Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP ...Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP remains challenging, particularly in patients with comorbidities or contraindications to standard therapies. Objectives: To evaluate the effectiveness of ozonated water as an adjunctive treatment for EP, delivered using a patented robotic therapy system designed for hygiene and infection prevention in non-self-sufficient patients. Methods: We report the case of a 90-year-old male patient with acute EP who received daily skin treatments with ozonated water in conjunction with supportive care, including rehydration and antibiotics. The intervention was facilitated by the robotic system “COPERNICO Surveillance & Prevention,” which ensured standardized hygiene practices and clinical documentation. Results: Within one week of treatment, the patient showed complete desquamation of necrotic skin, resolution of erythema, and significant metabolic recovery. Fever subsided, renal function improved, and the patient was discharged in stable condition. Follow-up confirmed sustained clinical improvement, and no adverse events were reported. Conclusions: Ozonated water demonstrated efficacy in alleviating the dermatological and systemic manifestations of EP in a high-risk elderly patient. This case highlights the potential of ozone therapy as a safe, cost-effective adjunctive treatment for EP and underscores the utility of robotic systems in managing complex dermatological conditions. Further research is warranted to validate these findings in larger cohorts.展开更多
This study tries to highlight the role of magnetic and seismic data in the prevention of building cracking, which constitutes a geotechnical risk in Agadez City. This city is built on the faulted and fractured sandsto...This study tries to highlight the role of magnetic and seismic data in the prevention of building cracking, which constitutes a geotechnical risk in Agadez City. This city is built on the faulted and fractured sandstone formations of the “Agadez Sandstones Formations”, which were deposited in unconformity on the basement of the Aïr Mountain. This study focuses on the prevention of geotechnical damages related to building cracking in the Agadez region through geophysical methods, which are well known for investigating tectonic structures and their directions on the surface and subsurface. A methodological approach integrated the seismic and magnetic data interpretation combined with field measurement on the cracked building and its underlying substratum, represented by Agadez sandstones and basement. The extraction of seismic lineaments from the West African seismic map showed the seismic directions oriented NW-SE (N135˚ to N160˚), passing through the studied area. The structural interpretation of the magnetic map shows that the Agadez region is also affected by the subsurface lineaments mainly oriented in NW-SE (N135˚) directions, which are similar to the identified seismic lineaments in the same zone. A structural study carried out on the Agadez sandstones and the underlying basement showed that faults and fractures oriented N120˚ to N165˚ affect both the basement of the Aïr Mountains and the sandstone formations on which the city of Agadez is built. These observations showed that building cracking in the Agadez region has a higher propagation tendency according to the directions ranging from NW-SE (N135˚) to NNW-SSE (N165˚). Therefore, the building’s cracking has a stronger propagation component according to these mean directions that are not recommended for building. To prevent and reduce the risks related to building cracking in Agadez region, it is highly recommended to build in the minor directions of cracking propagation, which correspond to NE and SW directions.展开更多
In sub nanometer carbon nanotubes,water exhibits unique dynamic characteristics,and in the high-frequency region of the infrared spectrum,where the stretching vibrations of the internal oxygen-hydrogen(O-H)bonds are c...In sub nanometer carbon nanotubes,water exhibits unique dynamic characteristics,and in the high-frequency region of the infrared spectrum,where the stretching vibrations of the internal oxygen-hydrogen(O-H)bonds are closely related to the hydrogen bonds(H-bonds)network between water molecules.Therefore,it is crucial to analyze the relationship between these two aspects.In this paper,the infrared spectrum and motion characteristics of the stretching vibrations of the O-H bonds in one-dimensional confined water(1DCW)and bulk water(BW)in(6,6)single-walled carbon nanotubes(SWNT)are studied by molecular dynamics simulations.The results show that the stretching vibrations of the two O-H bonds in 1DCW exhibit different frequencies in the infrared spectrum,while the O-H bonds in BW display two identical main frequency peaks.Further analysis using the spring oscillator model reveals that the difference in the stretching amplitude of the O-H bonds is the main factor causing the change in vibration frequency,where an increase in stretching amplitude leads to a decrease in spring stiffness and,consequently,a lower vibration frequency.A more in-depth study found that the interaction of H-bonds between water molecules is the fundamental cause of the increased stretching amplitude and decreased vibration frequency of the O-H bonds.Finally,by analyzing the motion trajectory of the H atoms,the dynamic differences between 1DCW and BW are clearly revealed.These findings provide a new perspective for understanding the behavior of water molecules at the nanoscale and are of significant importance in advancing the development of infrared spectroscopy detection technology.展开更多
This study investigates the application of carbon dioxide (CO2) sequestration to address challenges in water-drive gas reservoirs, specifically focusing on improving gas recovery and mitigating water invasion. Traditi...This study investigates the application of carbon dioxide (CO2) sequestration to address challenges in water-drive gas reservoirs, specifically focusing on improving gas recovery and mitigating water invasion. Traditional methods like blow-down and co-production have limitations, including sand production, water coning, and inefficiency in strong aquifers. To overcome these issues, this research explores CO2 injection near the edge aquifer, aiming to reduce water influx and enhance gas recovery through the propagation of a CO2 plume in the gas-water contact zone. Both synthetic and real compositional reservoir models were studied, with CO2 injection performed while maintaining reservoir pressure below 90% of the initial level. Results show that CO2 sequestration significantly improved recovery, particularly in higher permeability reservoirs, where it reduced aquifer influx and increased gas production by 26% under challenging conditions. While CO2 dissolution in water decreased aquifer influx by 39%, its adverse effect on sweep efficiency led to a reduction in gas and water production by 4.2% and 10%, respectively. The method's effectiveness was not significantly impacted by aquifer permeability, but it was sensitive to vertical-to-horizontal permeability ratios. When applied to a real gas reservoir, the proposed method increased gas production by 14% compared to conventional techniques, with minimal CO2 production over a 112-year period. This study demonstrates the potential of CO2 sequestration as a comprehensive solution for enhancing gas recovery, reducing water production, and mitigating environmental impacts in water-drive gas reservoirs.展开更多
