Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully a...Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas alone.Instead,they involve connectivity among brain areas,whether close or distant.At that time,this approach was considered the optimal way to dissect brain circuitry and function.These pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain function.However,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely elusive.Utilizing animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.展开更多
The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression tests.By establishing the constitutive equations for simulati...The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression tests.By establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow instability.We concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.展开更多
In engineering practice,it is often necessary to determine functional relationships between dependent and independent variables.These relationships can be highly nonlinear,and classical regression approaches cannot al...In engineering practice,it is often necessary to determine functional relationships between dependent and independent variables.These relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable solutions.Nevertheless,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely explored.This study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic materials.The ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree Regression(DTR),and Gaussian Process Regression(GPR)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon steel.Although the GPR method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.展开更多
The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La a...The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.展开更多
The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain functio...The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with emotions.Specifically, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal mice.After knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was obviously mitigated. Additionally, administration of an excitatory amino acid transporter 2 inhibitor in the basolateral amygdala yielded a notable reduction in anxiety level among mice subjected to stress. These results suggest that basolateral amygdala astrocytic excitatory amino acid transporter 2 plays a role in in the regulation of unpredictable chronic mild stress-induced anxiety-like behavior by impacting the activity of local glutamatergic neurons, and targeting excitatory amino acid transporter 2 in the basolateral amygdala holds therapeutic promise for addressing anxiety disorders.展开更多
BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current statu...BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.展开更多
To evaluate the impact of behavioral restrictions on perinatal care caused by the COVID-19 pandemic, we conducted a questionnaire survey of 1976 medical institutions handling deliveries across Japan. The survey examin...To evaluate the impact of behavioral restrictions on perinatal care caused by the COVID-19 pandemic, we conducted a questionnaire survey of 1976 medical institutions handling deliveries across Japan. The survey examined changes in the number of antenatal checkups due to behavioral restrictions, visit restrictions at medical institutions, and the acceptance of COVID-19-infected pregnant and nursing mothers. An increased burden was observed at delivery hospitals, irrespective of whether they accepted infected pregnant and nursing mothers. Some medical institutions were unable to manage infected pregnant women and transferred them to other facilities, highlighting the need for role-sharing among institutions. The number of antenatal checkups showed a decreasing trend, indicating that the pandemic negatively affected checkup attendance. However, no clear increase in perinatal deaths was observed during the observation period, despite the reduction in the number of checkups.展开更多
Background: Hip osteoarthritis (HOA) causes joint destruction, resulting in hip pain, limited range-of-motion, claudication, and joint deformity. In the conservative treatment of HOA, self-management is important to m...Background: Hip osteoarthritis (HOA) causes joint destruction, resulting in hip pain, limited range-of-motion, claudication, and joint deformity. In the conservative treatment of HOA, self-management is important to manage symptoms and control disease progression. In a previous study, the researchers conducted a conceptual analysis of 43 foreign studies on self-management during conservative therapy for patients with HOA. The results revealed a definition of self-management during conservative therapy for patients with HOA. However, because that study analyzed only the foreign literature, it remains unclear whether the findings reflect the characteristics of the Japanese health-care delivery system, health-care insurance system, or the lifestyles and cultural characteristics of Japanese patients with HOA. Objective: We aimed to clarify the self-management behaviors of patients with HOA. Methods: Semi-structured interviews were conducted with five patients diagnosed with HOA, and the results were subjected to inductive qualitative analysis. Results: Six categories of self-management behaviors were extracted for patients with HOA: [active information gathering about HOA], [personalized pain and weight management, and strategies for reducing hip joint load], [reflection on living conditions with individuals and professionals, and determination for future efforts], [continuation of exercise and weight management based on personal strengths and achievements, and mutual support with others], [coexistence with HOA while managing negative feelings], and [choosing treatment methods by trusting doctors while struggling with personal needs]. Conclusion: These findings suggest the need to develop health guidance and educational programs for patients with HOA that focus on how to prevent disease progression and cope with symptoms.展开更多
