Songpan County is a poverty-stricken county in Tibetan areas of Sichuan Province,it belongs to a concentrated poverty-stricken area in China.Through summarizing the specific conditions of multi-level cooperation and c...Songpan County is a poverty-stricken county in Tibetan areas of Sichuan Province,it belongs to a concentrated poverty-stricken area in China.Through summarizing the specific conditions of multi-level cooperation and complementary advantage poverty alleviation model in Songpan County,this paper analyzed the effect of this model.Through the analysis on the cooperative poverty alleviation model(eastern-western cooperation,provincial targeted assistance,county-wide"four-leading and four-assistance"inner-party assistance,social force"10000 enterprises helping 10000 villages",and"visiting every household and keeping every person busy"),it summarized the implementation and actual results of each level.In addition,it summarized the problems encountered in the implementation process of multi-level cooperation and complementary advantage poverty alleviation model and came up with recommendations.With the aid of this successful multi-level cooperation and complementary advantage poverty alleviation model,Songpan County has achieved a decisive victory in the fight against poverty.At the end of April 2019,the poverty rate in the whole region fell to 0.45%,and it successfully took off the poverty hat.This paper analyzed and refined the specific practice,main achievements,successful experience,implications and reference significance of multi-level cooperation and complementary advantage poverty alleviation model,to provide necessary references for innovation of poverty alleviation model in poverty-stricken Tibetan areas,or even other similar provinces and regions.展开更多
Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic ...Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random disturbances.Among them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level community.This study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control charts.The approach is demonstrated using Key West,Florida tide gauge records.The mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the present.Increasing oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.展开更多
BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,...BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.展开更多
The dynamic characteristics and influencing factors of groundwater level in Qianyang County were analyzed.The results showed that in the south bank of the Qianhe River,the change of groundwater level was mainly affect...The dynamic characteristics and influencing factors of groundwater level in Qianyang County were analyzed.The results showed that in the south bank of the Qianhe River,the change of groundwater level was mainly affected by precipitation,and the response of the groundwater level to the change of precipitation was one year later.The groundwater level presented a downward trend on the whole.In the north bank of the Qianhe River,the supply source of the groundwater level included precipitation and hydrology,and the groundwater level showed a rising trend on the whole.In the plain area,there was a sudden change in the groundwater level under the control of human activities.In a word,the main factors influencing the groundwater level in various geological conditions were different,so there were great differences between various regions in the dynamic characteristics of the groundwater level in Qianyang County.展开更多
In the period of Eleventh Five-Year Plan,the construction of county-level vocational education centers in Shanxi Province made great contribution to local social and economic development. Due to influence of special g...In the period of Eleventh Five-Year Plan,the construction of county-level vocational education centers in Shanxi Province made great contribution to local social and economic development. Due to influence of special geography,population environment and regional economic development situation,it forms the pattern of strong in southeast and weak in northwest. Thus,scientific making plan for construction of vocational education centers in northwestern counties( cities) and establishing long-term mechanism for construction of vocational education centers will be helpful for serving regional economic construction.展开更多
Remote sensing technique has played an important role in land use dynamic monitoring, but as for the land use dynamic monitoring at county level, traditional remote sensing methods such as satellite imagery visual int...Remote sensing technique has played an important role in land use dynamic monitoring, but as for the land use dynamic monitoring at county level, traditional remote sensing methods such as satellite imagery visual interpretation and computer classification can not meet its demand for accuracy. The result of 1:10 000 land use investigation map has high accuracy, but this method can not be used to dynamically monitor the land use because of its big expenses, long period and difficulty in updating data. In this paper, the characteristics of physiognomy, climate and the status of land use in Dehui County are taken into consideration and a set of method, which takes use of 3S techniques and applies to Northeast China Plain, is come up with. When the land use type of a land parcel changed as a whole, the date updating can be make by changing its land type ID in the attribute table in a GIS. When the land use type of an irregular area changed, GPS receivers are used to position its border. This set of method is characteristic of high accuracy and low expenses. It gets the information of land use change timely and can be used to dynamically monitor the land use. .展开更多
