Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the b...Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.展开更多
Electron spins confined in semiconductor quantum dots(QDs)are one of potential candidates for physical implementation of scalable quantum information processing technologies.Tunnel coupling based inter exchange intera...Electron spins confined in semiconductor quantum dots(QDs)are one of potential candidates for physical implementation of scalable quantum information processing technologies.Tunnel coupling based inter exchange interaction between QDs is crucial in achieving single-qubit manipulation,two-qubit gate,quantum communication and quantum simulation.This review first provides a theoretical perspective that surveys a general framework,including the Helter−London approach,the Hund−Mulliken approach,and the Hubbard model,to describe the inter exchange interactions between semiconductor quantum dots.An electrical method to control the inter exchange interaction in a realistic device is proposed as well.Then the significant achievements of inter exchange interaction in manipulating single qubits,achieving two-qubit gates,performing quantum communication and quantum simulation are reviewed.The last part is a summary of this review.展开更多
1概述肺癌是最常见的恶性肿瘤之一,在世界各地,肺癌均居恶性肿瘤死亡构成比的第一位,其发病率和死亡率仍在不断升高。据世界卫生组织（World Health Organization,WHO）下属的国际癌症研究机构（International Agency for Research on C...1概述肺癌是最常见的恶性肿瘤之一,在世界各地,肺癌均居恶性肿瘤死亡构成比的第一位,其发病率和死亡率仍在不断升高。据世界卫生组织（World Health Organization,WHO）下属的国际癌症研究机构（International Agency for Research on Cancer,IARC）出版的GLOBOCAN 2012估计：全世界肺癌新发病例1 8 2.5万（男性124.2万,女性58.3万）.展开更多
Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells（HAECs） in a simulated microenvironment in vitro comprisi...Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells（HAECs） in a simulated microenvironment in vitro comprising RPMI 1640 culture medium and the solution extracted from injured brain tissues.Some HAECs were round,triangular in form or irregularly shaped,with extended neuron-like processes;some of the processes were interconnected,representing neuron-like morphology and some HAECs were microtubule-associated protein 2-positive.HAECs survived for at least 4 weeks following transplantation into the center and edges of the trauma focus with traumatic brain injury,and were microtubule-associated protein 2-positive.Moreover,the motor function of rat hind limbs was significantly improved.展开更多
To determine the grid resolutions of the WRF model in the typhoon simulation,some sensitivity analysis of horizontal and vertical resolutions in different conditions has been carried out.Different horizontal resolutio...To determine the grid resolutions of the WRF model in the typhoon simulation,some sensitivity analysis of horizontal and vertical resolutions in different conditions has been carried out.Different horizontal resolutions(5,10,20,30 km),nesting grids(15 and 5 km),different vertical resolutions(35-layers,28-layers,20-layers)and different top maximum pressures(1 000,2 000,3 500,5 000 Pa)had been used in the mesoscale numerical model WRF to simulate the Typhoon Kai-tak.The simulation results of typhoon track,wind speed and sea level pressure at different horizontal and vertical resolutions have been compared and analyzed.The horizontal and vertical resolutions of the model have limited effect on the simulation effect of the typhoon track.Different horizontal and vertical resolutions have obvious effects on typhoon strength(defined by wind speed)and intensity(defined by sea level pressure,SLP),especially for sea level pressure.The typhoon intensity simulated by the high-resolution model is closer to the real situation and the nesting grids can improve computational accuracy and efficiency.The simulation results affected by vertical resolution using 35-layers is better than the simulation results using 20-layers and 28-layers simulations.Through comparison and analysis,the horizontal and vertical resolutions of WRF model are finally determined as follows:the two-way nesting grid of 15 and 5 km is comprehensively determined,and the vertical layers is 35-layers,the top maximum pressure is 2 000 Pa.展开更多
Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We a...Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.展开更多
Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes （microtubule-associated protein-2, glial fibrillary ...Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes （microtubule-associated protein-2, glial fibrillary acidic protein and nestin） in human amniotic epithelial cells. The conditioned medium of human amniotic epithelial cells promoted the growth and proliferation of rat glial cells cultured in vitro, and this effect was dose-dependent. Human amniotic epithelial cells were further transplanted into the corpus striatum of healthy adult rats and the grafted cells could integrate with the host and migrate 1 2 mm along the nerve fibers in corpus callosum. Our experimental findings indicate that human amniotic epithelial cells may be a new kind of seed cells for use in neurograft.展开更多
Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 ma...Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.展开更多
Standards and specifications are the premise of integrated reorganization of science specimen data, and data integration is the core of the reorganization. ETL [1] which is the abbreviation of extract, transform, and ...Standards and specifications are the premise of integrated reorganization of science specimen data, and data integration is the core of the reorganization. ETL [1] which is the abbreviation of extract, transform, and load [2], is very suitable for data integration. Kettle is a kind of ETL software. In this paper, it has been introduced into the integrated reorganization of science specimen data. Multi-source and heterogeneous specimen data are integrated using kettle, and good results have been achieved. It proved the effectiveness of kettle in the integrated reorganization of science specimen data. The application has practical significance, and the method can be referenced when reorganizing other resource data.展开更多
A 24-year-old man was seen 2 years prior for hematuria,hypertension(165/120 mmHg),and palpitations.The plasma normetanephrine(NMN)level was elevated(9812.4 pg/mL).Computed tomography(CT)showed bilateral adrenal tumors...A 24-year-old man was seen 2 years prior for hematuria,hypertension(165/120 mmHg),and palpitations.The plasma normetanephrine(NMN)level was elevated(9812.4 pg/mL).Computed tomography(CT)showed bilateral adrenal tumors(Fig.1).Of the two tumors on the left adrenal gland,the lesion on the head aspect was relatively large,while that on the feet aspect(arrow)was relatively small and adjacent to the left renal artery.There was one lesion on the right adrenal gland.Positron emission tomography(PET)-CT showed increased radioactive tracer uptake in the regions of the bilateral adrenal tumors(Fig.2).The clinical diagnosis was pheochromocytoma.展开更多
Objective:The tumor necrosis factor receptor-associated factor 7(TRAF7)is one of the components of the tumor necrosis factor alpha(TNF-α)/nuclear factor kappa B(NF-κB)pathway and a putative E3-ubiquitin ligase.This ...Objective:The tumor necrosis factor receptor-associated factor 7(TRAF7)is one of the components of the tumor necrosis factor alpha(TNF-α)/nuclear factor kappa B(NF-κB)pathway and a putative E3-ubiquitin ligase.This study aims to explore the biologic effects and the molecular mechanisms of deregulated TRAF7 signaling in hepatocellular carcinoma(HCC)progression.展开更多
Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed ...Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed on professional cross-presenting CD8α^+dendritic cells(DCs).展开更多
Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are...Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.展开更多
Objective:This general non-systematic review aimed to gather information on reported statistical models examing the effects of meteorological factors on coronavirus disease 2019(COVID-19)and compare these models.Metho...Objective:This general non-systematic review aimed to gather information on reported statistical models examing the effects of meteorological factors on coronavirus disease 2019(COVID-19)and compare these models.Methods:PubMed,Web of Science,and Google Scholar were searched for studies on"meteorological factors and COVID-19"published between January 1,2020,and October 1,2022.Results:The most commonly used approaches for analyzing the association between meteorological factors and COVID-19 were the linear regression model(LRM),generalized linear model(GLM),generalized additive model(GAM),and distributed lag non-linear model(DLNM).In addition to these classical models commonly applied in environmental epidemiology,machine learning techniques are increasingly being used to select risk factors for the outcome of interest and establishing robust prediction models.Conclusion:Selecting an appropriate model is essential before conducting research.To ensure the reliability of analysis results,it is important to consider including non-meteorological factors(e.g.,government policies on physical distancing,vaccination,and hygiene practices)along with meteorological factors in the model.展开更多
As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety...As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety,it is necessary to carry out research on the dynamic modeling of the cracked blade and breathing crack-induced vibration mechanisms.This paper summarizes the current research status on the dynamics of cracked blade,and the related topics mainly include four aspects:crack propagation path,mechanical model of open and breathing cracks,dynamic modeling methods of cracked blades such as lumped mass model,semi-analytical model and finite element model,and dynamic characteristics of cracked blades.The review will provide valuable references for future studies on dynamics and fault diagnosis of cracked blade in aeroengine.展开更多
