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Research on the X-ray polarization deconstruction method based on hexagonal convolutional neural network
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作者 Ya-Nan Li Jia-Huan Zhu +5 位作者 Huai-Zhong Gao Hong Li Ji-Rong Cang zhi zeng Hua Feng Ming zeng 《Nuclear Science and Techniques》 2025年第2期49-61,共13页
Track reconstruction algorithms are critical for polarization measurements.Convolutional neural networks(CNNs)are a promising alternative to traditional moment-based track reconstruction approaches.However,the hexagon... Track reconstruction algorithms are critical for polarization measurements.Convolutional neural networks(CNNs)are a promising alternative to traditional moment-based track reconstruction approaches.However,the hexagonal grid track images obtained using gas pixel detectors(GPDs)for better anisotropy do not match the classical rectangle-based CNN,and converting the track images from hexagonal to square results in a loss of information.We developed a new hexagonal CNN algorithm for track reconstruction and polarization estimation in X-ray polarimeters,which was used to extract the emission angles and absorption points from photoelectron track images and predict the uncer-tainty of the predicted emission angles.The simulated data from the PolarLight test were used to train and test the hexagonal CNN models.For individual energies,the hexagonal CNN algorithm produced 15%-30%improvements in the modulation factor compared to the moment analysis method for 100%polarized data,and its performance was comparable to that of the rectangle-based CNN algorithm that was recently developed by the Imaging X-ray Polarimetry Explorer team,but at a lower computational and storage cost for preprocessing. 展开更多
关键词 X-ray polarization Track reconstruction Deep learning Hexagonal conventional neural network
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One-step synthesis of cubic gauche polymeric nitrogen with high yield just by heating
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作者 Liangfei Wu Yuxuan Xu +4 位作者 Guo Chen Junfeng Ding Ming Li zhi zeng Xianlong Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第12期127-129,共3页
A high-efficient one-step synthesis of cubic gauche polymeric nitrogen was developed just by thermal treatment of KN3powders.Raman and infrared spectra confirm the formation of cubic gauche polymeric nitrogen.Further ... A high-efficient one-step synthesis of cubic gauche polymeric nitrogen was developed just by thermal treatment of KN3powders.Raman and infrared spectra confirm the formation of cubic gauche polymeric nitrogen.Further thermogravimetric differential scanning calorimeter measurements show that the content of cubic gauche polymeric nitrogen is as high as 1.5 wt%with high thermal stability,which is the highest content value reported so far. 展开更多
关键词 cg-N thermal treatment polymeric nitrogen high-energy-density materials KN_(3)
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Learning Sequential and Structural Dependencies Between Nucleotides for RNA N6-Methyladenosine Site Identification
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作者 Guodong Li Bowei Zhao +4 位作者 Xiaorui Su Dongxu Li Yue Yang zhi zeng Lun Hu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第10期2123-2134,共12页
N6-methyladenosine(m6A)is an important RNA methylation modification involved in regulating diverse biological processes across multiple species.Hence,the identification of m6A modification sites provides valuable insi... N6-methyladenosine(m6A)is an important RNA methylation modification involved in regulating diverse biological processes across multiple species.Hence,the identification of m6A modification sites provides valuable insight into the biological mechanisms of complex diseases at the post-transcriptional level.Although a variety of identification algorithms have been proposed recently,most of them capture the features of m6A modification sites by focusing on the sequential dependencies of nucleotides at different positions in RNA sequences,while