Terrain slope and climate zone(heat zone)are important factors affecting land use zoning and agricultural production layout in mountainous areas.Using"weight grade method",a quantitative index of comprehensi...Terrain slope and climate zone(heat zone)are important factors affecting land use zoning and agricultural production layout in mountainous areas.Using"weight grade method",a quantitative index of comprehensively evaluating terrain slope and climatic(thermal)conditions in mountainous areas was proposed:terrain-climate superiority degree(TCSD),and TCSD,terrain superiority degree(TSD),and climate superiority degree(CSD)in 129 counties(cities and districts)of Yunnan Province were measured and analyzed.The results showed that TCSD in 50.39%of counties of Yunnan Province was relatively better(levels I and II),and TCSD in 38.76%of counties was moderate(level III),while TCSD in 10.85%of counties was relatively poorer(levels IV and V).展开更多
County-level town is important space carrier of China's urbanization and the emphasis and key of strategic distribution for urbanization. Backwardness of county-level towns limits nearby transfer of surplus labor....County-level town is important space carrier of China's urbanization and the emphasis and key of strategic distribution for urbanization. Backwardness of county-level towns limits nearby transfer of surplus labor. To promote development of county-level towns,on the basis of classifying county-level towns,this paper analyzed motive and resistance factors of evolution of different county-level towns using historical data collection and statistical method,comparative approach,typical case study method,and studied development path for different county-level towns. From analysis,it reached the conclusion that industry exerts the most direct and fundamental influence on development of county-level towns,while the industrial development in county-level towns must base on their actual conditions. The county-level towns are not isolated,and their development should be established within the framework of national policy environment and superior and subordinate town system.展开更多
Based on field survey and research of Hanzhong, relocation of Nanzheng County was explored and the existing problems were analyzed. Furthermore, the re- gional characters of Nanzheng County were investigated to analyz...Based on field survey and research of Hanzhong, relocation of Nanzheng County was explored and the existing problems were analyzed. Furthermore, the re- gional characters of Nanzheng County were investigated to analyze the feasibility and necessity of relocation with lots of data and evaluation was made on relocation of Nanzheng County. In addition, the existing problems of relocation were concluded and the prospect of the county was discussed, which is of significance for relocation in Nanzheng County and even southern Shaanxi Province.展开更多
The evaluation of sustainable land use is the key issue in the field of studying the sustainable land utilization. In general analysis, the sustainable land use is evaluated respectively from its ecological sustainabi...The evaluation of sustainable land use is the key issue in the field of studying the sustainable land utilization. In general analysis, the sustainable land use is evaluated respectively from its ecological sustainability, economic sustainability and social sustainability in China and other countries in recent years. Although this evaluation is an important work, it seems insufficient and hard to comprehensively reflect the whole degree of land use sustainability. Thus, to make up this deficiency, this paper brings forward the evaluation indexes, which make it possible to quantitatively reflect the whole degree of land use sustainability, namely, the concept of ＂degrees of overall land use sustainability＂ （Dos）, and research and measurement development of the method of and calculation in Dos. Taking the evaluation of the degree of land use sustainability in county regions of Yunnan Province as the actual example for analysis, results are basically as follows： 1） The degree of land use sustainability （Dos） is the ration index to organically and systematically integrate the degree of ecological friendliness （DeF）, the degree of economic viability （Dev） and the degree of social acceptability （Dsa）, able to comprehensively reflect the whole sustainability degree of regional land use 2） Based on the value of Dos, the grading system and standard for the sustainability of land use may be established and totally divided into five grades, namely, the high-degree sustainability, middle-degree sustainability, low-degree sustainability, conditional sustainability and non-sustainability. Meanwhile, the standard for distinguishing sustainability grades has also been confirmed so as to determine the nature of sustainability degrees in different grades. This makes the possibility for the combination of nature determination with ration in research result and provides with the scientific guideline and decision-making gist for better implementation of sustainable land use strategy. 3） The practice in evaluation of sustainability degree in county regional land use in Yunnan shows that the value of the degree of land use sustainability （Dos） of whole Yunnan Province is only 58.39, belonging to the grade of low-degree sustainability. Two thirds of counties in the whole province represent the grade of ＂conditional sustainability＂ and ＂non-sustainability＂ in the sustainability of land use. Among these counties, 11.11 % shows ＂non- sustainability＇. The lowest degree of land use sustainability appears especially in the middle plateau mountain region of Northeast Yunnan, where the value of Dos in most counties （districts） is below 40 %, belonging to the grade of ＂non-sustainability＂. The sustainability degree in the karst mountainous region in lower-middle plateau mountain region in Southeast Yunnan is generally low and the value of sustainability degree （Dos） in most of the counties （cities and districts） is below 55. The value of sustainability degree （Dos） in most of the counties （cities and districts） in the north, west, northwest and southwest parts of Yunnan is below 55. This article also analyzes the reasons of low degree of sustainability in land use in Yunnan and puts forward the countermeasures to increase the degree of sustainability in land use in the whole province.展开更多
BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants signif...BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.展开更多
Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21...Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.展开更多
In the past decades,Moore’s law drives the semiconductor industry to continuously shrink the critical size of transistors down to 7 nm.As transistors further downscaling to smaller sizes,the law reaches its limitatio...In the past decades,Moore’s law drives the semiconductor industry to continuously shrink the critical size of transistors down to 7 nm.As transistors further downscaling to smaller sizes,the law reaches its limitation,and the increase of transistors density on the chip decelerates.Up to now,extreme ultraviolet lithography has been used in some key steps,and it is facing alignment precision and high costs for high-volume manufacturing.Meanwhile,the introduction of new materials and 3D complex structures brings serious challenges for top-down methods.Thus,bottom-up schemes are believed to be necessary methods combined with the top-down processes.In this article,atomic level deposition methods are reviewed and categorized to extend Moore’s law and beyond.Firstly,the deposition brings lateral angstrom resolution to the vertical direction as well as top-down etching,such as double patterning,transfer of nanowires,deposition of nanotubes,and so on.Secondly,various template-assisted selective deposition methods including dielectric templates,inhibitors and correction steps have been utilized for the alignment of 3D complex structures.Higher resolution can be achieved by inherently selective deposition,and the underlying selective mechanism is discussed.Finally,the requirements for higher precision and efficiency manufacturing are also discussed,including the equipment,integration processes,scale-up issues,etc.The article reviews low dimensional manufacturing and integration of 3D complex structures for the extension of Moore’s law in semiconductor fields,and emerging fields including but not limited to energy,catalysis,sensor and biomedicals.展开更多
文摘Songpan County is a poverty-stricken county in Tibetan areas of Sichuan Province,it belongs to a concentrated poverty-stricken area in China.Through summarizing the specific conditions of multi-level cooperation and complementary advantage poverty alleviation model in Songpan County,this paper analyzed the effect of this model.Through the analysis on the cooperative poverty alleviation model(eastern-western cooperation,provincial targeted assistance,county-wide"four-leading and four-assistance"inner-party assistance,social force"10000 enterprises helping 10000 villages",and"visiting every household and keeping every person busy"),it summarized the implementation and actual results of each level.In addition,it summarized the problems encountered in the implementation process of multi-level cooperation and complementary advantage poverty alleviation model and came up with recommendations.With the aid of this successful multi-level cooperation and complementary advantage poverty alleviation model,Songpan County has achieved a decisive victory in the fight against poverty.At the end of April 2019,the poverty rate in the whole region fell to 0.45%,and it successfully took off the poverty hat.This paper analyzed and refined the specific practice,main achievements,successful experience,implications and reference significance of multi-level cooperation and complementary advantage poverty alleviation model,to provide necessary references for innovation of poverty alleviation model in poverty-stricken Tibetan areas,or even other similar provinces and regions.
文摘Monitoring temporal changes in sea level is important in assessing coastal risk.Sea level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random disturbances.Among them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level community.This study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and S control charts.The approach is demonstrated using Key West,Florida tide gauge records.The mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the present.Increasing oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.
文摘BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.
基金Supported by the Key Laboratory Project of Shaanxi Province,China(09JS071)
文摘The dynamic characteristics and influencing factors of groundwater level in Qianyang County were analyzed.The results showed that in the south bank of the Qianhe River,the change of groundwater level was mainly affected by precipitation,and the response of the groundwater level to the change of precipitation was one year later.The groundwater level presented a downward trend on the whole.In the north bank of the Qianhe River,the supply source of the groundwater level included precipitation and hydrology,and the groundwater level showed a rising trend on the whole.In the plain area,there was a sudden change in the groundwater level under the control of human activities.In a word,the main factors influencing the groundwater level in various geological conditions were different,so there were great differences between various regions in the dynamic characteristics of the groundwater level in Qianyang County.
