Clinical trials play a crucial role in advancing the field of human health care.The registration of clinical trials can effectively identify potential publication bias and prevent unnecessary duplication of research e...Clinical trials play a crucial role in advancing the field of human health care.The registration of clinical trials can effectively identify potential publication bias and prevent unnecessary duplication of research efforts,serving as a source of transparent data for health care professionals and researchers,enhancing the quality of clinical research,and presenting more transparent,standardized,authentic,and useful clinical trials.To enhance the capacity for evidence production in traditional medicine from the source,the International TraditionalMedicine Clinical Trial Registry(ITMCTR),a cross-regional registry focusing on the theme of traditional medicine,was established.Under the current registration background,this study aims to introduce the problems and current status related to clinical trial registration,as well as the features and functions of the ITMCTR.The results of this study illustrate the necessity of establishing a specialized registration platform for traditional medicine to assist researchers in understanding the basic background of registration and relevant information regarding registration platforms,regardless of whether their research is related to traditional medicine or not.Ultimately,the results of this work will help researchers choose the appropriate platform for more efficient and transparent registration.展开更多
Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly preval...Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly prevalent in clinical practice.To address this,we adopted a dual leadership approach involving clinical and methodological experts,guided by evidence-based and clinical practice principles.We referred to existing guidelines,consensus statements,and treatment protocols,and designed relevant clinical questions based on the“3 specific”principles:specific CPM,specific disease stages,and specific outcomes.This allowed us to conduct evidencebased evaluations of the efficacy and application of CPMs specifically designed for children or with pediatric dosages.Using the“Checklist for Reporting Clinical Practice Guidelines for Chinese Patent Medicines V1.0”developed by our research team,we formulated recommendations for CPM.Ultimately,13 CPMs were recommended,providing clinicians with references on“how to select medication”and“how to use medication.”展开更多
基金supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2022E001No.CI2021A05505)by the Fundamental Research Funds for the Central public welfare research institutes(No.2020YJSZX-1).
文摘Clinical trials play a crucial role in advancing the field of human health care.The registration of clinical trials can effectively identify potential publication bias and prevent unnecessary duplication of research efforts,serving as a source of transparent data for health care professionals and researchers,enhancing the quality of clinical research,and presenting more transparent,standardized,authentic,and useful clinical trials.To enhance the capacity for evidence production in traditional medicine from the source,the International TraditionalMedicine Clinical Trial Registry(ITMCTR),a cross-regional registry focusing on the theme of traditional medicine,was established.Under the current registration background,this study aims to introduce the problems and current status related to clinical trial registration,as well as the features and functions of the ITMCTR.The results of this study illustrate the necessity of establishing a specialized registration platform for traditional medicine to assist researchers in understanding the basic background of registration and relevant information regarding registration platforms,regardless of whether their research is related to traditional medicine or not.Ultimately,the results of this work will help researchers choose the appropriate platform for more efficient and transparent registration.
基金funded by the National Natural Science Foundation of China(No.82105053)China Academy of Chinese Medical Sciences Key Collaborative Project of Innovation Fund(No.CI2022C004-01,No.CI2021A05505)+1 种基金Central Public Welfare Research Institute Basic Scientific Research Fund(No.ZZ14-YQ-039)Young Qihuang Scholars Program of the National Administration of Traditional Chinese Medicine(Z0841).
文摘Children are highly susceptible to influenza and are at high risk for severe cases.Chinese patent medicine(CPM)offers advantages in treating pediatric influenza,but the issue of its improper use is increasingly prevalent in clinical practice.To address this,we adopted a dual leadership approach involving clinical and methodological experts,guided by evidence-based and clinical practice principles.We referred to existing guidelines,consensus statements,and treatment protocols,and designed relevant clinical questions based on the“3 specific”principles:specific CPM,specific disease stages,and specific outcomes.This allowed us to conduct evidencebased evaluations of the efficacy and application of CPMs specifically designed for children or with pediatric dosages.Using the“Checklist for Reporting Clinical Practice Guidelines for Chinese Patent Medicines V1.0”developed by our research team,we formulated recommendations for CPM.Ultimately,13 CPMs were recommended,providing clinicians with references on“how to select medication”and“how to use medication.”
