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发酵棕榈粕对白羽肉鸡生长性能、抗氧化及免疫的影响 被引量:3
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作者 徐智鹏 周迪 +5 位作者 董毅 袁婧 左晓璇 黄鑫 张彦 覃先武 《中国饲料》 北大核心 2023年第13期167-171,共5页
为研究发酵棕榈粕的饲用价值,本试验评估了5种水平(0、1%、3%、5%、5%+100 mg/kg甘露聚糖酶)发酵棕榈粕对肉鸡生长性能、血清生化、抗氧化及免疫的影响。结果表明:发酵棕榈粕添加水平1%和3%时,肉鸡的日增重和采食量与对照组无显著差异(P... 为研究发酵棕榈粕的饲用价值,本试验评估了5种水平(0、1%、3%、5%、5%+100 mg/kg甘露聚糖酶)发酵棕榈粕对肉鸡生长性能、血清生化、抗氧化及免疫的影响。结果表明:发酵棕榈粕添加水平1%和3%时,肉鸡的日增重和采食量与对照组无显著差异(P>0.05);发酵棕榈粕添加量5%时,肉鸡的日增重、采食量相比对照组显著降低(P<0.05),但5%发酵棕榈粕+100 mg/kg甘露聚糖酶时,其日增重、采食量与对照组无明显变化;随发酵棕榈粕添加水平的提高,抗氧化指标超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)呈现线性增加(P<0.05),免疫指标IgG和IgA呈现线性增加(P<0.05)。综上所述,日粮中发酵棕榈粕添加3%时对肉鸡日增重、采食量无明显影响,发酵棕榈粕添加水平的提高,可以提高肉鸡的抗氧化和免疫力,且添加甘露聚糖酶可以提高发酵棕榈粕的添加量。 展开更多
关键词 发酵棕榈粕 肉鸡 甘露聚糖酶 生长性能 免疫
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广谱抗生素对CT26荷瘤小鼠氟尿嘧啶化疗疗效的影响
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作者 吴艳红 张治港 +4 位作者 徐爱萍 朱涛 刘辉 左小炫 唐晓磊 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2021年第12期934-943,共10页
目的研究结直肠癌荷瘤小鼠中广谱抗生素的使用及其诱导的抗生素耐药菌对氟尿嘧啶(5-fluorouracil,5-FU)化疗疗效的影响及其中的抗肿瘤免疫相关机制。方法结直肠癌细胞CT26皮下荷瘤小鼠随机分成4组:荷瘤对照组,氨苄青霉素、链霉素和多黏... 目的研究结直肠癌荷瘤小鼠中广谱抗生素的使用及其诱导的抗生素耐药菌对氟尿嘧啶(5-fluorouracil,5-FU)化疗疗效的影响及其中的抗肿瘤免疫相关机制。方法结直肠癌细胞CT26皮下荷瘤小鼠随机分成4组:荷瘤对照组,氨苄青霉素、链霉素和多黏菌素处理的抗生素组,5-FU化疗组和抗生素^(+)5-FU组。监测记录小鼠肿瘤体积、体重。末次化疗后第7天,流式细胞术检测脾脏中免疫细胞亚群比例和与CT26共培养后增殖的CD8^(+)T细胞比例;16S rRNA测序分析肠道菌群组成,并分离培养各组小鼠肠系膜淋巴结中的细菌。用分离的细菌刺激骨髓来源的巨噬细胞,定量PCR法检测M1型和M2型巨噬细胞标志分子的表达,流式细胞术检测与细菌处理的巨噬细胞进行共培养的CD8^(+)T细胞的增殖。将分离自抗生素^(+)5-FU组的细菌和等体积PBS分别灌胃至进行5-FU化疗的CT26荷瘤小鼠,检测小鼠肿瘤大小、肠道菌群组成和与CT26共培养后增殖的CD8^(+)T细胞比例。结果抗生素^(+)5-FU组小鼠的肿瘤体积大于5-FU组,小鼠体重显著低于5-FU组。抗生素的使用对脾脏CD4^(+)T细胞、CD8^(+)T细胞、中性粒细胞的比例影响不显著,但促进单核细胞比例升高;抗生素^(+)5-FU组体外增殖的肿瘤特异性CD8^(+)T细胞比例下降,低于5-FU组。与对照组和5-FU组比较,抗生素的使用导致肠道菌群组成发生变化,菌群α多样性指数明显降低;从抗生素组、5-FU组和抗生素^(+)5-FU组小鼠的淋巴结中分别培养出大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌。奇异变形杆菌处理的骨髓来源的巨噬细胞显著表达M2型巨噬细胞标志分子精氨酸酶,且与该组巨噬细胞共培养后增殖的CD8^(+)T细胞比例下降。奇异变形杆菌灌胃后小鼠肠道菌群中有变形杆菌属细菌富集,对肿瘤生长没有明显影响,但体外增殖的肿瘤特异性CD8^(+)T细胞比例下降。结论广谱抗生素抑制化疗疗效及肿瘤特异性CD8^(+)T细胞的增殖,抗生素耐药菌可能在其中发挥作用。 展开更多
关键词 肿瘤化疗 抗生素 CD8+T细胞 巨噬细胞 肠道菌群
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Planning,Investment,Construction and Operation of Rail Transit in Beijing 被引量:1
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作者 LIU Jian zuo xiaoxuan 《China City Planning Review》 2012年第2期29-39,共11页
In Beijing, the rail transit firstly came into existence in the mid 1960s and was officially put into operation for civil use in the early 1980s. It has entered a period of rapid development since 2001, with thanks to... In Beijing, the rail transit firstly came into existence in the mid 1960s and was officially put into operation for civil use in the early 1980s. It has entered a period of rapid development since 2001, with thanks to the coming of the Olympic Games in 2008, and has been playing a more and more important role in the passenger transport of Beijing since then on, as a key part of the public transportation. Based on a resume on the evolution of rail transit development in Beijing, this paper analyzes the mechanism of policy-making, the mode of investment and financing, the procedure of construction, and the management of operation of rail transit, all of which ensure its rapid development and effective performance. 展开更多
关键词 BEIJING RAIL TRANSIT development DECISION-MAKING
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Analysis on Beijing's Policy of Restricting Motor Vehicle Usage
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作者 LIU Jian zuo xiaoxuan 《China City Planning Review》 2012年第4期48-55,共8页
Along with the increase of car ownership,the problem of traffic congestion has appeared more and more serious since the 1990s in Beijing.In order to deal with the problem of traffic congestion,the policy of restrictin... Along with the increase of car ownership,the problem of traffic congestion has appeared more and more serious since the 1990s in Beijing.In order to deal with the problem of traffic congestion,the policy of restricting motor vehicle usage,as a measure of transportation demand management by decreasing the total number of on-road motor vehicles,was firstly implemented in 2006 in trial,which continued from 2008 during the period of Olympic Games up to day.Starting with an analysis on policy motivation,this paper describes the practices of restricting motor vehicle usage in Beijing since 2006,analyzes the effects on the performance of the city's transportation,and concludes after a comparative analysis that,in spite of the positive effects on relieving the traffic congestion,the policy of restricting motor vehicle usage could only constitute a temporary measure of traffic demand management,rather than a fundamental one,because the comprehensive effects would decrease along with the continuous growth of motor vehicle possession. 展开更多
关键词 BEIJING transportation demand management measure of restricting motor vehicle usage
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