The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 k...The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 key-informants were surveyed, including water-well owners, well-digging companies, water-trucking suppliers, agricultural pharmacies, and service offices within local councils. The surveys covered all nine districts in northwestern Syria across the Aleppo and the Idleb governorates. The survey findings reveal significant shifts in water sources, an almost halving in water availability and per capita consumption, and a notable decrease in water quality. Coping mechanisms include random well drilling and reduced hygiene practices. Water pumping stations face challenges with functionality, and there is a shift towards clean energy sources, particularly solar energy. Challenges identified by the survey respondents include drought, fuel costs, and damaged water networks. The study highlights the urgency of addressing the potable water crisis in Northwest Syria and suggests specific interventions to enhance water sustainability and governance.展开更多
Contrast-induced acute kidney injury(CI-AKI)is the third leading cause of acute kidney injury deriving from the intravascular administration of contrast media in diagnostic and therapeutic procedures and leading to lo...Contrast-induced acute kidney injury(CI-AKI)is the third leading cause of acute kidney injury deriving from the intravascular administration of contrast media in diagnostic and therapeutic procedures and leading to longer in-hospital stay and increased short and long-term mortality.Its pathophysiology,although not well-established,revolves around medullary hypoxia paired with the direct toxicity of the substance to the kidney.Critically ill patients,as well as those with pre-existing renal disease and cardiovascular comorbidities,are more susceptible to CI-AKI.Despite the continuous research in the field of CI-AKI prevention,clinical practice is based mostly on periprocedural hydration.In this review,all the investigated methods of prevention are presented,with an emphasis on the latest evidence regarding the potential of RenalGuard and contrast removal systems for CI-AKI prevention in high-risk individuals.展开更多
Water contamination in areas of formal and informal polymetallic mining is a growing concern in the Peruvian highlands. At the same time, there are agricultural activities that use contaminated water from these rivers...Water contamination in areas of formal and informal polymetallic mining is a growing concern in the Peruvian highlands. At the same time, there are agricultural activities that use contaminated water from these rivers for irrigation. This could contaminate the agricultural products grown on these lands, such as potatoes. It is, therefore, necessary and a priority to determine the adsorption characteristics of these derivatives and to be able to use these natural adsorbents to decontaminate water contaminated with heavy metals.展开更多
Upon ship lift chamber docking with approach channel in the case of water level difference, water in chamber will fluctuate evidently. The maximum or minimum fluctuation of water surface is an important parameter to m...Upon ship lift chamber docking with approach channel in the case of water level difference, water in chamber will fluctuate evidently. The maximum or minimum fluctuation of water surface is an important parameter to measure operational safety of ship lift. A simplified 3D mathematical model of ship lift chamber upon tumble gate opening was built based on standard k-ε model, FVM (Finite Volume Method) and VOF (Volume of Fluid) model. Based on π theorem, the dimensionless influencing factors of Δhmax/d and Δhmin/d were B/L, d/B and Δh/d. On this basis, 30 sets of working conditions were designed to respectively study the relationships between the maximum wave height and each influencing factor. Through regression analysis, the empirical formulas of Δhmax/d and Δhmin/d were obtained. Furthermore, taking into account the potential influence of the gate opening time on the wave height in practical applications, the relationship between the gate opening time and the error was fitted, and the modified empirical formulas of Δh′max/dand Δh′min/dwere derived, which had a wider scope of application. The results have practical value for engineering design and security operation of ship lift.展开更多
It is essential to investigate the impact of tropical highland open pit gold mines on surface and groundwater quality and flow dynamics. Samples from the Twangiza gold mine, with long term mining activities, including...It is essential to investigate the impact of tropical highland open pit gold mines on surface and groundwater quality and flow dynamics. Samples from the Twangiza gold mine, with long term mining activities, including small-scale mining were analyzed in an accredited South African Laboratory. Results indicate that TDS and EC were higher in the mine site due the concentration of many metals. DO values were higher downstream. ORP and pH levels were similar at all site positions. Upstream: Fe, Si, K, Mg, Al have the highest concentrations (14.0 - 23.1 mg∙l−1). P, Pb, B, Ti, Sr, Ag, Ni, Ba, and As have concentrations ranging from 0.1 - 0.9 mg∙l−1. Li and Au have the lowest concentrations (0.01 - 0.05 mg∙l−1). Zn was also relatively abundant upstream, most likely airborne by the plant generator smoke. Within the mine site: Si, Al, Mg, Fe are found in higher concentrations (19 - 50 mg∙l−1). These are followed by K, As, and P (1.4 - 4 mg∙l−1). Ni, Ti, Ag, Sr, Ba are also found in lesser concentrations (0.2 - 0.7 mg∙l−1). The groundwater flow remained consistent. This study has the advantage of having continuously followed up a large number of heavy metals during years.展开更多
Breast cancer(BC)is now the most common cancer and the fifth leading cause of cancer-associated mortality among women in China1.Germline pathogenic variants(PVs)of BC susceptibility genes,such as the well-known BRCA1/...Breast cancer(BC)is now the most common cancer and the fifth leading cause of cancer-associated mortality among women in China1.Germline pathogenic variants(PVs)of BC susceptibility genes,such as the well-known BRCA1/2 genes,increase the risk of BC and other cancers(ovarian and pancreatic cancer)^(2,3).Recent studies have demonstrated substantial benefits of poly(adenosine diphosphate ribose)polymerase inhibitors in the treatment of BC patients who carry BRCA1/2 PVs^(4).展开更多
