived. The probability density is a descending curve and converges to a delta function as n tends to infinity. The distribution of the minimum value is discussed in context of ordered statistics.展开更多
The author discusses necessary and sufficient conditions of the complete con- vergence for sums of B-valued independent but not necessarily identically distributed r.v.'s in Banach space of type p, and obtains cha...The author discusses necessary and sufficient conditions of the complete con- vergence for sums of B-valued independent but not necessarily identically distributed r.v.'s in Banach space of type p, and obtains characterization of Banach space of type p in terms of the complete convergence. A series of classical results on iid real valued r.v.'s are ex- tended. As application authors give the analogous results for randomly indexed sums.展开更多
In the paper,we study the strong uniform consistency for the kernal estimates of random window w■th of density function and its derivatives under the condition that the sequence{X_n}of the ■ are the identically Φ-m...In the paper,we study the strong uniform consistency for the kernal estimates of random window w■th of density function and its derivatives under the condition that the sequence{X_n}of the ■ are the identically Φ-mixing random variabks.展开更多
In this paper, the complete convergence and weak law of large numbers are established for ρ-mixing sequences of random variables. Our results extend and improve the Baum and Katz complete convergence theorem and the ...In this paper, the complete convergence and weak law of large numbers are established for ρ-mixing sequences of random variables. Our results extend and improve the Baum and Katz complete convergence theorem and the classical weak law of large numbers, etc. from independent sequences of random variables to ρ-mixing sequences of random variables without necessarily adding any extra conditions.展开更多
Outwash deposit is a unique type of geological materials, and its features such as heterogeneity, discontinuity and nonlinearity determine the complexity of mechanical characteristics and failure mechanism. In this wo...Outwash deposit is a unique type of geological materials, and its features such as heterogeneity, discontinuity and nonlinearity determine the complexity of mechanical characteristics and failure mechanism. In this work, random meso-structure of outwash deposits was constructed by the technique of computer random simulation based on characteristics of its meso-structure in the statistical sense and some simplifications, and a series of large direct shear tests on numerical samples of outwash deposits with stone contents of 15%, 30%, 45% and 60% were conducted using the discrete element method to further investigate its mechanical characteristics and failure mechanism under external load. The results show that the deformation characteristics and shear strength of outwash deposits are to some extent improved with the increase of stone content, and the shear stress–shear displacement curves of outwash deposits show great differences at the post-peak stage due to the random spatial distribution and content of stones. From the mesoscopic view, normal directions of contacts between "soil" and "stone" particles undergo apparent deflection as the shear displacement continues during the shearing process, accompanying redistribution of the magnitude of contact forces during the shearing process. For outwash deposits, the shear zone formed after shear failure is an irregular stripe due to the movements of stones near the shear zone, and it expands gradually with the increase of stone content. In addition, there is an approximately linear relation between the mean increment of internal friction angle and the stone content lying between 30% and 60%, and a concave nonlinear relation between the mean increment of cohesion and stone content, which are in good agreement with the existing research results.展开更多
To study the effect of uncertain factors on the temperature field of frozen soil, we propose a method to calculate the spatial average variance from just the point variance based on the local average theory of random ...To study the effect of uncertain factors on the temperature field of frozen soil, we propose a method to calculate the spatial average variance from just the point variance based on the local average theory of random fields. We model the heat transfer coefficient and specific heat capacity as spatially random fields instead of traditional random variables. An analysis for calculating the random temperature field of seasonal frozen soil is suggested by the Neumann stochastic finite element method, and here we provide the computational formulae of mathematical expectation, variance and variable coefficient. As shown in the calculation flow chart, the stochastic finite element calculation program for solving the random temperature field, as compiled by Matrix Laboratory （MATLAB） sottware, can directly output the statistical results of the temperature field of frozen soil. An example is presented to demonstrate the random effects from random field parameters, and the feasibility of the proposed approach is proven by compar- ing these results with the results derived when the random parameters are only modeled as random variables. The results show that the Neumann stochastic finite element method can efficiently solve the problem of random temperature fields of frozen soil based on random field theory, and it can reduce the variability of calculation results when the random parameters are modeled as spatial- ly random fields.展开更多
