纤维化疾病是多种慢性疾病的终末阶段,其特点是组织中纤维结缔组织的过度积累,导致器官结构破坏和功能丧失。S100A9作为S100蛋白家族的重要成员,在多种炎症性疾病和癌症中的作用已被广泛研究,但其在纤维化疾病中的作用及机制尚未完全阐...纤维化疾病是多种慢性疾病的终末阶段,其特点是组织中纤维结缔组织的过度积累,导致器官结构破坏和功能丧失。S100A9作为S100蛋白家族的重要成员,在多种炎症性疾病和癌症中的作用已被广泛研究,但其在纤维化疾病中的作用及机制尚未完全阐明。本文综述了S100A9在肺、肝、肾、心脏及皮肤等主要纤维化疾病中的研究进展,重点探讨其在细胞信号通路、免疫调节及炎症反应中的作用,旨在为纤维化疾病的诊断和治疗提供新的研究思路。Fibrosis is the terminal stage of various chronic diseases, characterized by excessive accumulation of fibrous connective tissue in tissues, leading to organ structural damage and loss of function. As an important member of the S100 protein family, the role of S100A9 in various inflammatory diseases and cancers has been widely studied, but its role and mechanism in fibrotic diseases have not been fully elucidated. This article reviews the research progress of S100A9 in major fibrotic diseases such as lung, liver, kidney, heart, and skin, with a focus on exploring its role in cellular signaling pathways, immune regulation, and inflammatory response, aiming to provide new research ideas for the diagnosis and treatment of fibrotic diseases.展开更多
文摘纤维化疾病是多种慢性疾病的终末阶段,其特点是组织中纤维结缔组织的过度积累,导致器官结构破坏和功能丧失。S100A9作为S100蛋白家族的重要成员,在多种炎症性疾病和癌症中的作用已被广泛研究,但其在纤维化疾病中的作用及机制尚未完全阐明。本文综述了S100A9在肺、肝、肾、心脏及皮肤等主要纤维化疾病中的研究进展,重点探讨其在细胞信号通路、免疫调节及炎症反应中的作用,旨在为纤维化疾病的诊断和治疗提供新的研究思路。Fibrosis is the terminal stage of various chronic diseases, characterized by excessive accumulation of fibrous connective tissue in tissues, leading to organ structural damage and loss of function. As an important member of the S100 protein family, the role of S100A9 in various inflammatory diseases and cancers has been widely studied, but its role and mechanism in fibrotic diseases have not been fully elucidated. This article reviews the research progress of S100A9 in major fibrotic diseases such as lung, liver, kidney, heart, and skin, with a focus on exploring its role in cellular signaling pathways, immune regulation, and inflammatory response, aiming to provide new research ideas for the diagnosis and treatment of fibrotic diseases.
