The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was measured.The experimental result...The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was measured.The experimental results show that most specimens mainly failed at the 7075 side weld toes even though the base material tensile strength of 7075 is higher than that of 6061.The maximum stress-strain concentration in the two finite element models is located at the 7075 side weld toe,which is basically consistent with the actual fracture location.The weld zone on the 7075 side experiences severe material softening,with a large gradient.However,the Vickers hardness value on the 6061 side negligibly changes and fluctuates around 70 HV.No obvious defects are found on the fatigue fracture,but a large number of secondary cracks appear.Cracks germinate from the weld toe and propagate in the direction of the plate thickness.Weld reinforcement has a serious impact on fatigue life.Fatigue life will decrease exponentially as the weld reinforcement increases under low stress.It is found that the notch stress method can give a better fatigue life prediction for TIG weldments,and the errors of the predicted results are within the range of two factors,while the prediction accuracy decreases under low stress.The equivalent structural stress method can also be used for fatigue life prediction of TIG weldments,but the errors of prediction results are within the range of three factors,and the accuracy decreases under high stress.展开更多
Objective: This study assessed the effects of consuming acetic acid bacteria (Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placeb...Objective: This study assessed the effects of consuming acetic acid bacteria (Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placebo-controlled, parallel-group study included 100 healthy male and female adults aged 20 - 64 years. Participants consumed either the G. hansenii GK-1 supplement (9 × 10⁹ cells/day) or a placebo daily for 12 weeks. The impact of temporary mental stress on fatigue in G. hansenii GK-1 was assessed using a Visual Analog Scale (VAS) before the study began and after 12 weeks of supplementation. Results: Subjective fatigue measured by Visual Analog Scale (VAS) showed a significant decrease in fatigue induced by temporary mental stress after 12 weeks of consumption in the G. hansenii GK-1 group compared with the placebo group. No adverse events were attributed to G. hansenii GK-1. These findings confirm that continuous oral ingestion of G. hansenii GK-1 by healthy Japanese adults reduces feelings of fatigue caused by temporary mental stress.展开更多
Patients with leukemia often suffer from the combined effects of cancer-related fatigue(CRF)and subthreshold depression,which mutually exacerbate each other in a vicious cycle.In this editorial,we comment on the artic...Patients with leukemia often suffer from the combined effects of cancer-related fatigue(CRF)and subthreshold depression,which mutually exacerbate each other in a vicious cycle.In this editorial,we comment on the article by Liu et al,published in the World Journal of Psychiatry.We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia.This editorial highlights the importance of early identification and treatment of subclinical depression,and advocates for a multidisciplinary and integrated treatment approach that includes social support,psychological interventions,and individualized treatment plans.Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.展开更多
Deep rocks encountered in underground engineering are frequently in complex in situ environments and experience both excavation disturbance during construction and cyclic loading throughout the long-term operation. Un...Deep rocks encountered in underground engineering are frequently in complex in situ environments and experience both excavation disturbance during construction and cyclic loading throughout the long-term operation. Understanding the fatigue behavior of excavation-disturbed rocks in complex stress environments is critical for assessing the long-term stability of deep rock structures. Hence, an experimental method has been developed to capture the fatigue damage process of rocks while considering the in situ environment and excavation disturbance. Using this method, a series of triaxial fatigue damage experiments were conducted on Jinping deep marble samples from various in situ environments of 100 m, 1000 m, 1800 m, and 2400 m to better understand the variation in fatigue characteristics at different depths. With increasing depth, the samples experienced more cycles and greater fatigue deformation before failure. Further insights were gained into the fatigue damage behavior in terms of stiffness degradation, energy dissipation and irreversible strain accumulation. A decrease in the elastic modulus and an increase in the dissipated energy and irreversible strain exhibit an evolution pattern of initial→stabilization→acceleration, reflecting the nonlinear fatigue process that occurs inside marble. With increasing depth, marble samples have longer fatigue lives but exhibit more significant stiffness loss, energy dissipation and irrecoverable deformation accumulation;thus, evaluating the instability of deep rock structures solely using fatigue life alone is inadequate. Moreover, the previously reported inverted S-shaped evolution of fatigue damage was observed, and it was found that an increase in depth leads to an earlier onset of the accelerated fatigue damage stage with greater dominance of fatigue failure. Based on the nonlinear strain, loading cycle variable and fatigue life, a highly accurate nonlinear fatigue model was developed to describe the complete inverted S-shaped evolution pattern of fatigue damage, which demonstrated excellent practical implications for the theoretical characterization of anisotropic fatigue damage in disturbed Jinping marble.展开更多
Energy is an important resource that supports the development of human society,and energy security is even more relevant to the strength of a country.In order to ensure energy security,countries around the world are t...Energy is an important resource that supports the development of human society,and energy security is even more relevant to the strength of a country.In order to ensure energy security,countries around the world are taking measures to carry out energy transformation and construct new energy systems.As an important part of the new energy system,energy storage technology is highly valued by all countries.Among many large-scale energy storage technologies,salt cavern compressed air energy storage(CAES)technology stands out for its safety and economy,which is recognized and valued by scholars from various countries.For the construction of salt cavern CAES power station,it is very important to ensure the stability of salt cavern.Therefore,scholars have investigated the mechanical properties of salt rocks and the stability of salt caverns for CAES.This paper synthesizes the findings of current research on the creep and fatigue properties of salt rock,highlighting three key points:The factors influencing the creep and fatigue characteristics of salt rock include its composition,stress levels,and temperature.Notably,impurities and surrounding pressure tend to inhibit the deformation of salt rock,whereas elevated temperature and differential stress facilitate its deformation;The mechanisms governing creep and fatigue damage in salt rock are primarily associated with dislocation movement and microcracking;Most existing constitutive models for creep and fatigue are based on viscoelastic-plasticity theory,with fewer models derived from micro-mechanical perspectives.Additionally,this paper reviews studies on the stability of salt cavern CAES reservoirs utilizing numerical simulation methods and offers insights into future research directions concerning the creep and fatigue properties of salt rocks.展开更多