This study provides an in-depth exploration of seaweed biodiversity in Nigeria’s coastal waters, a largely unexplored area for marine resources. There is a dearth of sufficient data on seaweed biodiversity in Nigeria...This study provides an in-depth exploration of seaweed biodiversity in Nigeria’s coastal waters, a largely unexplored area for marine resources. There is a dearth of sufficient data on seaweed biodiversity in Nigeria. The research aimed to assess the diversity and distribution of seaweeds in this region. Seaweed samples were collected by hand, using scrapers, at low tide from four stations identified by local fisherfolk and commercial divers. These samples were analyzed in the laboratory for species identification. A total of 39 seaweed taxa were identified, with Rhodophyta (red algae) being the most abundant (74%), followed by Chlorophyta (green algae) (21%) and Heterokontophyta (brown algae) (5%). The highest biomass species included Grateloupia sp., Chaetomorpha antennina, Gracilaria sp., Ceratodictyon variabile, Cladophora sp., Gelidium pusillum, Ulva sp., Blidingia minima, and Caloglossa leprieurii. Species abundance was highest on breakwater rocks and on the bodies of anchored or sunken vessels, while sandy beaches exhibited lower abundance. The findings reveal significant potential for Nigeria’s seaweed in aquaculture, climate change mitigation, and biotechnology. The study recommends further molecular research, expansion of sampling areas, and the development of sustainable seaweed cultivation practices to support Nigeria’s blue economy.展开更多
Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, espe...Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, especially through high-risk group. Henceforth, the aim of this study was to evaluate the effect of nursing intervention on improving awareness of high-risk people about stroke prevention. Methods: A quasi-experimental design was used to carry out this study, where a purposive sample of 80 adult patients at high risk for stroke were enrolled while they were attending the out-patient clinics of Zagazig University Hospitals for follow-up treatment;they were divided into two groups: case (40 patients) and control (40 patients). An interview questionnaire was used to assess patients’ knowledge regarding warning signs, risk factors, and immediate treatment;attitude;and their practice for prevention for stroke at pretest and posttest. Results: The study revealed the poor level of knowledge, bad level of preventive behavior, and negative attitude regarding stroke prevention at pre-intervention. However, after intervention, the high-risk people had fair level of knowledge with moderate practice for stroke prevention and positive attitude, with statistically significant difference between pre-post intervention and between the case and control groups. Conclusions: The study revealed that the nursing intervention seemed to change the knowledge, practice, and attitude of subjects regarding stroke prevention. This, in turn, implies that awareness of prevention of stroke and high-risk factor control could be important to reduce the burden of stroke in Egypt. Thus, further research on a larger scale is required to improve population knowledge and behavior for stroke prevention and control.展开更多
This study examines the impacts of heavy metals in irrigation water on soil quality and crop productivity in Ghana. Data was synthesized from 41 studies across 10 study areas spanning seven regions in Ghana. 10 heavy ...This study examines the impacts of heavy metals in irrigation water on soil quality and crop productivity in Ghana. Data was synthesized from 41 studies across 10 study areas spanning seven regions in Ghana. 10 heavy metals were identified from the synthetized data, namely, cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg), manganese (Mn), zinc (Zn), copper (Cu), cobalt (Co), nickel (Ni), iron (Fe) and chromium (Cr). The synthesized data revealed that certain regions such as Upper East, Ashanti and Ahafo exhibits elevated cadmium level in soil and the western region showed high concentrations of Hg, As, Pb, and Cu exceeding WHO limits in irrigation water. Due to their economic importance and susceptibility to metal contamination, the analysis of the effects of these metals on crop productivity focused on maize and leafy vegetables. The findings show that metals such as As, Ni, and Cu, in irrigation water significantly affect soil metal concentration but do not affect crop productivity, but Hg, Zn, Pb, and Co rather influence crop yield. Interestingly, while Hg and Pb reduce yield in leafy vegetables, they positively affect maize productivity, highlighting the potential for tailored crop selection based on soil metal concentration to improve Agricultural outcomes.展开更多
In 2022, an eddy covariance site was established in a young oil palm plantation in southeast Dangbo, Bénin, to study the exchange of CO2, energy, and water vapor. This study aims to present the first one-year ana...In 2022, an eddy covariance site was established in a young oil palm plantation in southeast Dangbo, Bénin, to study the exchange of CO2, energy, and water vapor. This study aims to present the first one-year analysis of seasonal dynamics in energy balance components and net ecosystem exchange above this type of ecosystem in Africa. The first results show that on average during the 2023 year, 55% of net radiation is consumed into actual evapotranspiration, demonstrating the significant amount of latent heat flux in the energy balance, as expected at this tropical humid site. The sensible heat flux was substantial, ranging between 60 and 200 W·m−2, while net radiation varied between 440 and 650 W·m−2. Carbon uptake and net release of CO2 into the atmosphere were permanent at the site. However, the CO2 uptake increases more when rainy events become regular. On average, the mean nighttime CO2 flux was ~8 µmol·m−2·s−1, while during the daytime it was ~−20 µmol·m−2·s−1.展开更多
