In this paper, Indian monsoon of 1980 and 1981 is analysed based on the seasonal and half-month averaged data of 850 hPa of ECMWF analysis. The results show that Indian monsoon is related to Somali jet, the low-latitu...In this paper, Indian monsoon of 1980 and 1981 is analysed based on the seasonal and half-month averaged data of 850 hPa of ECMWF analysis. The results show that Indian monsoon is related to Somali jet, the low-latitude easterlies and the mid-latitude westerlies over southern Indian Ocean, which are associated with the stationary wave of Southern Hemisphere. The forces affecting on the low-level flow are diagnosed, which display the relationship between Indian monsoon and the associated low-level flow.展开更多
In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure o...In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure of anomalies of the atmospheric circulations during 1982 winter which may be related to the variations of the convection in the equatorial region.展开更多
A demand for renewable alternatives that would be able to deal with the problems related to well-being is directly linked to the world’s growing needs to save energy and reduce environmental costs. For a project impl...A demand for renewable alternatives that would be able to deal with the problems related to well-being is directly linked to the world’s growing needs to save energy and reduce environmental costs. For a project implementation addressing these issues, it is essential to know the climatic conditions of the target area. Taking natural ventilation, climatic factors, and renewable alternatives as important sources of comfort, in this work, passive strategies, through the utilization of microclimate elements as well as the location of outside obstacles, were imposed on an initial and specific project. The objective was to introduce obstacles which could interfere in the field of external wind and evaluate whether this outside intervention is able to make changes in indoor air circulation. The wind fields for the studied cases were obtained by computational simulations, and their consequences were analyzed to attain thermal comfort. The method adopted to obtain the wind fields was a Petrov-Galerkin type method, which is a stabilized mixed finite element method of the Navier-Stokes equations considering the incompressibility and formulated in primitive variables, velocity and pressure. The obtained results point to the solutions that promote the increase or decrease of the wind-field intensity.展开更多
How to deal with colored noises of GOCE （Gravity field and steady - state Ocean Circulation Explorer） satellite has been the key to data processing. This paper focused on colored noises of GOCE gradient data and the...How to deal with colored noises of GOCE （Gravity field and steady - state Ocean Circulation Explorer） satellite has been the key to data processing. This paper focused on colored noises of GOCE gradient data and the frequency spectrum analysis. According to the analysis results, gravity field model of the optima] degrees 90-240 is given, which is recovered by COCE gradient data. This paper presents an iterative Wiener filtering method based on the gravity gradient invariants. By this method a degree-220 model was calculated from GOCE SGG （Satellite Gravity Gradient） data. The degrees above 90 of ITG2010 were taken as the prior gravity field model, replacing the low degree gravity field model calculated by GOCE orbit data. GOCE gradient colored noises was processed by Wiener filtering. Finally by Wiener filtering iterative calculation, the gravity field model was restored by space-wise harmonic analysis method. The results show that the model＇s accuracy matched well with the ESA＇s （European Space Agency） results by using the same data,展开更多
Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses ...Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses that are situated over the Balkan Peninsula during the year. The method for differentiation of climatic zones is cluster analysis. A hierarchical clustering technique–average linkage between groups with Pearson correlation for measurement of intervals was employed in the research. The climate of the Balkan Peninsula is transitional between oceanic and continental and also between subtropical and temperate climates. Several major changes in atmospheric circulation over the Balkan Peninsula have happened over the period 1950–2012. There is a serious increase of the influence of the Azores High in the period January–Marchwhich leads to an increase of SLP and enhances oceanic influence. There is an increase of the influence of the north-west extension of the monsoonal low in the period June–September. This leads to more continental climatebut also to more tropical air masses over the Balkan Peninsula. Accordinglythe extent of subtropical climate widens in northern direction. There is an increase of the influence of the Siberian High in the period October–December. This influence covers central and eastern part of the peninsula in October and Novemberand it reaches western parts in December. Thusthe climate becomes more continental.展开更多