Salt cavern energy storage technology contributes to energy reserves and renewable energy scale-up.This study focuses on salt cavern gas storage in Jintan to assess the long-term stability of its surrounding rock unde...Salt cavern energy storage technology contributes to energy reserves and renewable energy scale-up.This study focuses on salt cavern gas storage in Jintan to assess the long-term stability of its surrounding rock under frequent operation.The fatigue test results indicate that stress holding significantly reduces fatigue life,with the magnitude of stress level outweighing the duration of holding time in determining peak strain.Employing a machine learning approach,the impact of various factors on fatigue life and peak strain was quantified,revealing that higher stress limits and stress holding adversely impact the fatigue index,whereas lower stress limits and rate exhibit a positive effect.A novel fatigue-creep composite damage constitutive model is constructed,which is able to consider stress magnitude,rate,and stress holding.The model,validated through multi-path tests,accurately captures the elasto-viscous behavior of salt rock during loading,unloading,and stress holding.Sensitivity analysis further reveals the time-and stress-dependent behavior of model parameters,clarifying that strain changes stem not only from stress variations but are also influenced by alterations in elasto-viscous parameters.This study provides a new method for the mechanical assessment of salt cavern gas storage surrounding rocks.展开更多
Health information spreads rapidly,which can effectively control epidemics.However,the swift dissemination of information also has potential negative impacts,which increasingly attracts attention.Message fatigue refer...Health information spreads rapidly,which can effectively control epidemics.However,the swift dissemination of information also has potential negative impacts,which increasingly attracts attention.Message fatigue refers to the psychological response characterized by feelings of boredom and anxiety that occur after receiving an excessive amount of similar information.This phenomenon can alter individual behaviors related to epidemic prevention.Additionally,recent studies indicate that pairwise interactions alone are insufficient to describe complex social transmission processes,and higher-order structures representing group interactions are crucial.To address this,we develop a novel epidemic model that investigates the interactions between information,behavioral responses,and epidemics.Our model incorporates the impact of message fatigue on the entire transmission system.The information layer is modeled using a static simplicial network to capture group interactions,while the disease layer uses a time-varying network based on activity-driven model with attractiveness to represent the self-protection behaviors of susceptible individuals and self-isolation behaviors of infected individuals.We theoretically describe the co-evolution equations using the microscopic Markov chain approach(MMCA)and get the epidemic threshold.Experimental results show that while the negative impact of message fatigue on epidemic transmission is limited,it significantly weakens the group interactions depicted by higher-order structures.Individual behavioral responses strongly inhibit the epidemic.Our simulations using the Monte Carlo(MC)method demonstrate that greater intensity in these responses leads to clustering of susceptible individuals in the disease layer.Finally,we apply the proposed model to real networks to verify its reliability.In summary,our research results enhance the understanding of the information-epidemic coupling dynamics,and we expect to provide valuable guidance for managing future emerging epidemics.展开更多
The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigat...The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing care.This minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.Overall,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life span.The results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology.展开更多
BACKGROUND Patients not only experience symptoms caused by cancer but also suffer from the accompanying psychological pain.Therefore,these patients do not have high quality of life.According to the World Health Organi...BACKGROUND Patients not only experience symptoms caused by cancer but also suffer from the accompanying psychological pain.Therefore,these patients do not have high quality of life.According to the World Health Organization,the incidence of leukemia in China in 2020 was 5.1/100000,the mortality rate was 3.3/100000,and the prevalence rate was 16.7/100000.Therefore,it is important to examine the influence of comorbid subthreshold depressive symptoms on leukemia patients.AIM To determine the impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in leukemia patients,thereby providing a basis for early diagnosis and treatment in clinical practice.METHODS A questionnaire survey was conducted among leukemia patients admitted to a tertiary hospital in Xi'an,Shaanxi Province,China,from August 2022 to December 2023.Patients with a score>16 on the Chinese Classification of Mental Disorders(CCMD-3)and a Hamilton Depression Rating Scale score of 8-17 were classified as the subthreshold depressive group(n=95),while 100 leukemia patients admitted during the same period were classified as the control group.Data were collected using Epidata 3.1 software,and comparisons were made between the two groups regarding general clinical data,the Piper Fatigue Scale(PFS),the Pittsburgh Sleep Quality Index(PSQI),the Numeric Rating Scale for pain assessment,laboratory indicators,and the occurrence of complications.RESULTS In this survey,120 leukemia patients with depression were preliminarily screened,95 patients with subthreshold depression were ultimately selected as the subthreshold depression group,and 100 leukemia patients admitted during the same period were enrolled as the normal group.Comparison of basic clinical data between the two groups revealed no significant differences in age,sex,body mass index,cognitive function,or comorbidity with other chronic diseases.However,there were statistically significant differences in the use of radiotherapy and regular exercise between the two groups(P<0.05).Comparisons of scales and laboratory indicators revealed no significant differences in albumin or PSQI scores between the two groups,but there were statistically significant differences in pain scores,PSQI scores,PFS scores,hemoglobin levels,and C-reactive protein levels(P<0.05).Spearman’s correlation analysis indicated that cancer-related fatigue was correlated with age,hemoglobin levels,C-reactive protein levels,pain,and regular exercise among leukemia patients with subthreshold depression.Multivariate regression analysis revealed that advanced age,combined radiotherapy,pain,and low hemoglobin levels were risk factors for cancer-related fatigue in leukemia patients with comorbid subthreshold depression,while regular exercise was a protective factor against cancer-related fatigue.Follow-up comparisons revealed a significantly lower overall incidence of complications in the control group(4%)than in the depressive group(24.21%;P<0.001).CONCLUSION Leukemia patients with comorbid subthreshold depressive symptoms experience more severe cancer-related fatigue and a higher incidence of complications.These findings may be related to advanced age,combined radiotherapy,pain,and low hemoglobin levels,while regular exercise may effectively alleviate symptoms.展开更多
