Demand response transactions between electric consumers,load aggregators,and the distribution network manager based on the"combination of price and incentive"are feasible and efficient.However,the incentive ...Demand response transactions between electric consumers,load aggregators,and the distribution network manager based on the"combination of price and incentive"are feasible and efficient.However,the incentive payment of demand re-sponse is quantified based on private information,which gives the electric consumers and load aggregators the possibility of defrauding illegitimate interests by declaring false information.This paper proposes a method based on Vickrey-Clark-Groves(VCG)theory to prevent electric consumers and load aggregators from taking illegitimate interests through deceptive behaviors in the demand response transactions.Firstly,a demand response transaction framework with the price-and-incentive com-bined mode is established to illustrate the deceptive behaviors in the demand response transactions.Then,the idea for eradi-cating deceptive behaviors based on VCG theory is given,and a detailed VCG-based mathematical model is constructed follow-ing the demand response transaction framework.Further,the proofs of incentive compatibility,individual rationality,cost minimization,and budget balance of the proposed VCG-based method are given.Finally,a modified IEEE 33-node system and a modified IEEE 123-node system are used to illustrate and validate the proposed method.展开更多
Objective:This study aims to evaluate the surgical morbidity and obstetric outcomes following in-pregnancy or pre-pregnancy laparoscopic abdominal cerclage(LAC)for patients who were diagnosed with refractory cervical ...Objective:This study aims to evaluate the surgical morbidity and obstetric outcomes following in-pregnancy or pre-pregnancy laparoscopic abdominal cerclage(LAC)for patients who were diagnosed with refractory cervical insufficiency or had a short cervix.Methods:A retrospective study was conducted on patients undergoing LAC between May 2017 and May 2019 at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital.The patients were diagnosed with refractory cervical insufficiency based upon a previous failed transvaginal cervical cerclage(TVC),or had a short cervix who were considered unsuitable for a TVC after a previous cervical procedure.All patients were followed-up after surgery with transperineal ultrasonography until May 2020.Subsequently,surgical and obstetric data were collected and analyzed.Results:In total,44 patients underwent LAC,with 8 patients in-pregnancy and 36 pre-pregnancy.For the patient with pre-pregancy LAC,the pregnancy rate was 80.6%(29/36),including 3 patients with first-trimester loss,1 patient with an ectopic pregnancy,and 25 patients with a delivery.For the remaining 7 patients,3 did not conceive,and another 4 had no pregnancy plans.All the patients with in-pregnancy LAC had a delivery.The“take-home baby”rate was 89.2%(33/37),with a live-birth rate of 100%and a neonatal survival rate of 100%for both patients with in-pregnancy and pre-pregnancy LAC.For patients with in-pregnancy LAC,75.0%(6/8)patients delivered at≥37 wk of gestation,12.5%(1/8)delivered between 34 and 36^(+6)wk,and 12.5%(1/8)delivered between 28 and 33^(+6)wk.For patients with pre-pregnancy LAC,80.0%(20/25)patients delivered at≥37 wk of gestation,16.0%(4/25)delivered between 34 and 36^(+6)wk,and 4.0%(1/25)delivered between 28 and 33^(+6)wk.No adverse-event intra-operative or post-operative sequelae were noted.Conclusions:LAC is an effective and safe procedure that results in remarkable obstetric outcomes for women with refractory cervical insufficiency,or with a short cervix who are considered unsuitable for a TVC.The success rate of in-pregnancy or pre-pregnancy LAC depends on a full evaluation of patients,a proper peri-operative management and close follow-up.展开更多
The corrosion susceptibility of magnesium(Mg)alloys presents a significant challenge for their broad application.Although there have been extensive experimental and theoretical investigations,the corrosion mechanisms ...The corrosion susceptibility of magnesium(Mg)alloys presents a significant challenge for their broad application.Although there have been extensive experimental and theoretical investigations,the corrosion mechanisms of Mg alloys are still unclear,especially the anodic dissolution process.Here,a thorough theoretical investigation based on ab initio molecular dynamics and metadynamics simulations has been conducted to clarify the underlying corrosion mechanism of Mg anode and propose effective strategies for enhancing corrosion resistance.Through comprehensive analyses of interfacial structures and equilibrium potentials for Mg(0001)/H_(2)O interface models with different water thicknesses,the Mg(0001)/72 H_(2)O model is identified to be reasonable with−2.17 V vs.standard hydrogen electrode equi-librium potential.In addition,utilizing metadynamics,the free energy barrier for Mg dissolution is calculated to be 0.835 eV,enabling the theoretical determination of anodic polarization curves for pure Mg that aligns well with experimental data.Based on the Mg(0001)/72 H_(2)O model,we further explore the effects of various alloying elements on anodic corrosion resistance,among which Al and Mn alloying elements are found to enhance corrosion resistance of Mg.This study provides valuable atomic-scale insights into the corrosion mechanism of magnesium alloys,offering theoretical guidance for developing novel corrosion-resistant Mg alloys.展开更多