An optimized device structure for reducing the RESET current of phase-change random access memory （PCRAM） with blade-type like （BTL） phase change layer is proposed. The electrical thermal analysis of the BTL cell ...An optimized device structure for reducing the RESET current of phase-change random access memory （PCRAM） with blade-type like （BTL） phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.展开更多
A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties....A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties. Although 3 D random finite element analysis can well reflect the spatial variability of soil properties, it is often time-consuming for probabilistic stability analysis. For this reason, we also examined the least advantageous(or most pessimistic) cross-section of the studied slope. The concept of"most pessimistic" refers to the minimal cross-sectional average of undrained shear strength. The selection of the most pessimistic section is achievable by simulating the undrained shear strength as a 3 D random field. Random finite element analysis results suggest that two-dimensional(2 D) plane strain analysis based the most pessimistic cross-section generally provides a more conservative result than the corresponding full 3 D analysis. The level of conservativeness is around 15% on average. This result may have engineering implications for slope design where computationally tractable 2 D analyses based on the procedure proposed in this study could ensure conservative results.展开更多
Some theoretical methods have been reported to deal with nonlinear problems of composite materials but the accuracy is not so good. In the meantime, a lot of linear problems are difficult to be managed by the theoreti...Some theoretical methods have been reported to deal with nonlinear problems of composite materials but the accuracy is not so good. In the meantime, a lot of linear problems are difficult to be managed by the theoretical methods. The present study aims to use the developed method, the random microstructure finite element method, to deal with these nonlinear problems. In this paper, the random microstructure finite element method is used to deal with all three kinds of nonlinear property problems of composite materials. The analyzed results suggest the influences of the nonlinear phenomena on the effective properties of composite materials are significant and the random microstructure finite element method is an effective tool to investigate the nonlinear problems.展开更多
We mainly study the almost sure limiting behavior of weighted sums of the form ∑ni=1 aiXi/bn , where {Xn, n ≥ 1} is an arbitrary Banach space valued random element sequence or Banach space valued martingale differen...We mainly study the almost sure limiting behavior of weighted sums of the form ∑ni=1 aiXi/bn , where {Xn, n ≥ 1} is an arbitrary Banach space valued random element sequence or Banach space valued martingale difference sequence and {an, n ≥ 1} and {bn,n ≥ 1} are two sequences of positive constants. Some new strong laws of large numbers for such weighted sums are proved under mild conditions.展开更多
基金funded by grants from the NIH R01LM010185-03(Zhou),NIH U01HL111560-01(Zhou),NIH 1R01DE022676-01(Zhou),and DoD TATRC (Zhou)
文摘By altering the electrostatic charge of histones or providing binding sites to protein recognition molecules, Chromatin marks have been proposed to regulate gene expression, a property that has motivated researchers to link these marks to cis-regulatory elements. With the help of next generation sequencing technologies, we can now correlate one specific chromatin mark with regulatory elements (e.g. enhancers or promoters) and also build tools, such as hidden Markov models, to gain insight into mark combinations. However, hidden Markov models have limitation for their character of generative models and assume that a current observation depends only on a current hidden state in the chain. Here, we employed two graphical probabilistic models, namely the linear conditional random field model and multivariate hidden Markov model, to mark gene regions with different states based on recurrent and spatially coherent character of these eight marks. Both models revealed chromatin states that may correspond to enhancers and promoters, transcribed regions, transcriptional elongation, and low-signal regions. We also found that the linear conditional random field model was more effective than the hidden Markov model in recognizing regulatory elements, such as promoter-, enhancer-, and transcriptional elongation-associated regions, which gives us a better choice.
基金National Natural Science Foundation of China! (No. 19701O11) Foundation of "151 talent project" of Zhejiang provience.
文摘By using a Rosenthal type inequality established in this paper, the complete convergence and almost sure summability on the convergence rates with respect to the strong law of large numbers are discussed for *-mixing random fields.
基金Supported by the National Natural Science Foundation of China（11061012） Supported by the Natural Science Foundation of Guangxi（2010GXNSFA013121）
文摘This paper discusses complete convergence properties of the sums of -mixing random sequences.As a result,we improve the corresponding results of Wu Qunying(2001). And extended the Baum and Katz complete convergence to the case of -mixing random sequences by moment inequality and truncating without necessarily adding any extra conditions.
文摘The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.
基金Supported by the University Students Science Research Training Program of Anhui University(KYXL20110004)
文摘In this paper, we will present some strong convergence results for sequences of ψ-mixing random variables. The results for sequences of ψ-mixing random variables generalize the corresponding results for independent random variable sequences without any extra conditions.