ignoring the structural dependencies of nucleotides in their threedimensional structures.To overcome this issue,we propose a cross-species end-to-end deep learning model,namely CR-NSSD,which conduct a cross-domain representation learning process integrating nucleotide structural and sequential dependencies for RNA m6A site identification.Specifically,CR-NSSD first obtains the pre-coded representations of RNA sequences by incorporating the position information into single-nucleotide states with chaos game representation theory.It then constructs a crossdomain reconstruction encoder to learn the sequential and structural dependencies between nucleotides.By minimizing the reconstruction and binary cross-entropy losses,CR-NSSD is trained to complete the task of m6A site identification.Extensive experiments have demonstrated the promising performance of CR-NSSD by comparing it with several state-of-the-art m6A identification algorithms.Moreover,the results of cross-species prediction indicate that the integration of sequential and structural dependencies allows CR-NSSD to capture general features of m6A modification sites among different species,thus improving the accuracy of cross-species identification. 展开更多
关键词 Cross-domain reconstruction cross-species prediction N6-methyladenosine(m6A)modification site RNA sequence sequential and structural dependencies
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High-performance self-driven broadband photoelectrochemical photodetector based on reduced graphene oxide/Bi_(2)Te_(3)heterojunction
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作者 Chenchen Zhao Yangyang Liu +11 位作者 Dongbo Wang Wen He Bingke Zhang Jingwen Pan zhi zeng Donghao Liu Sihang Liu Shujie Jiao Xuan Fang Dan Fang Liancheng Zhao Jinzhong Wang 《Nano Materials Science》 CSCD 2024年第6期741-751,共11页
Attributed to its excellent physicochemical properties,graphene(GR)has very active applications in the fields of catalysis,optoelectronic devices,and battery electrode materials.However,until now,regulating the type a... Attributed to its excellent physicochemical properties,graphene(GR)has very active applications in the fields of catalysis,optoelectronic devices,and battery electrode materials.However,until now,regulating the type and density of carriers in GR is still crucial for its practical applications.Here,reduced graphene oxide(RGO)-Bi_(2)Te_(3)heterojunctions doped with different contents were prepared by a simple one-step method.The Bi_(2)Te_(3)materials containing different RGO were made into broadband(365–850 nm)photoelectrochemical-type detectors,and the effects of the doping amount of RGO on the optoelectronic behavior of the devices and the intrinsic operation mechanism of the devices were investigated in detail.The results show that the values of Iph/Idark,Ri,and D*of Bi_(2)Te_(3)/RGO heterojunction devices obtained with 1 mg of RGO doping are 412,6.072 mA/W,and 2.4061010 Jones,respectively.It is anticipated that this work will provide a research basis for future quantitative tuning of the performance of micro-nano devices by GR. 展开更多
关键词 PHOTOELECTROCHEMICAL Bi_(2)Te_(3)/RGO heterojunctions Doping regulation Self-driven BROADBAND
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醒脑静注射液联合曲克芦丁脑蛋白水解物治疗老年脑卒中并发意识障碍的疗效及机制研究 被引量:17
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作者 曾志 何亮 杨雪梅 《中国现代医学杂志》 CAS 北大核心 2021年第9期67-71,共5页
目的分析醒脑静注射液联合曲克芦丁脑蛋白水解物治疗老年脑卒中并发意识障碍的疗效及对患者神经功能、炎症反应的影响,并探讨药物相关机制。方法选取2018年3月—2019年10月于重庆市涪陵中心医院就诊的104例老年脑卒中并发意识障碍患者,... 目的分析醒脑静注射液联合曲克芦丁脑蛋白水解物治疗老年脑卒中并发意识障碍的疗效及对患者神经功能、炎症反应的影响,并探讨药物相关机制。方法选取2018年3月—2019年10月于重庆市涪陵中心医院就诊的104例老年脑卒中并发意识障碍患者,按照数字随机对照原则以1∶1分为对照组和联合组,每组52例。患者均接受常规治疗。对照组实施醒脑静注射液治疗,联合组实施静注射液+曲克芦丁脑蛋白水解物治疗,均为2个疗程。对比两组疗效、体温、白细胞计数、中性粒细胞计数、用药安全性,观察治疗前、治疗2个疗程后白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、超氧化物歧化酶(SOD)、丙二醛(MDA)、神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)、脑源性神经细胞营养因子(BDNF)的变化。结果联合组总有效率高于对照组(P<0.05)。两组患者治疗后体温、白细胞计数、中性粒细胞计数比较,差异无统计学意义(P>0.05)。联合组治疗前后血清IL-6、IL-8、MDA、SOD、NSE、NGF、BDNF水平差值高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论给予老年脑卒中并发意识障碍患者醒脑静注射液联合曲克芦丁脑蛋白水解物疗效明显,促进意识状态改善,且未明显增加不良反应,其机制可能与联合用药提高神经功能、减轻炎症反应及增强清除自由基能力相关。 展开更多