The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone t...The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue failure.The structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue evaluation.Here,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural stress.Besides,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into account.The research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR.展开更多
BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat it.Although advancements of science and technology have resulted in more and...BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat it.Although advancements of science and technology have resulted in more and more patients being able to receive effective treatment,they still face side effects such as fatigue and weakness.It is important to thoroughly investigate the factors that contribute to cancer-related fatigue(CRF)during chemotherapy.AIM To explore the factors related to CRF,anxiety,depression,and mindfulness levels in patients with DLBCL during chemotherapy.METHODS General information was collected from the electronic medical records of eligible patients.Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form.The Piper Fatigue Scale was used to evaluate the CRF status.The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status.Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF.RESULTS The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74±2.51.In 25 patients,the highest rate of mild fatigue was in the cognitive dimension(40.32%),and in 35 patients the highest moderate fatigue rate in the behavioral dimension(56.45%).In the emotional dimension,severe fatigue had the highest rate of occurrence,34 cases or 29.03%.The CRF score was positively correlated with cancer experience(all P<0.01)and negatively correlated with cancer treatment efficacy(all P<0.01).Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy.CONCLUSION There was a significant correlation between CRF and perceptual control level in patients.Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.展开更多
Although magnesium(Mg)alloys are the lightest among structural metals,their inadequate corrosion resistance makes them difficult to be used in energy-saving lightweight structures.Moreover,the improvement in corrosion...Although magnesium(Mg)alloys are the lightest among structural metals,their inadequate corrosion resistance makes them difficult to be used in energy-saving lightweight structures.Moreover,the improvement in corrosion resistance by the conventional surface treatments is always achieved at the expense of sacrificing the fatigue lifetime.In this study,high purity aluminum(Al)and AlMgSi alloy coatings were deposited on Mg alloys via an in-situ micro-forging(MF)assisted cold spray(MFCS)process for simultaneous higher corrosion resistance and longer fatigue lifetime.Besides contributing to a highly dense microstructure,the in-situ MF also greatly refines the grain of the deposited Al alloy coating to the sub-micrometer range due to the enhanced dynamic recrystallization and also generates notable compressive residual stress up to 210 MPa within the AlMgSi coating.The absence of secondary phases in the AlMgSi alloy coatings enable the coated Mg alloy with corrosion resistance,which is even better than its bulk AlMgSi counterparts.The unique combination of refined microstructure and the prominent compressive residual stress within the AlMgSi coatings,effectively delayed the crack initiation upon repeated dynamic loading,thereby leading to∼10 times increase in the fatigue lifetime of the Mg Alloy.However,although residual stress is also generated in the submmicro-sized grained pure Al coating,the low intrinsic strength of the coating layer leads to a lower fatigue lifetime than the uncoated Mg alloy substrate.The present work is aimed to provide a facile approach to break the trade-off between corrosion resistance improvement and fatigue lifetime of the coated Mg alloys.展开更多
Understanding the interaction between cyclic stresses and corrosion of magnesium(Mg)and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials.This review is...Understanding the interaction between cyclic stresses and corrosion of magnesium(Mg)and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials.This review is dedicated to exploring the corrosion-fatigue mechanisms of these materials,with an emphasis on microscale processes,and the possibility of expanding current knowledge on this topic using scanning electrochemical techniques.The interaction between fatigue and corrosion of Mg alloys is analyzed by considering the microstructural aspects(grain size,precipitates,deformation twins),as well as the formation of pits.Furthermore,in the case of coated alloys,the role of coating defects in these phenomena is also described.In this context,the feasibility of using scanning electrochemical microscopy(SECM),scanning vibrating electrode technique(SVET),scanning ion-selective electrode technique(SIET),localized electrochemical impedance spectroscopy(LEIS)and scanning Kelvin probe(SKP)methods to study the corrosion-fatigue interaction of Mg alloys is examined.A comprehensive review of the current literature in this field is presented,and the opportunities and limitations of consolidating the use of these techniques to study the microscale processes involved in Mg corrosion-fatigue are discussed.展开更多
Objective:To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa(Schenk)Wight(C.tubulosa,Rou Cong Rong),focusing on central and exercise-induced fatigue in mice.This study investigated the ...Objective:To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa(Schenk)Wight(C.tubulosa,Rou Cong Rong),focusing on central and exercise-induced fatigue in mice.This study investigated the pharmacological effects of the total oligosaccharides,polysaccharides,and phenylethanoid glycosides(CPhGs)extracted from C.tubulosa.Methods: Models of sleep deprivation and forced swimming fatigue were established to simulate central and exercise-induced fatigue.The mice were treated with different extracts of C.tubulosa,and their effects were assessed using behavioral tests to measure exercise capacity,learning,and memory function.Biochemical analyses were performed to evaluate the changes in serum and brain neurotransmitter levels,liver and muscle glycogen storage,and various fatigue-related biomarkers.Results: This study found that treatment with C.tubulosa extract improved exercise capacity,learning,and memory in mice.Total oligosaccharides from C.tubulosa enhanced adrenocorticotropic hormone,cholinesterase,and thyroid-stimulating hormone levels,reduced cortisol levels in central fatigue models,and ameliorated biochemical markers of exercise-induced fatigue,including lowering lactic acid,blood urea nitrogen,and malondialdehyde levels.Among the tested extracts,the total oligosaccharides showed the most comprehensive anti-fatigue effects.Conclusion: The anti-fatigue effects of C.tubulosa,particularly those of its total oligosaccharides,are pronounced in both central and exercise-induced fatigue.These effects are mediated by the regulation of neurotransmitter levels,enhancement of glycogen storage,and improvement of antioxidant enzyme activity,suggesting potential therapeutic benefits in fatigue-related conditions.展开更多