Minimally invasive surgery,including laparoscopic and thoracoscopic procedures,benefits patients in terms of improved postoperative outcomes and short recovery time.The challenges in hand–eye coordination and manipul...Minimally invasive surgery,including laparoscopic and thoracoscopic procedures,benefits patients in terms of improved postoperative outcomes and short recovery time.The challenges in hand–eye coordination and manipulation dexterity during the aforementioned procedures have inspired an enormous wave of developments on surgical robotic systems to assist keyhole and endoscopic procedures in the past decades.This paper presents a systematic review of the state-of-the-art systems,picturing a detailed landscape of the system configurations,actuation schemes,and control approaches of the existing surgical robotic systems for keyhole and endoscopic procedures.The development challenges and future perspectives are discussed in depth to point out the need for new enabling technologies and inspire future researches.展开更多
Lithium(Li)metal is regarded as the best anode material for lithium metal batteries(LMBs)due to its high theoretical specific capacity and low redox potential.However,the notorious dendrites growth and extreme instabi...Lithium(Li)metal is regarded as the best anode material for lithium metal batteries(LMBs)due to its high theoretical specific capacity and low redox potential.However,the notorious dendrites growth and extreme instability of the solid electrolyte interphase(SEI)layers have severely retarded the commercialization process of LMBs.Herein,a double-layered polymer/alloy composite artificial SEI composed of a robust poly(1,3-dioxolane)(PDOL)protective layer,Sn and LiCl nanoparticles,denoted as PDOL@Sn-LiCl,is fabricated by the combination of in-situ substitution and polymerization processes on the surface of Li metal anode.The lithiophilic Sn-LiCl multiphase can supply plenty of Li-ion transport channels,contributing to the homogeneous nucleation and dense accumulation of Li metal.The mechanically tough PDOL layer can maintain the stability and compact structure of the inorganic layer in the long-term cycling,and suppress the volume fluctuation and dendrites formation of the Li metal anode.As a result,the symmetrical cell under the double-layered artificial SEI protection shows excellent cycling stability of 300 h at 5.0 mA·cm^(−2)for 1 mAh·cm^(−2).Notably,the Li||LiFePO_(4)full cell also exhibits enhanced capacity retention of 150.1 mAh·g^(−1)after 600 cycles at 1.0 C.Additionally,the protected Li foil can effectively resist the air and water corrosion,signifying the safe operation of Li metal in practical applications.This present finding proposed a different tactic to achieve safe and dendrite-free Li metal anodes with excellent cycling stability.展开更多
A Chinese Compilation of Physical Activities was compiled to estimate the energy costs of physical activities(PAs)using data on adults aged 18–64.Data were obtained from published articles and laboratory measurements...A Chinese Compilation of Physical Activities was compiled to estimate the energy costs of physical activities(PAs)using data on adults aged 18–64.Data were obtained from published articles and laboratory measurements.Databases,including PubMed,Embase,Scopus,Ebsco,Web of Science,Chinese National Knowledge Infrastructure,Wan Fang Data,National Science and Technology Report Service,Public Health Scientific Data were searched to collect data from inception to January 2022,on energy expenditure associated with PA in the healthy Chinese population.Two reviewers independently screened the literature and extracted,classified,and summarized data.Data were measured for 36 PAs using indirect calorimetry.Detailed descriptions of specific activities and metabolic equivalent values were provided by summarizing 241 physical activities in 13 categories.The first edition of the Chinese Compilation of PAs in Healthy Adults Aged 18–64(CCPA)was created.It provides valuable resources for people who regularly engage in physical exercise,researchers,educators,fitness professionals,and health or commercial sectors to quickly obtain various PA MET intensities.In the future,the energy expenditure of various PAs of different ages within the Chinese population can be measured based on the CCPA.展开更多
The biochemical consequences induced by xenobiotic stress are featured in dose-response and timeresolved landscapes.Understanding the dynamic process of cellular adaptations is crucial in conducting the risk assessmen...The biochemical consequences induced by xenobiotic stress are featured in dose-response and timeresolved landscapes.Understanding the dynamic process of cellular adaptations is crucial in conducting the risk assessment for chemical exposure.As one of the most phenotype-related omics,metabolome in response to environmental stress can vary from seconds to days.Up to now,very few dynamic metabolomics studies have been conducted to provide time-dependent mechanistic interpretations in understanding xenobiotics-induced cellular adaptations.This study aims to explore the time-resolved metabolite