关键词 卒中 意识障碍 老年人
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Improving diversity of speech-driven gesture generation with memory networks as dynamic dictionaries
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作者 Zeyu Zhao Nan Gao +3 位作者 zhi zeng Guixuan Zhang Jie Liu Shuwu Zhang 《CAAI Transactions on Intelligence Technology》 2024年第5期1275-1289,共15页
Generating co-speech gestures for interactive digital humans remains challenging because of the indeterministic nature of the problem.The authors observe that gestures generated from speech audio or text by existing n... Generating co-speech gestures for interactive digital humans remains challenging because of the indeterministic nature of the problem.The authors observe that gestures generated from speech audio or text by existing neural methods often contain less movement shift than expected,which can be viewed as slow or dull.Thus,a new generative model coupled with memory networks as dynamic dictionaries for speech-driven gesture generation with improved diversity is proposed.More specifically,the dictionary network dynamically stores connections between text and pose features in a list of key-value pairs as the memory for the pose generation network to look up;the pose generation network then merges the matching pose features and input audio features for generating the final pose sequences.To make the improvements more accurately measurable,a new objective evaluation metric for gesture diversity that can remove the influence of low-quality motions is also proposed and tested.Quantitative and qualitative experiments demonstrate that the proposed architecture succeeds in generating gestures with improved diversity. 展开更多
关键词 artificial intelligence GESTURE
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Experimental validation of material discrimination ability of muon scattering tomography at the TUMUTY facility 被引量:10
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作者 Xing-Yu Pan Yi-Fan Zheng +2 位作者 zhi zeng Xue-Wu Wang Jian-Ping Cheng 《Nuclear Science and Techniques》 SCIE CAS CSCD 2019年第8期26-34,共9页
Muon scattering tomography is believed to be a promising technique for cargo container inspection, owing to the ability of natural muons to penetrate into dense materials and the absence of artificial radiation. In th... Muon scattering tomography is believed to be a promising technique for cargo container inspection, owing to the ability of natural muons to penetrate into dense materials and the absence of artificial radiation. In this work, the material discrimination ability of muon scattering tomography is evaluated based on experiments at the Tsinghua University cosmic ray muon tomography facility,with four materials: flour(as drugs substitute), aluminum,steel, and lead. The features of the different materials could be discriminated with cluster analysis and classifiers based on support vector machine. The overall discrimination precisions for these four materials could reach 70, 95, and 99% with 1-, 5-, and 10-min-long measurement,respectively. 展开更多
关键词 MUON TOMOGRAPHY CARGO containerinspection MATERIAL DISCRIMINATION SVM CLASSIFIER
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Evaluation of cosmogenic activation of copper and germanium during production in Jinping Underground Laboratory 被引量:8
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作者 Wei-He zeng Hao Ma +4 位作者 Ming zeng zhi zeng Qian Yue Jian-Ping Cheng Jun-Li Li 《Nuclear Science and Techniques》 SCIE CAS CSCD 2020年第5期70-76,共7页