基金Supported by the National Natural Science Foundation of China (10671149)
文摘We give some theorems of strong law of large numbers and complete convergence for sequences of φ-mixing random variables. In particular, Wittmann＇s strong law of large numbers and Teicher＇s strong law of large nnumbers for independent random variables are generalized to the case of φ -minxing random variables.
基金Supported by the National Science Foundation（10661006） Supported by Innovation Project of Guangxi Graduate Education（2007105960812M18）
文摘In this paper,we establish a Rosenthal-type inequality of partial sums for ρ~mixing random variables.As its applications,we get the complete convergence rates in the strong laws for ρ^-mixing random variables.The result obtained extends the corresponding result.
基金supported by the International Science and Technology Cooperation Programme of Hainan Province,China (Grant No.ZDYF2016226)the National Natural Science Foundation of China(Grant No.51879203)
文摘To investigate the strong random nature of the geometric interfaces between soil and rock, a rock-soil slope is considered as a two-phase random medium. A nonlinear translation of a Gaussian field is utilized to simulate the two-phase random media, such that the soil(or rock) volume fraction and the inclination of the soil layer can be examined. The finite element method with random media incorporated as the material properties is used to determine the factor of safety of the rock-soil slope. Monte-Carlo simulations are used to estimate the statistical characteristics of the factor of safety. The failure mode of the rock-soil slope is examined by observing the maximum principal plastic strain at incipient slope failure. It is found that the critical surface of a rock-soil slope is fairly irregular, and it significantly differs from that of a pure soil slope. The factor of safety is sensitive to the soil volume faction, but it is predictable. The average factor of safety could be well predicted by the weighted harmonic average between the strength of soil and rock; the prediction model is practical and simple. Parametric studies on the inclination of the soil layer demonstrate that the most instable scenario occurs when the slope angle is consistent with the inclination of the soil layer.
基金Project supported by the National Science Foundation of USA (No.CMS-0503910)
文摘The probability distribution function of n random elements subjected to the flexible boundary condition is derived. The probability density is a descending curve and converges to a delta function as n tends to infinity. The distribution of the minimum value is discussed in context of ordered statistics.
基金Supported by the Science Fund of Tongji University
文摘The author discusses necessary and sufficient conditions of the complete con- vergence for sums of B-valued independent but not necessarily identically distributed r.v.'s in Banach space of type p, and obtains characterization of Banach space of type p in terms of the complete convergence. A series of classical results on iid real valued r.v.'s are ex- tended. As application authors give the analogous results for randomly indexed sums.
基金supported by Natural Science Foun■ion of Henan P■visial Commission of Bdusation
文摘In the paper,we study the strong uniform consistency for the kernal estimates of random window w■th of density function and its derivatives under the condition that the sequence{X_n}of the ■ are the identically Φ-mixing random variabks.
文摘In this paper, the complete convergence and weak law of large numbers are established for ρ-mixing sequences of random variables. Our results extend and improve the Baum and Katz complete convergence theorem and the classical weak law of large numbers, etc. from independent sequences of random variables to ρ-mixing sequences of random variables without necessarily adding any extra conditions.
基金Project(2011CB013504) supported by the National Basic Research Program(973 Program)of ChinaProject(2013BAB06B01) supported by the National Science&Technology Pillar Program during the Twelfth Five-year Plan Period+2 种基金Projects(11772118,51479049,51709282) supported by the National Natural Science Foundation of ChinaProject(2017M620838) supported by the Postdoctoral Science Foundation of ChinaProject(487237) supported by the Natural Sciences and Engineering Research Council of Canada
文摘Outwash deposit is a unique type of geological materials, and its features such as heterogeneity, discontinuity and nonlinearity determine the complexity of mechanical characteristics and failure mechanism. In this work, random meso-structure of outwash deposits was constructed by the technique of computer random simulation based on characteristics of its meso-structure in the statistical sense and some simplifications, and a series of large direct shear tests on numerical samples of outwash deposits with stone contents of 15%, 30%, 45% and 60% were conducted using the discrete element method to further investigate its mechanical characteristics and failure mechanism under external load. The results show that the deformation characteristics and shear strength of outwash deposits are to some extent improved with the increase of stone content, and the shear stress–shear displacement curves of outwash deposits show great differences at the post-peak stage due to the random spatial distribution and content of stones. From the mesoscopic view, normal directions of contacts between "soil" and "stone" particles undergo apparent deflection as the shear displacement continues during the shearing process, accompanying redistribution of the magnitude of contact forces during the shearing process. For outwash deposits, the shear zone formed after shear failure is an irregular stripe due to the movements of stones near the shear zone, and it expands gradually with the increase of stone content. In addition, there is an approximately linear relation between the mean increment of internal friction angle and the stone content lying between 30% and 60%, and a concave nonlinear relation between the mean increment of cohesion and stone content, which are in good agreement with the existing research results.
