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Statistical characteristics and classification of ionospheric mid-latitude trough as revealed by the observations of DMSP-F18
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作者 Yi Liu JiuHou Lei +1 位作者 FuQing Huang Su Zhou 《Earth and Planetary Physics》 EI CAS 2025年第1期137-147,共11页
Statistical characteristics and the classification of the topside ionospheric mid-latitude trough are systemically analyzed,using observations from the Defense Meteorological Satellite Program F18(DMSP-F18)satellite.T... Statistical characteristics and the classification of the topside ionospheric mid-latitude trough are systemically analyzed,using observations from the Defense Meteorological Satellite Program F18(DMSP-F18)satellite.The data was obtained at an altitude of around 860 km in near polar orbit,throughout 2013.Our study identified the auroral boundary based on the in-situ electron density and electron spectrum,allowing us to precisely determine the location of the mid-latitude trough.This differs from most previous works,which only use Total Electron Content(TEC)or in-situ electron density.In our study,the troughs exhibited a higher occurrence rate in local winter than in summer,and extended to lower latitudes with increasing geomagnetic activity.It was found that the ionospheric mid-latitude trough,which is associated with temperature changes or enhanced ion drift,exhibited distinct characteristics.Specifically,the ionospheric mid-latitude troughs related to electron temperature(Te)peak were located more equatorward of auroral oval boundary in winter than in summer.The ionospheric mid-latitude troughs related to Te-maximum were less frequently observed at 60−70°S magnetic latitude and 90−240°E longitude.Furthermore,the troughs related to ion temperature(Ti)maximums were observed at relatively higher latitudes,occurring more frequently in winter.In addition,the troughs related to ion velocity(Vi)maximums could be observed in all seasons.The troughs with the maximum-Ti and maximum-Vi were located closer to the equatorward boundary of the auroral oval at the nightside,and in both hemispheres.This implies that enhanced ion drift velocity contributes to increased collisional frictional heating and enhanced ion temperatures,resulting in a density depletion within the trough region. 展开更多
关键词 topside ionosphere mid-latitude trough ionospheric main trough auroral oval boundary temperature maximum
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Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
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作者 Thanaboon Chaemsupaphan Aviv Pudipeddi +4 位作者 Hui-Yu Lin Sudarshan Paramsothy Viraj C Kariyawasam Melissa Kermeen Rupert W Leong 《World Journal of Gastroenterology》 SCIE CAS 2025年第2期102-112,共11页
BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thio... BACKGROUND Ulcerative colitis(UC)is a chronic inflammatory condition requiring continuous treatment and monitoring.There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is unknown.AIM To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in UC patients who have achieved sustained clinical and endoscopic remission during maintenance therapy.METHODS This is a post-hoc analysis of prospective randomized clinical trial(VIEWS)involving UC patients across 8 centers in Australia from 2018 to 2022.Patients in clinical and endoscopic remission were randomized to continue or withdraw thiopurine while receiving vedolizumab.We evaluated vedolizumab serum trough concentrations,presence of anti-vedolizumab antibodies,and clinical outcomes over 48 weeks to assess exposure-response asso-ciation and impact of thiopurine withdrawal.RESULTS There