To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe...To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe Urine samples were collected in 2-6 hours after a cup of 140?mg coffee was taken, and the caffeine metabolites, 5 acetylamino 6 formylamino 1 methyluracil (AFMU) and 1 methylxanthine (1X) were analyzed by high performance liquid chromatography (HPLC) The frequency histogram and probit plot were constructed to select the critical value which was used to assess slow and fast acetylation status both in healthy volunteers and patients with bladder cancer Results The peak height ratios of AFMU and 1X (AFMU/1X) were from 0 06 to 6 50 for healthy volunteers and 0 10 to 6 31 for patients with bladder cancer, both with the critical value of 1 10 Of 203 healthy volunteers involved in this study, 26 3% were slow acetylacors, as compared to 46 3% with slow acetylacors in patients with bladder cancer The odds ratio is 2 376, and the gene frequency for healthy volunteers and patients with urinary bladder cancer were 0 5218 and 0 6804, respectively Conclusions N acetylation status in the Chinese population is polymorphic and completely concordant with that determined with other metabolic probes Slow acetylators are significantly associated with bladder cancer展开更多
Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the tr...Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed. Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group ( P <0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly ( P <0.01), while Tamm Horfau protein increased significantly ( P <0.01). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.展开更多
文摘To study the relationship between metabolic phenotype of acetylation and bladder cancer Methods Totally 203 healthy volunteers and 67 patients with bladder cancer were investigated with caffeine as a metabolic probe Urine samples were collected in 2-6 hours after a cup of 140?mg coffee was taken, and the caffeine metabolites, 5 acetylamino 6 formylamino 1 methyluracil (AFMU) and 1 methylxanthine (1X) were analyzed by high performance liquid chromatography (HPLC) The frequency histogram and probit plot were constructed to select the critical value which was used to assess slow and fast acetylation status both in healthy volunteers and patients with bladder cancer Results The peak height ratios of AFMU and 1X (AFMU/1X) were from 0 06 to 6 50 for healthy volunteers and 0 10 to 6 31 for patients with bladder cancer, both with the critical value of 1 10 Of 203 healthy volunteers involved in this study, 26 3% were slow acetylacors, as compared to 46 3% with slow acetylacors in patients with bladder cancer The odds ratio is 2 376, and the gene frequency for healthy volunteers and patients with urinary bladder cancer were 0 5218 and 0 6804, respectively Conclusions N acetylation status in the Chinese population is polymorphic and completely concordant with that determined with other metabolic probes Slow acetylators are significantly associated with bladder cancer
文摘Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed. Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group ( P <0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly ( P <0.01), while Tamm Horfau protein increased significantly ( P <0.01). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.
