An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However,most of the existing evaluation methods in basic research and clinical practice...An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However,most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also difficult to use to qualify the extent of damage and recovery. In the present study, we established a big animal model of traumatic brain injury by impacting the cortical motor region of beagles. At 2 weeks after successful modeling, we detected neurological deficiencies in the animal model using a series of techniques, including three-dimensional motion capture, electromyogram and ground reaction force. These novel technologies may play an increasingly important role in the field of traumatic brain injury diagnosis and rehabilitation in the future. The experimental protocol was approved by the Animal Care and Use Committee of Logistics University of People's Armed Police Force(approval No. 2017-0006.2).展开更多
BACKGROUND Acute renal artery thrombosis is a relatively rare disease.Early diagnosis and emergent treatment can prevent the loss of renal function and the development of hypertension.CASE SUMMARY We report a patient ...BACKGROUND Acute renal artery thrombosis is a relatively rare disease.Early diagnosis and emergent treatment can prevent the loss of renal function and the development of hypertension.CASE SUMMARY We report a patient with acute renal artery thrombosis who presented to our hospital with acute-onset right flank pain and was treated by percutaneous mechanical thrombectomy using the Rotarex device.After 2 mo,right kidney function had recovered slightly.CONCLUSION Renal artery thrombosis may lead to loss of renal function and the development of hypertension.Rotarex mechanical thrombectomy may be a viable treatment option for rapid recanalization of the renal artery in patients with renal artery thrombosis.展开更多
BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of osteoclasts.Approximately,80%of autosomal dominant osteopetrosis type II(ADO-II)patients ...BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of osteoclasts.Approximately,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent fractures.In this study,we report a case of persistent joint pain without bone injury or underlying history.CASE SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with ADO-II.The clinical diagnosis was based on increased bone density and typical radiographic features.Two heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her daughter.The missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across species.The TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent transcription.CONCLUSION This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical symptoms.For the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised.展开更多
Sodium-ion batteries(SIBs),as highly promising alternatives to lithium-ion batteries(LIBs),can be widely used in a variety of next-generation energy storage systems.However,the current commercial graphite anodes of LI...Sodium-ion batteries(SIBs),as highly promising alternatives to lithium-ion batteries(LIBs),can be widely used in a variety of next-generation energy storage systems.However,the current commercial graphite anodes of LIBs could not intercalate sodium ions to appreciable extent,and the electrochemical irreversibility hinders further application.Searching for a suitable anode material is a critical issue for the successful development of SIBs.Herein,we report a convenient,fast,and large-scale preparation method of mesoporous FeS_(2) nanorods.Our specially designed one-dimensional mesoporous structure of FeS_(2) takes full advantage of ultra-high strain relaxation as well as fast Na^(+)transport rate arising from microstructural characteristics.As a result,the mesoporous FeS_(2) nanorods exhibited excellent sodium storage performance.The discharge capacity was retained at 711.1 mAh·g^(-1) after 450 cycles at a current density of 1000 mA·g^(-1).The special microstructure and superior performance of mesoporous FeS_(2) nanorods represent a critical step for transition metal sulfides electrode materials toward practical SIBs application.展开更多
基金supported by the National Natural Science Foundation of China,No.11672332,11102235 and 31200809(all to XYC)the National Key Research and Development Plan of China,No.2016YFC1101500(to SZ)the Science and Technology Program of Tianjin,China,No.17YFZCSY00620 and 16ZXHLSY00120(both to XYC)
文摘An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However,most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also difficult to use to qualify the extent of damage and recovery. In the present study, we established a big animal model of traumatic brain injury by impacting the cortical motor region of beagles. At 2 weeks after successful modeling, we detected neurological deficiencies in the animal model using a series of techniques, including three-dimensional motion capture, electromyogram and ground reaction force. These novel technologies may play an increasingly important role in the field of traumatic brain injury diagnosis and rehabilitation in the future. The experimental protocol was approved by the Animal Care and Use Committee of Logistics University of People's Armed Police Force(approval No. 2017-0006.2).
文摘BACKGROUND Acute renal artery thrombosis is a relatively rare disease.Early diagnosis and emergent treatment can prevent the loss of renal function and the development of hypertension.CASE SUMMARY We report a patient with acute renal artery thrombosis who presented to our hospital with acute-onset right flank pain and was treated by percutaneous mechanical thrombectomy using the Rotarex device.After 2 mo,right kidney function had recovered slightly.CONCLUSION Renal artery thrombosis may lead to loss of renal function and the development of hypertension.Rotarex mechanical thrombectomy may be a viable treatment option for rapid recanalization of the renal artery in patients with renal artery thrombosis.
基金Supported by the Science and Technology Plan Program of Sichuan of China,No.2018JY0608。
文摘BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of osteoclasts.Approximately,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent fractures.In this study,we report a case of persistent joint pain without bone injury or underlying history.CASE SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with ADO-II.The clinical diagnosis was based on increased bone density and typical radiographic features.Two heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her daughter.The missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across species.The TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent transcription.CONCLUSION This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical symptoms.For the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised.
基金This study was financially supported by the National Natural Science Foundation of China(Nos.21905239 and U1910208)the Natural Science Foundation of Shanxi Province of China(Nos.201901D211265,201901D211257,201901D111137 and 201901D211208)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Nos.2019L0609 and 2019L0605).
文摘Sodium-ion batteries(SIBs),as highly promising alternatives to lithium-ion batteries(LIBs),can be widely used in a variety of next-generation energy storage systems.However,the current commercial graphite anodes of LIBs could not intercalate sodium ions to appreciable extent,and the electrochemical irreversibility hinders further application.Searching for a suitable anode material is a critical issue for the successful development of SIBs.Herein,we report a convenient,fast,and large-scale preparation method of mesoporous FeS_(2) nanorods.Our specially designed one-dimensional mesoporous structure of FeS_(2) takes full advantage of ultra-high strain relaxation as well as fast Na^(+)transport rate arising from microstructural characteristics.As a result,the mesoporous FeS_(2) nanorods exhibited excellent sodium storage performance.The discharge capacity was retained at 711.1 mAh·g^(-1) after 450 cycles at a current density of 1000 mA·g^(-1).The special microstructure and superior performance of mesoporous FeS_(2) nanorods represent a critical step for transition metal sulfides electrode materials toward practical SIBs application.