were 62 UC participants with mean age of 43.4 years and 42%were females.All participants received vedolizumab as maintenance therapy with 67.7%withdrew thiopurine.Vedolizumab serum trough concentrations remained stable over 48 weeks regardless of thiopurine use,with no anti-vedolizumab antibodies detected.Pa-tients with clinical remission had higher trough concentrations at week 48.In quartile analysis,a threshold of>11.3μg/mL was associated with sustained clinical remission,showing a sensitivity of 82.4%,specificity of 60.0%,and an area of receiver operating characteristic of 0.71(95%CI:0.49-0.93).Patients discontinuing thiopurine required higher vedolizumab concentrations for achieving remission.CONCLUSION A positive exposure-response relationship between vedolizumab trough concentrations and UC outcomes suggests that monitoring drug levels may be beneficial.While thiopurine did not influence vedolizumab levels,its with-drawal may necessitate higher vedolizumab trough concentrations to maintain remission. 展开更多
关键词 PHARMACOKINETIC Vedolizumab THIOPURINE Ulcerative colitis trough concentration Antibody Inflammatory bowel diseases
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Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit
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作者 Teng Guo Li-Ying Du +2 位作者 Ming-Feng Liu Xia-Jin Zhou Xin-Ran Chen 《World Journal of Clinical Cases》 2025年第16期18-28,共11页
BACKGROUND Plasma concentration monitoring is crucial for optimizing vancomycin use,particularly in patients in the intensive care unit(ICU).However,the reference interval for vancomycin plasma concentration remains u... BACKGROUND Plasma concentration monitoring is crucial for optimizing vancomycin use,particularly in patients in the intensive care unit(ICU).However,the reference interval for vancomycin plasma concentration remains undetermined.AIM To evaluate the correlations of area under the curve(AUC_(0-24))and trough concentration(C_(min))with efficacy and nephrotoxicity in patients in the ICU.METHODS A total of 103 patients treated with vancomycin for methicillin-resistant Staphylococcus aureus infections were analyzed in this study.The associations of clinicodemographic characteristics(including sex,age,weight,infection sites,main etiologies of ICU cases,comorbidities,acute physiological chronic health evaluation II score,and mechanical ventilation)and pharmacokinetics(daily dose,C_(min),AUC_(0-24),and AUC_(0-24)/minimum inhibitory concentration)with efficacy and nephrotoxicity of vancomycin were evaluated with univariate and multivariate logistic regression analyses.AUC_(0-24)was calculated using VCM-TDM software based on vancomycin population pharmacokinetics and Bayesian feedback method.RESULTS Cmin over 9.4μg/mL and AUC_(0-24)exceeding 359.6μg×hour/mL indicated good efficacy against infection.Cmin below 14.0μg/mL predicted no significant nephrotoxicity.CONCLUSION In this study,the effective and safe concentration interval for vancomycin in patients in the ICU was Cmin 9.4-14.0μg/mL.Close attention should be paid to adverse effects and renal function during vancomycin treatment. 展开更多
关键词 VANCOMYCIN Therapeutic drug monitoring Intensive care unit trough concentration Methicillin-resistant Staphylococcus aureus infection Area under the curve
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Performance Enhancement of Parabolic Trough Collector by Using Homogenizer and Spiral 被引量:2
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作者 LI Peijing LIU Taixiu +3 位作者 QIN Yuanlong ZHENG Zhimei ZHAO Kai LIU Qibin 《Journal of Thermal Science》 SCIE EI CAS CSCD 2024年第2期658-674,共17页