Intrinsic radiation of materials is one of the major backgrounds for many rare-event search experiments.Thus,the production of pure materials in an underground laboratory is a promising approach for eliminating cosmog... Intrinsic radiation of materials is one of the major backgrounds for many rare-event search experiments.Thus,the production of pure materials in an underground laboratory is a promising approach for eliminating cosmogenic radionuclides.In this paper,we demonstrate a procedure to evaluate the yields of cosmogenic radionuclides in copper and germanium in the second phase of the China Jinping Underground Laboratory.Our results show that for copper and germanium materials,the largest cosmogenic background comes from 3 H and57,58,60Co,and 3 H and 68Ge,respectively,which all have yields on the order of 10-7 kg-1 day-1.The corresponding radioactivities after 90 days pf exposure underground are estimated to be lower than 10-6μBq kg-1. 展开更多
关键词 COSMIC RAYS COSMOGENIC radionuclides UNDERGROUND laboratory MONTE Carlo simulation
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幽门螺杆菌感染与胃癌中PRC2和H3K27me3的表达关系 被引量:7
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作者 张宁 曾智 +3 位作者 阎丽萍 杨珂 孙庆文 黄鹏 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第13期667-672,共6页
目的:研究幽门螺杆菌(Helicobacter pylori,HP)感染对胃癌组织中多梳抑制复合物2(polycomb repressive complex 2,PRC2)和组蛋白H3K27me3表达的影响,探索HP感染在胃癌发生过程中的作用。方法:利用快速尿素酶检测、Giemsa染色和PCR方法... 目的:研究幽门螺杆菌(Helicobacter pylori,HP)感染对胃癌组织中多梳抑制复合物2(polycomb repressive complex 2,PRC2)和组蛋白H3K27me3表达的影响,探索HP感染在胃癌发生过程中的作用。方法:利用快速尿素酶检测、Giemsa染色和PCR方法检测复旦大学附属上海市第五人民医院2014年1月至2017年10月行胃癌手术的84例患者HP感染情况,应用免疫组织化学法检测胃癌和癌旁组织PRC2和H3K27me3蛋白的表达,分析两者表达与HP感染之间的相关性。结果:3种方法检测HP感染率分别为70.24%、61.90%和76.19%。PRC2家族成员果蝇zeste基因增强子同源物2(enhancer of zeste homolog 2,EZH2)、SUZ12、EED和H3K27me3蛋白在胃癌组织中的阳性表达率分别为79.76%(67/84)、77.38%(65/84)、40.48%(34/84)和69.05%(58/84),均显著高于癌旁组织(22.62%、34.52%、8.33%和14.29%,P<0.05)。临床资料分析表明,EZH2和H3K27me3蛋白在胃癌中的表达与淋巴结转移呈正相关。在HP阳性胃癌组织中,EZH2、SUZ12、EED和H3K27me3蛋白阳性表达率分别为89.06%(57/64)、84.38%(54/64)、46.88%(30/64)和82.81%(53/64),均显著高于HP阴性胃癌组织(50.00%、55.00%、20.00%和25.00%,P<0.05)。结论:HP感染与胃癌组织中PRC2和H3K27me3蛋白表达上调相关。 展开更多
关键词 幽门螺杆菌 多梳抑制复合物2 果蝇zeste基因增强子同源物2 H3K27me3 胃癌
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Compact CubeSat Gamma-ray detector for GRID mission 被引量:4
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作者 Jia-Xing Wen Xu-Tao Zheng +18 位作者 Jian-Dong Yu Yue-Peng Che Dong-Xin Yang Huai-Zhong Gao Yi-Fei Jin Xiang-Yun Long Yi-Hui Liu Da-Cheng Xu Yu-Chong Zhang Ming zeng Yang Tian Hua Feng zhi zeng Ji-Rong Cang Qiong Wu Zong-Qing Zhao Bin-Bin Zhang Peng An GRID collaboration 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2021年第9期105-115,共11页
Gamma-Ray Integrated Detectors(GRID)mis-sion is a student project designed to use multiple gamma-ray detectors carried by nanosatellites(CubeSats),forming a full-time all-sky gamma-ray detection network that monitors ... Gamma-Ray Integrated Detectors(GRID)mis-sion is a student project designed to use multiple gamma-ray detectors carried by nanosatellites(CubeSats),forming a full-time all-sky gamma-ray detection network that monitors the transient gamma-ray sky in the multi-mes-senger astronomy era.A compact CubeSat gamma-ray detector,including its hardware and firmware,was designed and implemented for the mission.The detector employs four Gd 2 Al 2 Ga 3 O 12:Ce(GAGG:Ce)scintillators coupled with four silicon photomultiplier(SiPM)arrays to achieve a high gamma-ray detection efficiency between 10 keV and 2 MeV with low power and small dimensions.The first detector designed by the undergraduate student team onboard a commercial CubeSat was launched into a Sun-synchronous orbit on October 29,2018.The detector was in a normal observation state and accumulated data for approximately one month after on-orbit functional and performance tests,which were conducted in 2019. 展开更多
关键词 Gamma-ray bursts Scintillation detectors SIPM CUBESAT
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Characterization of a broad-energy germanium detector for its use in CJPL 被引量:3
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作者 zhi zeng Yu-Hao Mi +6 位作者 Ming zeng Hao Ma Qian Yue Jian-Ping Cheng Jun-Li Li Rui Qiu Hui Zhang 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第1期42-48,共7页