In the paper, we study a compressible two-fluid model in ℝ3, where γ±>1. The pressure of the two fluids is equal. Different from previous research, we consider that viscosity coefficient both μand λare func...In the paper, we study a compressible two-fluid model in ℝ3, where γ±>1. The pressure of the two fluids is equal. Different from previous research, we consider that viscosity coefficient both μand λare functions of density. The global well-posedness of the three-dimensional compressible two-phase flow model is an open problem due to its dissipative, nonlinear structure. In the paper, setting m±=M±and Z=P−P¯, by exploiting the dissipation structure, we obtain energy estimates for (Z,w,n)and its derivatives, then we obtain the time decay rates for (Z,w,n). So we derive global well-posedness and large time behavior to the three dimensional compressible two-fluid model.展开更多
This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analys...This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.展开更多
Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (m...Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations.展开更多
One of the main objectives of artificial intelligence lies in the simulation of the behavior of living organisms;emotions are a fundamental part of life, and they cannot be left aside when simulating behavior. In this...One of the main objectives of artificial intelligence lies in the simulation of the behavior of living organisms;emotions are a fundamental part of life, and they cannot be left aside when simulating behavior. In this research, software is developed that simulates the behavior of birds with different characteristics. The latter interacts by considering different stimuli from the environment (external), and the internal state of the subject (objectives). To achieve this, a model of birds in the role of prey and predators is developed that focuses on the study of the interaction between these organisms that exhibit specific behaviors in their environment. This project is a seminal work that aims to represent the emotions of birds, and the latter caused by stimuli from a dynamic environment.展开更多
Community-based ecotourism (CBET) aims to empower local communities through engagement and participation. Cambodia serves as a prime example of a developing country where the local community necessitates sustained sta...Community-based ecotourism (CBET) aims to empower local communities through engagement and participation. Cambodia serves as a prime example of a developing country where the local community necessitates sustained stakeholder support to foster empowerment and promote local economic development. Ecotourism and conservation are among the major issues of concern in the study of community development. This study used the main five eco-tourism areas in Cambodia as examples. It looks at the connections between eco-innovations in tourism products, community engagement, co-creation experiences, support for CBET, perceived impact likelihood outcomes, community economic benefits, environmentally responsible behavior in ecotourism sites, and biodiversity conservation. The study employed a quantitative research approach to investigate and parameterize the dynamic ecotourism components as well as to explore key factors that influence the CBET. We collected the data using a self-administered survey on 398 local eco-based tourism communities that sell services and products to tourists. We also asked for structured questionnaire items of local communities that provide tourism services to visitors in eco-tourism destination sites in 2022-2023. The SEM results showed that this study significantly impacted and confirmed all relationships among research variables, as proposed in the conceptual model. We also discuss in detail the research findings of this study.展开更多
Objective: To investigate the current state of caring behavior among nursing students in a 3A hospital and analyze its influencing factors. Methods: A convenient sampling method was employed to survey 157 nursing stud...Objective: To investigate the current state of caring behavior among nursing students in a 3A hospital and analyze its influencing factors. Methods: A convenient sampling method was employed to survey 157 nursing students in a 3A hospital from October 2023 to March 2024, using a self-designed general data questionnaire and the Chinese version of the Caring Behavior Scale. Results: The caring behavior score of the nursing students was 102.39 ± 14.42. Among the three dimensions, the highest score was observed in “respect and connection” (40.29 ± 6.65), while the lowest score was in “knowledge and skill” (22.25 ± 3.53). Statistically significant differences in caring behavior scores were found in relation to education level, relationship with parents (general), and unwillingness to engage in nursing work after graduation (P < 0.05). Conclusion: The caring behavior scores of the nursing students in this study were at a moderate level. Education level, the quality of the relationship with parents (general), and an unwillingness to pursue nursing as a career after graduation were identified as the primary influencing factors.展开更多
