A new species of Rosaceae from Central China, Prunus sunhangii D. G. Zhang & T. Deng, sp. nov., is described and illustrated. The new species is placed in Prunus subgenus Cerasus by flower and fruit characteristic...A new species of Rosaceae from Central China, Prunus sunhangii D. G. Zhang & T. Deng, sp. nov., is described and illustrated. The new species is placed in Prunus subgenus Cerasus by flower and fruit characteristics. It is most similar to Prunus cerasoides, but differs by having longitudinally 2-lobed apical petals, an acuminate leaf apex, 17—25 stamens, white petals, dark black drupes, brown hypanthium, and different phenology. The phylogenetic placement of this species was assessed based on morphological and molecular data. Molecular analysis(cp DNA + ITS) corroborated its placement in subgenus Cerasus,specifically Prunus section Serrula.展开更多
For the implementation of power market in China,medium-and Iong-term security checks are essential for bilateral transactions,of which the electricity quantity that constitutes the generation feasible region(GFR)is th...For the implementation of power market in China,medium-and Iong-term security checks are essential for bilateral transactions,of which the electricity quantity that constitutes the generation feasible region(GFR)is the target.However,uncertainties from load forecasting errors and transmission contingencies are threats to medium-and Iong-term electricity tradi ng in terms of their in flue nces on the GFR.In this paper,we prese nt a graphic distortio n pattern in a typical threegenerator system using the Monte Carlo method and projection theory based on security constrained economic dispatch.The underlying potential risk to GFR from uncertainties is clearly visualized,and their impact characteristics are discussed.A case study on detailed GFR distortion was included to dem on strate the effectiveness of this visualization model.The result implies that a small uncertainty could distort the GFR to a remarkable extent and that different line-contingency precipitates disparate the GFR distortion patterns,thereby eliciting great emphasis on load forecasting and line reliability in electricity transacti ons.展开更多
In the paper, the animal and plant diversity and its main characteristics in Pu'er City were summarized, and reviewedthe development and utilization of main special biological industry. The policies and research i...In the paper, the animal and plant diversity and its main characteristics in Pu'er City were summarized, and reviewedthe development and utilization of main special biological industry. The policies and research institutions on protection and utilization of biodiversity in Pu'er City were introduced. At the last, we analyzed the deficiencies in the conservation and utilization of biodiversity in Pu'er City and proposed the relevant measures to strengthen protection and utilization of biological diversity in the future.展开更多
Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 rema...Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020).展开更多
The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigat...The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19.展开更多
Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide associati...Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort.展开更多
Traditional Chinese medicine(TCM)with a long history in China has demonstrated unique advantages in treating a variety of cardiovascular diseases,with promising prospects.We exemplify the TCM advantages with 3 major c...Traditional Chinese medicine(TCM)with a long history in China has demonstrated unique advantages in treating a variety of cardiovascular diseases,with promising prospects.We exemplify the TCM advantages with 3 major cardiovascular diseases:coronary heart disease,hypertension,and chronic heart failure.With both national and international guidelines,consensus,systematic reviews,and randomized controlled trials as evidence,we used the modified Jadad and AMSTAR-1 scales to evaluate the evidence quality and then systematically evaluated the clinical effects and benefits of TCM on cardiovascular diseases,aiming to provide fresh insights into the research methodologies and future development directions for TCM-dominant diseases.展开更多
基金supported by the Major Program of the National Natural Science Foundation of China (31590823)the National Natural Science Foundation of China (31700165)+4 种基金the National Key R & D Program of China (2017YFC0505200)the Strategic Priority Research Program of Chinese Academy of Sciences (XDA20050203)the Fund for Reserve Talents of Young and Middle-aged Academic and Technical Leaders of Yunnan Province (2014HB027)the CAS "Light of West China" Program, the Comprehensive Scientific Investigation of Biodiversity from the Wuling Mountains (2014FY110100)the survey on baseline resources of Wufeng Houhe National Nature Reserve in Hubei Province
文摘A new species of Rosaceae from Central China, Prunus sunhangii D. G. Zhang & T. Deng, sp. nov., is described and illustrated. The new species is placed in Prunus subgenus Cerasus by flower and fruit characteristics. It is most similar to Prunus cerasoides, but differs by having longitudinally 2-lobed apical petals, an acuminate leaf apex, 17—25 stamens, white petals, dark black drupes, brown hypanthium, and different phenology. The phylogenetic placement of this species was assessed based on morphological and molecular data. Molecular analysis(cp DNA + ITS) corroborated its placement in subgenus Cerasus,specifically Prunus section Serrula.
基金the National Key R&D Program of China under Grant No.2020YFB0905900in part by the State Grid Corporation of China project“Research on inter-provincial price coupling mechanism of national unified electricity spot market”.