Objective:To make an overview of global research trends in the etiology of auditory neuropathy(AN)over the past 30 years using a bibliometric approach.Methods:Bibliometric analyses were conducted by GraphPad Prism 9.0...Objective:To make an overview of global research trends in the etiology of auditory neuropathy(AN)over the past 30 years using a bibliometric approach.Methods:Bibliometric analyses were conducted by GraphPad Prism 9.0,Citespace 6.2.R2,and an online analysis platform to analyze and visualize publications related to etiology of AN from the Web of Science Core Collection(WoSCC)database from 1996 to 2022.Additionally,genetic factors in human AN were analyzed.Results:In total,604 original articles and reviews related to the etiology of AN from the WoSCC were included for bibliometric analysis.The results showed that annual publications and trend on etiology of AN increased linearly from 2000.Among them,the United States and China published nearly 400 records(40.32%).From the 604 records,a total of 752 keywords and 10 clustered network maps were extracted by Citespace,and‘mutations’was among the top 10 keywords.Analysis of genetic factors found that more than 30 genes were related to AN,and the latest burst occurred in 2022.Conclusion:The bibliometric analysis mapped the global research trends and analyzed hotspots for future.The results indicated that the annual publications increased linearly from 2000.Notably,there was a burst in genetic factors in 2022,which identified that genetic factor would remain a focus of future research.展开更多
Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in redu...Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.展开更多
Objective:Sleep quality in kidney transplant recipients is closely associated with symptoms of fatigue and depression.Although subjective assessment tools like the Pittsburgh Sleep Quality Index and the Richards-Campb...Objective:Sleep quality in kidney transplant recipients is closely associated with symptoms of fatigue and depression.Although subjective assessment tools like the Pittsburgh Sleep Quality Index and the Richards-Campbell Sleep Questionnaire(RCSQ)are widely used to evaluate sleep quality,there is a lack of studies utilizing polysomnography for objective evaluation.This study aims to investigate the correlation between sleep quality,fatigue,and depression in kidney transplant recipients using both subjective and objective methods,providing scientific evidence for improving their quality of life.Methods:The cross-sectional study conveniently sampled 50 kidney transplant recipients from a transplant center in a general hospital between August 2018 and March 2020.Subjective and objective sleep parameters were evaluated using the RCQS and polysomnography,respectively.The Fatigue Severity Scale was used to assess fatigue,and the Hamilton Depression Scale was employed to measure depression levels.Results:A lower proportion of rapid eye movement(REM)sleep was associated with increased fatigue.Additionally,higher wake time percentages and poorer sleep quality were significantly correlated with greater depression severity.Conclusion:This study underscores the critical importance of effectively managing sleep quality in kidney transplant recipients and addressing their fatigue and depression symptoms.These findings lay a foundation for developing targeted nursing and therapeutic strategies.展开更多
Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.Methods A network pharmacological approach was used to explore potential mechanisms of actio...Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.Methods A network pharmacological approach was used to explore potential mechanisms of action of Fructus lycii.Skeletal muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological analysis.Results Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling pathways.The immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the control.Furthermore,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin treatment.Conclusion Fructus lycii might alleviate exercise fatigue through multiple components and pathways.Among these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative stress.The PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.展开更多
In this paper,(0.2-1 wt%)Yb was added to improve the tensile properties and high-cycle fatigue behavior of the as-cast and as-extruded Mg-10Li-5Zn-0.5Er alloys.It is found that Yb mainly affects the mechanical propert...In this paper,(0.2-1 wt%)Yb was added to improve the tensile properties and high-cycle fatigue behavior of the as-cast and as-extruded Mg-10Li-5Zn-0.5Er alloys.It is found that Yb mainly affects the mechanical properties of the alloy by changing the grain size,type and morphology of the second phases.Yb mainly exists in the formation of Mg_(2)Yb and Mg-Zn-Yb phases in the metallographic structure.With the addition of Yb,the grains are refined and these Yb-containing phases replace the large-sized MgLiZn phase to be enriched at the grain boundaries.While the addition of excess Yb reduces the number of small-sized MgLiZn phases in the grain,thus reducing the alloys’mechanical performance.After extrusion,the small-sized MgLiZn phase is refined and the number increases,which effectively improves the tensile and fatigue strength of the alloy.The fatigue strength is mainly affected by the number and morphology of the second phase,positively correlated with the strength.Balanced in grain size and number and size of second phases,the extruded alloy with 0.2Yb added exhibits excellent mechanical properties with the yield strength,ultimate tensile strength and elongation of 292 MPa,303 MPa and 11.7%,and an fatigue strength of 130 MPa.展开更多
Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tes...Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.展开更多
基金Partially funded by the National Natural Science Foundation of China(No.51065012)。
文摘The constant amplitude loading fatigue tests were carried out on the 6061/7075 aluminum alloy TIG fillet welded lap specimens in this study,and the weld seam cross-section hardness was measured.The experimental results show that most specimens mainly failed at the 7075 side weld toes even though the base material tensile strength of 7075 is higher than that of 6061.The maximum stress-strain concentration in the two finite element models is located at the 7075 side weld toe,which is basically consistent with the actual fracture location.The weld zone on the 7075 side experiences severe material softening,with a large gradient.However,the Vickers hardness value on the 6061 side negligibly changes and fluctuates around 70 HV.No obvious defects are found on the fatigue fracture,but a large number of secondary cracks appear.Cracks germinate from the weld toe and propagate in the direction of the plate thickness.Weld reinforcement has a serious impact on fatigue life.Fatigue life will decrease exponentially as the weld reinforcement increases under low stress.It is found that the notch stress method can give a better fatigue life prediction for TIG weldments,and the errors of the predicted results are within the range of two factors,while the prediction accuracy decreases under low stress.The equivalent structural stress method can also be used for fatigue life prediction of TIG weldments,but the errors of prediction results are within the range of three factors,and the accuracy decreases under high stress.
文摘Objective: This study assessed the effects of consuming acetic acid bacteria (Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placebo-controlled, parallel-group study included 100 healthy male and female adults aged 20 - 64 years. Participants consumed either the G. hansenii GK-1 supplement (9 × 10⁹ cells/day) or a placebo daily for 12 weeks. The impact of temporary mental stress on fatigue in G. hansenii GK-1 was assessed using a Visual Analog Scale (VAS) before the study began and after 12 weeks of supplementation. Results: Subjective fatigue measured by Visual Analog Scale (VAS) showed a significant decrease in fatigue induced by temporary mental stress after 12 weeks of consumption in the G. hansenii GK-1 group compared with the placebo group. No adverse events were attributed to G. hansenii GK-1. These findings confirm that continuous oral ingestion of G. hansenii GK-1 by healthy Japanese adults reduces feelings of fatigue caused by temporary mental stress.