基金funded by the National Basic Research Program of China (No. 2012CB026103)the National High Technology Research and Development Program of China (No. 2012AA06A401)the National Natural Science Foundation of China (No. 41271096)
文摘To study the effect of uncertain factors on the temperature field of frozen soil, we propose a method to calculate the spatial average variance from just the point variance based on the local average theory of random fields. We model the heat transfer coefficient and specific heat capacity as spatially random fields instead of traditional random variables. An analysis for calculating the random temperature field of seasonal frozen soil is suggested by the Neumann stochastic finite element method, and here we provide the computational formulae of mathematical expectation, variance and variable coefficient. As shown in the calculation flow chart, the stochastic finite element calculation program for solving the random temperature field, as compiled by Matrix Laboratory （MATLAB） sottware, can directly output the statistical results of the temperature field of frozen soil. An example is presented to demonstrate the random effects from random field parameters, and the feasibility of the proposed approach is proven by compar- ing these results with the results derived when the random parameters are only modeled as random variables. The results show that the Neumann stochastic finite element method can efficiently solve the problem of random temperature fields of frozen soil based on random field theory, and it can reduce the variability of calculation results when the random parameters are modeled as spatial- ly random fields.
基金Supported by the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No XDA09020402the National Integrate Circuit Research Program of China under Grant No 2009ZX02023-003+1 种基金the National Natural Science Foundation of China under Grant Nos 61261160500,61376006,61401444 and 61504157the Science and Technology Council of Shanghai under Grant Nos 14DZ2294900,15DZ2270900 and 14ZR1447500
文摘An optimized device structure for reducing the RESET current of phase-change random access memory （PCRAM） with blade-type like （BTL） phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.
基金supported by the Key Research&Development Plan Science and Technology Cooperation Programme of Hainan Province,China(Grant No.ZDYF2016226)the National Natural Science Foundation of China(Grant Nos.51879203,51808421)
文摘A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties. Although 3 D random finite element analysis can well reflect the spatial variability of soil properties, it is often time-consuming for probabilistic stability analysis. For this reason, we also examined the least advantageous(or most pessimistic) cross-section of the studied slope. The concept of"most pessimistic" refers to the minimal cross-sectional average of undrained shear strength. The selection of the most pessimistic section is achievable by simulating the undrained shear strength as a 3 D random field. Random finite element analysis results suggest that two-dimensional(2 D) plane strain analysis based the most pessimistic cross-section generally provides a more conservative result than the corresponding full 3 D analysis. The level of conservativeness is around 15% on average. This result may have engineering implications for slope design where computationally tractable 2 D analyses based on the procedure proposed in this study could ensure conservative results.
基金This work is supported by the National Natural Science Foundation of China under the Grant 19772037 and 19902014
文摘Some theoretical methods have been reported to deal with nonlinear problems of composite materials but the accuracy is not so good. In the meantime, a lot of linear problems are difficult to be managed by the theoretical methods. The present study aims to use the developed method, the random microstructure finite element method, to deal with these nonlinear problems. In this paper, the random microstructure finite element method is used to deal with all three kinds of nonlinear property problems of composite materials. The analyzed results suggest the influences of the nonlinear phenomena on the effective properties of composite materials are significant and the random microstructure finite element method is an effective tool to investigate the nonlinear problems.
基金Supported by the National Natural Science Foundationof China (10671149)
文摘We mainly study the almost sure limiting behavior of weighted sums of the form ∑ni=1 aiXi/bn , where {Xn, n ≥ 1} is an arbitrary Banach space valued random element sequence or Banach space valued martingale difference sequence and {an, n ≥ 1} and {bn,n ≥ 1} are two sequences of positive constants. Some new strong laws of large numbers for such weighted sums are proved under mild conditions.