Here we complete our work on the asymptotics of Hankel determinants studying the case wherein the entries are “ultrarapidly”-varying functions in the sense that their logarithms are rapidly varying. Moreover, the la...Here we complete our work on the asymptotics of Hankel determinants studying the case wherein the entries are “ultrarapidly”-varying functions in the sense that their logarithms are rapidly varying. Moreover, the last results in the paper highlight analogies between algebraic identities for Hankelians with special entries and asymptotic relations valid for large classes of entries.展开更多
Na_(3)V_(2)(PO_(4))_(2)O_(2)F (VP) is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific capacity.Density functional theory (DFT) and finite el...Na_(3)V_(2)(PO_(4))_(2)O_(2)F (VP) is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific capacity.Density functional theory (DFT) and finite element simulations show that incorporating SO_(4)^(2-)into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge cycles.Consequently,the average Na+diffusion coefficient of Na_(3)V_(2)(PO_(4))_(1.95)(SO_(4))_(0.05)O_(2)F(VPS-1) is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g^(-1)) and cycling stability (111.0 mAh g^(-1)capacity after 1000 cycles at 10 C current density) for VPS-1.VPS-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 min.The assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.展开更多
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,brexanolone,zuranolone)targeting the GABA-A receptor were introduced.The zona incerta(ZI),an inhibitory subthalamic region mainly composed of GABAergic neurons,has been implicated in emotional regulation.Deep brain stimulation of the ZI in humans affects anxiety and depression symptoms,while activation of ZI neurons in mice can either worsen or alleviate anxiety.Currently,there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in rodents.AIM To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in mice.METHODS A chronic restraint stress(CRS)model was utilized to induce depression in mice.Whole-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ZI.Additionally,chemogenetic techniques were employed to modulate ZI GABAergic neurons.The performance of the mice in behavioral tests for depression and anxiety was observed.RESULTS The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in mice.Twenty-eight days after the CRS model was established,depression-like and anxiety-like behaviors were observed in the mice.The excitability of GABAergic neurons in the ZI was reduced.Chemogenetic activation of these neurons alleviated CRS-induced depression-like and anxiety-like behaviors.Conversely,inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in mice.CONCLUSION Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice,suggesting that these neurons could be a potential therapeutic target for treating depression.展开更多
BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Mo...BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Moreover,it has not been confirmed whether,considering the effect of daytime sleepiness on suicide risk,daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.AIM To explore the pathway relationships among nurses'work-family behavioral role conflict,daytime sleepiness,and suicide risk.METHODS Convenience and purposive sampling methods were used to select 750 nurses from six provinces,including Jiangxi,Sichuan,and Shanxi.The work-family behavioral role conflict scale,the Chinese adult daytime sleepiness scale,and the suicide behavior questionnaire were used for the survey.The data were statistically analyzed via SPSS 25.0 software,Pearson correlation analysis was used to explore the correlations between the variables,the PROCESS 4.0 program was used for the mediation effect analysis,and the mediation effect model was tested via the bootstrap method.RESULTS Nurses'work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk(r=734,0.717).Work-family behavioral role conflict positively predicted suicide risk(β=0.118),and daytime sleepiness positively predicted suicide risk(β=0.152).Daytime sleepiness partially mediated the role of nurses'work-family behavioral role conflict and suicide risk,with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.CONCLUSION The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses'work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.展开更多
The insufficient damping capabilities of aluminum alloy under low temperatures(<120℃)were addressed by developing high-damping laminated composites of NiTip/5052Al.This is achieved through the incorporation of var...The insufficient damping capabilities of aluminum alloy under low temperatures(<120℃)were addressed by developing high-damping laminated composites of NiTip/5052Al.This is achieved through the incorporation of varied pre-aging states of NiTi particles into the 5052Al matrix using a rolling composite technique.The aim is to enhance the application scope of aluminum alloy for vibration and noise reduction.The results demonstrated a distinct and integrated interface between the particle layer and the 5052Al alloy,with numerous interparticle interfaces within the particle layer.Increasing the aging temperature of the NiTi particles from 450 to 550℃ shifted the phase transition peaks of the composites to lower temperatures.The damping capacity of the laminated NiTip/5052Al composites notably surpasses that of the 5052Al alloy.At 28 and 66℃,the phase transformation damping peaks of the pre-aged NiTi particle layer reinforced 5052Al matrix composites are 1.93 and 2 times those of the 5052Al alloy at the corresponding temperatures,respectively.The collaborative impact of interparticle interface damping mechanism and the phase transformation damping mechanism of NiTi-reinforced particles significantly amplify the low-temperature damping performance of the laminated NiTip/5052Al composites.展开更多