文摘Patients with leukemia often suffer from the combined effects of cancer-related fatigue(CRF)and subthreshold depression,which mutually exacerbate each other in a vicious cycle.In this editorial,we comment on the article by Liu et al,published in the World Journal of Psychiatry.We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia.This editorial highlights the importance of early identification and treatment of subclinical depression,and advocates for a multidisciplinary and integrated treatment approach that includes social support,psychological interventions,and individualized treatment plans.Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.
基金funded by the National Natural Science Foundation of China(Grant No.U23B20146)the Natural Science Foundation of Sichuan Province,China(Grant Nos.2024NSFSC0825 and 2022NSFSC0406)We are also grateful for the support provided by the China Scholarship Council(CSC).
文摘Deep rocks encountered in underground engineering are frequently in complex in situ environments and experience both excavation disturbance during construction and cyclic loading throughout the long-term operation. Understanding the fatigue behavior of excavation-disturbed rocks in complex stress environments is critical for assessing the long-term stability of deep rock structures. Hence, an experimental method has been developed to capture the fatigue damage process of rocks while considering the in situ environment and excavation disturbance. Using this method, a series of triaxial fatigue damage experiments were conducted on Jinping deep marble samples from various in situ environments of 100 m, 1000 m, 1800 m, and 2400 m to better understand the variation in fatigue characteristics at different depths. With increasing depth, the samples experienced more cycles and greater fatigue deformation before failure. Further insights were gained into the fatigue damage behavior in terms of stiffness degradation, energy dissipation and irreversible strain accumulation. A decrease in the elastic modulus and an increase in the dissipated energy and irreversible strain exhibit an evolution pattern of initial→stabilization→acceleration, reflecting the nonlinear fatigue process that occurs inside marble. With increasing depth, marble samples have longer fatigue lives but exhibit more significant stiffness loss, energy dissipation and irrecoverable deformation accumulation;thus, evaluating the instability of deep rock structures solely using fatigue life alone is inadequate. Moreover, the previously reported inverted S-shaped evolution of fatigue damage was observed, and it was found that an increase in depth leads to an earlier onset of the accelerated fatigue damage stage with greater dominance of fatigue failure. Based on the nonlinear strain, loading cycle variable and fatigue life, a highly accurate nonlinear fatigue model was developed to describe the complete inverted S-shaped evolution pattern of fatigue damage, which demonstrated excellent practical implications for the theoretical characterization of anisotropic fatigue damage in disturbed Jinping marble.
基金supported by the Natural Science Fund of China(No.51834003,52274073,52022014).
文摘Energy is an important resource that supports the development of human society,and energy security is even more relevant to the strength of a country.In order to ensure energy security,countries around the world are taking measures to carry out energy transformation and construct new energy systems.As an important part of the new energy system,energy storage technology is highly valued by all countries.Among many large-scale energy storage technologies,salt cavern compressed air energy storage(CAES)technology stands out for its safety and economy,which is recognized and valued by scholars from various countries.For the construction of salt cavern CAES power station,it is very important to ensure the stability of salt cavern.Therefore,scholars have investigated the mechanical properties of salt rocks and the stability of salt caverns for CAES.This paper synthesizes the findings of current research on the creep and fatigue properties of salt rock,highlighting three key points:The factors influencing the creep and fatigue characteristics of salt rock include its composition,stress levels,and temperature.Notably,impurities and surrounding pressure tend to inhibit the deformation of salt rock,whereas elevated temperature and differential stress facilitate its deformation;The mechanisms governing creep and fatigue damage in salt rock are primarily associated with dislocation movement and microcracking;Most existing constitutive models for creep and fatigue are based on viscoelastic-plasticity theory,with fewer models derived from micro-mechanical perspectives.Additionally,this paper reviews studies on the stability of salt cavern CAES reservoirs utilizing numerical simulation methods and offers insights into future research directions concerning the creep and fatigue properties of salt rocks.
基金supported by the National Natural Science Foundation of China(Nos.52374078,U24A20616 and 52074043)the Sichuan-Chongqing Science and Technology Innovation Cooperation Program Project(No.2024TIAD-CYKJCXX0011)the Fundamental Research Funds for the Central Universities(No.2023CDJKYJH021)。
文摘Salt cavern energy storage technology contributes to energy reserves and renewable energy scale-up.This study focuses on salt cavern gas storage in Jintan to assess the long-term stability of its surrounding rock under frequent operation.The fatigue test results indicate that stress holding significantly reduces fatigue life,with the magnitude of stress level outweighing the duration of holding time in determining peak strain.Employing a machine learning approach,the impact of various factors on fatigue life and peak strain was quantified,revealing that higher stress limits and stress holding adversely impact the fatigue index,whereas lower stress limits and rate exhibit a positive effect.A novel fatigue-creep composite damage constitutive model is constructed,which is able to consider stress magnitude,rate,and stress holding.The model,validated through multi-path tests,accurately captures the elasto-viscous behavior of salt rock during loading,unloading,and stress holding.Sensitivity analysis further reveals the time-and stress-dependent behavior of model parameters,clarifying that strain changes stem not only from stress variations but are also influenced by alterations in elasto-viscous parameters.This study provides a new method for the mechanical assessment of salt cavern gas storage surrounding rocks.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.72171136 and 72134004)Humanities and Social Science Research Project,Ministry of Education of China(Grant No.21YJC630157)+1 种基金the Natural Science Foundation of Shandong Province(Grant No.ZR2022MG008)Shandong Provincial Colleges and Universities Youth Innovation Technology of China(Grant No.2022RW066)。
文摘Health information spreads rapidly,which can effectively control epidemics.However,the swift dissemination of information also has potential negative impacts,which increasingly attracts attention.Message fatigue refers to the psychological response characterized by feelings of boredom and anxiety that occur after receiving an excessive amount of similar information.This phenomenon can alter individual behaviors related to epidemic prevention.Additionally,recent studies indicate that pairwise interactions alone are insufficient to describe complex social transmission processes,and higher-order structures representing group interactions are crucial.To address this,we develop a novel epidemic model that investigates the interactions between information,behavioral responses,and epidemics.Our model incorporates the impact of message fatigue on the entire transmission system.The information layer is modeled using a static simplicial network to capture group interactions,while the disease layer uses a time-varying network based on activity-driven model with attractiveness to represent the self-protection behaviors of susceptible individuals and self-isolation behaviors of infected individuals.We theoretically describe the co-evolution equations using the microscopic Markov chain approach(MMCA)and get the epidemic threshold.Experimental results show that while the negative impact of message fatigue on epidemic transmission is limited,it significantly weakens the group interactions depicted by higher-order structures.Individual behavioral responses strongly inhibit the epidemic.Our simulations using the Monte Carlo(MC)method demonstrate that greater intensity in these responses leads to clustering of susceptible individuals in the disease layer.Finally,we apply the proposed model to real networks to verify its reliability.In summary,our research results enhance the understanding of the information-epidemic coupling dynamics,and we expect to provide valuable guidance for managing future emerging epidemics.
