Objective:To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency(POI)of the kidney deficiency and liver constraint pattern.Methods:Ni...Objective:To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency(POI)of the kidney deficiency and liver constraint pattern.Methods:Ninety patients with POI who consulted with Professor Guo at Dongzimen Hospital,Beijing University of Chinese Medicine from January 2012 to December 2015 were enrolled.Treatment consisted of sequential therapy using traditional Chinese medicine formulae with the actions of nourishing the liver and kidney.Course of treatment was 3 consecutive menstrual cycles for each participant except for those who became pregnant during treatment.Baseline data including age,course of disease,past medical history,lifestyle,pregnancy outcome,menstrual status(cycle length,menstrual flow duration and volume),as well as gonadal hormone levels before and after treatment were recorded and analyzed.Results:During treatment,18(20.0%)participants became pregnant.Symptoms including scanty menstrual flow,irritability,low libido,insomnia and excessive dreaming at night,nightsweats,hot flashes,and depression were markedly alleviated.Changes in follicle-stimulating hormone(FSH)and luteinizing hormone(LH)levels at early follicular stage were observed(P=.009 and P=.002,respectively),and FSH/LH differed significantly pre-and posttreatment(P=.0.44).Conclusion:Professor Guo's sequential Chinese herbal therapy with the actions of nourishing the liver and kidney to treat POI can enhance ovarian function,promote pregnancy,and improve quality of life.展开更多
The objective of this paper is to outline Chief Physician Defen Wang’s clinical experience in perimenopausal sweating syndrome differentiation and treatment,to inherit Mr.Gao’s academic concept of mediation techniqu...The objective of this paper is to outline Chief Physician Defen Wang’s clinical experience in perimenopausal sweating syndrome differentiation and treatment,to inherit Mr.Gao’s academic concept of mediation technique,and to integrate multiple prescriptions under Mr.Gao’s thinking.The deficiency is based on the deficiency of liver and kidney Yin,the weakness of spleen and stomach,and the standard is the imbalance of Ying and Wei,the imbalance of Qi,blood and body fluid,and the main method of treatment is nourishing liver and kidney,soothing liver and invigorating spleen,regulating Ying and Wei,as well as tonifying Qi and absorbing fluid.展开更多
目的评价补肝益肾活血法治疗中重度斑秃的临床疗效并探究其对患者外周血CD4^+CD25^+调节性T细胞亚群的影响。方法选择中重度斑秃患者50例,根据就诊先后顺序将其随机分为治疗组和对照组各25例,对照组服用复方甘草酸苷片,治疗组给予补肝...目的评价补肝益肾活血法治疗中重度斑秃的临床疗效并探究其对患者外周血CD4^+CD25^+调节性T细胞亚群的影响。方法选择中重度斑秃患者50例,根据就诊先后顺序将其随机分为治疗组和对照组各25例,对照组服用复方甘草酸苷片,治疗组给予补肝益肾活血之剂治疗,观察两组治疗前后斑秃严重程度评分(severity of alopecia tool,SALT)的变化,评价临床疗效,并利用流式细胞仪分析两组患者治疗前后外周血清CD4^+CD25^+调节性T细胞亚群的变化情况。结果两组患者治疗12周后,SALT评分均显著低于治疗前(P<0.05);两组患者治疗前后SALT评分差值比较,差异有统计学意义(P<0.05)。两组临床疗效的分布比较,差异有统计学意义(P<0.05)。两组患者血清CD4^+CD25^+调节性T细胞表达水平均较治疗前升高(P<0.05),但均未达到正常组水平。结论补肝益肾活血法能够有效治疗中重度斑秃,并可以提高患者外周血CD4^+CD25^+调节性T细胞水平,效果优于复方甘草酸苷。展开更多
文摘Objective:To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency(POI)of the kidney deficiency and liver constraint pattern.Methods:Ninety patients with POI who consulted with Professor Guo at Dongzimen Hospital,Beijing University of Chinese Medicine from January 2012 to December 2015 were enrolled.Treatment consisted of sequential therapy using traditional Chinese medicine formulae with the actions of nourishing the liver and kidney.Course of treatment was 3 consecutive menstrual cycles for each participant except for those who became pregnant during treatment.Baseline data including age,course of disease,past medical history,lifestyle,pregnancy outcome,menstrual status(cycle length,menstrual flow duration and volume),as well as gonadal hormone levels before and after treatment were recorded and analyzed.Results:During treatment,18(20.0%)participants became pregnant.Symptoms including scanty menstrual flow,irritability,low libido,insomnia and excessive dreaming at night,nightsweats,hot flashes,and depression were markedly alleviated.Changes in follicle-stimulating hormone(FSH)and luteinizing hormone(LH)levels at early follicular stage were observed(P=.009 and P=.002,respectively),and FSH/LH differed significantly pre-and posttreatment(P=.0.44).Conclusion:Professor Guo's sequential Chinese herbal therapy with the actions of nourishing the liver and kidney to treat POI can enhance ovarian function,promote pregnancy,and improve quality of life.
基金Shanglin Gao national famous traditional Chinese medicine inheritance studio construction project of the National Administration of Traditional Chinese Medicine(Department of Human Education,State Administration of Traditional Chinese Medicine[2011]No.41)Key research and development projects of Shaanxi Province in 2020(2020SF-276)Science and technology project of Xi’an Health Bureau(J201902018).
文摘The objective of this paper is to outline Chief Physician Defen Wang’s clinical experience in perimenopausal sweating syndrome differentiation and treatment,to inherit Mr.Gao’s academic concept of mediation technique,and to integrate multiple prescriptions under Mr.Gao’s thinking.The deficiency is based on the deficiency of liver and kidney Yin,the weakness of spleen and stomach,and the standard is the imbalance of Ying and Wei,the imbalance of Qi,blood and body fluid,and the main method of treatment is nourishing liver and kidney,soothing liver and invigorating spleen,regulating Ying and Wei,as well as tonifying Qi and absorbing fluid.
文摘目的评价补肝益肾活血法治疗中重度斑秃的临床疗效并探究其对患者外周血CD4^+CD25^+调节性T细胞亚群的影响。方法选择中重度斑秃患者50例,根据就诊先后顺序将其随机分为治疗组和对照组各25例,对照组服用复方甘草酸苷片,治疗组给予补肝益肾活血之剂治疗,观察两组治疗前后斑秃严重程度评分(severity of alopecia tool,SALT)的变化,评价临床疗效,并利用流式细胞仪分析两组患者治疗前后外周血清CD4^+CD25^+调节性T细胞亚群的变化情况。结果两组患者治疗12周后,SALT评分均显著低于治疗前(P<0.05);两组患者治疗前后SALT评分差值比较,差异有统计学意义(P<0.05)。两组临床疗效的分布比较,差异有统计学意义(P<0.05)。两组患者血清CD4^+CD25^+调节性T细胞表达水平均较治疗前升高(P<0.05),但均未达到正常组水平。结论补肝益肾活血法能够有效治疗中重度斑秃,并可以提高患者外周血CD4^+CD25^+调节性T细胞水平,效果优于复方甘草酸苷。
