BACKGROUND Gastric glomus tumor(GGT)is rare submucosal mesenchymal tumor that lacks specific clinical manifestations and is usually treated mainly by traditional surgical resection.This paper presents a case of a GGT,...BACKGROUND Gastric glomus tumor(GGT)is rare submucosal mesenchymal tumor that lacks specific clinical manifestations and is usually treated mainly by traditional surgical resection.This paper presents a case of a GGT,exhibited both intraluminally and extraluminally growth that was removed by laparoscopy-gastroscopy cooperative surgery.CASE SUMMARY A 52-year-old male presented with epigastric discomfort accompanied by a sense of fullness for 3 mo.Upper gastrointestinal endoscopy identified a submucosal lump located in the gastric antrum.Endoscopic ultrasonography identified a 2.4 cm×1.8 cm lump located in the gastric antrum.It originated from the muscularis propria and exhibited both intraluminally and extraluminally growth,with hypoechoicity on the periphery,hyperechoicity in the middle,and unclear boundaries.Computed tomography showed nodular thickening of 3.0 cm×2.2 cm in the gastric wall of the gastric antrum,and after enhancement,the lesion exhibited obvious enhancement We suspected that it was a gastrointestinal stromal tumor(glomus tumor and schwannoma were not excluded)and planned to perform laparoscopy-gastroscopy cooperative surgery.Immunohistochemical staining after the operation revealed that spinal muscular atrophy(+),hcaldesmon(+),cluster of differentiation 34(CD34)(+),2%Ki-67-positive rate,CD56,melanoma antigen,CD117,discovered on GIST-1,leukocyte common antigen,caudal type homeobox 2,cytokeratin,and S-100 were all negative.The tumor was finally diagnosed as a GGT.CONCLUSION GGTs are rare submucosal tumors of the stomach and should be considered in the differential diagnosis of gastric submucosal tumors.Laparoscopy-gastroscopy cooperative surgery is less invasive and more precise and could be an effective method for the treatment of GGTs.展开更多
Terahertz(THz)waves show great potential in nondestructive testing,biodetection and cancer imaging.Despite recent progress in THz wave near-field probes/apertures enabling raster scanning of an object’s surface,an ef...Terahertz(THz)waves show great potential in nondestructive testing,biodetection and cancer imaging.Despite recent progress in THz wave near-field probes/apertures enabling raster scanning of an object’s surface,an efficient,nonscanning,noninvasive,deep subdiffraction imaging technique remains challenging.Here,we demonstrate THz near-field microscopy using a reconfigurable spintronic THz emitter array(STEA)based on the computational ghost imaging principle.By illuminating an object with the reconfigurable STEA followed by computing the correlation,we can reconstruct an image of the object with deep subdiffraction resolution.By applying an external magnetic field,inline polarization rotation of the THz wave is realized,making the fused image contrast polarization-free.Time-of-flight(TOF)measurements of coherent THz pulses further enable objects at different distances or depths to be resolved.The demonstrated ghost spintronic THz-emitter-array microscope(GHOSTEAM)is a radically novel imaging tool for THz near-field imaging,opening paradigm-shifting opportunities for nonintrusive label-free bioimaging in a broadband frequency range from 0.1 to 30 THz(namely,3.3-1000 cm^(−1)).展开更多
There is still a lack of high-performance terahertz(THz) modulators with wide operation bandwidth and large modulation depth due to the underlying physics limitation behind existing approaches. Meanwhile, for many app...There is still a lack of high-performance terahertz(THz) modulators with wide operation bandwidth and large modulation depth due to the underlying physics limitation behind existing approaches. Meanwhile, for many applications, simple compact THz modulators working straightforward in the transmission mode are also highly desired. Here, we demonstrate a THz modulator with a maximal transmission-amplitude modulation depth of 99.9%(switching ratio of 1000) based on a commonly used silica-on-silicon structure. Different from those reported graphene or metamaterials enhanced proposals, the device we proposed works within a reversible avalanche breakdown region of silicon that has not been studied yet and has the potential to modulate/switch THz waves efficiently. Further, we proved that the modulation depth exceeds 97% in the frequency range from 0.2 to 1 THz in the experiment. The simplicity and generality of this new type of near-perfect THz modulator will undoubtedly attract lots of attention of researchers in the near future due to its potential to be engineered into integrated devices.展开更多
基金Key Program of Shandong Provincial Natural Science Foundation,No.ZR2020KE018The Project of Shandong Province Higher Educational Science and Technology Program,No.J17KA253+1 种基金The Medical Science and Technology Development Project of Shandong,No.2018WS062Weifang Science and Technology Development Plan,No.2020YX040.