In conventional parabolic trough collectors(PTCs),sunlight is concentrated at the bottom of the absorber tube,resulting in a significant circumferential temperature gradient across the absorber tube,heat loss and ther... In conventional parabolic trough collectors(PTCs),sunlight is concentrated at the bottom of the absorber tube,resulting in a significant circumferential temperature gradient across the absorber tube,heat loss and thermal deformation,which affects the safety and thermal performance of PTCs.In this study,a new receiver with homogenizer and spiral(RHS) is proposed,achieving the optical and thermal synergy to ameliorate the thermal deformation of the absorber tube and enhance thermal efficiency.A plane structure homogenizer is designed to improve uniformity of the concentrated solar flux of absorber tube through second reflection.In combination with the spiral,it improves the optical-thermal efficiency of the PTC by enhancing heat exchange between the fluid and the backlight side of the absorber tube.The performance of the collector is numerically studied by building a three-dimensional coupled light-thermal-structure model.The results show that the thermal deformation of the RHS is reduced by more than 96% and the optical-thermal efficiency is improved by 1.2%-0.63% compared with conventional receivers(CRs) under the same inlet temperature conditions.The proposed receiver is validated to be effective in reducing thermal deformation and improving optical-thermal efficiency. 展开更多
关键词 parabolic trough collector HOMOGENIZER thermal deformation SPIRAL
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Morphological and Sulfur-Isotopic Characteristics of Pyrites in the Deep Sediments from Xisha Trough,South China Sea
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作者 CHANG Jingyi LIU Yujia +4 位作者 LU Hailong LU Jing’an SU Xin YE Jianliang XIE Wenwei 《Journal of Ocean University of China》 CAS CSCD 2024年第1期138-148,共11页
Pyrite is one of the common authigenic minerals in marine sediments.Previous studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it... Pyrite is one of the common authigenic minerals in marine sediments.Previous studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it is formed.To better understand the for-mation mechanism of authigenic pyrite,we analyzed the isotopic composition,morphology,and distribution of pyrite in the sediment at 500m below the seafloor from Xisha Trough,South China Sea.Mineral morphologies were observed by scanning electron micros-copy and Raman spectrography.X-Ray computed tomography was applied to measure the particle size of pyrite.The size of pyrite crystals in the matrix sediment mainly ranged between 25 and 65µm(av.ca.40µm),although crystals were larger(av.ca.50μm)in the veins.The pyrites had a fine-grained truncated octahedral shape with occasionally well-developed growth steps,which implies the low growth rate and weak anaerobic oxidation of methane-sulfate reduction when pyrite was formed.Theδ^(34)S values of pyrites ranged from+20.8‰Vienna-defined Canyon Diablo Troilite(V-CDT)to+33.2‰V-CDT and from+44.8‰V-CDT to+48.9‰,which suggest two growth stages.In the first stage,with the continuous low methane flux,the pyrite possibly formed in an environment with good access to seawater.In the second stage,the pyrites mainly developed in sediment fractures and appeared in veins,probably due to the limited availability of sulfate.The less exposure of pyrite to the environment in the second stage was probably caused by sediment accumulation or perturbation.In this study,an episodic pyritization process was identified,and the paleoenvironment was reconstructed for the sediment investigated. 展开更多
关键词 PYRITE sulfur isotope AOM methane flux Xisha trough South China Sea
