Regulatory T cells（Tregs） play a pivotal role in the pathological development of hypertension.Helios,a transcription factor from the Ikaros family,was recently reported to be a bona fide marker for natural Tregs or ...Regulatory T cells（Tregs） play a pivotal role in the pathological development of hypertension.Helios,a transcription factor from the Ikaros family,was recently reported to be a bona fide marker for natural Tregs or activated Tregs with suppression function,however,little has been known about its role in hypertension.This study was aimed to find whether Helios＋ Tregs really play a vital role in hypertension.A total of 60 hypertension patients,and 46 normotension subjects were enrolled in this study.Frequencies of different Tregs subsets in peripheral blood were measured by flow cytometry.Plasma cytokine level was determined by ELISA.The m RNA expression of Foxp3 and Helios in purified CD4＋ T cells was detected by RT-PCR.Proportion of CD4＋Foxp3＋Helios＋ Tregs was decreased significantly in patients with hypertension（62.52%±1.18% vs.71.89%±1.03%,P〈0.01）,and it was correlated with plasma level of IL-10 positively（r=0.505,P〈0.05） and plasma level of IFN-gamma negatively（r=–0.551,P〈0.05）.The m RNA expression of Foxp3（7.23±1.00 vs.10.58±0.54,P〈0.05） and Helios（8.47±0.95 vs.15.52±2.0,P〈0.05） was decreased in CD4＋ T cells from patients with hypertension.Helios＋ Tregs were decreased in patients with hypertension and may play a protective role in hypertension progression.展开更多
Studies estimating eye movements have demonstrated that non-human primates have fixation patterns similar to humans at the first sight of a picture.In the current study,three sets of pictures containing monkeys,humans...Studies estimating eye movements have demonstrated that non-human primates have fixation patterns similar to humans at the first sight of a picture.In the current study,three sets of pictures containing monkeys,humans or both were presented to rhesus monkeys and humans.The eye movements on these pictures by the two species were recorded using a Tobii eye-tracking system.We found that monkeys paid more attention to the head and body in pictures containing monkeys,whereas both monkeys and humans paid more attention to the head in pictures containing humans.The humans always concentrated on the eyes and head in all the pictures,indicating the social role of facial cues in society.Although humans paid more attention to the hands than monkeys,both monkeys and humans were interested in the hands and what was being done with them in the pictures.This may suggest the importance and necessity of hands for survival.Finally,monkeys scored lower in eye-tracking when fixating on the pictures,as if they were less interested in looking at the screen than humans.The locations of fixation in monkeys may provide insight into the role of eye movements in an evolutionary context.展开更多
基金supported by the National Natural Science Foundation of China(No.81370324)
文摘Regulatory T cells（Tregs） play a pivotal role in the pathological development of hypertension.Helios,a transcription factor from the Ikaros family,was recently reported to be a bona fide marker for natural Tregs or activated Tregs with suppression function,however,little has been known about its role in hypertension.This study was aimed to find whether Helios＋ Tregs really play a vital role in hypertension.A total of 60 hypertension patients,and 46 normotension subjects were enrolled in this study.Frequencies of different Tregs subsets in peripheral blood were measured by flow cytometry.Plasma cytokine level was determined by ELISA.The m RNA expression of Foxp3 and Helios in purified CD4＋ T cells was detected by RT-PCR.Proportion of CD4＋Foxp3＋Helios＋ Tregs was decreased significantly in patients with hypertension（62.52%±1.18% vs.71.89%±1.03%,P〈0.01）,and it was correlated with plasma level of IL-10 positively（r=0.505,P〈0.05） and plasma level of IFN-gamma negatively（r=–0.551,P〈0.05）.The m RNA expression of Foxp3（7.23±1.00 vs.10.58±0.54,P〈0.05） and Helios（8.47±0.95 vs.15.52±2.0,P〈0.05） was decreased in CD4＋ T cells from patients with hypertension.Helios＋ Tregs were decreased in patients with hypertension and may play a protective role in hypertension progression.
基金supported by the National Basic Research Development Program (973 program) of China (2012CB825500, 2011CB707800)Basic Research Frontier Project of Chinese Academy of Sciences, China (KSCX2-EW-J23)+3 种基金the National Natural Science Foundation of China (31271167, 31271168, 81271495, 31070963, 31070965)the Strategic Priority Research Program of the Chinese Academy of Sciences, China (XDB02020000)the Academy of Finland (National Centers of Excellence Program 2006-2011, Grant No.259752) the aivoAALTO Project of the Aalto University, Finland
文摘Studies estimating eye movements have demonstrated that non-human primates have fixation patterns similar to humans at the first sight of a picture.In the current study,three sets of pictures containing monkeys,humans or both were presented to rhesus monkeys and humans.The eye movements on these pictures by the two species were recorded using a Tobii eye-tracking system.We found that monkeys paid more attention to the head and body in pictures containing monkeys,whereas both monkeys and humans paid more attention to the head in pictures containing humans.The humans always concentrated on the eyes and head in all the pictures,indicating the social role of facial cues in society.Although humans paid more attention to the hands than monkeys,both monkeys and humans were interested in the hands and what was being done with them in the pictures.This may suggest the importance and necessity of hands for survival.Finally,monkeys scored lower in eye-tracking when fixating on the pictures,as if they were less interested in looking at the screen than humans.The locations of fixation in monkeys may provide insight into the role of eye movements in an evolutionary context.