Objective:To study the measures and effects of advanced lung cancer patients in terms of complication prevention and care.Methods:50 cases of advanced lung cancer patients were selected for data study during January-D...Objective:To study the measures and effects of advanced lung cancer patients in terms of complication prevention and care.Methods:50 cases of advanced lung cancer patients were selected for data study during January-December 2023,where the patients were divided into two groups.The study group used complication prevention and nursing care,while the control group used conventional care.The differences between the groups were compared.Results:Compared with the control group,the study group had significantly fewer complications,significantly lower psychological state scores,significantly higher quality of life scores,and significantly lower pain scores(P<0.05).Comparing the psychological state scores,quality of life scores,and pain scores before care,both groups showed insignificant differences(P>0.05).Conclusion:The results of patients with advanced lung cancer are ideal after the application of measures in the area of complication prevention and care.展开更多
This study investigates the performance of a solar photovoltaic (PV)-powered reverse osmosis (RO) desalination system applied to diverse water sources in the Al-Baha region, Saudi Arabia, including seawater, groundwat...This study investigates the performance of a solar photovoltaic (PV)-powered reverse osmosis (RO) desalination system applied to diverse water sources in the Al-Baha region, Saudi Arabia, including seawater, groundwater, rainwater, municipal water, and brackish water. Key water quality parameters including Total Dissolved Solids (TDS), pH, Electrical Conductivity (EC), salinity, and Specific Gravity (SG) were measured before and after desalination to assess system effectiveness. Results showed significant reductions in TDS, EC, and salinity levels across all water types, with seawater and brackish water achieving salt rejection rates of 98.32% and 99.16%, respectively. Post-desalination TDS for seawater decreased from 25,000 mg/L to 420 mg/L and for brackish water from 11,900 mg/L to 100 mg/L, achieving potable standards. pH values remained stable within potable standards, while EC values for seawater and brackish water dropped from 50,000 µS/cm to 484 µS/cm and from 12,000 µS/cm to 95 µS/cm, respectively. Water recovery rates varied from 70% to 95.33%, with the highest recovery observed in rainwater and groundwater samples. The overall desalination efficiency was highest for seawater and brackish water, at 82.96% and 84.5%, respectively, demonstrating the PV-RO system’s capability to provide high-quality, potable water from a variety of sources. This study underscores the potential of solar-powered RO technology as a sustainable solution for desalination in regions with diverse water sources and limited access to electricity.展开更多
Objective Alzheimer’s disease(AD)presents a significant global health challenge with a steadily increasing prevalence and impact.This comprehensive review aimed to delve into the epidemiology,pathophysiology,pharmaco...Objective Alzheimer’s disease(AD)presents a significant global health challenge with a steadily increasing prevalence and impact.This comprehensive review aimed to delve into the epidemiology,pathophysiology,pharmacological therapies,emerging research,challenges,and future directions of AD.Major findings from recent studies were synthesised,encompassing insights into the global prevalence,molecular pathology,high-risk factors,and therapeutic interventions,including cholinesterase inhibitors,glutamate receptor antagonists,and antibodies against Aβand tau proteins.Additionally,emerging research areas such as gene therapy and lipid nanoparticles were highlighted.This review emphasised the urgent need for ongoing research on novel therapeutic avenues and addressing the challenges in AD diagnosis,treatment,and care.Future perspectives underscore the potential of disease-modifying treatments,personalised medical approaches,and holistic interventions to alleviate the growing burden of AD on individuals,families,and healthcare systems worldwide.By fostering collaboration and innovation,we can strive towards a future where effective prevention,early detection,and personalised treatments enhance the lives of millions affected by AD globally.展开更多
Groundwater is a crucial water source for urban areas in Africa, particularly where surface water is insufficient to meet demand. This study analyses the water quality of five shallow wells (WW1-WW5) in Half-London Wa...Groundwater is a crucial water source for urban areas in Africa, particularly where surface water is insufficient to meet demand. This study analyses the water quality of five shallow wells (WW1-WW5) in Half-London Ward, Tunduma Town, Tanzania, using Principal Component Analysis (PCA) to identify the primary factors influencing groundwater contamination. Monthly samples were collected over 12 months and analysed for physical, chemical, and biological parameters. The PCA revealed between four and six principal components (PCs) for each well, explaining between 84.61% and 92.55% of the total variance in water quality data. In WW1, five PCs captured 87.53% of the variability, with PC1 (33.05%) dominated by pH, EC, TDS, and microbial contamination, suggesting significant influences from surface runoff and pit latrines. In WW2, six PCs explained 92.55% of the variance, with PC1 (36.17%) highlighting the effects of salinity, TDS, and agricultural runoff. WW3 had four PCs explaining 84.61% of the variance, with PC1 (39.63%) showing high contributions from pH, hardness, and salinity, indicating geological influences and contamination from human activities. Similarly, in WW4, six PCs explained 90.83% of the variance, where PC1 (43.53%) revealed contamination from pit latrines and fertilizers. WW5 also had six PCs, accounting for 92.51% of the variance, with PC1 (42.73%) indicating significant contamination from agricultural runoff and pit latrines. The study concludes that groundwater quality in Half-London Ward is primarily affected by a combination of surface runoff, pit latrine contamination, agricultural inputs, and geological factors. The presence of microbial contaminants and elevated nitrate and phosphate levels underscores the need for improved sanitation and sustainable agricultural practices. Recommendations include strengthening sanitation infrastructure, promoting responsible farming techniques, and implementing regular groundwater monitoring to safeguard water resources and public health in the region.展开更多
In this article, we have addressed the recent published article by Wang et al whichexamines risk factors associated with surgical site infections (SSIs) and evaluatesthe effectiveness of prophylactic antibiotics in th...In this article, we have addressed the recent published article by Wang et al whichexamines risk factors associated with surgical site infections (SSIs) and evaluatesthe effectiveness of prophylactic antibiotics in their prevention. Wang et al identifiedseveral significant risk factors of SSIs, including age ≥ 60 years, diabetesmellitus, and surgical complications such as insufficient cystic duct stump closure,gallbladder perforation, empyema, and postoperative hematoma. Their findingssuggest that prophylactic antibiotics can serve as a protective factor against SSIs.However, other reported risk factors and preventive strategies warrant considerationto further reduce the incidence of SSIs, lower healthcare costs, and enhancepatient outcomes. Additionally, the judicious use of prophylactic antibioticsis crucial in light of the growing global challenge of antibiotic resistance caused bythe misuse and overuse of antibiotics. Effective management strategies forprophylactic antibiotic use should be prioritized to balance infection control withthe need to combat antimicrobial resistance.展开更多