The broad-energy germanium(BEGe)detector,with the ability of background discrimination using pulse shape discrimination,is a competitive candidate for neutrinoless double beta decay(ovββ)experiments.In this paper,we... The broad-energy germanium(BEGe)detector,with the ability of background discrimination using pulse shape discrimination,is a competitive candidate for neutrinoless double beta decay(ovββ)experiments.In this paper,we report our measurements of key parameters for detector modeling in a commercial p-type BEGe detector.Point-like sources are used to investigate energy resolution and linearity of the detector.A cylindrical volume source is used for efficiency calibration.With an assembled device for source positioning and a collimated ^(133)Ba source,the detector is scanned to check its active volume.Using an^(241)Am point-like source,the dead layer thicknesses is measured at about 0.17 mm on the front and 1.18 mm on the side.The detector characterization is of importance for BEGe detectors to be used in the ovββ experiments at China JinPing underground Laboratory(CJPL). 展开更多
关键词 BEGe CHARACTERIZATION DEAD LAYER 0mbb CJPL
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A numerical study of generation and propagation of type-a and type-b internal solitary waves in the northern South China Sea 被引量:2
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作者 zhi zeng Xueen Chen +2 位作者 Chunxin Yuan Shengquan Tang Lequan Chi 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2019年第11期20-30,共11页
Numerical simulations based on a high-resolution three-dimensional MIT general circulation model(MITgcm)using realistic topography and tidal forcing are conducted to investigate the generation and propagation of the s... Numerical simulations based on a high-resolution three-dimensional MIT general circulation model(MITgcm)using realistic topography and tidal forcing are conducted to investigate the generation and propagation of the so-called type-a waves(large-amplitude rank-ordered wave packets)and type-b waves(isolated wave packets)in the northern South China Sea.At first,we summarized and analyzed the generation and propagation characteristics of these waves.Then,energy budget at the Luzon Strait is calculated.Energy generation has three local maxima every day,of which the largest one corresponds to the emergence of the type-a wave.Energy flux at the west boundary of the Luzon Strait shows two local maxima each day.The larger one is consistent with the generation of the type-a wave and the smaller one is in correspondence with the generation of the type-b wave.Sensitivity experiments are designed to explore the role of the east and west ridge of the Luzon Strait on the generation and propagation of the type-a and type-b waves.It is found that the east ridge is indispensable on the generation of the type-a wave while the west ridge has little contribution.The west ridge diminishes the type-a waves'amplitude but hardly changes their propagation speed.The type-b waves also come from perturbation signals which originate from the east ridge and are enhanced in amplitude and reduced in propagation speed by the west ridge. 展开更多
关键词 numerical simulation internal SOLITARY WAVE type-a WAVE type-b WAVE LUZON STRAIT
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Transient Spectroscopic Properties of [60]Fullerene-Containing Cyclic Sulphoxide 被引量:3
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作者 He Ping zeng zhi zeng Ding Qiao YANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第6期567-570,共4页
The properties of the triplet excited state of [60]fullerene-containing cyclic sulphoxide have been investigated by time-resolved absorption spectroscopy. Transient absorption bands of [60]fullerene-containing cyclic... The properties of the triplet excited state of [60]fullerene-containing cyclic sulphoxide have been investigated by time-resolved absorption spectroscopy. Transient absorption bands of [60]fullerene-containing cyclic sulphoxide showed two decay-components, which were attributed to triplet excited states of different spin multiplicity. The properties of photoexcited states of [60]fullerene-containing cyclic sulphoxide are also reported. 展开更多
关键词 Fullerene-containing cyclic sulphoxide triplet excited state transient spectroscopic property time-resolved absorption spectroscopy.
