L波段数字航空通信系统(L-band digital aeronautical communication system,LDACS)作为未来航空数据链的重要技术手段之一,非常容易受到相邻波道的测距机系统信号的干扰。为此,提出一种基于稀疏贝叶斯推断的LDACS波束形成方法。首先,将...L波段数字航空通信系统(L-band digital aeronautical communication system,LDACS)作为未来航空数据链的重要技术手段之一,非常容易受到相邻波道的测距机系统信号的干扰。为此,提出一种基于稀疏贝叶斯推断的LDACS波束形成方法。首先,将LDACS地面站的粗略来向信息作为先验,并根据空域信号来向的稀疏性构建稀疏信号。随后,通过贝叶斯推断估算干扰和噪声的功率,估计各个信源的来向。最后,重构干扰噪声协方差矩阵,获得波束形成权矢量。该方法无需知晓干扰数量、干扰来向等信息。仿真结果表明,该方法在低信噪比和少快拍条件下也能稳定输出波束方向图,表现出较好性能。展开更多
Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanis...Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanisms of EBM in the treatment of breast cancer to facilitate the discovery of new drugs and their clinical application.Methods: Network pharmacology was used to identify and screen the components and targets of EBM for breast cancer treatment.Molecular docking was further screened the effective components and targets of EBM.Wound-healing assays and flow cytometry analysis were used to detect the ability of two compounds to intervene in the migration and apoptosis of MDA-MB-231 cells,and their mechanism of action was further explored using western blotting experiments.Results: EBM contained 19 active components.Among them wereβ-anhydroicaritin(Anhy)and isoliquiritigenin(Iso),which were selected for in vitro experiments.Treatment resulted in a dose-dependent suppression of MDA-MB-231 cell viability,with an IC_(50) of 23.73μmol/L for Iso and 21.28μmol/L for Anhy.In the wound healing assay,cells in Anhy and Iso groups exhibited considerable inhibition of migration at 48 h.In flow cytometry analysis,treatment with Iso(20μmol/L)for 96 h resulted in significantly higher levels of both early and late apoptosis in the Iso group than that in the control group(P=.004 and P=.014,respectively).Additionally,both Iso(20μmol/L)and Anhy(10 and 20μmol/L)induced cell necrosis at 96 h.Western blotting revealed that Anhy and Iso increased the expression of Bax and TBK1/NAK.Conclusion: These findings suggested that Anhy and Iso,the two components of EBM,inhibit MDA-MB-231 cell proliferation and migration of and induce their apoptosis,providing substantial support for future studies on breast cancer.展开更多
文摘L波段数字航空通信系统(L-band digital aeronautical communication system,LDACS)作为未来航空数据链的重要技术手段之一,非常容易受到相邻波道的测距机系统信号的干扰。为此,提出一种基于稀疏贝叶斯推断的LDACS波束形成方法。首先,将LDACS地面站的粗略来向信息作为先验,并根据空域信号来向的稀疏性构建稀疏信号。随后,通过贝叶斯推断估算干扰和噪声的功率,估计各个信源的来向。最后,重构干扰噪声协方差矩阵,获得波束形成权矢量。该方法无需知晓干扰数量、干扰来向等信息。仿真结果表明,该方法在低信噪比和少快拍条件下也能稳定输出波束方向图,表现出较好性能。
基金supported by the National Natural Science Foundation of China(81774319).
文摘Objective:To evaluate the therapeutic effects of Epimedium brevicornu Maxim.(EBM,Yin Yang Huo)on breast cancer using network pharmacology and in vitro validation.It also aimed to explore the novel targets and mechanisms of EBM in the treatment of breast cancer to facilitate the discovery of new drugs and their clinical application.Methods: Network pharmacology was used to identify and screen the components and targets of EBM for breast cancer treatment.Molecular docking was further screened the effective components and targets of EBM.Wound-healing assays and flow cytometry analysis were used to detect the ability of two compounds to intervene in the migration and apoptosis of MDA-MB-231 cells,and their mechanism of action was further explored using western blotting experiments.Results: EBM contained 19 active components.Among them wereβ-anhydroicaritin(Anhy)and isoliquiritigenin(Iso),which were selected for in vitro experiments.Treatment resulted in a dose-dependent suppression of MDA-MB-231 cell viability,with an IC_(50) of 23.73μmol/L for Iso and 21.28μmol/L for Anhy.In the wound healing assay,cells in Anhy and Iso groups exhibited considerable inhibition of migration at 48 h.In flow cytometry analysis,treatment with Iso(20μmol/L)for 96 h resulted in significantly higher levels of both early and late apoptosis in the Iso group than that in the control group(P=.004 and P=.014,respectively).Additionally,both Iso(20μmol/L)and Anhy(10 and 20μmol/L)induced cell necrosis at 96 h.Western blotting revealed that Anhy and Iso increased the expression of Bax and TBK1/NAK.Conclusion: These findings suggested that Anhy and Iso,the two components of EBM,inhibit MDA-MB-231 cell proliferation and migration of and induce their apoptosis,providing substantial support for future studies on breast cancer.