In recent years,nosocomial infections caused by Clostridium difficile(C.difficile)have risen,becoming a leading cause of hospital-acquired diarrhea.The global prevalence of C.difficile infection(CDI)varies across regi...In recent years,nosocomial infections caused by Clostridium difficile(C.difficile)have risen,becoming a leading cause of hospital-acquired diarrhea.The global prevalence of C.difficile infection(CDI)varies across regions and populations.The diagnosis relies primarily on laboratory testing,including toxin,glutamate dehy-drogenase,and nucleic acid amplification tests.Treatment strategies for CDI in-clude antimicrobial therapy(e.g.,metronidazole,vancomycin,and fidamycin),fecal transplantation,and immunotherapy(e.g.,belotozumab),depending on the patient’s specificity and severity.This paper reviews recent research on CDI’s epidemiological characteristics,risk factors,diagnosis,treatment,and prevention,aiming to support hospitals and public health initiatives in implementing effective detection,prevention,and treatment strategies.展开更多
文摘Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP remains challenging, particularly in patients with comorbidities or contraindications to standard therapies. Objectives: To evaluate the effectiveness of ozonated water as an adjunctive treatment for EP, delivered using a patented robotic therapy system designed for hygiene and infection prevention in non-self-sufficient patients. Methods: We report the case of a 90-year-old male patient with acute EP who received daily skin treatments with ozonated water in conjunction with supportive care, including rehydration and antibiotics. The intervention was facilitated by the robotic system “COPERNICO Surveillance & Prevention,” which ensured standardized hygiene practices and clinical documentation. Results: Within one week of treatment, the patient showed complete desquamation of necrotic skin, resolution of erythema, and significant metabolic recovery. Fever subsided, renal function improved, and the patient was discharged in stable condition. Follow-up confirmed sustained clinical improvement, and no adverse events were reported. Conclusions: Ozonated water demonstrated efficacy in alleviating the dermatological and systemic manifestations of EP in a high-risk elderly patient. This case highlights the potential of ozone therapy as a safe, cost-effective adjunctive treatment for EP and underscores the utility of robotic systems in managing complex dermatological conditions. Further research is warranted to validate these findings in larger cohorts.
文摘This study tries to highlight the role of magnetic and seismic data in the prevention of building cracking, which constitutes a geotechnical risk in Agadez City. This city is built on the faulted and fractured sandstone formations of the “Agadez Sandstones Formations”, which were deposited in unconformity on the basement of the Aïr Mountain. This study focuses on the prevention of geotechnical damages related to building cracking in the Agadez region through geophysical methods, which are well known for investigating tectonic structures and their directions on the surface and subsurface. A methodological approach integrated the seismic and magnetic data interpretation combined with field measurement on the cracked building and its underlying substratum, represented by Agadez sandstones and basement. The extraction of seismic lineaments from the West African seismic map showed the seismic directions oriented NW-SE (N135˚ to N160˚), passing through the studied area. The structural interpretation of the magnetic map shows that the Agadez region is also affected by the subsurface lineaments mainly oriented in NW-SE (N135˚) directions, which are similar to the identified seismic lineaments in the same zone. A structural study carried out on the Agadez sandstones and the underlying basement showed that faults and fractures oriented N120˚ to N165˚ affect both the basement of the Aïr Mountains and the sandstone formations on which the city of Agadez is built. These observations showed that building cracking in the Agadez region has a higher propagation tendency according to the directions ranging from NW-SE (N135˚) to NNW-SSE (N165˚). Therefore, the building’s cracking has a stronger propagation component according to these mean directions that are not recommended for building. To prevent and reduce the risks related to building cracking in Agadez region, it is highly recommended to build in the minor directions of cracking propagation, which correspond to NE and SW directions.
基金Supported by the Natural Science Foundation of China(51705326,52075339)。
文摘In sub nanometer carbon nanotubes,water exhibits unique dynamic characteristics,and in the high-frequency region of the infrared spectrum,where the stretching vibrations of the internal oxygen-hydrogen(O-H)bonds are closely related to the hydrogen bonds(H-bonds)network between water molecules.Therefore,it is crucial to analyze the relationship between these two aspects.In this paper,the infrared spectrum and motion characteristics of the stretching vibrations of the O-H bonds in one-dimensional confined water(1DCW)and bulk water(BW)in(6,6)single-walled carbon nanotubes(SWNT)are studied by molecular dynamics simulations.The results show that the stretching vibrations of the two O-H bonds in 1DCW exhibit different frequencies in the infrared spectrum,while the O-H bonds in BW display two identical main frequency peaks.Further analysis using the spring oscillator model reveals that the difference in the stretching amplitude of the O-H bonds is the main factor causing the change in vibration frequency,where an increase in stretching amplitude leads to a decrease in spring stiffness and,consequently,a lower vibration frequency.A more in-depth study found that the interaction of H-bonds between water molecules is the fundamental cause of the increased stretching amplitude and decreased vibration frequency of the O-H bonds.Finally,by analyzing the motion trajectory of the H atoms,the dynamic differences between 1DCW and BW are clearly revealed.These findings provide a new perspective for understanding the behavior of water molecules at the nanoscale and are of significant importance in advancing the development of infrared spectroscopy detection technology.