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血栓弹力图和凝血四项在髋部骨折术后凝血功能中的相关性 被引量:6
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作者 陈敏 曾志 +1 位作者 刘建 项惠灿 《数理医药学杂志》 CAS 2023年第1期16-23,共8页
目的探究血栓弹力图(TEG)和凝血四项各参数在髋部骨折术后患者凝血功能中的相关性。方法选择2019年7月至2022年6月于我院接受人工髋关节置换术的60例患者作为研究对象,对患者围术期开展观察,记录其TEG、凝血四项、血小板(PLT)的检测结果... 目的探究血栓弹力图(TEG)和凝血四项各参数在髋部骨折术后患者凝血功能中的相关性。方法选择2019年7月至2022年6月于我院接受人工髋关节置换术的60例患者作为研究对象,对患者围术期开展观察,记录其TEG、凝血四项、血小板(PLT)的检测结果,将TEG的主要参数凝血因子激活时间(R)、血块形成速率参数(K)、弹力图最大切角(Angle角)、弹力图最大振幅(MA)与凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及PLT进行相关性分析,并通过绘制ROC曲线,分析TEG对人工髋关节置换术后患者凝血功能的诊断价值。结果TEG中的R值与PT值无相关性(r=0.014,P=0.488),与APTT同样无相关性(r=-0.014,P=0.467)。K值与FIB呈明显负相关性(r=-0.288,P<0.001),Angle与FIB呈明显正相关性(r=0.273,P<0.001),MA值与FIB值呈现明显正相关性(r=0.415,P<0.001)。K值与PLT呈现明显的负相关性(r=-0.164,P=0.010),Angle与PLT呈现明显的正相关(r=0.190,P=0.005),MA值与PLT呈现明显的正相关(r=0.237,P=0.002)。R、K、Angle及MA值对高凝的鉴别曲线下面积(AUC)为0.556(P=0.624)、0.923(P<0.001)、0.885(P<0.001)、0.923(P<0.001)。R、K、Angle及MA值对低凝的鉴别AUC为0.6308(P=0.361)、0.8308(P=0.021)、0.808(P=0.032)、0.7654(P=0.064)。结论人工髋关节置换术患者围手术期TEG和凝血四项指标存在一定的相关性,TEG中K、Angle及MA值对于患者的凝血状态具有较高诊断价值,可以考虑将TEG和凝血四项应用于人工髋关节置换术患者围手术期凝血状态评估中,从而为患者的血栓检测和风险评估提供参考依据。 展开更多
关键词 髋部骨折内固定 人工关节置换术 血栓弹力图 凝血四项
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Effects of Different Proportions of Spent Pleurotus ostreatus Substrate on Seed Germination and Seedling Growth of Mung Beans 被引量:1
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作者 Ling WANG Shuang YANG +2 位作者 Yihong HU Chenzhong JIN zhi zeng 《Agricultural Biotechnology》 CAS 2019年第2期81-85,共5页
[Objectives] This study was conducted to investigate the effects of different proportions of spent Pleurotus ostreatus substrate on the germination and seedling growth of mung beans. [Methods] The cellulose-degrading ... [Objectives] This study was conducted to investigate the effects of different proportions of spent Pleurotus ostreatus substrate on the germination and seedling growth of mung beans. [Methods] The cellulose-degrading bacteria HB8 and HF1 were mixed with a commercially available microbial composting agent, respectively, for the composting of spent P. ostreatus substrate. Mung beans were cultivated with different proportions of spent mushroom substrate compost and soil. The seed germination rate, plant height, fresh weight and chlorophyll content of mung bean were used as indicators to investigate the effects of the organic fertilizer from spent P. ostreatus substrate on the growth of mung bean seedlings. [Results] The addition of cellulose-degrading bacteria can significantly improve the composting effect of the spent mushroom substrate. After 8 d of cultivation of mung beans with different ratios of the mushroom substrate organic fertilizer, 50% of the organic fertilizer can make the plant height, fresh weight and leaf chlorophyll content of mung bean seedlings reach the highest value and was suitable for mung bean breeding and cultivation. [Conclusions] This study provides scientific basis and technical indicators for the rapid and harmless treatment of spent mushroom substrate and its application in crop cultivation and nursery. 展开更多
关键词 Cellulose-degrading bacteria Organic fertilizer from SPENT PLEUROTUS ostreatus SUBSTRATE MUNG bean Seed germination rate
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基于序列相似性和Z曲线方法重注释原核生物蛋白编码基因
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作者 刘硕 曾志 +1 位作者 曾凡才 杜萌泽 《遗传》 CAS CSCD 北大核心 2020年第7期691-702,I0003,共13页