The sediment particles play a huge role in shaping the bed load transport.In this research,240 water-tunnel experiments are carried out to investigate the incipient velocity of the observation particles in two particl...The sediment particles play a huge role in shaping the bed load transport.In this research,240 water-tunnel experiments are carried out to investigate the incipient velocity of the observation particles in two particle arrangements.To accurately predict the incipient velocity of the observation particles,the equation is conceived by the rolling instability mechanism.The incipient velocity equations and experimental data are used to analyze the trend of dispersive pressure and the effect of arrangement position on velocity.We find that it is appropriate to choose the coefficient of drag as 0.261 and the coefficient of lift as 0.198 for the incipient velocity equation of spherical particles on the hemispherical bed surface.Furthermore,the dispersive pressure is closely related to the flow state,particle size,and particle arrangement,which leads to the incipient velocity of the observation particle being at a minimum when the interference particle angle is 45°.Finally,the particle spacing and the projected area changed with the arrangements,directly affecting the incipient velocity of the observed particle.The analysis of four aspects for the coefficients,dispersive pressure,different particle spacing,and projected area will facilitate the prediction of particle incipient velocity,especially on hemispherical beds.展开更多
Background and Aims:Hepatocellular carcinoma(HCC)cases with small nodules are commonly treated with radi-ofrequency ablation(RFA),but the recurrence rate remains high.This study aimed to establish a blood signature fo...Background and Aims:Hepatocellular carcinoma(HCC)cases with small nodules are commonly treated with radi-ofrequency ablation(RFA),but the recurrence rate remains high.This study aimed to establish a blood signature for identifying HCC with metastatic traits pre-RFA.Methods:Data from HCC patients treated between 2010 and 2017 were retrospectively collected.A blood signature for meta-static HCC was established based on blood levels of alpha-fetoprotein and des-γ-carboxy-prothrombin,cell-free DNA(cfDNA)mutations,and methylation changes in target genes in frozen-stored plasma samples that were collected before RFA performance.The HCC blood signature was validated in patients prospectively enrolled in2021.Results:Of 251 HCC patients in the retrospective study,33.9% experienced recurrence within 1 year post-RFA.The HCC blood signature identified from these patients included des-γ-carboxy-prothrombin≥40mAU/mL with cfDNA mutation score,where cfDNA mutations occurred in the genes of TP53,CTNNB1,and TERT promoter.This signature effectively predicted 1-year post-RFArecurrence of HCC with 92% specificity and 91% sensitivity in the retrospective dataset,and with 87% specificity and 76% sensitivity in the prospective dataset(n=32 patients).Among 14 cases in the prospective study with biopsy tissues available,positivity for the HCC blood signature was associated with a higher HCC tissue score and shorter distance between HCC cells and microvasculature.Conclusions:This study established an HCC blood signature in pre-RFA blood that potentially reflects HCC with metastatic traits and may be valuable for predicting the disease’s early recurrence post-RFA.展开更多
基金Project supported by the National Science and Technology Major Project of China (No. 2017-V-0009)the National Natural Science Foundation of China (Nos. 12032015 and 12121002)the National Funding Program for Postdoctoral Researchers of China (No. GZC20231586)。
文摘Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.
基金funded by National Natural Science Foundation of China,(Grant Nos.11974030 and 92165208)。
文摘Electron spins confined in semiconductor quantum dots(QDs)are one of potential candidates for physical implementation of scalable quantum information processing technologies.Tunnel coupling based inter exchange interaction between QDs is crucial in achieving single-qubit manipulation,two-qubit gate,quantum communication and quantum simulation.This review first provides a theoretical perspective that surveys a general framework,including the Helter−London approach,the Hund−Mulliken approach,and the Hubbard model,to describe the inter exchange interactions between semiconductor quantum dots.An electrical method to control the inter exchange interaction in a realistic device is proposed as well.Then the significant achievements of inter exchange interaction in manipulating single qubits,achieving two-qubit gates,performing quantum communication and quantum simulation are reviewed.The last part is a summary of this review.