文摘BACKGROUND Gastric glomus tumor(GGT)is rare submucosal mesenchymal tumor that lacks specific clinical manifestations and is usually treated mainly by traditional surgical resection.This paper presents a case of a GGT,exhibited both intraluminally and extraluminally growth that was removed by laparoscopy-gastroscopy cooperative surgery.CASE SUMMARY A 52-year-old male presented with epigastric discomfort accompanied by a sense of fullness for 3 mo.Upper gastrointestinal endoscopy identified a submucosal lump located in the gastric antrum.Endoscopic ultrasonography identified a 2.4 cm×1.8 cm lump located in the gastric antrum.It originated from the muscularis propria and exhibited both intraluminally and extraluminally growth,with hypoechoicity on the periphery,hyperechoicity in the middle,and unclear boundaries.Computed tomography showed nodular thickening of 3.0 cm×2.2 cm in the gastric wall of the gastric antrum,and after enhancement,the lesion exhibited obvious enhancement We suspected that it was a gastrointestinal stromal tumor(glomus tumor and schwannoma were not excluded)and planned to perform laparoscopy-gastroscopy cooperative surgery.Immunohistochemical staining after the operation revealed that spinal muscular atrophy(+),hcaldesmon(+),cluster of differentiation 34(CD34)(+),2%Ki-67-positive rate,CD56,melanoma antigen,CD117,discovered on GIST-1,leukocyte common antigen,caudal type homeobox 2,cytokeratin,and S-100 were all negative.The tumor was finally diagnosed as a GGT.CONCLUSION GGTs are rare submucosal tumors of the stomach and should be considered in the differential diagnosis of gastric submucosal tumors.Laparoscopy-gastroscopy cooperative surgery is less invasive and more precise and could be an effective method for the treatment of GGTs.
基金supported by the National Key Research and Development Program(No.2017YFC1200400)the Science Challenge Project(No.TZ2018003)+2 种基金the Distinguished Young Scholars of Sichuan Province(No.2020JDJQ0008)the National Natural Science Foundation of China(NSFC)(Nos.U1730246 and 11704358)the Foundation of President of China Academy of Engineering Physics(No.201501033).
文摘Terahertz(THz)waves show great potential in nondestructive testing,biodetection and cancer imaging.Despite recent progress in THz wave near-field probes/apertures enabling raster scanning of an object’s surface,an efficient,nonscanning,noninvasive,deep subdiffraction imaging technique remains challenging.Here,we demonstrate THz near-field microscopy using a reconfigurable spintronic THz emitter array(STEA)based on the computational ghost imaging principle.By illuminating an object with the reconfigurable STEA followed by computing the correlation,we can reconstruct an image of the object with deep subdiffraction resolution.By applying an external magnetic field,inline polarization rotation of the THz wave is realized,making the fused image contrast polarization-free.Time-of-flight(TOF)measurements of coherent THz pulses further enable objects at different distances or depths to be resolved.The demonstrated ghost spintronic THz-emitter-array microscope(GHOSTEAM)is a radically novel imaging tool for THz near-field imaging,opening paradigm-shifting opportunities for nonintrusive label-free bioimaging in a broadband frequency range from 0.1 to 30 THz(namely,3.3-1000 cm^(−1)).
基金National Key Research and Development Program of China (2017YFC1200400)Distinguished Young Scholars of Sichuan Province (2020JDJQ0008)+1 种基金Foundation of President of China Academy of Engineering Physics(YZJJLX2018001)National Natural Science Foundation of China (11604316, 11704358, 61427814, 61771327,U1730138, U1730246, U1930123)。
文摘There is still a lack of high-performance terahertz(THz) modulators with wide operation bandwidth and large modulation depth due to the underlying physics limitation behind existing approaches. Meanwhile, for many applications, simple compact THz modulators working straightforward in the transmission mode are also highly desired. Here, we demonstrate a THz modulator with a maximal transmission-amplitude modulation depth of 99.9%(switching ratio of 1000) based on a commonly used silica-on-silicon structure. Different from those reported graphene or metamaterials enhanced proposals, the device we proposed works within a reversible avalanche breakdown region of silicon that has not been studied yet and has the potential to modulate/switch THz waves efficiently. Further, we proved that the modulation depth exceeds 97% in the frequency range from 0.2 to 1 THz in the experiment. The simplicity and generality of this new type of near-perfect THz modulator will undoubtedly attract lots of attention of researchers in the near future due to its potential to be engineered into integrated devices.