随着测序技术的不断发展,产生了海量的基因组测序数据,极大地丰富了公共遗传数据资源。同时为了应对大量基因组数据的产生,基因组比较和注释算法、工具不断更新,使得联合多种注释工具得到更准确的蛋白编码基因的注释信息成为可能。目前... 随着测序技术的不断发展,产生了海量的基因组测序数据,极大地丰富了公共遗传数据资源。同时为了应对大量基因组数据的产生,基因组比较和注释算法、工具不断更新,使得联合多种注释工具得到更准确的蛋白编码基因的注释信息成为可能。目前公共数据库的原核生物基因组测序和装配有些是10多年前的,存在大量预测的功能未知的编码基因。为了提升美国国家生物信息中心(National Center for Biotechnology Information,NCBI)数据库中基因组的注释质量,本研究联合使用多种原核基因识别算法/软件和基因表达数据重注释1587个细菌和古细菌基因组。首先,利用Z曲线的33个变量从177个基因组原注释中识别获得3092个被过度注释为蛋白编码基因的序列;其次,通过同源比对为939个基因组中的4447个功能未知的蛋白编码基因注释上具体功能;最后,通过联合采用ZCURVE 3.0和Glimmer 3.02以及Prodigal这3种高精度的、广泛使用且基于算法不同而互补的基因识别软件来寻找漏注释基因。最终,从9个基因组中找到了2003个被漏注释的蛋白编码基因,这些基因属于多个蛋白质直系同源簇(clusters of orthologous groups of proteins, COG)。本研究使用新的工具并结合多组学数据重新注释早期测序的细菌和古细菌基因组,不仅为新测序菌株提供注释方法参考,而且这些重注释后得到的细菌基因序列也会对后续基础研究有所帮助。 展开更多
关键词 细菌 重注释 Z曲线 假定ORFs 非蛋白编码ORFs
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Learning physical states of bulk crystalline materials from atomic trajectories in molecular dynamics simulation
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作者 Tian-Shou Liang Peng-Peng Shi +1 位作者 San-Qing Su zhi zeng 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第12期405-410,共6页
Melting of crystalline material is a common physical phenomenon,yet it remains elusive owing to the diversity in physical pictures.In this work,we proposed a deep learning architecture to learn the physical states(sol... Melting of crystalline material is a common physical phenomenon,yet it remains elusive owing to the diversity in physical pictures.In this work,we proposed a deep learning architecture to learn the physical states(solid-or liquidphase)from the atomic trajectories of the bulk crystalline materials with four typical lattice types.The method has ultrahigh accuracy(higher than 95%)for the classification of solid-liquid atoms during the phase transition process and is almost insensitive to temperature.The atomic physical states are identified from atomic behaviors without considering any characteristic threshold parameter,which yet is necessary for the classical methods.The phase transition of bulk crystalline materials can be correctly predicted by learning from the atomic behaviors of different materials,which confirms the close correlation between atomic behaviors and atomic physical states.These evidences forecast that there should be a more general undiscovered physical quantity implicated in the atomic behaviors and elucidate the nature of bulk crystalline melting. 展开更多
关键词 melting phase transition crystalline materials physical states deep learning molecular dynamics simulation
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Numerical investigation of the South China Sea deep circulation
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作者 Shengquan Tang Xueen Chen +1 位作者 zhi zeng Xin Liu 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2022年第5期1-11,共11页
Based on a two-level nested model from the global ocean to the western Pacific and then to the South China Sea(SCS),the high-resolution SCS deep circulation is numerically investigated.The SCS deep circulation shows a... Based on a two-level nested model from the global ocean to the western Pacific and then to the South China Sea(SCS),the high-resolution SCS deep circulation is numerically investigated.The SCS deep circulation shows a basin-scale cyclonic structure with a strong southward western boundary current in summer(July),a northeast-southwest through-flow pattern across the deep basin without a western boundary current in winter(January),and a transitional pattern in spring and autumn.The sensitivity model experiments illustrate that the Luzon Strait deep overflow is the main factor controlling the seasonal variation in the SCS deep circulation.The