文摘1概述肺癌是最常见的恶性肿瘤之一,在世界各地,肺癌均居恶性肿瘤死亡构成比的第一位,其发病率和死亡率仍在不断升高。据世界卫生组织（World Health Organization,WHO）下属的国际癌症研究机构（International Agency for Research on Cancer,IARC）出版的GLOBOCAN 2012估计：全世界肺癌新发病例1 8 2.5万（男性124.2万,女性58.3万）.
基金the Grant from National Basic Research Program of China (973 Program) for Traumatic Projects, No. 2005CB522604
文摘Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells（HAECs） in a simulated microenvironment in vitro comprising RPMI 1640 culture medium and the solution extracted from injured brain tissues.Some HAECs were round,triangular in form or irregularly shaped,with extended neuron-like processes;some of the processes were interconnected,representing neuron-like morphology and some HAECs were microtubule-associated protein 2-positive.HAECs survived for at least 4 weeks following transplantation into the center and edges of the trauma focus with traumatic brain injury,and were microtubule-associated protein 2-positive.Moreover,the motor function of rat hind limbs was significantly improved.
基金The National Natural Science Foundation of China under contract Nos 51809023,51839002 and 51879015the Open Research Foundation of the Key Laboratory of the Pearl River Estuarine Dynamics and Associated Process Regulation,the Ministry of Water Resources under contract No.2018KJ03
文摘To determine the grid resolutions of the WRF model in the typhoon simulation,some sensitivity analysis of horizontal and vertical resolutions in different conditions has been carried out.Different horizontal resolutions(5,10,20,30 km),nesting grids(15 and 5 km),different vertical resolutions(35-layers,28-layers,20-layers)and different top maximum pressures(1 000,2 000,3 500,5 000 Pa)had been used in the mesoscale numerical model WRF to simulate the Typhoon Kai-tak.The simulation results of typhoon track,wind speed and sea level pressure at different horizontal and vertical resolutions have been compared and analyzed.The horizontal and vertical resolutions of the model have limited effect on the simulation effect of the typhoon track.Different horizontal and vertical resolutions have obvious effects on typhoon strength(defined by wind speed)and intensity(defined by sea level pressure,SLP),especially for sea level pressure.The typhoon intensity simulated by the high-resolution model is closer to the real situation and the nesting grids can improve computational accuracy and efficiency.The simulation results affected by vertical resolution using 35-layers is better than the simulation results using 20-layers and 28-layers simulations.Through comparison and analysis,the horizontal and vertical resolutions of WRF model are finally determined as follows:the two-way nesting grid of 15 and 5 km is comprehensively determined,and the vertical layers is 35-layers,the top maximum pressure is 2 000 Pa.
基金supported by State Key Projects Specialized on Infectious Diseases (No. 2017ZX10201201-006)Key research projects for precision medicine (No. 2017YFC0908103)+1 种基金Innovation Fund for Medical Sciences of Chinese Academy of Medical Sciences (CIFMS, No. 2019-I2M-2-004, 2016-I2M-1-007, 2019-I2M-1-003)National Natural Science Foundation Fund (No. 81972628, No. 81974492)。
文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance.
基金sponsored by the National Natural Science Foundation of China, No. 30271325the Natural Science Foundation of Jiangsu Province, No. BK2001170the National Basic Research Program of China (973 Program), No.2005CB522604
文摘Human amniotic epithelial cells were isolated from a piece of fresh amnion. Using immunocytochemical methods, we investigated the expression of neuronal phenotypes （microtubule-associated protein-2, glial fibrillary acidic protein and nestin） in human amniotic epithelial cells. The conditioned medium of human amniotic epithelial cells promoted the growth and proliferation of rat glial cells cultured in vitro, and this effect was dose-dependent. Human amniotic epithelial cells were further transplanted into the corpus striatum of healthy adult rats and the grafted cells could integrate with the host and migrate 1 2 mm along the nerve fibers in corpus callosum. Our experimental findings indicate that human amniotic epithelial cells may be a new kind of seed cells for use in neurograft.