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Persistent Variations in the East Asian Trough from March to April and the Possible Mechanism
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作者 Shui YU Jianqi SUN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第4期737-753,I0002-I0004,共20页
The East Asian trough(EAT)profoundly influences the East Asian spring climate.In this study,the relationship of the EATs among the three spring months is investigated.Correlation analysis shows that the variation in M... The East Asian trough(EAT)profoundly influences the East Asian spring climate.In this study,the relationship of the EATs among the three spring months is investigated.Correlation analysis shows that the variation in March EAT is closely related to that of April EAT.Extended empirical orthogonal function(EEOF)analysis also confirms the co-variation of the March and April EATs.The positive/negative EEOF1 features the persistent strengthened/weakened EAT from March to April.Further investigation indicates that the variations in EEOF1 are related to a dipole sea surface temperature(SST)pattern over the North Atlantic and the SST anomaly over the tropical Indian Ocean.The dipole SST pattern over the North Atlantic,with one center east of Newfoundland Island and another east of Bermuda,could trigger a Rossby wave train to influence the EAT in March−April.The SST anomaly over the tropical Indian Ocean can change the Walker circulation and influence the atmospheric circulation over the tropical western Pacific,subsequently impacting the southern part of the EAT in March−April.Besides the SST factors,the Northeast Asian snow cover could change the regional thermal conditions and lead to persistent EAT anomalies from March to April.These three impact factors are generally independent of each other,jointly explaining large variations in the EAT EEOF1.Moreover,the signals of the three factors could be traced back to February,consequently providing a potential prediction source for the EAT variation in March and April. 展开更多
关键词 spring East Asian trough sea surface temperature snow cover
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Heat Transfer Enhancement of the Absorber Tube in a Parabolic Trough Solar Collector through the Insertion of Novel Cylindrical Turbulators
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作者 Yasser Jebbar Fadhil Fluiful Wisam Khudhayer 《Fluid Dynamics & Materials Processing》 EI 2024年第6期1279-1297,共19页
This study includes an experimental and numerical analysis of the performances of a parabolic trough collector(PTC)with and without cylindrical turbulators.The PTC is designed with dimensions of 2.00 m in length and 1... This study includes an experimental and numerical analysis of the performances of a parabolic trough collector(PTC)with and without cylindrical turbulators.The PTC is designed with dimensions of 2.00 m in length and 1.00 m in width.The related reflector is made of lined sheets of aluminum,and the tubes are made of stainless steel used for the absorption of heat.They have an outer diameter of 0.051 m and a wall thickness of 0.002 m.Water,used as a heat transfer fluid(HTF),flows through the absorber tube at a mass flow rate of 0.7 kg/s.The dimensions of cylindrical turbulators are 0.04 m in length and 0.047 m in diameter.Simulations are performed using the ANSYS Fluent 2020 R2 software.The PTC performance is evaluated by comparing the experimental and numerical outcomes,namely,the outlet temperature,useful heat,and thermal efficiency for a modified tube(MT)(tube with novel cylindrical turbulators)and a plain tube(PT)(tube without novel cylindrical turbulators).According to the results,the experimental outlet temperatures recorded 63.2°C and 50.5°C for the MT and PT,respectively.The heat gain reaches 1137.5 Win the MT and 685.8 Win the PT.Compared to the PT collector,the PTC exhibited a(1.64 times)higher efficiency. 展开更多