This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers f...This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers face increasing challenges in teaching practice.Their inappropriate behaviors not only affect the classroom atmosphere but may also negatively impact students’learning outcomes.Therefore,researching the characteristics of novice teachers’inappropriate behaviors and their intervention strategies holds significant scientific and social value.This study employs a combination of quantitative and qualitative methods to analyze the behavioral patterns of novice teachers in classroom teaching and proposes corresponding intervention strategies.The results indicate that novice teachers’inappropriate behaviors mainly manifest as poor classroom management,monotonous teaching methods,and insufficient interaction with students.Based on these findings,the study proposes a series of effective intervention strategies,including enhancing teacher training,optimizing teaching design,and promoting positive interactions between teachers and students.The conclusions of the study not only provide practical guidance for educational practice but also point out directions for future research,emphasizing the crucial role of teacher professional development in improving teaching quality.展开更多
基金supported by ANID Fondecyt Iniciacion 11180540(to FJB)ANID PAI 77180077(to FJB)+2 种基金UNAB DI-02-22/REG(to FJB)Exploración-ANID 13220203(to FJB)ANID-MILENIO(NCN2023_23,to FJB)。
文摘Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas alone.Instead,they involve connectivity among brain areas,whether close or distant.At that time,this approach was considered the optimal way to dissect brain circuitry and function.These pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain function.However,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely elusive.Utilizing animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.
基金financial support from the National Natural Science Foundation of China(Nos.52233018 and 51831002)the China Baowu Low Carbon Metallurgy Innovation Foudation(No.BWLCF202213)。
文摘The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression tests.By establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow instability.We concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.
基金supported by the SP2024/089 Project by the Faculty of Materials Science and Technology,VˇSB-Technical University of Ostrava.
文摘In engineering practice,it is often necessary to determine functional relationships between dependent and independent variables.These relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable solutions.Nevertheless,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely explored.This study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic materials.The ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree Regression(DTR),and Gaussian Process Regression(GPR)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon steel.Although the GPR method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.
基金financially supported by the National Key R &D Program of China (No.2022YFB3709300)。
文摘The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.
基金supported by the National Natural Science Foundation of China,Nos.32371070 (to JT),31761163005 (to JT),32100824 (to QX)the Shenzhen Science and Technology Program,Nos.RCBS20210609104606024 (to QX),JCY20210324101813035 (to DL)+4 种基金the Guangdong Provincial Key S&T Program,No.2018B030336001 (to JT)the Key Basic Research Program of Shenzhen Science and Technology Innovation Commission,Nos.JCYJ20200109115405930 (to JT),JCYJ20220818101615033 (to DL),JCYJ20210324115811031 (to QX),JCYJ20200109150717745 (to QX)Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases,No.ZDSYS20220304163558001 (to JT)Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,No.2023B1212060055 (to JT)the China Postdoctoral Science Foundation,No.2021M693298 (to QX)。
文摘The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with emotions.Specifically, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal mice.After knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was obviously mitigated. Additionally, administration of an excitatory amino acid transporter 2 inhibitor in the basolateral amygdala yielded a notable reduction in anxiety level among mice subjected to stress. These results suggest that basolateral amygdala astrocytic excitatory amino acid transporter 2 plays a role in in the regulation of unpredictable chronic mild stress-induced anxiety-like behavior by impacting the activity of local glutamatergic neurons, and targeting excitatory amino acid transporter 2 in the basolateral amygdala holds therapeutic promise for addressing anxiety disorders.
