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中国西南地区藏族人群遗传亚结构研究 被引量:6
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作者 王小娟 钱恩芳 +6 位作者 李悦 宋正阳 赵慧 谢何鑫 李彩霞 黄江 江丽 《遗传》 CAS CSCD 北大核心 2020年第6期565-576,I0002,共13页
藏族为中国西南地区典型的少数民族,分为卫藏、康巴、安多和嘉绒等多个支系。然而,对藏族支系人群的遗传结构,特别是各分支人群的父系、母系遗传结构却缺乏深度解析。本研究基于个体水平的常染色体、父系来源的Y染色体和母系来源的线粒... 藏族为中国西南地区典型的少数民族,分为卫藏、康巴、安多和嘉绒等多个支系。然而,对藏族支系人群的遗传结构,特别是各分支人群的父系、母系遗传结构却缺乏深度解析。本研究基于个体水平的常染色体、父系来源的Y染色体和母系来源的线粒体3个类别遗传信息,对西藏地区卫藏藏族、四川甘孜地区康巴藏族、青海地区安多藏族和四川阿坝地区嘉绒藏族共4个藏族群体进行研究,以揭示其遗传亚结构关系。采用微测序技术检测各位点分型,利用PowerPlex^■Y23和DNATyper^TM Y26试剂盒检测Y-STRs基因座分型,通过热图和主成分分析、祖先成分分析、单倍群频率统计、网络图及多维尺度分析等探讨其遗传亚结构。结果表明,常染色体和Y染色体遗传标记可将4个藏族人群分为3类:青藏高原的卫藏藏族为一类,高原周边地区的康巴藏族和安多藏族的遗传结构类似分为一类,“藏彝走廊”中嘉绒藏族的遗传结构与其他藏族人群差异显著而为一类。不同藏族分支人群在线粒体遗传信息方面无明显差异性。上述多类别遗传信息的分析结果为深入了解藏族不同分支人群的遗传亚结构提供了新视角。 展开更多
关键词 群体遗传学 藏族 单倍型 遗传亚结构
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Drawing mechanisms for top coal in longwall top coal caving(LTCC):A review of two decades of literature 被引量:5
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作者 Jiachen Wang Shengli Yang +2 位作者 Weijie Wei Jinwang Zhang zhengyang song 《International Journal of Coal Science & Technology》 EI CAS CSCD 2021年第6期1171-1196,共26页
This review details the state of the art in research on top coal drawing mechanisms in Longwall top coal caving(LTCC)by examining the relevant literature over the last two decades.It startswith an introduction of the ... This review details the state of the art in research on top coal drawing mechanisms in Longwall top coal caving(LTCC)by examining the relevant literature over the last two decades.It startswith an introduction of the brief history and basic procedures of LTCC.The framework of research on the drawing mechanism,basic concepts,and some theoretical models of LTCC are detailed in sect.research framework of top coal drawingmechanism.The authors note that theTop coal drawbody(TCD),Top coal boundary(TCB)and Top coal recovery ratio(TCRR)are key factors in the drawingmechanism.TheBody-boundary-ratio(BBR)research system has been the classic framework for research over the last 20 years.The modified Bergmark-Roos model,which considers the effects of the supporting rear canopy,flowing velocity of top coal,and its shape factor,is optimal for characterizing the TCD.A 3Dmodel to describe the TCB that considers the thicknesses of the coal seam and roof strata is reviewed.In sect.physical testing and numerical simulation,the physical tests and numerical simulations in the literature are classified for ease of bibliographical review,and classic conclusions regarding the drawing mechanism of top coal are presented and discussedwith elaborate illustrations and descriptions.The deflection of the TCDis noted,and is caused by the shape of the rear canopy.The inclined coal seam always induces a largerTCD,and a deflection in theTCDhas also been observed in it.The effects of the drawing sequence and drawing interval on the TCRR are reviewed,where a long drawing interval is found to lead to significant loss of top coal.Its flowing behavior and velocity distribution are also presented.Sect.practical applications of drawingmechanisms forLTCCmines 4 summarizes over 10 cases where the TCRRof LTCCmines improved due to the guidance of the drawing mechanism.The final section provides a summary of the work here and some open questions.Prospective investigations are highlighted to give researchers guidance on promising issues in future research on LTCC. 展开更多
关键词 Longwall top coal caving(LTCC) Top coal drawing Top coal drawbody(TCD) Top coal boundary(TCB) Top coal recovery ratio(TCRR)
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A review of investigations on ground support requirements in coal burst‑prone mines 被引量:4
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作者 Chunchen Wei Chengguo Zhang +2 位作者 Ismet Canbulat zhengyang song Lianpeng Dai 《International Journal of Coal Science & Technology》 EI CAS CSCD 2022年第1期1-20,共20页
Ground support is widely implemented to mitigate dynamic rock failures in underground mines.This paper investigated the ground support requirements in burst-prone mines to mitigate the catastrophic dynamic rock failur... Ground support is widely implemented to mitigate dynamic rock failures in underground mines.This paper investigated the ground support requirements in burst-prone mines to mitigate the catastrophic dynamic rock failures of rock and/or coal bursts.First,the ground support principles and considerations in burst-prone conditions are identified.The objective of a ground support system is to increase the capacity to accommodate rock fracturing in a rockburst and,in turn,to minimize the kinetic energy of the ejected material.The support capacities of various yielding rockbolts and integrated support systems are then investigated using the test results in the laboratory.Apart from the energy absorption and yielding deformation capacity,the initial stiffness and energy absorption rate are also critical factors when applying yielding rockbolts in practice.Adding rope lacing and mesh strap to surface support elements can substantially enhance the support performance of the system.In practice,semi-analytical and empirical approaches are often used to determine the ground support elements in burst-prone areas.Semi-analytical methods first evaluate the support demand in burst risk zones and then select support elements according to their laboratory test results.Alternatively,empirical methods determine the ground support elements according to the locally established empirical rating scheme,which usually ranks the support capacities of various support systems based on ground support conditions and damage conditions.The outcomes of this study can provide insights into ground support strategies and assist the mining industry to develop effective coal burst control technologies. 展开更多
