High-speed and wide-band LiNbO3 waveguide electro-optic intensity modulator has drawn great attention in the field of optical fiber communication and sensor. This paper reports the research results on the measurement ...High-speed and wide-band LiNbO3 waveguide electro-optic intensity modulator has drawn great attention in the field of optical fiber communication and sensor. This paper reports the research results on the measurement of frequency shift characteristics of Mach-Zehnder electro-optic intensity modulator. Two measurement methods of frequency shift characteristics for high and low frequency modulations are studied in theory and experiment and demonstrate different results. The realization of a multi-wavelength optical source based on Mach-Zehnder electro-optic intensity modulator has been introduced. The technique to reach the maximum intensity for interesting shift frequency, particularly for heterodyne detection of Brillouin distributed optical fiber sensing, has been given.展开更多
We propose and demonstrate a novel variable PDL emulator based on a LiNbO3 modulator. The proposed emulator could vary the PDL values simply by adjusting the bias voltage of modulator. The results show that the propos...We propose and demonstrate a novel variable PDL emulator based on a LiNbO3 modulator. The proposed emulator could vary the PDL values simply by adjusting the bias voltage of modulator. The results show that the proposed PDL emulator could generate a wide range of PDL values (0 ~ 35 dB). The generated PDL value could be maintained within ±0.02 dB for >70 minutes. The wavelength dependency was about 0.03 dB in the range of 1520 nm~ 1590 nm.展开更多
Electronic-state modulation strategy offers great potential in designing RuO_(2)-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries(ZABs).Various three-dimensional(3D)transition metal oxides are atte...Electronic-state modulation strategy offers great potential in designing RuO_(2)-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries(ZABs).Various three-dimensional(3D)transition metal oxides are attempted to couple with RuO_(2)for constructing an appropriate Ru—O—M interface.This work aims to construct Co_(3)O_(4)-RuO_(2)heterostructures on carbon sheets(Co_(3)O_(4)/RuO_(2)/NCNS)for boosting electronic transfer and regulation.Experiments and theoretical calculations identify the electronic transfer from Co_(3)O_(4)to RuO_(2)that modulates the electronic structure of metal surfaces/interfaces.Specifically,it leads to the increase in Co3+content,electron-rich state at RuO_(2)surface and electronic accumulation at interfaces.Moreover,this electronic-state modulation optimizes the d-band center in Co_(3)O_(4)/RuO_(2)that lowers the reaction barriers and endows interfaces as the biggest contributor to oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)performance,The Co_(3)O_(4)/RuO_(2)/NCNS shows a quite low potential difference of 0.62 V and remarkable durability for ORR/OER.Co_(3)O_(4)/RuO_(2)/NCNS-assembled ZABs exhibit an excellent specific capacity of 818.3 mA h g^(-1)and a superior lifespan over 750 h.展开更多
We report three-dimensional fluorescence emission difference(3D-FED)microscopy using a spatial light modulator(SLM).Zero phase,0–2vortex phase and binary 0-pi phase are loaded on the SLM to generate the correspondin...We report three-dimensional fluorescence emission difference(3D-FED)microscopy using a spatial light modulator(SLM).Zero phase,0–2vortex phase and binary 0-pi phase are loaded on the SLM to generate the corresponding solid,doughnut and z-axis hollow excitation spot,respectively.Our technique achieves super-resolved image by subtracting three di®erently acquired images with proper subtractive factors.Detailed theoretical analysis and simulation tests are proceeded to testify the performance of 3D-FED.Also,the improvement of lateral and axial resolution is demonstrated by imaging 100 nm°uorescent beads.The experiment yields lateral resolution of 140 nm and axial resolution of approximate 380 nm.展开更多
AIM: To describe the long term follow-up of kidney allograft recipients receiving ketoconazole with calcineurin inhibitors(CNI) alone or combined with everolimus. METHODS: This is an open-label, prospective observatio...AIM: To describe the long term follow-up of kidney allograft recipients receiving ketoconazole with calcineurin inhibitors(CNI) alone or combined with everolimus. METHODS: This is an open-label, prospective observational clinical trial in low immunologic risk patients who, after signing an Institutional Review Board approved consent form, were included in one of two groups. The first one(n = 59) received everolimus(target blood level, 3-8 ng/m L) and the other(n = 114) azathioprine 2 mg/kg per day or mycophenolate mofetyl(MMF) 2 g/d. Both groups also received tapering steroids, the cytochrome P-450 3A4(CYP3A4) modulator, ketoconazole 50-100 mg/d, and cyclosporine with C0 targets in the everolimus group of 200-250 ng/mL in 1 mo, 100-125 ng/m L in 2 mo, and 50-65 ng/m L thereafter, and in the azathioprine or MMF group of 250-300 ng/mL in 1 mo, 200-250 ng/mL in 2 mo, 180-200 ng/m L until 3-6 mo, and 100-125 ng/mL thereafter. Clinical visits were performed monthly the first year and quarterly thereafter by treating physicians and all data was extracted by the investigators.RESULTS: The clinical