The developing secondary flow fields in the entrance section of a rotating straight channel were experimentally investigated using Particle Image Velocimetry（PIV）. The effects of streamwise position, Reynolds number...The developing secondary flow fields in the entrance section of a rotating straight channel were experimentally investigated using Particle Image Velocimetry（PIV）. The effects of streamwise position, Reynolds number and rotation number on the development of the secondary flow fields were revealed. The results show that the absolute values of vorticity flux of the trailing side roll cells increase with increasing radius of the measured plane and rotation number. When the absolute value of vorticity flux exceeds a critical value, the merging of the trailing side roll cells appears. Moreover, when the number of the trailing side vortex pairs is even, the absolute values of vorticity flux of the leading side vortices increase along streamwise direction. Otherwise, the absolute values decrease along the streamwise direction. By the circulation analysis, this phenomenon was found to have relationship with the merging of the trailing side roll cells, and further concluded that the secondary flow field in a rotating channel has to be treated as a whole. At last,the increase of the Reynolds number was found to be able to induce the merging position moves upstream.展开更多
Analysis of patient＇s materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potentia...Analysis of patient＇s materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnostic applications. Circulating cell-free DNA（cfDNA） is explored as a prognostic or predictive marker of liquid biopsies with the improvements in genomic and molecular methods. DNA methylation is an important epigenetic marker known to affect gene expression. cfDNA methylation detection is a very promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This re？view summarizes the various investigational applications of cfDNA methylation and its oxidized de？rivatives as biomarkers for cancer diagnosis, prenatal diagnosis and organ transplantation monitoring.The review also provides a brief overview of the technologies for cfDNA methylation analysis based on next generation sequencing.展开更多
A design-of-experiments methodology is used to develop a statistical model for the prediction of the hydrodynamics of a liquid–solid circulating fluidized bed. To illustrate the multilevel factorial design approach, ...A design-of-experiments methodology is used to develop a statistical model for the prediction of the hydrodynamics of a liquid–solid circulating fluidized bed. To illustrate the multilevel factorial design approach, a step by step methodology is taken to study the effects of the interactions among the independent factors considered on the performance variables. A multilevel full factorial design with three levels of the two factors and five levels of the third factor has been studied. Various statistical models such as the linear, two-factor interaction, quadratic, and cubic models are tested. The model has been developed to predict responses, viz., average solids holdup and solids circulation rate. The validity of the developed regression model is verified using the analysis of variance. Furthermore, the model developed was compared with an experimental dataset to assess its adequacy and reliability. This detailed statistical design methodology for non-linear systems considered here provides a very important tool for design and optimization in a cost-effective approach展开更多
We determine using a compound model the influence of the mass of granular matter on the behavior of a supercritical circulating fluidized bed （CFB） reactor. Population balance enables a stationary-regime modeling of...We determine using a compound model the influence of the mass of granular matter on the behavior of a supercritical circulating fluidized bed （CFB） reactor. Population balance enables a stationary-regime modeling of the mass flow of granular matter inside a CFB unit in a large-scale. The simulation includes some important dynamic processes of gas-particle flows in fluidized bed such as attrition, fragmenta- tion, elutriation, and fuel combustion. Numerical calculations with full boiler loading were performed of operational parameters such as furnace temperature, furnace pressure, feeding materials mass flows, and excess air ratio. Furthermore, three bed inventory masses were adopted as experimental variables in the simulation model of mass balance. This approach enables a sensitivity study of mass flows of granular matter inside a CFB facility. Some computational results from this population balance model obtained for a supercritical CFB reactor are presented that show consistency with the operational data for large-scale CFB units.展开更多
Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we descr...Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we describe CytoExam,an automatic liquid biopsy instrument designed based on inertial microfluidics and impedance cytometry,which uses a deep learning algorithm for the analysis of circulating tumor cells(CTCs).In silico and in vitro experiments demonstrated that CytoExam could achieve label-free detection of CTCs in the peripheral blood of cancer patients within 15 min.The clinical applicability of CytoExam was also verified using peripheral blood samples from 10 healthy donors and>50 patients with breast,colorectal,or lung cancer.Significant differences in the number of collected cells and predicted CTCs were observed between the 2 groups,with variations in the dielectric properties of the collected cells from cancer patients also being observed.The ultra-fast and minimally invasive features of CytoExam may pave the way for new paths for cancer diagnosis and scientific research.展开更多
文摘In this paper, Indian monsoon of 1980 and 1981 is analysed based on the seasonal and half-month averaged data of 850 hPa of ECMWF analysis. The results show that Indian monsoon is related to Somali jet, the low-latitude easterlies and the mid-latitude westerlies over southern Indian Ocean, which are associated with the stationary wave of Southern Hemisphere. The forces affecting on the low-level flow are diagnosed, which display the relationship between Indian monsoon and the associated low-level flow.