文摘This study investigates the application of carbon dioxide (CO2) sequestration to address challenges in water-drive gas reservoirs, specifically focusing on improving gas recovery and mitigating water invasion. Traditional methods like blow-down and co-production have limitations, including sand production, water coning, and inefficiency in strong aquifers. To overcome these issues, this research explores CO2 injection near the edge aquifer, aiming to reduce water influx and enhance gas recovery through the propagation of a CO2 plume in the gas-water contact zone. Both synthetic and real compositional reservoir models were studied, with CO2 injection performed while maintaining reservoir pressure below 90% of the initial level. Results show that CO2 sequestration significantly improved recovery, particularly in higher permeability reservoirs, where it reduced aquifer influx and increased gas production by 26% under challenging conditions. While CO2 dissolution in water decreased aquifer influx by 39%, its adverse effect on sweep efficiency led to a reduction in gas and water production by 4.2% and 10%, respectively. The method's effectiveness was not significantly impacted by aquifer permeability, but it was sensitive to vertical-to-horizontal permeability ratios. When applied to a real gas reservoir, the proposed method increased gas production by 14% compared to conventional techniques, with minimal CO2 production over a 112-year period. This study demonstrates the potential of CO2 sequestration as a comprehensive solution for enhancing gas recovery, reducing water production, and mitigating environmental impacts in water-drive gas reservoirs.
文摘The study investigates the impact of the Syrian crisis and the recent drought on the potable water situation in Northwest Syria, comparing various aspects of water availability and quality before and after 2011. 380 key-informants were surveyed, including water-well owners, well-digging companies, water-trucking suppliers, agricultural pharmacies, and service offices within local councils. The surveys covered all nine districts in northwestern Syria across the Aleppo and the Idleb governorates. The survey findings reveal significant shifts in water sources, an almost halving in water availability and per capita consumption, and a notable decrease in water quality. Coping mechanisms include random well drilling and reduced hygiene practices. Water pumping stations face challenges with functionality, and there is a shift towards clean energy sources, particularly solar energy. Challenges identified by the survey respondents include drought, fuel costs, and damaged water networks. The study highlights the urgency of addressing the potable water crisis in Northwest Syria and suggests specific interventions to enhance water sustainability and governance.
文摘Contrast-induced acute kidney injury(CI-AKI)is the third leading cause of acute kidney injury deriving from the intravascular administration of contrast media in diagnostic and therapeutic procedures and leading to longer in-hospital stay and increased short and long-term mortality.Its pathophysiology,although not well-established,revolves around medullary hypoxia paired with the direct toxicity of the substance to the kidney.Critically ill patients,as well as those with pre-existing renal disease and cardiovascular comorbidities,are more susceptible to CI-AKI.Despite the continuous research in the field of CI-AKI prevention,clinical practice is based mostly on periprocedural hydration.In this review,all the investigated methods of prevention are presented,with an emphasis on the latest evidence regarding the potential of RenalGuard and contrast removal systems for CI-AKI prevention in high-risk individuals.
文摘Water contamination in areas of formal and informal polymetallic mining is a growing concern in the Peruvian highlands. At the same time, there are agricultural activities that use contaminated water from these rivers for irrigation. This could contaminate the agricultural products grown on these lands, such as potatoes. It is, therefore, necessary and a priority to determine the adsorption characteristics of these derivatives and to be able to use these natural adsorbents to decontaminate water contaminated with heavy metals.
文摘Upon ship lift chamber docking with approach channel in the case of water level difference, water in chamber will fluctuate evidently. The maximum or minimum fluctuation of water surface is an important parameter to measure operational safety of ship lift. A simplified 3D mathematical model of ship lift chamber upon tumble gate opening was built based on standard k-ε model, FVM (Finite Volume Method) and VOF (Volume of Fluid) model. Based on π theorem, the dimensionless influencing factors of Δhmax/d and Δhmin/d were B/L, d/B and Δh/d. On this basis, 30 sets of working conditions were designed to respectively study the relationships between the maximum wave height and each influencing factor. Through regression analysis, the empirical formulas of Δhmax/d and Δhmin/d were obtained. Furthermore, taking into account the potential influence of the gate opening time on the wave height in practical applications, the relationship between the gate opening time and the error was fitted, and the modified empirical formulas of Δh′max/dand Δh′min/dwere derived, which had a wider scope of application. The results have practical value for engineering design and security operation of ship lift.
文摘It is essential to investigate the impact of tropical highland open pit gold mines on surface and groundwater quality and flow dynamics. Samples from the Twangiza gold mine, with long term mining activities, including small-scale mining were analyzed in an accredited South African Laboratory. Results indicate that TDS and EC were higher in the mine site due the concentration of many metals. DO values were higher downstream. ORP and pH levels were similar at all site positions. Upstream: Fe, Si, K, Mg, Al have the highest concentrations (14.0 - 23.1 mg∙l−1). P, Pb, B, Ti, Sr, Ag, Ni, Ba, and As have concentrations ranging from 0.1 - 0.9 mg∙l−1. Li and Au have the lowest concentrations (0.01 - 0.05 mg∙l−1). Zn was also relatively abundant upstream, most likely airborne by the plant generator smoke. Within the mine site: Si, Al, Mg, Fe are found in higher concentrations (19 - 50 mg∙l−1). These are followed by K, As, and P (1.4 - 4 mg∙l−1). Ni, Ti, Ag, Sr, Ba are also found in lesser concentrations (0.2 - 0.7 mg∙l−1). The groundwater flow remained consistent. This study has the advantage of having continuously followed up a large number of heavy metals during years.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82272932,81974422,and 92359201).
文摘Breast cancer(BC)is now the most common cancer and the fifth leading cause of cancer-associated mortality among women in China1.Germline pathogenic variants(PVs)of BC susceptibility genes,such as the well-known BRCA1/2 genes,increase the risk of BC and other cancers(ovarian and pancreatic cancer)^(2,3).Recent studies have demonstrated substantial benefits of poly(adenosine diphosphate ribose)polymerase inhibitors in the treatment of BC patients who carry BRCA1/2 PVs^(4).