基金This work was supported by the Shanghai Pujiang Program(16PJ1406200)the Scientific Research Innovation Projects of Shanghai Municipal Education Commission(15ZZ060)
文摘Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.
文摘Standards and specifications are the premise of integrated reorganization of science specimen data, and data integration is the core of the reorganization. ETL [1] which is the abbreviation of extract, transform, and load [2], is very suitable for data integration. Kettle is a kind of ETL software. In this paper, it has been introduced into the integrated reorganization of science specimen data. Multi-source and heterogeneous specimen data are integrated using kettle, and good results have been achieved. It proved the effectiveness of kettle in the integrated reorganization of science specimen data. The application has practical significance, and the method can be referenced when reorganizing other resource data.
基金supported by Shanghai Municipal Key Clinical Specialty(shslczdzk06002)
文摘A 24-year-old man was seen 2 years prior for hematuria,hypertension(165/120 mmHg),and palpitations.The plasma normetanephrine(NMN)level was elevated(9812.4 pg/mL).Computed tomography(CT)showed bilateral adrenal tumors(Fig.1).Of the two tumors on the left adrenal gland,the lesion on the head aspect was relatively large,while that on the feet aspect(arrow)was relatively small and adjacent to the left renal artery.There was one lesion on the right adrenal gland.Positron emission tomography(PET)-CT showed increased radioactive tracer uptake in the regions of the bilateral adrenal tumors(Fig.2).The clinical diagnosis was pheochromocytoma.
基金funded by National Natural Science Foundation of China(8177120753)China-Australia International Collaborative Grant(NHMRC APP1112767,NSFC 81561128020)to Wei Wang+1 种基金Zhiyuan Wu was supported by the China Scholarship Council(201908110447)Yulu Zheng and Zheng Guo were supported by the Edith Cowan University Higher Degree by Research Scholarship(ECU-HDR ST10469322 and ST10468211).
文摘Objective:The tumor necrosis factor receptor-associated factor 7(TRAF7)is one of the components of the tumor necrosis factor alpha(TNF-α)/nuclear factor kappa B(NF-κB)pathway and a putative E3-ubiquitin ligase.This study aims to explore the biologic effects and the molecular mechanisms of deregulated TRAF7 signaling in hepatocellular carcinoma(HCC)progression.
文摘Objective:To induce potent CD8^+T-cells against glypican-3(GPC3),which is overexpressed in hepatocellular carcinoma(HCC),to suspend tumor development.Methods:Since the chemokine receptor XCR1 is selectively expressed on professional cross-presenting CD8α^+dendritic cells(DCs).
基金Supported by SJTU-HUAWEI TECH Cybersecurity Innovation Lab。
文摘Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.
基金funded by the National Natural Science Foundation of China(8177120753)the China-Australia International Collaborative Grant(NHMRC APP1112767,NSFC 81561128020)Zheng Y L and Guo Z were supported by the Edith Cowan University Higher Degree by Research Scholarship(ECU-HDR ST10469322 and ST10468211).
文摘Objective:This general non-systematic review aimed to gather information on reported statistical models examing the effects of meteorological factors on coronavirus disease 2019(COVID-19)and compare these models.Methods:PubMed,Web of Science,and Google Scholar were searched for studies on"meteorological factors and COVID-19"published between January 1,2020,and October 1,2022.Results:The most commonly used approaches for analyzing the association between meteorological factors and COVID-19 were the linear regression model(LRM),generalized linear model(GLM),generalized additive model(GAM),and distributed lag non-linear model(DLNM).In addition to these classical models commonly applied in environmental epidemiology,machine learning techniques are increasingly being used to select risk factors for the outcome of interest and establishing robust prediction models.Conclusion:Selecting an appropriate model is essential before conducting research.To ensure the reliability of analysis results,it is important to consider including non-meteorological factors(e.g.,government policies on physical distancing,vaccination,and hygiene practices)along with meteorological factors in the model.