关键词 Parabolic trough collector turbulators absorber tube ANSYS thermal efficiency
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Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin
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作者 GUO Kun ZHAI Shikui +3 位作者 FAN Di ZHANG Xia ZHANG Yu ZHU Zhimin 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第3期643-653,共11页
The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initi... The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental margin.The clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and Ti.The clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the magma.The calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 kbar.The geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of clinopyroxene.Combined with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust. 展开更多
关键词 trace elements CLINOPYROXENES southern Okinawa trough seafloor spreading back-arc basin
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Investigative Review of Design Techniques of Parabolic Trough Solar Collectors
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作者 Roba Tarek AbdelFatah Irene S.Fahim Mohamed Mahran Kasem 《Frontiers in Heat and Mass Transfer》 EI 2024年第1期317-339,共23页
Parabolic trough solar collectors(PTCs)are among the most cost-efficient solar thermal technologies.They have several applications,such as feed heaters,boilers,steam generators,and electricity generators.A PTC is a co... Parabolic trough solar collectors(PTCs)are among the most cost-efficient solar thermal technologies.They have several applications,such as feed heaters,boilers,steam generators,and electricity generators.A PTC is a concentrated solar power system that uses parabolic reflectors to focus sunlight onto a tube filled with heattransfer fluid.PTCs performance can be investigated using optical and thermal mathematical models.These models calculate the amount of energy entering the receiver,the amount of usable collected energy,and the amount of heat loss due to convection and radiation.There are several methods and configurations that have been developed so far;however,it is usually difficult for a designer to choose the appropriate method or configuration for his application.The present work investigates different PTC configurations and methods of solution,compares their efficiency and accuracy,summarizes their key behaviors and trends,and improves the available methods by maximizing the positives and minimizing the negatives among them.We investigated three methods and seven configurations.The findings suggest that optimizing the collector structure,tracking system,and reflector can lead to high PTC performance and reduced capital costs.After investigating and comparing the recent mathematical models,the study identified a clear deficiency in estimating the output temperature.Three PTC’s solution methods are investigated,and a novel method is developed to give more accurate estimations of the output temperature. 展开更多
关键词 Parabolic trough collectors solar collector PTC mathematical models
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Design and Development of a Parabolic Trough Solar Air Heater for a Greenhouse Dryer
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作者 Eric King’ori Isaac N. Simate 《Journal of Power and Energy Engineering》 2024年第9期1-18,共18页