基金Supported by Project of Shanxi Provincial Soft Science Research Plan(2013041006-01)
文摘In the period of Eleventh Five-Year Plan,the construction of county-level vocational education centers in Shanxi Province made great contribution to local social and economic development. Due to influence of special geography,population environment and regional economic development situation,it forms the pattern of strong in southeast and weak in northwest. Thus,scientific making plan for construction of vocational education centers in northwestern counties( cities) and establishing long-term mechanism for construction of vocational education centers will be helpful for serving regional economic construction.
基金Under the auspices of the key project of the National Ninth Five-year Plan (96-B02-01-07).
文摘Remote sensing technique has played an important role in land use dynamic monitoring, but as for the land use dynamic monitoring at county level, traditional remote sensing methods such as satellite imagery visual interpretation and computer classification can not meet its demand for accuracy. The result of 1:10 000 land use investigation map has high accuracy, but this method can not be used to dynamically monitor the land use because of its big expenses, long period and difficulty in updating data. In this paper, the characteristics of physiognomy, climate and the status of land use in Dehui County are taken into consideration and a set of method, which takes use of 3S techniques and applies to Northeast China Plain, is come up with. When the land use type of a land parcel changed as a whole, the date updating can be make by changing its land type ID in the attribute table in a GIS. When the land use type of an irregular area changed, GPS receivers are used to position its border. This set of method is characteristic of high accuracy and low expenses. It gets the information of land use change timely and can be used to dynamically monitor the land use. .
基金Graduate Program from Science Research Fund of Yunnan Department of Education(2021Y547).
文摘Terrain slope and climate zone(heat zone)are important factors affecting land use zoning and agricultural production layout in mountainous areas.Using"weight grade method",a quantitative index of comprehensively evaluating terrain slope and climatic(thermal)conditions in mountainous areas was proposed:terrain-climate superiority degree(TCSD),and TCSD,terrain superiority degree(TSD),and climate superiority degree(CSD)in 129 counties(cities and districts)of Yunnan Province were measured and analyzed.The results showed that TCSD in 50.39%of counties of Yunnan Province was relatively better(levels I and II),and TCSD in 38.76%of counties was moderate(level III),while TCSD in 10.85%of counties was relatively poorer(levels IV and V).
基金Supported by Key Project of National Social Science Foundation(11&ZD009)
文摘County-level town is important space carrier of China's urbanization and the emphasis and key of strategic distribution for urbanization. Backwardness of county-level towns limits nearby transfer of surplus labor. To promote development of county-level towns,on the basis of classifying county-level towns,this paper analyzed motive and resistance factors of evolution of different county-level towns using historical data collection and statistical method,comparative approach,typical case study method,and studied development path for different county-level towns. From analysis,it reached the conclusion that industry exerts the most direct and fundamental influence on development of county-level towns,while the industrial development in county-level towns must base on their actual conditions. The county-level towns are not isolated,and their development should be established within the framework of national policy environment and superior and subordinate town system.
基金Supported by the Fundamental Research Funds for the Central Universities(GK261002145)Key Teaching Reform Research of Shaanxi Normal University in 2014(14JG07)Teacher Education Program of Shaanxi Normal University in 2014(JSJY2014J014)~~
文摘Based on field survey and research of Hanzhong, relocation of Nanzheng County was explored and the existing problems were analyzed. Furthermore, the re- gional characters of Nanzheng County were investigated to analyze the feasibility and necessity of relocation with lots of data and evaluation was made on relocation of Nanzheng County. In addition, the existing problems of relocation were concluded and the prospect of the county was discussed, which is of significance for relocation in Nanzheng County and even southern Shaanxi Province.