关键词 Coal burst Dynamic ground support Support capacity Best-practice support design
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Numerical and theoretical investigations of the effect of the gangue-coal density ratio on the drawing mechanism in longwall top-coal caving 被引量:2
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作者 Jinwang Zhang Dongliang Cheng +3 位作者 Yinchao Yang Weijie Wei Zhaolong Li zhengyang song 《International Journal of Coal Science & Technology》 EI CAS CSCD 2022年第2期147-166,共20页
Discrete element calculations of the top-coal drawing process for diferent gangue-coal density ratios were conducted to investigate the efect of the gangue-coal density ratio on the drawing mechanism in longwall top-c... Discrete element calculations of the top-coal drawing process for diferent gangue-coal density ratios were conducted to investigate the efect of the gangue-coal density ratio on the drawing mechanism in longwall top-coal caving.The efects were analyzed for the drawing body,the top-coal boundary,and the recovery of top coal.The results show that for increasing density ratio,the initial drawing body on the goaf side is farther away from the drawing support and its width and volume gradually increase.The upper part of the sickle-shaped drawing body extends near the initial drawing body with increasing density ratio in the normal cycling stage,and the distance from the drawing body to the initial drawing body is its maximum width.The larger the density ratio,the smaller the height of the top coal above the goaf at the end of the initial drawing process.The height of the top-coal boundary decreases with increasing density ratio,until it reaches a limit.In a normal cycle,due to hysteretic development,the top-coal boundary moves toward the goaf until the density ratio is approximately 2.0,which is consistent with the physical experiment results.Finally,increasing the advance length of the working face is benefcial for increasing the overall recovery of top coal. 展开更多
关键词 Longwall top-coal caving Gangue-coal density ratio Drawing body Top-coal boundary Recovery of top coal
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Three-dimensional experimental study of loose top-coal drawing law for longwall top-coal caving mining technology 被引量:13
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作者 Jiachen Wang Jinwang Zhang +1 位作者 zhengyang song Zhaolong Li 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2015年第3期318-326,共9页
Based on the loose medium flow field theory, the loose top-coal drawing law of longwall top-coal caving(LTCC) mining technology is studied by using self-developed three-dimensional(3D) test device. The loose top-c... Based on the loose medium flow field theory, the loose top-coal drawing law of longwall top-coal caving(LTCC) mining technology is studied by using self-developed three-dimensional(3D) test device. The loose top-coal drawing test with shields and the controlled test without shields are performed in the condition without any boundary effect. Test results show that shields will cause reduction in drawing volume of coal in the LTCC mining. The deflection phenomenon of drawing body is also observed in the controlled test, which is verified that the deflection of drawing body is caused by shield. It is found that the deflection angle decreases with increasing caving height, with the maximum value of atailand the minimum value of 0. In addition, the formula to calculate the drawing volume is proposed subsequently.The deflection of drawing body is numerically simulated using particle flow code PFC3 Dand the proposed formula to calculate drawing volume in LTCC is also verified. 展开更多
关键词 Longwall top-coal caving(LTCC) Caving shield Three-dimensional(3D) physical model test Deflection of drawing body PFC3D
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Effect of heterogeneity on mechanical and micro-seismic behaviors of sandstone subjected to multi-level cyclic loading: A discrete element method investigation
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作者 zhengyang song Zhen Yang +3 位作者 Min Zhang Fei Wang Martin Herbst Heinz Konietzky 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第10期2556-2581,共26页