基金Supported by the Coordination of Improvement of Higher Education Personnel(CAPES)and National Council for Scientific and Technological Development(CNPq),No.311427/2023-5.
文摘The international scientific literature presents still incipient results regarding the management of cancer symptom clusters by oncology nursing,especially in pediatric oncology.This is a promising field of investigation for clinical nurses and researchers,and when it is subsidized by medium-range theories,they co-rroborate the diagnoses and interventions of nursing in oncology,enhancing the science of nursing care.This minireview article aims to discuss the utilizing the hospital clowns as a complementary therapy,to enhance quality of life and reduce stress and fatigue in pediatric cancer patients.Overall,the evidence presented so far pointed out that complementary therapy might help improve the quality of life of pediatric cancer patients,and that complementary therapy usage should be part of a health comprehensive care model,delivering therapeutic approaches that might enhance the mind-body during a pediatric cancer patients’life span.The results of scientific investigations by nurses,particularly those linked to the basic sciences,play a critical role in advancing personalized care in pediatric integrative oncology.
文摘BACKGROUND Patients not only experience symptoms caused by cancer but also suffer from the accompanying psychological pain.Therefore,these patients do not have high quality of life.According to the World Health Organization,the incidence of leukemia in China in 2020 was 5.1/100000,the mortality rate was 3.3/100000,and the prevalence rate was 16.7/100000.Therefore,it is important to examine the influence of comorbid subthreshold depressive symptoms on leukemia patients.AIM To determine the impact of comorbid subthreshold depressive symptoms on cancer-related fatigue and complications in leukemia patients,thereby providing a basis for early diagnosis and treatment in clinical practice.METHODS A questionnaire survey was conducted among leukemia patients admitted to a tertiary hospital in Xi'an,Shaanxi Province,China,from August 2022 to December 2023.Patients with a score>16 on the Chinese Classification of Mental Disorders(CCMD-3)and a Hamilton Depression Rating Scale score of 8-17 were classified as the subthreshold depressive group(n=95),while 100 leukemia patients admitted during the same period were classified as the control group.Data were collected using Epidata 3.1 software,and comparisons were made between the two groups regarding general clinical data,the Piper Fatigue Scale(PFS),the Pittsburgh Sleep Quality Index(PSQI),the Numeric Rating Scale for pain assessment,laboratory indicators,and the occurrence of complications.RESULTS In this survey,120 leukemia patients with depression were preliminarily screened,95 patients with subthreshold depression were ultimately selected as the subthreshold depression group,and 100 leukemia patients admitted during the same period were enrolled as the normal group.Comparison of basic clinical data between the two groups revealed no significant differences in age,sex,body mass index,cognitive function,or comorbidity with other chronic diseases.However,there were statistically significant differences in the use of radiotherapy and regular exercise between the two groups(P<0.05).Comparisons of scales and laboratory indicators revealed no significant differences in albumin or PSQI scores between the two groups,but there were statistically significant differences in pain scores,PSQI scores,PFS scores,hemoglobin levels,and C-reactive protein levels(P<0.05).Spearman’s correlation analysis indicated that cancer-related fatigue was correlated with age,hemoglobin levels,C-reactive protein levels,pain,and regular exercise among leukemia patients with subthreshold depression.Multivariate regression analysis revealed that advanced age,combined radiotherapy,pain,and low hemoglobin levels were risk factors for cancer-related fatigue in leukemia patients with comorbid subthreshold depression,while regular exercise was a protective factor against cancer-related fatigue.Follow-up comparisons revealed a significantly lower overall incidence of complications in the control group(4%)than in the depressive group(24.21%;P<0.001).CONCLUSION Leukemia patients with comorbid subthreshold depressive symptoms experience more severe cancer-related fatigue and a higher incidence of complications.These findings may be related to advanced age,combined radiotherapy,pain,and low hemoglobin levels,while regular exercise may effectively alleviate symptoms.
基金financially supported by the Director Fund of National Energy Deepwater Oil and Gas Engineering Technology Research and Development Center(Grant No.KJQZ-2024-2103)。
文摘The Steel Catenary Riser(SCR)is a vital component for transporting oil and gas from the seabed to the floating platform.The harsh environmental conditions and complex platform motion make the SCR’s girth-weld prone to fatigue failure.The structural stress fatigue theory and Master S-N curve method provide accurate predictions for the fatigue damage on the welded joints,which demonstrate significant potential and compatibility in multi-axial and random fatigue evaluation.Here,we propose a new frequency fatigue model subjected to welded joints of SCR under multiaxial stress,which fully integrates the mesh-insensitive structural stress and frequency domain random process and transforms the conventional welding fatigue technique of SCR into a spectrum analysis technique utilizing structural stress.Besides,a full-scale FE model of SCR with welds is established to obtain the modal structural stress of the girth weld and the frequency response function(FRF)of modal coordinate,and a biaxial fatigue evaluation about the girth weld of the SCR can be achieved by taking the effects of multi-load correlation and pipe-soil interaction into account.The research results indicate that the frequency-domain fatigue results are aligned with the time-domain results,meeting the fatigue evaluation requirements of the SCR.