Design and Development of a Parabolic Trough Solar Air Heater (PTSAH) for a Greenhouse Dryer (GD) was done to improve the dryer’s performance. The materials used for the fabrication of the PTSAH included galvanized s... Design and Development of a Parabolic Trough Solar Air Heater (PTSAH) for a Greenhouse Dryer (GD) was done to improve the dryer’s performance. The materials used for the fabrication of the PTSAH included galvanized sheets covered with aluminium foil, an absorber tube made of GI pipe painted matt black to increase heat absorbance at the focal line, mild steel square tubes, shutter plywood, and an axial fan to push air through the absorber tube. Key geometrical parameters used for the design of the PTSAH were a rim angle of 98 degrees, focal length of 0.2608 m, height of 0.3451 m, length of 2 m, and an aperture width of 1.2 m. The PTSAH’s total aperture surface area was 2.4 m2, while its absorber tube surface area was 0.1587 m2. The PTSAH was experimentally tested to establish its thermal performance. It was found that the ambient air recorded an average value of 31.1˚C and that the air heater could increase the air temperature by 45.6˚C above ambient with a thermal efficiency of 5.3%. It can, therefore, be concluded that the PTSAH can significantly improve the performance of a GD by supplying the GD with air at a higher temperature than ambient. 展开更多
关键词 Solar Air Heater Greenhouse Dryer Parabolic trough Thermal Performance
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Improving Heat Transfer in Parabolic Trough Solar Collectors by Magnetic Nanofluids
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作者 Ritesh Singh Abhishek Gupta +2 位作者 Akshoy Ranjan Paul Bireswar Paul Suvash C.Saha 《Energy Engineering》 EI 2024年第4期835-848,共14页
A parabolic trough solar collector(PTSC)converts solar radiation into thermal energy.However,low thermal efficiency of PTSC poses a hindrance to the deployment of solar thermal power plants.Thermal performance of PTSC... A parabolic trough solar collector(PTSC)converts solar radiation into thermal energy.However,low thermal efficiency of PTSC poses a hindrance to the deployment of solar thermal power plants.Thermal performance of PTSC is enhanced in this study by incorporating magnetic nanoparticles into the working fluid.The circular receiver pipe,with dimensions of 66 mm diameter,2 mm thickness,and 24 m length,is exposed to uniform temperature and velocity conditions.The working fluid,Therminol-66,is supplemented with Fe3O4 magnetic nanoparticles at concentrations ranging from 1%to 4%.The findings demonstrate that the inclusion of nanoparticles increases the convective heat transfer coefficient(HTC)of the PTSC,with higher nanoparticle volume fractions leading to greater heat transfer but increased pressure drop.The thermal enhancement factor(TEF)of the PTSC is positively affected by the volume fraction of nanoparticles,both with and without a magnetic field.Notably,the scenario with a 4%nanoparticle volume fraction and a magnetic field strength of 250 G exhibits the highest TEF,indicating superior thermal performance.These findings offer potential avenues for improving the efficiency of PTSCs in solar thermal plants by introducing magnetic nanoparticles into the working fluid. 展开更多
关键词 Parabolic trough solar collector(PTSC) magnetic nanofluid(MNF) heat transfer convective heat transfer coefficient(HTC) thermal enhancement factor(TEF)
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奶牛个体精准饲喂装置的设计与试验
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作者 叶岩 马君 +4 位作者 孙先明 李源源 祝天宇 王婷婷 李尧 《农机化研究》 北大核心 2025年第6期179-184,共6页
为了提高奶牛个体产奶量、降低生产成本,设计了一种集奶牛个体自动识别、采食量自动监测、控制奶牛进食权限、数据自动采集、数据分析与处理于一体的奶牛个体精准饲喂装置。装置利用无线射频识别技术识别奶牛身份,对射探测器判定奶牛个... 为了提高奶牛个体产奶量、降低生产成本,设计了一种集奶牛个体自动识别、采食量自动监测、控制奶牛进食权限、数据自动采集、数据分析与处理于一体的奶牛个体精准饲喂装置。装置利用无线射频识别技术识别奶牛身份,对射探测器判定奶牛个体位置,称重传感器实时监测饲喂槽内饲料质量变化,控制系统根据设定的个体奶牛日粮采食量实现奶牛个体采食量的自动计量和差异化饲喂。试验结果表明:奶牛个体识别率为100%,对射探测器的识别准确率不低于98%,饲喂闸门开启响应时间不大于2.5 s,个体奶牛采食量测量误差为8.6%,较好地实现了奶牛个体采食量、采食次数、采食行为的在线、实时和自动化的数据采集与分析。装置可作为奶牛个体精细化饲养、新饲料配方和养殖模式创新等相关研究的试验平台。 展开更多