文摘For the implementation of power market in China,medium-and Iong-term security checks are essential for bilateral transactions,of which the electricity quantity that constitutes the generation feasible region(GFR)is the target.However,uncertainties from load forecasting errors and transmission contingencies are threats to medium-and Iong-term electricity tradi ng in terms of their in flue nces on the GFR.In this paper,we prese nt a graphic distortio n pattern in a typical threegenerator system using the Monte Carlo method and projection theory based on security constrained economic dispatch.The underlying potential risk to GFR from uncertainties is clearly visualized,and their impact characteristics are discussed.A case study on detailed GFR distortion was included to dem on strate the effectiveness of this visualization model.The result implies that a small uncertainty could distort the GFR to a remarkable extent and that different line-contingency precipitates disparate the GFR distortion patterns,thereby eliciting great emphasis on load forecasting and line reliability in electricity transacti ons.
基金Supported by the National Natural Science Foundation of China(Grant 31360456,31060252)the Fund for Applied Basic Research of Yunnan Province(Grant2011FB050)+1 种基金the Fund for Reserve Talents of Young and Middle-aged Academic and Technical Leaders of Yunnan Province(Grant 2014HB027)the Fund for science and technology plan of Pu'er city(Science and technology bureau Pu'er city,No.2014-38)
文摘In the paper, the animal and plant diversity and its main characteristics in Pu'er City were summarized, and reviewedthe development and utilization of main special biological industry. The policies and research institutions on protection and utilization of biodiversity in Pu'er City were introduced. At the last, we analyzed the deficiencies in the conservation and utilization of biodiversity in Pu'er City and proposed the relevant measures to strengthen protection and utilization of biological diversity in the future.
基金supported by the grants from Sichuan Science and Technology Program(2020YFS0014 and 2020YFS0558)the Chinese Academy of Medical Sciences(2019-I2M-5032)Technology&Science&Technology Bureau of Chengdu(2020YF05-00060-SN and 2020-YF05-00075-SN)。
文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020).
基金This work was supported by the Sichuan Science and Technology Program(2020YFS0014 and 2020YFS0558)the Chinese Academy of Medical Sciences(NO.2019-I2M-5-032)+1 种基金the National Key Research and Development Program of China(2016YFC20160905200)the National Natural Science Foundation of China(81790643,81970839 and 81670895).
文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19.
基金the National Natural Science Foundation of China(81971671)the National Key Research and Development Program of China(2018YFA0208800)+3 种基金the Jiangsu Provincial Key Research and Development Program(BE2019660)Suzhou Municipal Science and Technology Bureau(N312861019)the Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(GZK1202012)the Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection,the Priority Academic Development Program of Jiangsu Higher Education Institutions(PAPD)。
基金We thank all the patients and their families for participating in this study.This research project was supported by the National Precision Medicine Project(2016YFC0905200)the National Natural Science Foundation of China(81790643,81970839,81871722,82121003 and 82072373)+2 种基金the Sichuan Science and Technology Program(2020YFS0014,2020YFS0558,2020ZYD035,2020ZYD037,2021ZYD0082,2019JDJQ0031,2021YFS0369,2021JDGD0036,2021YFS0033,2021YFS0404,2021YFS0388,2022JDTD0024 and 2020JDTD0028)the Grant from Chinese Academy of Medical Sciences(No.2019-I2M5-032)Sichuan Provincial Health Commission(20ZDCX002).
文摘Critical coronavirus disease 2019(COVID-19)is associated with high mortality and potential genetic factors have been reported to be involved in the development of critical COVID-19.We performed a genome-wide association study to identify the genetic factors responsible for developing critical COVID-19.632 critical patients with COVID-19 and 3021 healthy controls from the Chinese population were recruited.First,we identified a genome-wide significant difference of IL-6 rs2069837(p=9.73×10^(−15),OR=0.41)between 437 critical patients with COVID-19 and 2551 normal controls in the discovery cohort.
基金This work was supported by the National Natural Science Foundation of China(Key Program)(no.82230124)National Natural Science Foundation of China(General Program)(no.81974556)+1 种基金Traditional Chinese Medicine Inheritance and Innovation“Ten Million”Talent Project-Qihuang Project Chief Scientist Project(0201000401)State Administration of Traditional Chinese Medicine 2nd National Traditional Chinese Medicine Inheritance Studio Construction Project(Official Letter of the State Office of Traditional Chinese Medicine[2022],no.245).
文摘Traditional Chinese medicine(TCM)with a long history in China has demonstrated unique advantages in treating a variety of cardiovascular diseases,with promising prospects.We exemplify the TCM advantages with 3 major cardiovascular diseases:coronary heart disease,hypertension,and chronic heart failure.With both national and international guidelines,consensus,systematic reviews,and randomized controlled trials as evidence,we used the modified Jadad and AMSTAR-1 scales to evaluate the evidence quality and then systematically evaluated the clinical effects and benefits of TCM on cardiovascular diseases,aiming to provide fresh insights into the research methodologies and future development directions for TCM-dominant diseases.
