OBJECTIVE： To evaluate the relationship between purple-bluish tongue and platelet counts, and further to examine their associations with the recurrence of epithelial ovarian cancer.METHODS： A total of 82 epithelial ...OBJECTIVE： To evaluate the relationship between purple-bluish tongue and platelet counts, and further to examine their associations with the recurrence of epithelial ovarian cancer.METHODS： A total of 82 epithelial ovarian cancer patients were enrolled in this study. Cluster analysis was used for grouping patients＇ P_（RGB）（Red-R;Green-G; Blue-B; Average percentage of RGB, P_（RGB））values. Receiver operating characteristic（ROC）curve was performed for detecting the diagnostic standard of purple-bluish tongue. χ~2 test was used to assess the relationship between purple-bluishtongue and platelet counts, and the recurrence of epithelial ovarian cancer. The perioperative（preoperative） platelet level was examinedwith tongue image and disease recurrence.RESULTS： Tongue images were classified into two groups basing on P_（RGB） values of images by cluster analysis. The numbers of cases in cluster ＂1＂（normal color tongue） was 16 and cluster ＂2＂（purple-bluish tongue） was 66. Two groups of P_（RGB） values, classified by cluster analysis, were significantly correlated with vision-based tongue color recognition（Kappa = 0.852, P 0.001）. ROC curve showed that the ratio of P_B to PRhad the highest diagnostic value. The sensitivity and the specificity of the ratio of P_B to P_R were 95.3% and 88.9% respectively and the optimal cut-off point was 0.71. Purple-bluish tongue was significantly correlated with increased platelet counts（P 0.001）. Both the increased platelet counts（P = 0.01） and purple-bluish tongue were associated with recurrence of epithelial ovarian cancer（P 0.001）.CONCLUSION： The ratio of P_B to P_R greater than 0.71 could serve as an indicator for purple-bluish tongue diagnosing used in symptom pattern identification in Traditional Chinese Medicine. Purple-bluish tongue, associated with increased platelet counts, was also closely correlated with the recurrence of epithelial ovarian cancer.展开更多
OBJECTIVE: To investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant neoplasia.METHODS: The data of 191 patients with malignant neoplasia were analyzed. Al...OBJECTIVE: To investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant neoplasia.METHODS: The data of 191 patients with malignant neoplasia were analyzed. All photos of patients' tongue image were recorded and lingual flange protrusion was the positive standard. χ~2 test for paired data and Kappa test were used to determine the diagnostic value of lingual flange protrusion for metastatic liver cancer. Mann-Whitney U test was used to compare the levels of liver serolog-ical markers. The area under receiver operating characteristic curve(ROC) and logistic regression model were used to analyze the predictive values of lingual flange protrusion, alkaline phosphatase(ALP), and lactate dehydrogenase(LDH) levels.RESULTS: Patients with lingual flange protrusion had a higher risk of liver metastasis than those without it(P < 0.001). There was no significant difference in diagnosis of liver metastasis between lingual flange protrusion and traditional diagnostic criteria(P = 0.541). Kappa was 0.738(P < 0.001). Lingual flange protrusion was significantly correlated with increased serum ALP and LDH levels(P < 0.01).Comparison of ROC curves showed that the diagnostic value of lingual flange protrusion is better than ALP, LDH and the combination of ALP and LDH(P < 0.01). Furthermore, the combined diagnostic values of lingual flange protrusion and ALP,lingual flange protrusion and LDH, and lingual flange protrusion, ALP and LDH are not better than lingual flange protrusion alone(P > 0.05).CONCLUSION: Lingual flange protrusion is a potential diagnostic marker for liver metastasis of patients with malignant neoplasia.展开更多
基金the National Science Foundation of China(Inhibitory Effects of Sulfated Polysaccharides/Sulfated Polypeptides from Softenning Indurated Mass Herbs on Tumor Associated Fibroblast,No.81173376)New Century Excellent Talent(No.NCET-11-1068)
文摘OBJECTIVE： To evaluate the relationship between purple-bluish tongue and platelet counts, and further to examine their associations with the recurrence of epithelial ovarian cancer.METHODS： A total of 82 epithelial ovarian cancer patients were enrolled in this study. Cluster analysis was used for grouping patients＇ P_（RGB）（Red-R;Green-G; Blue-B; Average percentage of RGB, P_（RGB））values. Receiver operating characteristic（ROC）curve was performed for detecting the diagnostic standard of purple-bluish tongue. χ~2 test was used to assess the relationship between purple-bluishtongue and platelet counts, and the recurrence of epithelial ovarian cancer. The perioperative（preoperative） platelet level was examinedwith tongue image and disease recurrence.RESULTS： Tongue images were classified into two groups basing on P_（RGB） values of images by cluster analysis. The numbers of cases in cluster ＂1＂（normal color tongue） was 16 and cluster ＂2＂（purple-bluish tongue） was 66. Two groups of P_（RGB） values, classified by cluster analysis, were significantly correlated with vision-based tongue color recognition（Kappa = 0.852, P 0.001）. ROC curve showed that the ratio of P_B to PRhad the highest diagnostic value. The sensitivity and the specificity of the ratio of P_B to P_R were 95.3% and 88.9% respectively and the optimal cut-off point was 0.71. Purple-bluish tongue was significantly correlated with increased platelet counts（P 0.001）. Both the increased platelet counts（P = 0.01） and purple-bluish tongue were associated with recurrence of epithelial ovarian cancer（P 0.001）.CONCLUSION： The ratio of P_B to P_R greater than 0.71 could serve as an indicator for purple-bluish tongue diagnosing used in symptom pattern identification in Traditional Chinese Medicine. Purple-bluish tongue, associated with increased platelet counts, was also closely correlated with the recurrence of epithelial ovarian cancer.
基金Supported by National Natural Science Foundation of China(Biomechanics Mechanism of the Anti-Tumor Effects of Softing and Resolving Hard Mass Drugs,No.81473441)
文摘OBJECTIVE: To investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant neoplasia.METHODS: The data of 191 patients with malignant neoplasia were analyzed. All photos of patients' tongue image were recorded and lingual flange protrusion was the positive standard. χ~2 test for paired data and Kappa test were used to determine the diagnostic value of lingual flange protrusion for metastatic liver cancer. Mann-Whitney U test was used to compare the levels of liver serolog-ical markers. The area under receiver operating characteristic curve(ROC) and logistic regression model were used to analyze the predictive values of lingual flange protrusion, alkaline phosphatase(ALP), and lactate dehydrogenase(LDH) levels.RESULTS: Patients with lingual flange protrusion had a higher risk of liver metastasis than those without it(P < 0.001). There was no significant difference in diagnosis of liver metastasis between lingual flange protrusion and traditional diagnostic criteria(P = 0.541). Kappa was 0.738(P < 0.001). Lingual flange protrusion was significantly correlated with increased serum ALP and LDH levels(P < 0.01).Comparison of ROC curves showed that the diagnostic value of lingual flange protrusion is better than ALP, LDH and the combination of ALP and LDH(P < 0.01). Furthermore, the combined diagnostic values of lingual flange protrusion and ALP,lingual flange protrusion and LDH, and lingual flange protrusion, ALP and LDH are not better than lingual flange protrusion alone(P > 0.05).CONCLUSION: Lingual flange protrusion is a potential diagnostic marker for liver metastasis of patients with malignant neoplasia.