In numerical simulation of the mechanical responses and acoustic emission(AE)characteristics of rocks under cyclic loading,the impacts of compositional heterogeneities of mineral grains have barely been considered.Thi... In numerical simulation of the mechanical responses and acoustic emission(AE)characteristics of rocks under cyclic loading,the impacts of compositional heterogeneities of mineral grains have barely been considered.This will lead to a poor reproduction of rock’s behaviors in terms of stress-strain relationship and micro-seismic characteristics in numerical simulation.This work aims to analyze and reveal the impact of parameter heterogeneity on the rock’s fatigue and micro-seismic properties based on PFC3D.Two distribution patterns(uniform and Weibull distributions),are implemented to assign four critical parameters(i.e.tensile strength,cohesion,parallel bond stiffness and linear stiffness)for 32 sets of numerical schemes.The results show that the models with high heterogeneity of tensile strength and cohesion can better reproduce the stress-strain relationship as well as the patterns of cumulative AE counts and energy magnitude.The evolution of the proportion of three-level AE events in the laboratory test is consistent with the numerical results when the highly heterogeneous tensile strength and cohesion are distributed.The numerical results can provide practical guidance to the PFC-based modeling of rock heterogeneity when exposed to multi-level cyclic loading and AE monitoring. 展开更多
关键词 Discrete element method(DEM) HETEROGENEITY Weibull distribution PFC3D Cyclic loading Acoustic emission(AE)
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Mechanical responses and acoustic emission behaviors of coal under compressive differential cyclic loading(DCL):a numerical study via 3D heterogeneous particle model
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作者 zhengyang song Yunfeng Wu +2 位作者 Yong Zhang Yi Yang Zhen Yang 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第3期136-154,共19页
The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acous... The stability of coal walls(pillars)can be seriously undermined by diverse in-situ dynamic disturbances.Based on a 3D par-ticle model,this work strives to numerically replicate the major mechanical responses and acoustic emission(AE)behaviors of coal samples under multi-stage compressive cyclic loading with different loading and unloading rates,which is termed differential cyclic loading(DCL).A Weibull-distribution-based model with heterogeneous bond strengths is constructed by both considering the stress-strain relations and AE parameters.Six previously loaded samples were respectively grouped to indicate two DCL regimes,the damage mechanisms for the two groups are explicitly characterized via the time-stress-dependent variation of bond size multiplier,and it is found the two regimes correlate with distinct damage patterns,which involves the competition between stiffness hardening and softening.The numerical b-value is calculated based on the mag-nitudes of AE energy,the results show that both stress level and bond radius multiplier can impact the numerical b-value.The proposed numerical model succeeds in replicating the stress-strain relations of lab data as well as the elastic-after effect in DCL tests.The effect of damping on energy dissipation and phase shift in numerical model is summarized. 展开更多
关键词 Differential cyclic loading(DCL) Particle model Acoustic emission(AE) Discrete element method(DEM)Damage mechanism
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Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking
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作者 Junyu Liu zhengyang song +12 位作者 Haihong Chen Wen Zeng Guirong Han Wei Li Bing Xu Yuan Lu Canyang Zhang Zhenglian Xue Bin Lü Chong Zhang song Yang Yi Wang Xinhui Xing 《Food Science and Human Wellness》 2025年第2期450-468,共19页
Pu-erh tea,a traditional Chinese beverage,performs an anti-obesity function,but the correlation between its components and efficacy remains unknown.Here,we screened two Pu-erh teas with significant anti-obesity effica... Pu-erh tea,a traditional Chinese beverage,performs an anti-obesity function,but the correlation between its components and efficacy remains unknown.Here,we screened two Pu-erh teas with significant anti-obesity efficacies from 11 teas.In vitro experiments revealed that lipid accumulation in L02 cells and lipid synthesis in 3T3-L1 cells were significantly better inhibited by Tea-B than Tea-A.Further in vivo experiments using model mice revealed that the differences in chemical components generated two pathways in the anti-obesity efficacy and mechanism of Pu-erh teas.Tea-A changes the histomorphology of brown adipose tissue(BAT)and increases the abundance of Coriobacteriaceae_UCG_002 and cyclic AMP in guts through high chemical contents of cyclopentasiloxane,decamethyl,tridecane and 1,2,3-trimethoxybenzene,eventually increasing BAT activation and fat browning gene expression;the high content of hexadecane and 1,2-dimethoxybenzene in Tea-B reduces white adipose tissue(WAT)accumulation and the process of fatty liver,increases the abundance of Odoribacter and sphinganine 1-phosphate,inhibits the expression of lipid synthesis and transport genes.These mechanistic findings on the association of the representative bioactive components in Pu-erh teas with the anti-obesity phenotypes,gut microbes,gut metabolite structure and anti-obesity pathways,which were obtained for the first time,provide foundations for developing functional Pu-erh tea. 展开更多
关键词 Anti-obesity Bioactive components Lipid metabolism Multiomics analysis Pu-erh tea
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