Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinico...Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion.展开更多
Developing high-efficiency and low-cost catalysts towards oxygen evolution reaction(OER)is extremely important for overall water splitting and rechargeable metal-air batteries.Herein we propose a promising organometal...Developing high-efficiency and low-cost catalysts towards oxygen evolution reaction(OER)is extremely important for overall water splitting and rechargeable metal-air batteries.Herein we propose a promising organometallic coordination polymer(OCP)induced strategy to construct hierarchical N-doped carbon framework with NiFe nanoparticles encapsulated inside(NxFe@N-C)as a highly active and stable OER catalyst.The synthesis of OCP precursor depends on the unique molecular structure of iminodiacetonitrile(IDAN),which can coordinate with metal ions to form Ni2Fe(CN)6 with prussian blue analogs(PBA)structure.Unlike previous PBA-induced methods,the thickness of the carbon layer covering the surface of the metal core can be well controlled during the pyrolysis through adjusting the amount of IDAN,which builds a wonderful bridge for investigating the relationship between carbon layer thickness and catalytic performance.Both the experimental characterizations and theoretical studies validate that a suitable carbon layers thickness leads to optimal OER activity and stability.By optimizing the structure and composition,the optimized Ni_(3)Fe@N-C with hierarchical framework exhibits the low overpotentials(260 mV at 10 mA cm^(-2);320 mV at 50 mA cm^(-2)),improved kinetics(79 mV dec^(-1)),and robust long-term stability,which exceeds those of benchmark RuO_(2).展开更多
Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent diseas...Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent disease 1)or OCRL1(Dent disease 2).The condition is characterized by proximal renal tubular dysfunction that manifests as low molecular weight proteinuria(LMWP),hypercalciuria,nephrocalcinosis or nephrolithiasis,and progressive renal failure.Typically,the total protein excretion in tubular proteinuria is lower than that in glomerular diseases;therefore,nephrotic range proteinuria(NP)is not prevalent in patients with documented CLCN5 or OCRL1 mutations.Here,we report the cases of six Chinese children with Dent disease who manifested NP and were finally diagnosed using genetic analysis.Our aim was to elucidate the characteristics of Dent disease in Shaanxi area to facilitate possible improvements in its detection and treatment.展开更多
The cascade O-insertion/1,6 conjugate addition between benzynes and ortho-hydroxyphenyl substituted para-quinone methides has been reported, affording 9-phenol substituted xanthenes in 49%-84% yields.
基金Supported by two grants from the Science and Technology Program of Shenyang (No.1071166-9-00 and No.1081232-1-00)
文摘Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion.
基金the financial supported by the National Natural Science Foundation of China(Nos.22109073,22072067 and 21875112)the Natural Science Foundation of Jiangsu Province(No.BK20200711)+2 种基金supported from the National and Local Joint Engineering Research Center of Biomedical Functional Materials and a project sponsored by the Priority Academic Program Development of Jiangsu Higher Education InstitutionsZ.Li thanks Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_1326)China Scholarship Council(No.202006860026).
文摘Developing high-efficiency and low-cost catalysts towards oxygen evolution reaction(OER)is extremely important for overall water splitting and rechargeable metal-air batteries.Herein we propose a promising organometallic coordination polymer(OCP)induced strategy to construct hierarchical N-doped carbon framework with NiFe nanoparticles encapsulated inside(NxFe@N-C)as a highly active and stable OER catalyst.The synthesis of OCP precursor depends on the unique molecular structure of iminodiacetonitrile(IDAN),which can coordinate with metal ions to form Ni2Fe(CN)6 with prussian blue analogs(PBA)structure.Unlike previous PBA-induced methods,the thickness of the carbon layer covering the surface of the metal core can be well controlled during the pyrolysis through adjusting the amount of IDAN,which builds a wonderful bridge for investigating the relationship between carbon layer thickness and catalytic performance.Both the experimental characterizations and theoretical studies validate that a suitable carbon layers thickness leads to optimal OER activity and stability.By optimizing the structure and composition,the optimized Ni_(3)Fe@N-C with hierarchical framework exhibits the low overpotentials(260 mV at 10 mA cm^(-2);320 mV at 50 mA cm^(-2)),improved kinetics(79 mV dec^(-1)),and robust long-term stability,which exceeds those of benchmark RuO_(2).
基金funded by the Natural Science Foundation of Shaanxi Province (S2018-JC-YB-2307)
文摘Dear Editor,Dent disease is a rare X-linked recessive disease that was first reported by Charles Enrique Dent and M.Friedman in 1964(Dent and Friedman,1964).Dent disease is caused by mutations in the CLCN5(Dent disease 1)or OCRL1(Dent disease 2).The condition is characterized by proximal renal tubular dysfunction that manifests as low molecular weight proteinuria(LMWP),hypercalciuria,nephrocalcinosis or nephrolithiasis,and progressive renal failure.Typically,the total protein excretion in tubular proteinuria is lower than that in glomerular diseases;therefore,nephrotic range proteinuria(NP)is not prevalent in patients with documented CLCN5 or OCRL1 mutations.Here,we report the cases of six Chinese children with Dent disease who manifested NP and were finally diagnosed using genetic analysis.Our aim was to elucidate the characteristics of Dent disease in Shaanxi area to facilitate possible improvements in its detection and treatment.
基金supported by the National Natural Science Foundation of China(No. 21462034)the Young Scientists Foundation of Shihezi University(Nos. RCZX201546, 2015ZRKXJQ05)the Excellent Young Teachers Plan of Bingtuan(No. CZ027203)
文摘The cascade O-insertion/1,6 conjugate addition between benzynes and ortho-hydroxyphenyl substituted para-quinone methides has been reported, affording 9-phenol substituted xanthenes in 49%-84% yields.