文摘The evaluation of sustainable land use is the key issue in the field of studying the sustainable land utilization. In general analysis, the sustainable land use is evaluated respectively from its ecological sustainability, economic sustainability and social sustainability in China and other countries in recent years. Although this evaluation is an important work, it seems insufficient and hard to comprehensively reflect the whole degree of land use sustainability. Thus, to make up this deficiency, this paper brings forward the evaluation indexes, which make it possible to quantitatively reflect the whole degree of land use sustainability, namely, the concept of ＂degrees of overall land use sustainability＂ （Dos）, and research and measurement development of the method of and calculation in Dos. Taking the evaluation of the degree of land use sustainability in county regions of Yunnan Province as the actual example for analysis, results are basically as follows： 1） The degree of land use sustainability （Dos） is the ration index to organically and systematically integrate the degree of ecological friendliness （DeF）, the degree of economic viability （Dev） and the degree of social acceptability （Dsa）, able to comprehensively reflect the whole sustainability degree of regional land use 2） Based on the value of Dos, the grading system and standard for the sustainability of land use may be established and totally divided into five grades, namely, the high-degree sustainability, middle-degree sustainability, low-degree sustainability, conditional sustainability and non-sustainability. Meanwhile, the standard for distinguishing sustainability grades has also been confirmed so as to determine the nature of sustainability degrees in different grades. This makes the possibility for the combination of nature determination with ration in research result and provides with the scientific guideline and decision-making gist for better implementation of sustainable land use strategy. 3） The practice in evaluation of sustainability degree in county regional land use in Yunnan shows that the value of the degree of land use sustainability （Dos） of whole Yunnan Province is only 58.39, belonging to the grade of low-degree sustainability. Two thirds of counties in the whole province represent the grade of ＂conditional sustainability＂ and ＂non-sustainability＂ in the sustainability of land use. Among these counties, 11.11 % shows ＂non- sustainability＇. The lowest degree of land use sustainability appears especially in the middle plateau mountain region of Northeast Yunnan, where the value of Dos in most counties （districts） is below 40 %, belonging to the grade of ＂non-sustainability＂. The sustainability degree in the karst mountainous region in lower-middle plateau mountain region in Southeast Yunnan is generally low and the value of sustainability degree （Dos） in most of the counties （cities and districts） is below 55. The value of sustainability degree （Dos） in most of the counties （cities and districts） in the north, west, northwest and southwest parts of Yunnan is below 55. This article also analyzes the reasons of low degree of sustainability in land use in Yunnan and puts forward the countermeasures to increase the degree of sustainability in land use in the whole province.
基金Supported by the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030+1 种基金The National Key Research and Development Program,No.2016YFC0905003the 111 Project,No.B16047
文摘BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
文摘Due to global climate warming and natural and man-made land subsidence etc., relative sea level rise in the coastal plains of China will exceed 2-3 times over the golbal mean value during the first half part of the 21st century. It will result in a series of adverse impacts on evolution of natural environment and socioeconomic development of the coastal area. This paper analyses environmental and resource effects induced by relative sea level rise in China's coastal areas on the basis of rough estimate of future relative sea level rise. These effects include inundating tidal flat and wetlands and increase in inundated risk of coastal habitable land,exacerbating storm surge. coastal erosion, flooding and salt water intrusion hazards.as well as endangering land. water. tourism and living resources and their utilization.
基金the National Natural Science Foundation of China(51835005,51702106,51911540476,and 51575217)HUST state key lab project(DMETKF2019003)。
文摘In the past decades,Moore’s law drives the semiconductor industry to continuously shrink the critical size of transistors down to 7 nm.As transistors further downscaling to smaller sizes,the law reaches its limitation,and the increase of transistors density on the chip decelerates.Up to now,extreme ultraviolet lithography has been used in some key steps,and it is facing alignment precision and high costs for high-volume manufacturing.Meanwhile,the introduction of new materials and 3D complex structures brings serious challenges for top-down methods.Thus,bottom-up schemes are believed to be necessary methods combined with the top-down processes.In this article,atomic level deposition methods are reviewed and categorized to extend Moore’s law and beyond.Firstly,the deposition brings lateral angstrom resolution to the vertical direction as well as top-down etching,such as double patterning,transfer of nanowires,deposition of nanotubes,and so on.Secondly,various template-assisted selective deposition methods including dielectric templates,inhibitors and correction steps have been utilized for the alignment of 3D complex structures.Higher resolution can be achieved by inherently selective deposition,and the underlying selective mechanism is discussed.Finally,the requirements for higher precision and efficiency manufacturing are also discussed,including the equipment,integration processes,scale-up issues,etc.The article reviews low dimensional manufacturing and integration of 3D complex structures for the extension of Moore’s law in semiconductor fields,and emerging fields including but not limited to energy,catalysis,sensor and biomedicals.