文摘This study provides an in-depth exploration of seaweed biodiversity in Nigeria’s coastal waters, a largely unexplored area for marine resources. There is a dearth of sufficient data on seaweed biodiversity in Nigeria. The research aimed to assess the diversity and distribution of seaweeds in this region. Seaweed samples were collected by hand, using scrapers, at low tide from four stations identified by local fisherfolk and commercial divers. These samples were analyzed in the laboratory for species identification. A total of 39 seaweed taxa were identified, with Rhodophyta (red algae) being the most abundant (74%), followed by Chlorophyta (green algae) (21%) and Heterokontophyta (brown algae) (5%). The highest biomass species included Grateloupia sp., Chaetomorpha antennina, Gracilaria sp., Ceratodictyon variabile, Cladophora sp., Gelidium pusillum, Ulva sp., Blidingia minima, and Caloglossa leprieurii. Species abundance was highest on breakwater rocks and on the bodies of anchored or sunken vessels, while sandy beaches exhibited lower abundance. The findings reveal significant potential for Nigeria’s seaweed in aquaculture, climate change mitigation, and biotechnology. The study recommends further molecular research, expansion of sampling areas, and the development of sustainable seaweed cultivation practices to support Nigeria’s blue economy.
文摘Objective: Stroke is perceived as a serious illness although it is preventable, and lifestyle alterations can be made to reduce its risk. Improvement of stroke care should be achieved through awareness of public, especially through high-risk group. Henceforth, the aim of this study was to evaluate the effect of nursing intervention on improving awareness of high-risk people about stroke prevention. Methods: A quasi-experimental design was used to carry out this study, where a purposive sample of 80 adult patients at high risk for stroke were enrolled while they were attending the out-patient clinics of Zagazig University Hospitals for follow-up treatment;they were divided into two groups: case (40 patients) and control (40 patients). An interview questionnaire was used to assess patients’ knowledge regarding warning signs, risk factors, and immediate treatment;attitude;and their practice for prevention for stroke at pretest and posttest. Results: The study revealed the poor level of knowledge, bad level of preventive behavior, and negative attitude regarding stroke prevention at pre-intervention. However, after intervention, the high-risk people had fair level of knowledge with moderate practice for stroke prevention and positive attitude, with statistically significant difference between pre-post intervention and between the case and control groups. Conclusions: The study revealed that the nursing intervention seemed to change the knowledge, practice, and attitude of subjects regarding stroke prevention. This, in turn, implies that awareness of prevention of stroke and high-risk factor control could be important to reduce the burden of stroke in Egypt. Thus, further research on a larger scale is required to improve population knowledge and behavior for stroke prevention and control.
文摘This study examines the impacts of heavy metals in irrigation water on soil quality and crop productivity in Ghana. Data was synthesized from 41 studies across 10 study areas spanning seven regions in Ghana. 10 heavy metals were identified from the synthetized data, namely, cadmium (Cd), lead (Pb), arsenic (As), mercury (Hg), manganese (Mn), zinc (Zn), copper (Cu), cobalt (Co), nickel (Ni), iron (Fe) and chromium (Cr). The synthesized data revealed that certain regions such as Upper East, Ashanti and Ahafo exhibits elevated cadmium level in soil and the western region showed high concentrations of Hg, As, Pb, and Cu exceeding WHO limits in irrigation water. Due to their economic importance and susceptibility to metal contamination, the analysis of the effects of these metals on crop productivity focused on maize and leafy vegetables. The findings show that metals such as As, Ni, and Cu, in irrigation water significantly affect soil metal concentration but do not affect crop productivity, but Hg, Zn, Pb, and Co rather influence crop yield. Interestingly, while Hg and Pb reduce yield in leafy vegetables, they positively affect maize productivity, highlighting the potential for tailored crop selection based on soil metal concentration to improve Agricultural outcomes.
文摘In 2022, an eddy covariance site was established in a young oil palm plantation in southeast Dangbo, Bénin, to study the exchange of CO2, energy, and water vapor. This study aims to present the first one-year analysis of seasonal dynamics in energy balance components and net ecosystem exchange above this type of ecosystem in Africa. The first results show that on average during the 2023 year, 55% of net radiation is consumed into actual evapotranspiration, demonstrating the significant amount of latent heat flux in the energy balance, as expected at this tropical humid site. The sensible heat flux was substantial, ranging between 60 and 200 W·m−2, while net radiation varied between 440 and 650 W·m−2. Carbon uptake and net release of CO2 into the atmosphere were permanent at the site. However, the CO2 uptake increases more when rainy events become regular. On average, the mean nighttime CO2 flux was ~8 µmol·m−2·s−1, while during the daytime it was ~−20 µmol·m−2·s−1.
文摘Objective:To study the measures and effects of advanced lung cancer patients in terms of complication prevention and care.Methods:50 cases of advanced lung cancer patients were selected for data study during January-December 2023,where the patients were divided into two groups.The study group used complication prevention and nursing care,while the control group used conventional care.The differences between the groups were compared.Results:Compared with the control group,the study group had significantly fewer complications,significantly lower psychological state scores,significantly higher quality of life scores,and significantly lower pain scores(P<0.05).Comparing the psychological state scores,quality of life scores,and pain scores before care,both groups showed insignificant differences(P>0.05).Conclusion:The results of patients with advanced lung cancer are ideal after the application of measures in the area of complication prevention and care.