characteristics of these two cohorts were similar. During the follow up(66 + 31 mo), both groups showed comparable clinical courses, but the biopsy proven acute rejection rate during the full follow-up period seemed to be lower in the everolimus group(20% vs 36%; P = 0.04). The everolimus group did not show a higher surgical complication rate thanthe other group. By the end of the follow-up period, the everolimus group tended to show a higher glomerular filtration rate. Nevertheless, we found no evidence of a consistent negative slope of the temporal allograft function estimated by the modification of the diet in renal disease formula in any of both groups. At 6 years of follow-up, the uncensored and death-censored graft survivals were 91% and 93%, and 91% and 83% in the everolimus plus cyclosporine, and cyclosporine alone groups, respectively. The addition of ketoconazole saved 80% of cyclosporine and 56% of everolimus doses. CONCLUSION: Combining CYP3A4 modulators with CNI or mammalian target of rapamycin inhibitor, in low immunological risk kidney transplant recipients is feasible, effective, safe and affordable even in the long term.展开更多
A fractional frequency divider based on phase switching and negative feedback delta-sigma modulator(NF-DSM) is presented. The phase switching circuit, realized by switching 8 signals generated by a divider-by-4 circui...A fractional frequency divider based on phase switching and negative feedback delta-sigma modulator(NF-DSM) is presented. The phase switching circuit, realized by switching 8 signals generated by a divider-by-4 circuit, is adopted to reduce the frequency division step. The NF-DSM, which can obtain smooth output spectra, is proposed to generate the fractional part of the division ratio, moreover, the integer part of the division ratio is realized by a divider-by-2/3 circuit chain. Fabricated in TSMC 0.18 μm RF CMOS technology, the fractional frequency divider achieves a measured operation frequency from 0.5 GHz to 8 GHz. With a 1.8 V supply voltage, the maximum current consumption of the whole divider is 17.5 mA, and the chip area is 0.58 mm^2, including the pads.展开更多
Context: Since the discovery of toll-like receptor 3 (TLR3), no specific tools have been developed to modulate its activity in upper respiratory tract viral infections (URTIs). ContafluTM (antibodies to TLR3 cytoplasm...Context: Since the discovery of toll-like receptor 3 (TLR3), no specific tools have been developed to modulate its activity in upper respiratory tract viral infections (URTIs). ContafluTM (antibodies to TLR3 cytoplasmic fragment) is the first specific TLR3 modulator that showed efficacy in a mouse model of influenza. Objective: To evaluate the efficacy of Contaflu in URTI. Methods: A double-blind randomized placebo-controlled trial in adults with self-reported URTI (the ESTUAR trial) was conducted in 2012/2013 in Belgium. Adult outpatients started a 7-day treatment course with oral tablets of Contaflu or placebo within 36 h after onset of at least one of 4 typical symptoms of URTI. Patients were examined twice by their general practitioners, on days 2-3 and 10-14 after start of treatment. The primary endpoint was the overall severity of URTI calculated as the sum of Wisconsin Upper Respiratory Symptom Survey (WURSS-21) scores over the follow-up. Independent Student’s t test was used to compare the disease severity between groups. Results: A total of 243 patients were enrolled by 32 investigators (121 Contaflu, 122 placebo);92% of cases matched ICD codes J00 or J06. Most patients had very mild (41.8%) or mild (18.2%) URTI symptoms. In the ITT cohort, neither primary nor secondary outcome measures (duration of URTI, day-to-day and overall functional impairments) showed statistically significant differences between groups. The rate of adverse events was similar in both groups. In patients with moderate to severe URTI symptoms, Contaflu tended to reduce the overall disease severity, daily symptoms, and to improve the functional state. Due to the small size of the corresponding subgroups, Contaflu efficacy on daily scores was statistically significant (p < 0.05) only 1, 2, and 5 days after start of treatment. Conclusion: Contaflu was ineffective in mild URTI and showed efficacy in moderate to severe URTI cases.展开更多
In this work,a hybrid integrated optical transmitter module was designed and fabricated.A proton-exchanged Mach–Zehnder lithium niobate(LiNbO_(3))modulator chip was chosen to enhance the output extinction ratio.A fib...In this work,a hybrid integrated optical transmitter module was designed and fabricated.A proton-exchanged Mach–Zehnder lithium niobate(LiNbO_(3))modulator chip was chosen to enhance the output extinction ratio.A fiber was used to adjust the rotation of the polarization direction caused by the optical isolator.The whole optical path structure,including the laser chip,lens,fiber,and modulator chip,was simulated to achieve high optical output efficiency.After a series of process improvements,a module with an output extinction ratio of 34 dB and a bandwidth of 20.5 GHz(from 2 GHz)was obtained.The optical output efficiency of the whole module reached approximately 21%.The link performance of the module was also measured.展开更多
基金supported by Program for New Century Excellent Talents in University under Grand No. NCET-06-0925.