文摘BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat it.Although advancements of science and technology have resulted in more and more patients being able to receive effective treatment,they still face side effects such as fatigue and weakness.It is important to thoroughly investigate the factors that contribute to cancer-related fatigue(CRF)during chemotherapy.AIM To explore the factors related to CRF,anxiety,depression,and mindfulness levels in patients with DLBCL during chemotherapy.METHODS General information was collected from the electronic medical records of eligible patients.Sleep quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short Form.The Piper Fatigue Scale was used to evaluate the CRF status.The Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression status.Univariate analysis and multivariate regression analysis were used to investigate the factors related to CRF.RESULTS The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74±2.51.In 25 patients,the highest rate of mild fatigue was in the cognitive dimension(40.32%),and in 35 patients the highest moderate fatigue rate in the behavioral dimension(56.45%).In the emotional dimension,severe fatigue had the highest rate of occurrence,34 cases or 29.03%.The CRF score was positively correlated with cancer experience(all P<0.01)and negatively correlated with cancer treatment efficacy(all P<0.01).Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with DLBCL during chemotherapy.CONCLUSION There was a significant correlation between CRF and perceptual control level in patients.Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level influenced CRF in patients with DLBCL during chemotherapy.
基金supported by the National Natural Science Foundation of China(51875443)Guangdong Basic and Applied Basic Research Foundation(2019B1515120016,202002030290).
文摘Although magnesium(Mg)alloys are the lightest among structural metals,their inadequate corrosion resistance makes them difficult to be used in energy-saving lightweight structures.Moreover,the improvement in corrosion resistance by the conventional surface treatments is always achieved at the expense of sacrificing the fatigue lifetime.In this study,high purity aluminum(Al)and AlMgSi alloy coatings were deposited on Mg alloys via an in-situ micro-forging(MF)assisted cold spray(MFCS)process for simultaneous higher corrosion resistance and longer fatigue lifetime.Besides contributing to a highly dense microstructure,the in-situ MF also greatly refines the grain of the deposited Al alloy coating to the sub-micrometer range due to the enhanced dynamic recrystallization and also generates notable compressive residual stress up to 210 MPa within the AlMgSi coating.The absence of secondary phases in the AlMgSi alloy coatings enable the coated Mg alloy with corrosion resistance,which is even better than its bulk AlMgSi counterparts.The unique combination of refined microstructure and the prominent compressive residual stress within the AlMgSi coatings,effectively delayed the crack initiation upon repeated dynamic loading,thereby leading to∼10 times increase in the fatigue lifetime of the Mg Alloy.However,although residual stress is also generated in the submmicro-sized grained pure Al coating,the low intrinsic strength of the coating layer leads to a lower fatigue lifetime than the uncoated Mg alloy substrate.The present work is aimed to provide a facile approach to break the trade-off between corrosion resistance improvement and fatigue lifetime of the coated Mg alloys.
基金support provided by the Spanish Ministry of Science and Innovation(MICINN,Madrid,Spain)the European Regional Development Fund(Brussels,Belgium)MCIN/AEI/10.13039/501100011033/FEDER,UE under grant PID2021-127445NB-I00.
文摘Understanding the interaction between cyclic stresses and corrosion of magnesium(Mg)and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials.This review is dedicated to exploring the corrosion-fatigue mechanisms of these materials,with an emphasis on microscale processes,and the possibility of expanding current knowledge on this topic using scanning electrochemical techniques.The interaction between fatigue and corrosion of Mg alloys is analyzed by considering the microstructural aspects(grain size,precipitates,deformation twins),as well as the formation of pits.Furthermore,in the case of coated alloys,the role of coating defects in these phenomena is also described.In this context,the feasibility of using scanning electrochemical microscopy(SECM),scanning vibrating electrode technique(SVET),scanning ion-selective electrode technique(SIET),localized electrochemical impedance spectroscopy(LEIS)and scanning Kelvin probe(SKP)methods to study the corrosion-fatigue interaction of Mg alloys is examined.A comprehensive review of the current literature in this field is presented,and the opportunities and limitations of consolidating the use of these techniques to study the microscale processes involved in Mg corrosion-fatigue are discussed.
基金supported by the National Key Research and Development Program of China(2017YFC1702400).
文摘Objective:To evaluate the anti-fatigue effects of different extracts from Cistanche tubulosa(Schenk)Wight(C.tubulosa,Rou Cong Rong),focusing on central and exercise-induced fatigue in mice.This study investigated the pharmacological effects of the total oligosaccharides,polysaccharides,and phenylethanoid glycosides(CPhGs)extracted from C.tubulosa.Methods: Models of sleep deprivation and forced swimming fatigue were established to simulate central and exercise-induced fatigue.The mice were treated with different extracts of C.tubulosa,and their effects were assessed using behavioral tests to measure exercise capacity,learning,and memory function.Biochemical analyses were performed to evaluate the changes in serum and brain neurotransmitter levels,liver and muscle glycogen storage,and various fatigue-related biomarkers.Results: This study found that treatment with C.tubulosa extract improved exercise capacity,learning,and memory in mice.Total oligosaccharides from C.tubulosa enhanced adrenocorticotropic hormone,cholinesterase,and thyroid-stimulating hormone levels,reduced cortisol levels in central fatigue models,and ameliorated biochemical markers of exercise-induced fatigue,including lowering lactic acid,blood urea nitrogen,and malondialdehyde levels.Among the tested extracts,the total oligosaccharides showed the most comprehensive anti-fatigue effects.Conclusion: The anti-fatigue effects of C.tubulosa,particularly those of its total oligosaccharides,are pronounced in both central and exercise-induced fatigue.These effects are mediated by the regulation of neurotransmitter levels,enhancement of glycogen storage,and improvement of antioxidant enzyme activity,suggesting potential therapeutic benefits in fatigue-related conditions.