关键词 奶牛 精准饲喂 饲喂槽 身份识别 无线射频识别
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四川盆地北部二叠系大隆组页岩气富集高产主控因素及勘探潜力
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作者 雍锐 杨洪志 +3 位作者 吴伟 杨雪 杨雨然 黄浩勇 《石油勘探与开发》 北大核心 2025年第2期253-266,共14页
基于钻井、录井、测井、地质实验等基础资料,对四川盆地北部二叠系大隆组海相页岩地质特征及页岩气富集高产因素开展研究。结果表明:①大隆组优质页岩形成于二叠系吴家坪组沉积后,主要发育在四川盆地北部开江—梁平海槽内,深水陆棚沉积... 基于钻井、录井、测井、地质实验等基础资料,对四川盆地北部二叠系大隆组海相页岩地质特征及页岩气富集高产因素开展研究。结果表明:①大隆组优质页岩形成于二叠系吴家坪组沉积后,主要发育在四川盆地北部开江—梁平海槽内,深水陆棚沉积相和硅质生物繁盛的深水还原环境形成了富有机质的黑色硅质页岩。②大隆组页岩有机质孔与无机质孔发育,脆塑性矿物交互成层,4500 m以深的超深层依然发育大量无机质孔,总孔隙度大于5%,显著拓展了页岩气储集空间。③大隆组顶底板灰岩既有助于早期埋藏生烃持续处在封闭系统,又为页岩段持续生烃和富气保存提供有利条件,在后期改造中利于缝网横向延伸,达到最优改造效果,提高井控资源量。综合地质、工程、经济条件,优选出5500 m以浅的有利区面积为1800 km^(2),资源量达5400×10^(8) m^(3)。④大隆组页岩储层具有“薄而肥”的特征,埋深5500 m以浅的川东高陡构造区内远离主体断裂的向斜区,是当前工程技术条件下最有利的二叠系页岩气建产区域,主要包括南雅向斜、檀木场向斜和梁平向斜。 展开更多
关键词 四川盆地 开江—梁平海槽 二叠系 大隆组 硅质页岩 页岩气 富集因素
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大跨度槽形钢箱梁-混凝土桥面板组合梁斜拉桥整体受力特性与截面刚度分配
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作者 李晓斌 宋汶灵 +4 位作者 谢明志 张勇 杨灯 包杰 曾甲华 《铁道建筑》 北大核心 2025年第1期7-13,共7页
泉州湾跨海大桥主桥全联主梁采用槽形钢箱梁-混凝土桥面板组合结构,在高速铁路大跨度跨海斜拉桥中系首次采用。为探明槽形钢箱梁-混凝土桥面板组合主梁沿纵桥向的静力受力特点,建立主桥结构有限元分析模型,开展主桥在不同荷载组合作用... 泉州湾跨海大桥主桥全联主梁采用槽形钢箱梁-混凝土桥面板组合结构,在高速铁路大跨度跨海斜拉桥中系首次采用。为探明槽形钢箱梁-混凝土桥面板组合主梁沿纵桥向的静力受力特点,建立主桥结构有限元分析模型,开展主桥在不同荷载组合作用下的静力响应分析,揭示刚度分配和一期压重对主梁受力的影响规律。结果表明:在不同荷载组合作用下,截面应力峰值均出现在主墩及辅助墩处;主墩处主梁截面承受的轴向压力及负弯矩最大,辅助墩处主梁截面承受的竖向剪力最大,负弯矩较大,该处钢箱梁截面的正应力水平最高,尤其是钢箱梁顶缘的正应力水平远高于主墩处。综合分析主梁截面刚度及其分布情况、内力和应力分布情况,以及一期压重混凝土板对主梁受力的影响,辅助墩处主梁截面为最不利受力位置,其受力状态更加需要关注。与普通组合梁相比,槽形钢箱梁-混凝土桥面板组合梁的构件在工厂预制,可以在海湾深水区装配化实现快速建造,在工程经济性、抗风性能、海湾深水施工条件、高速列车行车性能适应性等方面具有显著优势,应用前景广泛。 展开更多
关键词 槽形钢-混组合梁 斜拉桥 有限元法 静力行为 刚度分配
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川南寒武系筇竹寺组拉张槽边缘型页岩气地质特征及富集高产地质因素研究
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作者 葛忠伟 史洪亮 +2 位作者 周桦 王鹏 张全林 《非常规油气》 2025年第1期19-29,共11页
四川盆地寒武系筇竹寺组为区域性烃源层系,是龙王庙组和灯影组等气藏主要供烃地层。近年来寒武系的勘探表明,除作为烃源层具有良好的生烃能力之外,其本身也是一套优质的非常规储集层,并且通过测试获得了高产工业气流。针对该套地层受沉... 四川盆地寒武系筇竹寺组为区域性烃源层系,是龙王庙组和灯影组等气藏主要供烃地层。近年来寒武系的勘探表明,除作为烃源层具有良好的生烃能力之外,其本身也是一套优质的非常规储集层,并且通过测试获得了高产工业气流。针对该套地层受沉积时期构造运动影响,盆地不同区域、不同构造单元成藏特征差异较大,油气富集规律不统一的问题,基于研究区所处构造位置,分析认为研究区所在的拉张槽边缘筇竹寺组稳定发育厚大的含气储层,保存条件良好,与龙马溪组页岩具有相似的地质特征,进而总结了影响筇竹寺组页岩气富集高产的地质因素。这些因素包括:1)储层厚度大、储层品质好是富集的地质基础;2)地压系数高,顶底板封盖条件好,保存条件良好是富集的重要保障;3)脆性好、地应力相对低,为储层改造提供了良好的工程地质条件;4)良好的成藏配置条件为油气富集起到了重要作用;5)适度发育的微裂缝,通过改造形成复杂缝网且沟通天然裂缝是高产的关键。该认识对指导该区稳步推进勘探开发具有重要指导意义。 展开更多
关键词 川南寒武系 筇竹寺组 拉张槽边缘型 页岩气 地质特征 富集高产
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滇黔桂地区垭紫罗裂陷海槽泥盆系—石炭系页岩气富集成藏主控因素
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作者 王玉芳 翟刚毅 +6 位作者 石万忠 王劲铸 张家政 康海霞 张云枭 周惠 张舒婷 《地质力学学报》 北大核心 2025年第2期248-266,共19页
相比于四川盆地及周缘五峰组—龙马溪组页岩气富集成藏特征,滇黔桂地区页岩气的富集成藏条件更加复杂,目前滇黔桂地区的页岩气勘探程度较低,页岩气富集成藏主控因素不清。基于滇黔桂地区页岩气的基础调查与已有的大量成果,对其泥盆系—... 相比于四川盆地及周缘五峰组—龙马溪组页岩气富集成藏特征,滇黔桂地区页岩气的富集成藏条件更加复杂,目前滇黔桂地区的页岩气勘探程度较低,页岩气富集成藏主控因素不清。基于滇黔桂地区页岩气的基础调查与已有的大量成果,对其泥盆系—石炭系页岩的沉积特征、成岩/生烃热演化特征、储集特征、成藏模式及保存条件进行了系统地分析与总结。研究表明,泥盆系—石炭系富有机质页岩的沉积主要受控于裂陷海槽,富有机质页岩甜点段主要形成于深水相沉积的海侵体系域和早期高水位体系域;区域性海平面上升带来丰富的营养物质,促进水体中生物繁殖,产生强大的生物生产力,为富有机质沉积物的形成提供了良好的物质基础。同时地震剖面解释发现,沿主裂陷槽分布的大部分地区受后期构造活动破坏影响大,导致页岩气保存条件变差;而主裂陷槽周缘的次级裂陷槽构造相对稳定,为页岩气保存提供了良好的条件。在此基础上,提出滇黔桂地区泥盆系—石炭系“裂陷槽沉积、深水岩相控烃、次级裂陷槽构造保存”的页岩气富集成藏主控模式,并已通过多口钻井钻探得到证实。研究成果可为今后该地区的页岩气有利区优选及参数井钻探提供指导。 展开更多
关键词 滇黔桂地区 泥盆系—石炭系 裂陷海槽 次级裂陷槽 富集成藏主控因素 页岩气
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马里亚纳海槽火山岩中斜长石熔体包裹体的均一温度及其对岩浆演化的指示意义
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作者 张保辉 曾志刚 +7 位作者 曾志斌 杨小双 王晓媛 齐海燕 殷学博 陈帅 陈祖兴 韩超 《海洋地质前沿》 北大核心 2025年第2期53-67,共15页