文摘In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure of anomalies of the atmospheric circulations during 1982 winter which may be related to the variations of the convection in the equatorial region.
基金the FAPERJ(State of Rio de Janeiro research supporting foundation)
文摘A demand for renewable alternatives that would be able to deal with the problems related to well-being is directly linked to the world’s growing needs to save energy and reduce environmental costs. For a project implementation addressing these issues, it is essential to know the climatic conditions of the target area. Taking natural ventilation, climatic factors, and renewable alternatives as important sources of comfort, in this work, passive strategies, through the utilization of microclimate elements as well as the location of outside obstacles, were imposed on an initial and specific project. The objective was to introduce obstacles which could interfere in the field of external wind and evaluate whether this outside intervention is able to make changes in indoor air circulation. The wind fields for the studied cases were obtained by computational simulations, and their consequences were analyzed to attain thermal comfort. The method adopted to obtain the wind fields was a Petrov-Galerkin type method, which is a stabilized mixed finite element method of the Navier-Stokes equations considering the incompressibility and formulated in primitive variables, velocity and pressure. The obtained results point to the solutions that promote the increase or decrease of the wind-field intensity.
基金supported by the National Natural Science Foundation of China(41404020)
文摘How to deal with colored noises of GOCE （Gravity field and steady - state Ocean Circulation Explorer） satellite has been the key to data processing. This paper focused on colored noises of GOCE gradient data and the frequency spectrum analysis. According to the analysis results, gravity field model of the optima] degrees 90-240 is given, which is recovered by COCE gradient data. This paper presents an iterative Wiener filtering method based on the gravity gradient invariants. By this method a degree-220 model was calculated from GOCE SGG （Satellite Gravity Gradient） data. The degrees above 90 of ITG2010 were taken as the prior gravity field model, replacing the low degree gravity field model calculated by GOCE orbit data. GOCE gradient colored noises was processed by Wiener filtering. Finally by Wiener filtering iterative calculation, the gravity field model was restored by space-wise harmonic analysis method. The results show that the model＇s accuracy matched well with the ESA＇s （European Space Agency） results by using the same data,
文摘Sea Level Pressure（SLP） data for the period 1950–2012 at 61 stations located in or around the Balkan Peninsula was used. The main concept is that intra-annual course of SLP represents the best different air masses that are situated over the Balkan Peninsula during the year. The method for differentiation of climatic zones is cluster analysis. A hierarchical clustering technique–average linkage between groups with Pearson correlation for measurement of intervals was employed in the research. The climate of the Balkan Peninsula is transitional between oceanic and continental and also between subtropical and temperate climates. Several major changes in atmospheric circulation over the Balkan Peninsula have happened over the period 1950–2012. There is a serious increase of the influence of the Azores High in the period January–Marchwhich leads to an increase of SLP and enhances oceanic influence. There is an increase of the influence of the north-west extension of the monsoonal low in the period June–September. This leads to more continental climatebut also to more tropical air masses over the Balkan Peninsula. Accordinglythe extent of subtropical climate widens in northern direction. There is an increase of the influence of the Siberian High in the period October–December. This influence covers central and eastern part of the peninsula in October and Novemberand it reaches western parts in December. Thusthe climate becomes more continental.