基金supported by the grants of the National Natural Science Foundation of China(82222016,8235005,82271189).
文摘Objective:To make an overview of global research trends in the etiology of auditory neuropathy(AN)over the past 30 years using a bibliometric approach.Methods:Bibliometric analyses were conducted by GraphPad Prism 9.0,Citespace 6.2.R2,and an online analysis platform to analyze and visualize publications related to etiology of AN from the Web of Science Core Collection(WoSCC)database from 1996 to 2022.Additionally,genetic factors in human AN were analyzed.Results:In total,604 original articles and reviews related to the etiology of AN from the WoSCC were included for bibliometric analysis.The results showed that annual publications and trend on etiology of AN increased linearly from 2000.Among them,the United States and China published nearly 400 records(40.32%).From the 604 records,a total of 752 keywords and 10 clustered network maps were extracted by Citespace,and‘mutations’was among the top 10 keywords.Analysis of genetic factors found that more than 30 genes were related to AN,and the latest burst occurred in 2022.Conclusion:The bibliometric analysis mapped the global research trends and analyzed hotspots for future.The results indicated that the annual publications increased linearly from 2000.Notably,there was a burst in genetic factors in 2022,which identified that genetic factor would remain a focus of future research.
文摘Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment in the development of moyamoya disease.
基金supported by the Clinical Medical Technology Innovation Guide Project of Hunan Province,China(2020SK53609).
文摘Objective:Sleep quality in kidney transplant recipients is closely associated with symptoms of fatigue and depression.Although subjective assessment tools like the Pittsburgh Sleep Quality Index and the Richards-Campbell Sleep Questionnaire(RCSQ)are widely used to evaluate sleep quality,there is a lack of studies utilizing polysomnography for objective evaluation.This study aims to investigate the correlation between sleep quality,fatigue,and depression in kidney transplant recipients using both subjective and objective methods,providing scientific evidence for improving their quality of life.Methods:The cross-sectional study conveniently sampled 50 kidney transplant recipients from a transplant center in a general hospital between August 2018 and March 2020.Subjective and objective sleep parameters were evaluated using the RCQS and polysomnography,respectively.The Fatigue Severity Scale was used to assess fatigue,and the Hamilton Depression Scale was employed to measure depression levels.Results:A lower proportion of rapid eye movement(REM)sleep was associated with increased fatigue.Additionally,higher wake time percentages and poorer sleep quality were significantly correlated with greater depression severity.Conclusion:This study underscores the critical importance of effectively managing sleep quality in kidney transplant recipients and addressing their fatigue and depression symptoms.These findings lay a foundation for developing targeted nursing and therapeutic strategies.
基金funded by China’s National Key R&D Programmers for“Hi-Tech Winter Olympics”Special Project[2020YFF0305001]。
文摘Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise fatigue.Methods A network pharmacological approach was used to explore potential mechanisms of action of Fructus lycii.Skeletal muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological analysis.Results Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling pathways.The immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the control.Furthermore,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin treatment.Conclusion Fructus lycii might alleviate exercise fatigue through multiple components and pathways.Among these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative stress.The PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.
基金financially supported by the Major Scientific and Technological Innovation Projects in Luoyang (No. 2201029A)Foundation Strengthening Plan Technical Field Fund (No. 2021-JJ-0112)+1 种基金National Natural Science Foundation of China (Nos. 51821001 and U2037601)Research Program of Joint Research Center of Advanced Spaceflight Technologies (No. USCAST2020-14)
文摘In this paper,(0.2-1 wt%)Yb was added to improve the tensile properties and high-cycle fatigue behavior of the as-cast and as-extruded Mg-10Li-5Zn-0.5Er alloys.It is found that Yb mainly affects the mechanical properties of the alloy by changing the grain size,type and morphology of the second phases.Yb mainly exists in the formation of Mg_(2)Yb and Mg-Zn-Yb phases in the metallographic structure.With the addition of Yb,the grains are refined and these Yb-containing phases replace the large-sized MgLiZn phase to be enriched at the grain boundaries.While the addition of excess Yb reduces the number of small-sized MgLiZn phases in the grain,thus reducing the alloys’mechanical performance.After extrusion,the small-sized MgLiZn phase is refined and the number increases,which effectively improves the tensile and fatigue strength of the alloy.The fatigue strength is mainly affected by the number and morphology of the second phase,positively correlated with the strength.Balanced in grain size and number and size of second phases,the extruded alloy with 0.2Yb added exhibits excellent mechanical properties with the yield strength,ultimate tensile strength and elongation of 292 MPa,303 MPa and 11.7%,and an fatigue strength of 130 MPa.
基金the National Natural Science Foundation of China(Nos.52175143 and 51571150)。
文摘Strong anisotropic corrosion and mechanical properties caused by specimen orientations greatly limit the applications of wrought magnesium alloys.To investigate the influences of specimen orientation,the corrosion tests and(corrosion)fatigue crack growth tests were conducted.The rolled and transverse surfaces of the materials show distinct corrosion rate differences in the stable corrosion stage,but the truth is the opposite for the initial stage of corrosion.In air,specimen orientations have a significant influence on the plastic deformation mechanisms near the crack tip,which results in different fatigue fracture surfaces and cracking paths.Compared with R-T specimens,N-T specimens show a slower fatigue crack growth(FCG)rate in air,which can be attributed to crack closure effects and deformation twinning near the crack tip.The corrosion environment will not significantly change the main plastic deformation mechanisms for the same type of specimen.However,the FCG rate in phosphate buffer saline(PBS)is one order of magnitude higher than that in air,which is caused by the combined effects of hydrogen-induced cracking and anodic dissolution.Owing to the similar corrosion rates at crack tips,the specimens with different orientations display close FCG rates in PBS.