文摘High-speed and wide-band LiNbO3 waveguide electro-optic intensity modulator has drawn great attention in the field of optical fiber communication and sensor. This paper reports the research results on the measurement of frequency shift characteristics of Mach-Zehnder electro-optic intensity modulator. Two measurement methods of frequency shift characteristics for high and low frequency modulations are studied in theory and experiment and demonstrate different results. The realization of a multi-wavelength optical source based on Mach-Zehnder electro-optic intensity modulator has been introduced. The technique to reach the maximum intensity for interesting shift frequency, particularly for heterodyne detection of Brillouin distributed optical fiber sensing, has been given.
文摘We propose and demonstrate a novel variable PDL emulator based on a LiNbO3 modulator. The proposed emulator could vary the PDL values simply by adjusting the bias voltage of modulator. The results show that the proposed PDL emulator could generate a wide range of PDL values (0 ~ 35 dB). The generated PDL value could be maintained within ±0.02 dB for >70 minutes. The wavelength dependency was about 0.03 dB in the range of 1520 nm~ 1590 nm.
基金supported by the National Natural Science Foundation of China(52273264)the Outstanding Youth Fund of Heilongjiang Province(JQ 2020B002).
文摘Electronic-state modulation strategy offers great potential in designing RuO_(2)-based bifunctionalelectrocatalysts for rechargeable Zn-air batteries(ZABs).Various three-dimensional(3D)transition metal oxides are attempted to couple with RuO_(2)for constructing an appropriate Ru—O—M interface.This work aims to construct Co_(3)O_(4)-RuO_(2)heterostructures on carbon sheets(Co_(3)O_(4)/RuO_(2)/NCNS)for boosting electronic transfer and regulation.Experiments and theoretical calculations identify the electronic transfer from Co_(3)O_(4)to RuO_(2)that modulates the electronic structure of metal surfaces/interfaces.Specifically,it leads to the increase in Co3+content,electron-rich state at RuO_(2)surface and electronic accumulation at interfaces.Moreover,this electronic-state modulation optimizes the d-band center in Co_(3)O_(4)/RuO_(2)that lowers the reaction barriers and endows interfaces as the biggest contributor to oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)performance,The Co_(3)O_(4)/RuO_(2)/NCNS shows a quite low potential difference of 0.62 V and remarkable durability for ORR/OER.Co_(3)O_(4)/RuO_(2)/NCNS-assembled ZABs exhibit an excellent specific capacity of 818.3 mA h g^(-1)and a superior lifespan over 750 h.
基金This work was financially supported by grants from the National Basic Research Program of China (973 Program)(No.2015CB352003)the National Natural Science Foundation of China (Nos.61377013,61335003,61378051,and 61427818)+1 种基金NSFC of Zhejiang province LR16F050001,Innovation Joint Research Center for iCPS (2015XZZX005-01)Open Foundation of the State Key Laboratory of Modern Optical Instrumentation.
文摘We report three-dimensional fluorescence emission difference(3D-FED)microscopy using a spatial light modulator(SLM).Zero phase,0–2vortex phase and binary 0-pi phase are loaded on the SLM to generate the corresponding solid,doughnut and z-axis hollow excitation spot,respectively.Our technique achieves super-resolved image by subtracting three di®erently acquired images with proper subtractive factors.Detailed theoretical analysis and simulation tests are proceeded to testify the performance of 3D-FED.Also,the improvement of lateral and axial resolution is demonstrated by imaging 100 nm°uorescent beads.The experiment yields lateral resolution of 140 nm and axial resolution of approximate 380 nm.