基金Supported by the Shijiazhuang Science and Technology Research and Development Program,No.221460383.
文摘BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.
文摘To evaluate the impact of behavioral restrictions on perinatal care caused by the COVID-19 pandemic, we conducted a questionnaire survey of 1976 medical institutions handling deliveries across Japan. The survey examined changes in the number of antenatal checkups due to behavioral restrictions, visit restrictions at medical institutions, and the acceptance of COVID-19-infected pregnant and nursing mothers. An increased burden was observed at delivery hospitals, irrespective of whether they accepted infected pregnant and nursing mothers. Some medical institutions were unable to manage infected pregnant women and transferred them to other facilities, highlighting the need for role-sharing among institutions. The number of antenatal checkups showed a decreasing trend, indicating that the pandemic negatively affected checkup attendance. However, no clear increase in perinatal deaths was observed during the observation period, despite the reduction in the number of checkups.
文摘Background: Hip osteoarthritis (HOA) causes joint destruction, resulting in hip pain, limited range-of-motion, claudication, and joint deformity. In the conservative treatment of HOA, self-management is important to manage symptoms and control disease progression. In a previous study, the researchers conducted a conceptual analysis of 43 foreign studies on self-management during conservative therapy for patients with HOA. The results revealed a definition of self-management during conservative therapy for patients with HOA. However, because that study analyzed only the foreign literature, it remains unclear whether the findings reflect the characteristics of the Japanese health-care delivery system, health-care insurance system, or the lifestyles and cultural characteristics of Japanese patients with HOA. Objective: We aimed to clarify the self-management behaviors of patients with HOA. Methods: Semi-structured interviews were conducted with five patients diagnosed with HOA, and the results were subjected to inductive qualitative analysis. Results: Six categories of self-management behaviors were extracted for patients with HOA: [active information gathering about HOA], [personalized pain and weight management, and strategies for reducing hip joint load], [reflection on living conditions with individuals and professionals, and determination for future efforts], [continuation of exercise and weight management based on personal strengths and achievements, and mutual support with others], [coexistence with HOA while managing negative feelings], and [choosing treatment methods by trusting doctors while struggling with personal needs]. Conclusion: These findings suggest the need to develop health guidance and educational programs for patients with HOA that focus on how to prevent disease progression and cope with symptoms.
文摘In the paper, we study a compressible two-fluid model in ℝ3, where γ±>1. The pressure of the two fluids is equal. Different from previous research, we consider that viscosity coefficient both μand λare functions of density. The global well-posedness of the three-dimensional compressible two-phase flow model is an open problem due to its dissipative, nonlinear structure. In the paper, setting m±=M±and Z=P−P¯, by exploiting the dissipation structure, we obtain energy estimates for (Z,w,n)and its derivatives, then we obtain the time decay rates for (Z,w,n). So we derive global well-posedness and large time behavior to the three dimensional compressible two-fluid model.
文摘This study investigates the prevalence of HIV high-risk behaviors among university students in S City, Sichuan Province. Using a sampling survey method, a total of 3262 valid questionnaires were collected. Data analysis revealed ten significant issues related to HIV risk behaviors among university students, leading to suggested intervention strategies to address these behaviors.
文摘Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations.
文摘One of the main objectives of artificial intelligence lies in the simulation of the behavior of living organisms;emotions are a fundamental part of life, and they cannot be left aside when simulating behavior. In this research, software is developed that simulates the behavior of birds with different characteristics. The latter interacts by considering different stimuli from the environment (external), and the internal state of the subject (objectives). To achieve this, a model of birds in the role of prey and predators is developed that focuses on the study of the interaction between these organisms that exhibit specific behaviors in their environment. This project is a seminal work that aims to represent the emotions of birds, and the latter caused by stimuli from a dynamic environment.