基金supported by the National Natural Science Foundation of China (Grant no.11972112,12032015,12121002 and 12202368)the Natural Science Foundation of Sichuan Province (Grant Nos.2022NSFSC1997).
文摘As one of the most important parts in the engine,the structure and state of the rotating blade directly affect the normal performance of the aeroengine.In order to monitor engine crack failure and ensure flight safety,it is necessary to carry out research on the dynamic modeling of the cracked blade and breathing crack-induced vibration mechanisms.This paper summarizes the current research status on the dynamics of cracked blade,and the related topics mainly include four aspects:crack propagation path,mechanical model of open and breathing cracks,dynamic modeling methods of cracked blades such as lumped mass model,semi-analytical model and finite element model,and dynamic characteristics of cracked blades.The review will provide valuable references for future studies on dynamics and fault diagnosis of cracked blade in aeroengine.
基金financially supported by the National Key Research and Development Program of China(Grant No.2021YFB2601100)the National Natural Science Foundation of China(Grant No.51839002,51979014 and 52271257)+1 种基金the Natural Science Foundation of Hunan Province(Grant No.2022JJ10047)the Hunan Provincial Innovation Foundation for Postgraduate(Grant No.CX20220909).
文摘The sediment particles play a huge role in shaping the bed load transport.In this research,240 water-tunnel experiments are carried out to investigate the incipient velocity of the observation particles in two particle arrangements.To accurately predict the incipient velocity of the observation particles,the equation is conceived by the rolling instability mechanism.The incipient velocity equations and experimental data are used to analyze the trend of dispersive pressure and the effect of arrangement position on velocity.We find that it is appropriate to choose the coefficient of drag as 0.261 and the coefficient of lift as 0.198 for the incipient velocity equation of spherical particles on the hemispherical bed surface.Furthermore,the dispersive pressure is closely related to the flow state,particle size,and particle arrangement,which leads to the incipient velocity of the observation particle being at a minimum when the interference particle angle is 45°.Finally,the particle spacing and the projected area changed with the arrangements,directly affecting the incipient velocity of the observed particle.The analysis of four aspects for the coefficients,dispersive pressure,different particle spacing,and projected area will facilitate the prediction of particle incipient velocity,especially on hemispherical beds.
基金funded by CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-066 to CQ)Open Funding of the State Key Lab of Molecular Oncology(SKLMOKF2021-06 to HX).
文摘Background and Aims:Hepatocellular carcinoma(HCC)cases with small nodules are commonly treated with radi-ofrequency ablation(RFA),but the recurrence rate remains high.This study aimed to establish a blood signature for identifying HCC with metastatic traits pre-RFA.Methods:Data from HCC patients treated between 2010 and 2017 were retrospectively collected.A blood signature for meta-static HCC was established based on blood levels of alpha-fetoprotein and des-γ-carboxy-prothrombin,cell-free DNA(cfDNA)mutations,and methylation changes in target genes in frozen-stored plasma samples that were collected before RFA performance.The HCC blood signature was validated in patients prospectively enrolled in2021.Results:Of 251 HCC patients in the retrospective study,33.9% experienced recurrence within 1 year post-RFA.The HCC blood signature identified from these patients included des-γ-carboxy-prothrombin≥40mAU/mL with cfDNA mutation score,where cfDNA mutations occurred in the genes of TP53,CTNNB1,and TERT promoter.This signature effectively predicted 1-year post-RFArecurrence of HCC with 92% specificity and 91% sensitivity in the retrospective dataset,and with 87% specificity and 76% sensitivity in the prospective dataset(n=32 patients).Among 14 cases in the prospective study with biopsy tissues available,positivity for the HCC blood signature was associated with a higher HCC tissue score and shorter distance between HCC cells and microvasculature.Conclusions:This study established an HCC blood signature in pre-RFA blood that potentially reflects HCC with metastatic traits and may be valuable for predicting the disease’s early recurrence post-RFA.