文摘AIM: To describe the long term follow-up of kidney allograft recipients receiving ketoconazole with calcineurin inhibitors(CNI) alone or combined with everolimus. METHODS: This is an open-label, prospective observational clinical trial in low immunologic risk patients who, after signing an Institutional Review Board approved consent form, were included in one of two groups. The first one(n = 59) received everolimus(target blood level, 3-8 ng/m L) and the other(n = 114) azathioprine 2 mg/kg per day or mycophenolate mofetyl(MMF) 2 g/d. Both groups also received tapering steroids, the cytochrome P-450 3A4(CYP3A4) modulator, ketoconazole 50-100 mg/d, and cyclosporine with C0 targets in the everolimus group of 200-250 ng/mL in 1 mo, 100-125 ng/m L in 2 mo, and 50-65 ng/m L thereafter, and in the azathioprine or MMF group of 250-300 ng/mL in 1 mo, 200-250 ng/mL in 2 mo, 180-200 ng/m L until 3-6 mo, and 100-125 ng/mL thereafter. Clinical visits were performed monthly the first year and quarterly thereafter by treating physicians and all data was extracted by the investigators.RESULTS: The clinical characteristics of these two cohorts were similar. During the follow up(66 + 31 mo), both groups showed comparable clinical courses, but the biopsy proven acute rejection rate during the full follow-up period seemed to be lower in the everolimus group(20% vs 36%; P = 0.04). The everolimus group did not show a higher surgical complication rate thanthe other group. By the end of the follow-up period, the everolimus group tended to show a higher glomerular filtration rate. Nevertheless, we found no evidence of a consistent negative slope of the temporal allograft function estimated by the modification of the diet in renal disease formula in any of both groups. At 6 years of follow-up, the uncensored and death-censored graft survivals were 91% and 93%, and 91% and 83% in the everolimus plus cyclosporine, and cyclosporine alone groups, respectively. The addition of ketoconazole saved 80% of cyclosporine and 56% of everolimus doses. CONCLUSION: Combining CYP3A4 modulators with CNI or mammalian target of rapamycin inhibitor, in low immunological risk kidney transplant recipients is feasible, effective, safe and affordable even in the long term.
基金Supported by the National Natural Science Foundation of China(No.61674037)National Key Research and Development Program of China(No.2016YFC0800400)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘A fractional frequency divider based on phase switching and negative feedback delta-sigma modulator(NF-DSM) is presented. The phase switching circuit, realized by switching 8 signals generated by a divider-by-4 circuit, is adopted to reduce the frequency division step. The NF-DSM, which can obtain smooth output spectra, is proposed to generate the fractional part of the division ratio, moreover, the integer part of the division ratio is realized by a divider-by-2/3 circuit chain. Fabricated in TSMC 0.18 μm RF CMOS technology, the fractional frequency divider achieves a measured operation frequency from 0.5 GHz to 8 GHz. With a 1.8 V supply voltage, the maximum current consumption of the whole divider is 17.5 mA, and the chip area is 0.58 mm^2, including the pads.
文摘Context: Since the discovery of toll-like receptor 3 (TLR3), no specific tools have been developed to modulate its activity in upper respiratory tract viral infections (URTIs). ContafluTM (antibodies to TLR3 cytoplasmic fragment) is the first specific TLR3 modulator that showed efficacy in a mouse model of influenza. Objective: To evaluate the efficacy of Contaflu in URTI. Methods: A double-blind randomized placebo-controlled trial in adults with self-reported URTI (the ESTUAR trial) was conducted in 2012/2013 in Belgium. Adult outpatients started a 7-day treatment course with oral tablets of Contaflu or placebo within 36 h after onset of at least one of 4 typical symptoms of URTI. Patients were examined twice by their general practitioners, on days 2-3 and 10-14 after start of treatment. The primary endpoint was the overall severity of URTI calculated as the sum of Wisconsin Upper Respiratory Symptom Survey (WURSS-21) scores over the follow-up. Independent Student’s t test was used to compare the disease severity between groups. Results: A total of 243 patients were enrolled by 32 investigators (121 Contaflu, 122 placebo);92% of cases matched ICD codes J00 or J06. Most patients had very mild (41.8%) or mild (18.2%) URTI symptoms. In the ITT cohort, neither primary nor secondary outcome measures (duration of URTI, day-to-day and overall functional impairments) showed statistically significant differences between groups. The rate of adverse events was similar in both groups. In patients with moderate to severe URTI symptoms, Contaflu tended to reduce the overall disease severity, daily symptoms, and to improve the functional state. Due to the small size of the corresponding subgroups, Contaflu efficacy on daily scores was statistically significant (p < 0.05) only 1, 2, and 5 days after start of treatment. Conclusion: Contaflu was ineffective in mild URTI and showed efficacy in moderate to severe URTI cases.
基金This work was supported by National Key Research and Development Program of China(2018YFB2201101)the Strategic Priority Research Program of Chinese Academy of Sciences,Grant No.XDB43000000Beijing Municipal Science&Technology Commission,Administrative Commission of Zhongguancun Science Park No.Z201100004020004。
文摘In this work,a hybrid integrated optical transmitter module was designed and fabricated.A proton-exchanged Mach–Zehnder lithium niobate(LiNbO_(3))modulator chip was chosen to enhance the output extinction ratio.A fiber was used to adjust the rotation of the polarization direction caused by the optical isolator.The whole optical path structure,including the laser chip,lens,fiber,and modulator chip,was simulated to achieve high optical output efficiency.After a series of process improvements,a module with an output extinction ratio of 34 dB and a bandwidth of 20.5 GHz(from 2 GHz)was obtained.The optical output efficiency of the whole module reached approximately 21%.The link performance of the module was also measured.