文摘Community-based ecotourism (CBET) aims to empower local communities through engagement and participation. Cambodia serves as a prime example of a developing country where the local community necessitates sustained stakeholder support to foster empowerment and promote local economic development. Ecotourism and conservation are among the major issues of concern in the study of community development. This study used the main five eco-tourism areas in Cambodia as examples. It looks at the connections between eco-innovations in tourism products, community engagement, co-creation experiences, support for CBET, perceived impact likelihood outcomes, community economic benefits, environmentally responsible behavior in ecotourism sites, and biodiversity conservation. The study employed a quantitative research approach to investigate and parameterize the dynamic ecotourism components as well as to explore key factors that influence the CBET. We collected the data using a self-administered survey on 398 local eco-based tourism communities that sell services and products to tourists. We also asked for structured questionnaire items of local communities that provide tourism services to visitors in eco-tourism destination sites in 2022-2023. The SEM results showed that this study significantly impacted and confirmed all relationships among research variables, as proposed in the conceptual model. We also discuss in detail the research findings of this study.
基金Demonstration Course Project of Ideological and Political Education in Henan Province-Fundamentals of Nursing(JiaoGao[2022]No.268)。
文摘Objective: To investigate the current state of caring behavior among nursing students in a 3A hospital and analyze its influencing factors. Methods: A convenient sampling method was employed to survey 157 nursing students in a 3A hospital from October 2023 to March 2024, using a self-designed general data questionnaire and the Chinese version of the Caring Behavior Scale. Results: The caring behavior score of the nursing students was 102.39 ± 14.42. Among the three dimensions, the highest score was observed in “respect and connection” (40.29 ± 6.65), while the lowest score was in “knowledge and skill” (22.25 ± 3.53). Statistically significant differences in caring behavior scores were found in relation to education level, relationship with parents (general), and unwillingness to engage in nursing work after graduation (P < 0.05). Conclusion: The caring behavior scores of the nursing students in this study were at a moderate level. Education level, the quality of the relationship with parents (general), and an unwillingness to pursue nursing as a career after graduation were identified as the primary influencing factors.
文摘Here we complete our work on the asymptotics of Hankel determinants studying the case wherein the entries are “ultrarapidly”-varying functions in the sense that their logarithms are rapidly varying. Moreover, the last results in the paper highlight analogies between algebraic identities for Hankelians with special entries and asymptotic relations valid for large classes of entries.
基金National Natural Science Foundation of China (52372224 and 52072299)Major Project of Shaanxi Coal Joint Fund of Shaanxi Provincial Science and Technology Department (2019JLZ-07)。
文摘Na_(3)V_(2)(PO_(4))_(2)O_(2)F (VP) is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific capacity.Density functional theory (DFT) and finite element simulations show that incorporating SO_(4)^(2-)into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge cycles.Consequently,the average Na+diffusion coefficient of Na_(3)V_(2)(PO_(4))_(1.95)(SO_(4))_(0.05)O_(2)F(VPS-1) is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g^(-1)) and cycling stability (111.0 mAh g^(-1)capacity after 1000 cycles at 10 C current density) for VPS-1.VPS-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 min.The assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.
基金Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
文摘BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,brexanolone,zuranolone)targeting the GABA-A receptor were introduced.The zona incerta(ZI),an inhibitory subthalamic region mainly composed of GABAergic neurons,has been implicated in emotional regulation.Deep brain stimulation of the ZI in humans affects anxiety and depression symptoms,while activation of ZI neurons in mice can either worsen or alleviate anxiety.Currently,there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in rodents.AIM To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in mice.METHODS A chronic restraint stress(CRS)model was utilized to induce depression in mice.Whole-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ZI.Additionally,chemogenetic techniques were employed to modulate ZI GABAergic neurons.The performance of the mice in behavioral tests for depression and anxiety was observed.RESULTS The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in mice.Twenty-eight days after the CRS model was established,depression-like and anxiety-like behaviors were observed in the mice.The excitability of GABAergic neurons in the ZI was reduced.Chemogenetic activation of these neurons alleviated CRS-induced depression-like and anxiety-like behaviors.Conversely,inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in mice.CONCLUSION Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice,suggesting that these neurons could be a potential therapeutic target for treating depression.
