Purpose: Levobupivacaine is thought to be a good alternative to bupivacaine for epidural labor analgesia because of its pharmacologic profile. However, the optimal concentration of levobupivacaine for labor analgesia ...Purpose: Levobupivacaine is thought to be a good alternative to bupivacaine for epidural labor analgesia because of its pharmacologic profile. However, the optimal concentration of levobupivacaine for labor analgesia has not been adequately studied. The objective of this retrospective study was to compare the analgesic effect of levobupivacaine between 0.06% and 0.1% both combined with 2 μg/mL of fentanyl. Methods: Primiparous women (ASA I, II) who delivered their babies to our hospital using combined spinal epidural analgesia and patient-controlled epidural analgesia between August 1, 2011 and September 30, 2011 were included into this retrospective study. The analgesic solution for epidural administration was 0.06% levobupivacaine with 2 μg/mL of fentanyl between August 1 and 31, and 0.1% levobupivacaine with 2 μg/mL of fentanyl between September 1 and 30. Their anesthetic and obstetric charts were reviewed to compare obstetric outcome, anesthetic intervention, and patients’ satisfaction. Results: There were 46 women fulfilling the inclusion criteria: 23 women in 0.06% group, and 23 women in 0.1% group. The number of patients who needed more than 3 requests for one actual bolus was significantly higher in the 0.06% group (P 0.05). Conclusion: Our results revealed that 0.06% levobupivacaine combined with 2 μg/mL fentanyl does not provide sufficient analgesic effects for epidural labor analgesia. It seems that levobupivacaine has not been adequately studied after its withdrawal from the US market. Further studies should be conducted to determine the optimal concentration of levobupivacaine for epidural labor analgesia.展开更多
目的探讨硬膜外每隔30 min 1次、60 min 1次及90 min 1次给药频率对足月初产妇行分娩镇痛的影响。方法选取2015年3月至2017年8月于我院分娩足月初产妇共210例,以随机数字表法分为A组(70例),B组(70例)及C组(70例),分别于硬膜外镇痛后以每...目的探讨硬膜外每隔30 min 1次、60 min 1次及90 min 1次给药频率对足月初产妇行分娩镇痛的影响。方法选取2015年3月至2017年8月于我院分娩足月初产妇共210例,以随机数字表法分为A组(70例),B组(70例)及C组(70例),分别于硬膜外镇痛后以每隔30 min、60 min及90 min频率行自控镇痛,比较三组产妇不同时间点疼痛视觉模拟评分(VAS)、胸椎和骶椎感觉阻滞平面、缩宫素使用率、器械助产率及自控镇痛使用次数。结果B组产妇镇痛后2 h、3 h、4 h、5 h及分娩时疼痛VAS评分显著低于A组(P<0.05);B组产妇镇痛后4 h和分娩时VAS评分显著低于C组(P<0.05);B组产妇镇痛后2 h、3 h、4 h、5 h及分娩时胸椎和骶椎感觉阻滞平面均显著优于A组(P<0.05);B组产妇镇痛后2 h、3 h及5 h胸椎和骶椎感觉阻滞平面均显著优于C组(P<0.05);B组产妇镇痛后4 h和分娩时胸椎感觉阻滞平面显著低于C组(P<0.05),而高于A组(P<0.05);三组产妇缩宫素使用率和器械助产率比较差异无统计学意义(P>0.05);同时B组患者自控镇痛使用次数均显著少于A、C组(P<0.05)。结论相较于每隔30 min和90 min频率下行自控镇痛,每隔60 min 1次硬膜外给药用于行分娩镇痛足月初产妇可有效提高镇痛效果,保证感觉阻滞平面稳定,并有助于降低麻醉用药剂量。展开更多
文摘Purpose: Levobupivacaine is thought to be a good alternative to bupivacaine for epidural labor analgesia because of its pharmacologic profile. However, the optimal concentration of levobupivacaine for labor analgesia has not been adequately studied. The objective of this retrospective study was to compare the analgesic effect of levobupivacaine between 0.06% and 0.1% both combined with 2 μg/mL of fentanyl. Methods: Primiparous women (ASA I, II) who delivered their babies to our hospital using combined spinal epidural analgesia and patient-controlled epidural analgesia between August 1, 2011 and September 30, 2011 were included into this retrospective study. The analgesic solution for epidural administration was 0.06% levobupivacaine with 2 μg/mL of fentanyl between August 1 and 31, and 0.1% levobupivacaine with 2 μg/mL of fentanyl between September 1 and 30. Their anesthetic and obstetric charts were reviewed to compare obstetric outcome, anesthetic intervention, and patients’ satisfaction. Results: There were 46 women fulfilling the inclusion criteria: 23 women in 0.06% group, and 23 women in 0.1% group. The number of patients who needed more than 3 requests for one actual bolus was significantly higher in the 0.06% group (P 0.05). Conclusion: Our results revealed that 0.06% levobupivacaine combined with 2 μg/mL fentanyl does not provide sufficient analgesic effects for epidural labor analgesia. It seems that levobupivacaine has not been adequately studied after its withdrawal from the US market. Further studies should be conducted to determine the optimal concentration of levobupivacaine for epidural labor analgesia.
