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忧遁草提取物对代谢相关性脂肪肝病的作用探究
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作者 孟林红 曾雨竹 +4 位作者 冯植琳 吴一凡 殷杰 丁文文 屈小芹 《湖北医药学院学报》 2025年第2期139-143,F0003,共6页
目的:探究忧遁草提取物对代谢相关性脂肪性肝病(metabolically associated fatty liver disease, MAFLD)小鼠的治疗作用。方法:将40只昆明小鼠随机分为对照组、模型组、忧遁草低剂量组(500 mg/kg)、忧遁草高剂量组(1 g/kg),对照组以普... 目的:探究忧遁草提取物对代谢相关性脂肪性肝病(metabolically associated fatty liver disease, MAFLD)小鼠的治疗作用。方法:将40只昆明小鼠随机分为对照组、模型组、忧遁草低剂量组(500 mg/kg)、忧遁草高剂量组(1 g/kg),对照组以普通饲料喂养,其余各组以高脂饲料喂养。喂养12周后每天灌胃给予等量0.9%氯化钠溶液或忧遁草提取物1次。连续给药2周后检测小鼠血清,采用油红O染色法观察分析肝脏组织的病理变化特征。结果:与对照组相比,模型组经过12周高脂饲料喂养后,油红O染色显示肝脏组织中大量脂质沉积,血清中ALT、AST、TG、TC、MPO及肝脏组织中LDL-C、MDA水平显著升高(P<0.05),肝脏组织中HDL-C及血清中SOD水平显著下降(P<0.05)。经过忧遁草提取物干预后,与模型组相比,忧遁草组小鼠肝脏脂质沉着明显减轻,AST、ALT、TG、TC、LDL-C、MPO和MDA均显著降低(P<0.05),HDL-C和SOD水平显著增加(P<0.05)。结论:忧遁草提取物对代谢相关性脂肪肝病具有潜在治疗作用。 展开更多
关键词 忧遁草提取物 代谢相关性脂肪肝病 脂质代谢
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A zero-voltage zero-current soft switching DC/DC converter
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作者 WANG Zheng-shi LOU Zhen-li +1 位作者 zeng yu-zhu ZHANG Zhong-chao 《Frontiers of Electrical and Electronic Engineering in China》 CSCD 2006年第4期385-389,共5页
A novel three-level zero-voltage zero-current switching(ZVZCS)DC/DC converter is proposed in this paper.A tapped-inductor is used to replace the normal out-put filter inductor,so that the circulating current in the ze... A novel three-level zero-voltage zero-current switching(ZVZCS)DC/DC converter is proposed in this paper.A tapped-inductor is used to replace the normal out-put filter inductor,so that the circulating current in the zero-state can be reset to zero.The reset voltage and the re-set time can be set conveniently just by simply changing the winding ratio of the tapped inductor.The converter achieves a zero-current tuning off for inner switching,and a zero-voltage tuning on for outer switching.No circulating current exists in the zero state,so that the loss in the on-state is reduced,and the efficiency can be improved.The experimental results verify that the ZVZCS has low voltage stress,zero-voltage and zero-current switching. 展开更多
关键词 three-level DC/DC converter tapped inductor SOFT-SWITCHING
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