文摘BACKGROUND Work-family conflicts and daytime sleepiness are related to the risk of suicide.At present,no study has investigated the relationship between nurses’work-family behavioral role conflict and suicide risk.Moreover,it has not been confirmed whether,considering the effect of daytime sleepiness on suicide risk,daytime sleepiness mediates the effect of work-family behavioral role conflict and suicide risk.AIM To explore the pathway relationships among nurses'work-family behavioral role conflict,daytime sleepiness,and suicide risk.METHODS Convenience and purposive sampling methods were used to select 750 nurses from six provinces,including Jiangxi,Sichuan,and Shanxi.The work-family behavioral role conflict scale,the Chinese adult daytime sleepiness scale,and the suicide behavior questionnaire were used for the survey.The data were statistically analyzed via SPSS 25.0 software,Pearson correlation analysis was used to explore the correlations between the variables,the PROCESS 4.0 program was used for the mediation effect analysis,and the mediation effect model was tested via the bootstrap method.RESULTS Nurses'work-family behavioral role conflict and daytime sleepiness were positively correlated with suicide risk(r=734,0.717).Work-family behavioral role conflict positively predicted suicide risk(β=0.118),and daytime sleepiness positively predicted suicide risk(β=0.152).Daytime sleepiness partially mediated the role of nurses'work-family behavioral role conflict and suicide risk,with a mediation effect value of 0.046 and a mediation effect accounting for 38.98%.CONCLUSION The results of the Pearson correlation analysis and mediation effect analysis revealed that nurses'work-family behavioral role conflict has a direct effect on suicide risk and indirectly affects suicide risk through daytime drowsiness symptoms.
基金National Natural Science Foundation of China (No. 52061011)Guangxi Natural Science Foundation,China (No. 2022GXNSFAA035574)Innovation Project of Guangxi Graduate Education,China (No. YCSW2023361)。
文摘The insufficient damping capabilities of aluminum alloy under low temperatures(<120℃)were addressed by developing high-damping laminated composites of NiTip/5052Al.This is achieved through the incorporation of varied pre-aging states of NiTi particles into the 5052Al matrix using a rolling composite technique.The aim is to enhance the application scope of aluminum alloy for vibration and noise reduction.The results demonstrated a distinct and integrated interface between the particle layer and the 5052Al alloy,with numerous interparticle interfaces within the particle layer.Increasing the aging temperature of the NiTi particles from 450 to 550℃ shifted the phase transition peaks of the composites to lower temperatures.The damping capacity of the laminated NiTip/5052Al composites notably surpasses that of the 5052Al alloy.At 28 and 66℃,the phase transformation damping peaks of the pre-aged NiTi particle layer reinforced 5052Al matrix composites are 1.93 and 2 times those of the 5052Al alloy at the corresponding temperatures,respectively.The collaborative impact of interparticle interface damping mechanism and the phase transformation damping mechanism of NiTi-reinforced particles significantly amplify the low-temperature damping performance of the laminated NiTip/5052Al composites.
文摘This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers face increasing challenges in teaching practice.Their inappropriate behaviors not only affect the classroom atmosphere but may also negatively impact students’learning outcomes.Therefore,researching the characteristics of novice teachers’inappropriate behaviors and their intervention strategies holds significant scientific and social value.This study employs a combination of quantitative and qualitative methods to analyze the behavioral patterns of novice teachers in classroom teaching and proposes corresponding intervention strategies.The results indicate that novice teachers’inappropriate behaviors mainly manifest as poor classroom management,monotonous teaching methods,and insufficient interaction with students.Based on these findings,the study proposes a series of effective intervention strategies,including enhancing teacher training,optimizing teaching design,and promoting positive interactions between teachers and students.The conclusions of the study not only provide practical guidance for educational practice but also point out directions for future research,emphasizing the crucial role of teacher professional development in improving teaching quality.