dysregulation manner and dynamically perturbed biological functions in MCF-7 cells exposed to bisphenol A(BPA),a well-known endocrine-disrupting chemical.By sampling at 11 time points from several minutes to hours,thirty seven significantly dysregulated metabolites were identified,ranging from amino acids,fatty acids,carboxylic acids and nucleoside phosphate compounds.The metabolites in different pathways basically showed distinct time-resolved changing patterns,while those within the common class or same pathways showed similar and synchronized dysregulation behaviors.The pathway enrichment analysis suggested that purine metabolism,pyrimidine metabolism,aminoacyl-tRNA biosynthesis as well as glutamine/glutamate(GABA)metabolism pathways were heavily disturbed.As exposure event continued,MCF-7 cells went through multiple sequential metabolic adaptations from cell proliferation to energy metabolism,which indicated an enhancing cellular requirement for elevated energy homeostasis,oxidative stress response and ER-αmediated cell growth.We further focused on the time-dependent metabolite dysregulation behavior in purine and pyrimidine metabolism,and identified the impaired glycolysis and oxidative phosphorylation by redox imbalance.Lastly,we established a restricted cubic splinebased model to fit and predict metabolite’s full range dysregulation cartography,with metabolite’sensitivity comparisons retrieved and novel biomarkers suggested.Overall,the results indicated that 8 h BPA exposure leaded to global dynamic metabolome adaptions including amino acid,nucleoside and sugar metabolism disorders,and the dysregulated metabolites with interfered pathways at different stages are of significant temporal distinctions.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(No.B230201048).
文摘Demand response transactions between electric consumers,load aggregators,and the distribution network manager based on the"combination of price and incentive"are feasible and efficient.However,the incentive payment of demand re-sponse is quantified based on private information,which gives the electric consumers and load aggregators the possibility of defrauding illegitimate interests by declaring false information.This paper proposes a method based on Vickrey-Clark-Groves(VCG)theory to prevent electric consumers and load aggregators from taking illegitimate interests through deceptive behaviors in the demand response transactions.Firstly,a demand response transaction framework with the price-and-incentive com-bined mode is established to illustrate the deceptive behaviors in the demand response transactions.Then,the idea for eradi-cating deceptive behaviors based on VCG theory is given,and a detailed VCG-based mathematical model is constructed follow-ing the demand response transaction framework.Further,the proofs of incentive compatibility,individual rationality,cost minimization,and budget balance of the proposed VCG-based method are given.Finally,a modified IEEE 33-node system and a modified IEEE 123-node system are used to illustrate and validate the proposed method.
基金supported by the Natural Science Foundation of Zhejiang Province(LGF20H180013).
文摘Objective:This study aims to evaluate the surgical morbidity and obstetric outcomes following in-pregnancy or pre-pregnancy laparoscopic abdominal cerclage(LAC)for patients who were diagnosed with refractory cervical insufficiency or had a short cervix.Methods:A retrospective study was conducted on patients undergoing LAC between May 2017 and May 2019 at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital.The patients were diagnosed with refractory cervical insufficiency based upon a previous failed transvaginal cervical cerclage(TVC),or had a short cervix who were considered unsuitable for a TVC after a previous cervical procedure.All patients were followed-up after surgery with transperineal ultrasonography until May 2020.Subsequently,surgical and obstetric data were collected and analyzed.Results:In total,44 patients underwent LAC,with 8 patients in-pregnancy and 36 pre-pregnancy.For the patient with pre-pregancy LAC,the pregnancy rate was 80.6%(29/36),including 3 patients with first-trimester loss,1 patient with an ectopic pregnancy,and 25 patients with a delivery.For the remaining 7 patients,3 did not conceive,and another 4 had no pregnancy plans.All the patients with in-pregnancy LAC had a delivery.The“take-home baby”rate was 89.2%(33/37),with a live-birth rate of 100%and a neonatal survival rate of 100%for both patients with in-pregnancy and pre-pregnancy LAC.For patients with in-pregnancy LAC,75.0%(6/8)patients delivered at≥37 wk of gestation,12.5%(1/8)delivered between 34 and 36^(+6)wk,and 12.5%(1/8)delivered between 28 and 33^(+6)wk.For patients with pre-pregnancy LAC,80.0%(20/25)patients delivered at≥37 wk of gestation,16.0%(4/25)delivered between 34 and 36^(+6)wk,and 4.0%(1/25)delivered between 28 and 33^(+6)wk.No adverse-event intra-operative or post-operative sequelae were noted.Conclusions:LAC is an effective and safe procedure that results in remarkable obstetric outcomes for women with refractory cervical insufficiency,or with a short cervix who are considered unsuitable for a TVC.The success rate of in-pregnancy or pre-pregnancy LAC depends on a full evaluation of patients,a proper peri-operative management and close follow-up.