文摘This study investigates the performance of a solar photovoltaic (PV)-powered reverse osmosis (RO) desalination system applied to diverse water sources in the Al-Baha region, Saudi Arabia, including seawater, groundwater, rainwater, municipal water, and brackish water. Key water quality parameters including Total Dissolved Solids (TDS), pH, Electrical Conductivity (EC), salinity, and Specific Gravity (SG) were measured before and after desalination to assess system effectiveness. Results showed significant reductions in TDS, EC, and salinity levels across all water types, with seawater and brackish water achieving salt rejection rates of 98.32% and 99.16%, respectively. Post-desalination TDS for seawater decreased from 25,000 mg/L to 420 mg/L and for brackish water from 11,900 mg/L to 100 mg/L, achieving potable standards. pH values remained stable within potable standards, while EC values for seawater and brackish water dropped from 50,000 µS/cm to 484 µS/cm and from 12,000 µS/cm to 95 µS/cm, respectively. Water recovery rates varied from 70% to 95.33%, with the highest recovery observed in rainwater and groundwater samples. The overall desalination efficiency was highest for seawater and brackish water, at 82.96% and 84.5%, respectively, demonstrating the PV-RO system’s capability to provide high-quality, potable water from a variety of sources. This study underscores the potential of solar-powered RO technology as a sustainable solution for desalination in regions with diverse water sources and limited access to electricity.
文摘Objective Alzheimer’s disease(AD)presents a significant global health challenge with a steadily increasing prevalence and impact.This comprehensive review aimed to delve into the epidemiology,pathophysiology,pharmacological therapies,emerging research,challenges,and future directions of AD.Major findings from recent studies were synthesised,encompassing insights into the global prevalence,molecular pathology,high-risk factors,and therapeutic interventions,including cholinesterase inhibitors,glutamate receptor antagonists,and antibodies against Aβand tau proteins.Additionally,emerging research areas such as gene therapy and lipid nanoparticles were highlighted.This review emphasised the urgent need for ongoing research on novel therapeutic avenues and addressing the challenges in AD diagnosis,treatment,and care.Future perspectives underscore the potential of disease-modifying treatments,personalised medical approaches,and holistic interventions to alleviate the growing burden of AD on individuals,families,and healthcare systems worldwide.By fostering collaboration and innovation,we can strive towards a future where effective prevention,early detection,and personalised treatments enhance the lives of millions affected by AD globally.
文摘Groundwater is a crucial water source for urban areas in Africa, particularly where surface water is insufficient to meet demand. This study analyses the water quality of five shallow wells (WW1-WW5) in Half-London Ward, Tunduma Town, Tanzania, using Principal Component Analysis (PCA) to identify the primary factors influencing groundwater contamination. Monthly samples were collected over 12 months and analysed for physical, chemical, and biological parameters. The PCA revealed between four and six principal components (PCs) for each well, explaining between 84.61% and 92.55% of the total variance in water quality data. In WW1, five PCs captured 87.53% of the variability, with PC1 (33.05%) dominated by pH, EC, TDS, and microbial contamination, suggesting significant influences from surface runoff and pit latrines. In WW2, six PCs explained 92.55% of the variance, with PC1 (36.17%) highlighting the effects of salinity, TDS, and agricultural runoff. WW3 had four PCs explaining 84.61% of the variance, with PC1 (39.63%) showing high contributions from pH, hardness, and salinity, indicating geological influences and contamination from human activities. Similarly, in WW4, six PCs explained 90.83% of the variance, where PC1 (43.53%) revealed contamination from pit latrines and fertilizers. WW5 also had six PCs, accounting for 92.51% of the variance, with PC1 (42.73%) indicating significant contamination from agricultural runoff and pit latrines. The study concludes that groundwater quality in Half-London Ward is primarily affected by a combination of surface runoff, pit latrine contamination, agricultural inputs, and geological factors. The presence of microbial contaminants and elevated nitrate and phosphate levels underscores the need for improved sanitation and sustainable agricultural practices. Recommendations include strengthening sanitation infrastructure, promoting responsible farming techniques, and implementing regular groundwater monitoring to safeguard water resources and public health in the region.
基金Supported by Scientific Research Foundation of Shanghai Municipal Health Commission of Changning District,No.20234Y038Medical Science and Technology Research Foundation of Guangdong Province,China,No.C2022023.
文摘In this article, we have addressed the recent published article by Wang et al whichexamines risk factors associated with surgical site infections (SSIs) and evaluatesthe effectiveness of prophylactic antibiotics in their prevention. Wang et al identifiedseveral significant risk factors of SSIs, including age ≥ 60 years, diabetesmellitus, and surgical complications such as insufficient cystic duct stump closure,gallbladder perforation, empyema, and postoperative hematoma. Their findingssuggest that prophylactic antibiotics can serve as a protective factor against SSIs.However, other reported risk factors and preventive strategies warrant considerationto further reduce the incidence of SSIs, lower healthcare costs, and enhancepatient outcomes. Additionally, the judicious use of prophylactic antibioticsis crucial in light of the growing global challenge of antibiotic resistance caused bythe misuse and overuse of antibiotics. Effective management strategies forprophylactic antibiotic use should be prioritized to balance infection control withthe need to combat antimicrobial resistance.
文摘In recent years,nosocomial infections caused by Clostridium difficile(C.difficile)have risen,becoming a leading cause of hospital-acquired diarrhea.The global prevalence of C.difficile infection(CDI)varies across regions and populations.The diagnosis relies primarily on laboratory testing,including toxin,glutamate dehy-drogenase,and nucleic acid amplification tests.Treatment strategies for CDI in-clude antimicrobial therapy(e.g.,metronidazole,vancomycin,and fidamycin),fecal transplantation,and immunotherapy(e.g.,belotozumab),depending on the patient’s specificity and severity.This paper reviews recent research on CDI’s epidemiological characteristics,risk factors,diagnosis,treatment,and prevention,aiming to support hospitals and public health initiatives in implementing effective detection,prevention,and treatment strategies.