SCS surface wind can significantly influence the SCS deep circulation in winter.The Luzon Strait deep overflow transport from the Pacific into the SCS ranges from 0.68×10^(6) m^(3)/s to 1.83×10^(6) m^(3)/s,reaching its maximum in summer(July,up to 1.83×10^(6) m^(3)/s),less in autumn and winter,and the minimum in spring(May,0.68×10^(6) m^(3)/s).In summer,the strong Luzon Strait deep overflow dominates the SCS deep circulation when the role of the SCS surface wind is small.In winter,the weaker Luzon Strait deep overflow and SCS surface wind jointly drive the SCS deep circulation into a northeast-southwest through-flow pattern.The potential vorticity(PV)dissipation in the SCS deep basin reaches its maximum(−0.122 m^(2)/s^(2))in May and its minimum(−0.380 m^(2)/s^(2))in July. 展开更多
关键词 South China Sea deep sea circulation deep overflow surface wind potential vorticity
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Route to Stabilize Cubic Gauche Polynitrogen to Ambient Conditions via Surface Saturation by Hydrogen
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作者 陈果 牛草萍 +3 位作者 夏文明 张洁 曾雉 王贤龙 《Chinese Physics Letters》 SCIE EI CAS CSCD 2023年第8期36-40,共5页
Cubic gauche polynitrogen(cg-N)is an attractive high-energy density material.However,high-pressure synthesized cg-N will decompose at low pressure and cannot exist under ambient conditions.Here,the stabilities of cg-N... Cubic gauche polynitrogen(cg-N)is an attractive high-energy density material.However,high-pressure synthesized cg-N will decompose at low pressure and cannot exist under ambient conditions.Here,the stabilities of cg-N surfaces with and without saturations at different pressures and temperatures are systematically investigated based on first-principles calculations and molecular dynamics simulations.Pristine surfaces at 0 GPa are very brittle and will decompose at 300 K,especially(110)surface will collapse completely just after structural relaxation,whereas the decompositions of surfaces can be suppressed by applying pressure,indicating that surface instability causes the cg-N decomposition at low pressure.Due to the saturation of dangling bonds and transferring electrons to the surfaces,saturation with H can stabilize surfaces under ambient conditions,while it is impossible for OH saturation to occur solely from obtaining electrons from surfaces.This suggests that polynitrogen is more stable in an acidic environment or when the surface is saturated with less electronegative adsorbates. 展开更多
关键词 SATURATION AMBIENT ATTRACTIVE
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Prolonged stay of spontaneous intracranial hemorrhage patients in the emergency department is correlated with worse outcomes
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作者 Qian He Rui Guo +3 位作者 Ke Zhang Chao You Yi Liu zhi zeng 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2022年第3期222-225,共4页
Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths w... Spontaneous intracerebral hemorrhage(ICH)represents the second most common type of stroke,with high mortality and disability rates.^([1,2])In 2010,there were approximately 5.3 million ICH cases,with 3 million deaths worldwide.^([1])However,there is still no validated medical treatment for ICH,with the role of surgery remaining controversial.^([2,3])Cusack et al^([4])demonstrated that lowering blood pressure rapidly in hypertensive ICH patients may be safe and at least partially effective in inhibiting hematoma expansion. 展开更多
关键词 PATIENTS HYPERTENSIVE MORTALITY
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