基金financially supported by the Academic Excellence Foundation of BUAA for Ph.D.studentsthe National Natural Science Foundation of China (No. 51506002)
文摘The developing secondary flow fields in the entrance section of a rotating straight channel were experimentally investigated using Particle Image Velocimetry（PIV）. The effects of streamwise position, Reynolds number and rotation number on the development of the secondary flow fields were revealed. The results show that the absolute values of vorticity flux of the trailing side roll cells increase with increasing radius of the measured plane and rotation number. When the absolute value of vorticity flux exceeds a critical value, the merging of the trailing side roll cells appears. Moreover, when the number of the trailing side vortex pairs is even, the absolute values of vorticity flux of the leading side vortices increase along streamwise direction. Otherwise, the absolute values decrease along the streamwise direction. By the circulation analysis, this phenomenon was found to have relationship with the merging of the trailing side roll cells, and further concluded that the secondary flow field in a rotating channel has to be treated as a whole. At last,the increase of the Reynolds number was found to be able to induce the merging position moves upstream.
基金supported by grants from the National Basic Research Program of China(MOST2016YFC0900301 and 2014CB964900)the National Natural Science Foundation of China(No. 91519325)the Beijing Natural Science Foundation (No. 5162012)
文摘Analysis of patient＇s materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnostic applications. Circulating cell-free DNA（cfDNA） is explored as a prognostic or predictive marker of liquid biopsies with the improvements in genomic and molecular methods. DNA methylation is an important epigenetic marker known to affect gene expression. cfDNA methylation detection is a very promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This re？view summarizes the various investigational applications of cfDNA methylation and its oxidized de？rivatives as biomarkers for cancer diagnosis, prenatal diagnosis and organ transplantation monitoring.The review also provides a brief overview of the technologies for cfDNA methylation analysis based on next generation sequencing.
文摘A design-of-experiments methodology is used to develop a statistical model for the prediction of the hydrodynamics of a liquid–solid circulating fluidized bed. To illustrate the multilevel factorial design approach, a step by step methodology is taken to study the effects of the interactions among the independent factors considered on the performance variables. A multilevel full factorial design with three levels of the two factors and five levels of the third factor has been studied. Various statistical models such as the linear, two-factor interaction, quadratic, and cubic models are tested. The model has been developed to predict responses, viz., average solids holdup and solids circulation rate. The validity of the developed regression model is verified using the analysis of variance. Furthermore, the model developed was compared with an experimental dataset to assess its adequacy and reliability. This detailed statistical design methodology for non-linear systems considered here provides a very important tool for design and optimization in a cost-effective approach
文摘We determine using a compound model the influence of the mass of granular matter on the behavior of a supercritical circulating fluidized bed （CFB） reactor. Population balance enables a stationary-regime modeling of the mass flow of granular matter inside a CFB unit in a large-scale. The simulation includes some important dynamic processes of gas-particle flows in fluidized bed such as attrition, fragmenta- tion, elutriation, and fuel combustion. Numerical calculations with full boiler loading were performed of operational parameters such as furnace temperature, furnace pressure, feeding materials mass flows, and excess air ratio. Furthermore, three bed inventory masses were adopted as experimental variables in the simulation model of mass balance. This approach enables a sensitivity study of mass flows of granular matter inside a CFB facility. Some computational results from this population balance model obtained for a supercritical CFB reactor are presented that show consistency with the operational data for large-scale CFB units.
基金supported by the National Natural Science Foundation of China(52375562,51875103,and 81727801)the Natural Science Foundation of Jiangsu Province(BK20190064)the“333”Project of Jiangsu Province.
文摘Rapid diagnosis and real-time monitoring are of great important in the fight against cancer.However,most available diagnostic technologies are time-consuming and labor-intensive and are commonly invasive.Here,we describe CytoExam,an automatic liquid biopsy instrument designed based on inertial microfluidics and impedance cytometry,which uses a deep learning algorithm for the analysis of circulating tumor cells(CTCs).In silico and in vitro experiments demonstrated that CytoExam could achieve label-free detection of CTCs in the peripheral blood of cancer patients within 15 min.The clinical applicability of CytoExam was also verified using peripheral blood samples from 10 healthy donors and>50 patients with breast,colorectal,or lung cancer.Significant differences in the number of collected cells and predicted CTCs were observed between the 2 groups,with variations in the dielectric properties of the collected cells from cancer patients also being observed.The ultra-fast and minimally invasive features of CytoExam may pave the way for new paths for cancer diagnosis and scientific research.