马里亚纳海槽南部安山岩(H5-T3-2)中斜长石结晶温度主要集中在1050~1150℃,未受到后期岩浆演化的影响。马里亚纳海槽中部玄武质安山岩(H5-T1-3)中斜长石结晶温度主要集中在900~1050℃;英安岩(H5-T1-1)中斜长石结晶温度主要集中在1050~1... 马里亚纳海槽南部安山岩(H5-T3-2)中斜长石结晶温度主要集中在1050~1150℃,未受到后期岩浆演化的影响。马里亚纳海槽中部玄武质安山岩(H5-T1-3)中斜长石结晶温度主要集中在900~1050℃;英安岩(H5-T1-1)中斜长石结晶温度主要集中在1050~1150℃。马里亚纳海槽18°N附近玄武岩(H5-T2-2、H5-T2-3)斜长石中熔体包裹体的均一温度主要集中在1050~1150℃,并呈连续降温趋势,只有少部分在1000~1050℃的较低温度结晶,边缘部An值骤降则反映岩浆喷出快速冷却的过程;玄武质安山岩(H5-T2-1)斜长石中熔体包裹体的均一温度具有“双峰”式特征,主要分布在850~950℃和1050~1150℃2个温度范围。结合斜长石的环带特征及其An值变化特征,分析结果表明,该斜长石有2个明显不同的结晶阶段,发生了岩浆混合作用,且在马里亚纳海槽浅部可能存在温度约为850~950℃的岩浆房,岩浆到达浅部岩浆房后发生岩浆混合,最终喷出洋底。马里亚纳海槽18°N附近的岩浆演化过程较为复杂,发生了不同周期的岩浆演化过程。 展开更多
关键词 马里亚纳海槽 斜长石 熔体包裹体 均一温度 岩浆演化
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葡萄牙栖盐田菌LLJ914的全基因组测序和比较基因组分析
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作者 李娟娟 刘子涵 +3 位作者 王雅楠 刘莉君 张晓华 于敏 《中国海洋大学学报(自然科学版)》 CAS 北大核心 2025年第1期51-65,共15页
栖盐田菌属细菌因具有较强渗透压耐受能力而备受关注。然而,目前对其适应高盐或其他海洋极端环境的机制尚未探明。为揭示分离自冲绳海槽热液区的葡萄牙栖盐田菌(Salinicola lusitanus)LLJ914与其同属菌株之间的遗传特征及代谢潜力的差异... 栖盐田菌属细菌因具有较强渗透压耐受能力而备受关注。然而,目前对其适应高盐或其他海洋极端环境的机制尚未探明。为揭示分离自冲绳海槽热液区的葡萄牙栖盐田菌(Salinicola lusitanus)LLJ914与其同属菌株之间的遗传特征及代谢潜力的差异,探究其在极端海洋生境下的适应机制。通过全基因组测序获得葡萄牙栖盐田菌LLJ914全基因组序列,选取同属其他菌株的基因组进行比较基因组学分析,探究栖盐田菌属各菌株及不同环境来源的葡萄牙栖盐田菌代谢潜力的差异。菌株LLJ914基因组大小为4781556 bp,GC含量为64.0%,共编码4229个蛋白,69个tRNA,12个rRNA。通过构建系统发育树,并进行平均核苷酸和平均氨基酸一致性分析,发现该菌株与马齿苋(Halimione portulacoides)内共生的葡萄牙栖盐田菌CR50^(T)亲缘关系最近。通过功能基因注释分析,发现葡萄牙栖盐田菌具有抵抗各种重金属的相关基因和利用甲基膦酸产生甲烷的phn基因簇;相比于植物内共生菌CR50^(T),菌株LLJ914基因组中包含更多与氨基酸和碳水化合物的运输代谢、能量生产和转换以及转录相关的功能基因。此外,菌株LLJ914基因组中还包含特有的与重金属抵抗、免疫防御及有氧呼吸相关的基因,这可能与其适应复杂极端的深海热液环境有关。本研究揭示了葡萄牙栖盐田菌LLJ914适应深海热液环境的遗传特征及代谢潜力,为更好地认识热液微生物的生态功能提供了参考。 展开更多
关键词 葡萄牙栖盐田菌 极端环境 热液区 冲绳海槽 全基因组测序 比较基因组分析
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谷浓度或24小时药时曲线下面积/最低抑菌浓度引导下万古霉素在肥胖患者中的个体化给药
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作者 张慧芳 范亚新 +5 位作者 周芳庆 崔泽林 朱冠华 陈梦婷 张菁 王瑞兰 《中国感染与化疗杂志》 北大核心 2025年第1期7-14,共8页
目的 比较谷浓度和24小时药时曲线下面积/最低抑菌浓度(AUC_(24h)/MIC)引导下万古霉素在肥胖患者中的安全性和有效性,为肥胖患者的万古霉素个体化用药提供数据支持。方法 回顾性收集2012—2024年上海市2所三甲医院因革兰阳性球菌引起的... 目的 比较谷浓度和24小时药时曲线下面积/最低抑菌浓度(AUC_(24h)/MIC)引导下万古霉素在肥胖患者中的安全性和有效性,为肥胖患者的万古霉素个体化用药提供数据支持。方法 回顾性收集2012—2024年上海市2所三甲医院因革兰阳性球菌引起的严重感染并使用万古霉素静脉治疗的成年肥胖[体重指数(BMI)≥30 kg/m~2]患者,根据患者入组时治疗药物浓度监测(TDM)的方法分为谷浓度和AUC_(24h)/MIC监测组,比较万古霉素两种TDM监测靶标下肥胖患者的肾毒性及疗效。结果 共纳入22例肥胖患者,其中谷浓度监测组12例,AUC_(24h)/MIC监测组10例。两组患者的性别、年龄、BMI、用药前肌酐清除率、基础疾病、感染类型、病原菌类型及合并用药差异均无统计学意义。AUC_(24h)/MIC监测组患者入住ICU的比例更高,但两组患者的ICU住院时间、万古霉素疗程、细菌清除率和综合有效率没有显著差异。万古霉素谷浓度监测组的平均日剂量显著低于AUC_(24h)/MIC监测组[(1.63±0.59) g对(2.29±0.72) g,P=0.026],两组患者的平均疗程差异无统计学意义[(15.33±10.28) d对(14.90±6.92) d,P=0.911]。与谷浓度监测组相比,AUC_(24h)/MIC监测组万古霉素初始峰浓度[(30.99±16.22)mg/L对(19.41±5.42)mg/L,P=0.025]和总体峰浓度[(33.67±16.53)mg/L对(22.08±3.96)mg/L,P=0.045]都更低,但两组患者初始谷浓度[(11.03±8.66)mg/L对(6.33±4.45)mg/L,P=0.139]、总体谷浓度[(13.75±9.74)mg/L对(9.74±4.24)mg/L,P=0.218]接近。两组患者均未发生万古霉素相关性肾损伤,但谷浓度监测组有41.7%的患者达到了谷浓度≥15 mg/L的肾毒性阈值。结论 在当前万古霉素常规治疗剂量下,肥胖感染患者仍具有较好的临床疗效。AUC_(24h)/MIC引导下的万古霉素个体化用药可在较低浓度或暴露量下实现目标参考值,在降低万古霉素相关肾毒性方面具有一定的前景。 展开更多
关键词 万古霉素 谷浓度 24小时药时曲线下面积/最低抑菌浓度 治疗药物监测 肥胖
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双级聚光集热的槽式太阳能热发电系统研究
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作者 盖忠睿 赵凯 +3 位作者 杨天龙 饶琼 潘莹 金红光 《西安交通大学学报》 北大核心 2025年第2期32-40,共9页
为了提高槽式光热发电系统的性能,通过高、低聚光比镜场的耦合布置,辅以两种传热介质的搭配,建立了双级聚光集热的槽式太阳能热发电系统模型,与传统槽式光热发电系统展开对比,得到了双级系统集热、换热性能提升的机理和系统关键过程[火... 为了提高槽式光热发电系统的性能,通过高、低聚光比镜场的耦合布置,辅以两种传热介质的搭配,建立了双级聚光集热的槽式太阳能热发电系统模型,与传统槽式光热发电系统展开对比,得到了双级系统集热、换热性能提升的机理和系统关键过程[火用]损失减小的原因。对双级系统进行能量分析和[火用]分析,展示了双级系统中的能量和[火用]流动情况,揭示了在镜场侧和动力侧的各项能量和[火用]损失的分布规律。结果表明:双级聚光集热系统中镜场的耦合布置有效地提高了系统的集热性能,两种传热介质的协同搭配改善了系统的换热性能。损失分布方面,光学损失仍是导致系统集热损失的重要因素,同时光热转化过程的不可逆损失在[火用]损失中占比较大,具有较大的提升潜力。双级系统的热效率可达到27.35%,[火用]效率达到28.84%,相较于传统单聚光比、单介质的槽式太阳能热发电系统,热效率和[火用]效率均可提升0.9%~1.5%,相同发电量下可节省镜场面积4%~6%。研究为槽式太阳能热发电系统提出了改进策略,为进一步优化研究提供了一定的理论依据。 展开更多
关键词 槽式太阳能热发电 聚光比 传热介质 热效率 [火用]损失
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