基金supported by the National Key Research and Development Program of China(Nos.2020YFB1505901,2021YFB3501002)the National Natural Science Foundation of China(Grant No.22106103,General Program No.52072240)+1 种基金the Shanghai Science and Technology Committee(No.18511109300)the Science and Technology Commission of the CMC(2019JCJQZD27300).
文摘The corrosion susceptibility of magnesium(Mg)alloys presents a significant challenge for their broad application.Although there have been extensive experimental and theoretical investigations,the corrosion mechanisms of Mg alloys are still unclear,especially the anodic dissolution process.Here,a thorough theoretical investigation based on ab initio molecular dynamics and metadynamics simulations has been conducted to clarify the underlying corrosion mechanism of Mg anode and propose effective strategies for enhancing corrosion resistance.Through comprehensive analyses of interfacial structures and equilibrium potentials for Mg(0001)/H_(2)O interface models with different water thicknesses,the Mg(0001)/72 H_(2)O model is identified to be reasonable with−2.17 V vs.standard hydrogen electrode equi-librium potential.In addition,utilizing metadynamics,the free energy barrier for Mg dissolution is calculated to be 0.835 eV,enabling the theoretical determination of anodic polarization curves for pure Mg that aligns well with experimental data.Based on the Mg(0001)/72 H_(2)O model,we further explore the effects of various alloying elements on anodic corrosion resistance,among which Al and Mn alloying elements are found to enhance corrosion resistance of Mg.This study provides valuable atomic-scale insights into the corrosion mechanism of magnesium alloys,offering theoretical guidance for developing novel corrosion-resistant Mg alloys.
基金This work was supported in part by the National Natural Science Foundation of China(Nos.51722507,51435010 and 91648103)in part by the National Key R&D Program of China(No.2017YFC0110800).
文摘Minimally invasive surgery,including laparoscopic and thoracoscopic procedures,benefits patients in terms of improved postoperative outcomes and short recovery time.The challenges in hand–eye coordination and manipulation dexterity during the aforementioned procedures have inspired an enormous wave of developments on surgical robotic systems to assist keyhole and endoscopic procedures in the past decades.This paper presents a systematic review of the state-of-the-art systems,picturing a detailed landscape of the system configurations,actuation schemes,and control approaches of the existing surgical robotic systems for keyhole and endoscopic procedures.The development challenges and future perspectives are discussed in depth to point out the need for new enabling technologies and inspire future researches.
基金support from the National Natural Science Foundation of China(Nos.22075042 and 52102310)Shanghai Rising-Star Program(No.22QA1400300)+2 种基金the Natural Science Foundation of Shanghai(No.20ZR1401400)the Shanghai Scientific and Technological Innovation Project(No.22520710100)the Fundamental Research Funds for the Central Universities,and the Donghua University(DHU)Distinguished Young Professor Program(No.LZB2021002).
文摘Lithium(Li)metal is regarded as the best anode material for lithium metal batteries(LMBs)due to its high theoretical specific capacity and low redox potential.However,the notorious dendrites growth and extreme instability of the solid electrolyte interphase(SEI)layers have severely retarded the commercialization process of LMBs.Herein,a double-layered polymer/alloy composite artificial SEI composed of a robust poly(1,3-dioxolane)(PDOL)protective layer,Sn and LiCl nanoparticles,denoted as PDOL@Sn-LiCl,is fabricated by the combination of in-situ substitution and polymerization processes on the surface of Li metal anode.The lithiophilic Sn-LiCl multiphase can supply plenty of Li-ion transport channels,contributing to the homogeneous nucleation and dense accumulation of Li metal.The mechanically tough PDOL layer can maintain the stability and compact structure of the inorganic layer in the long-term cycling,and suppress the volume fluctuation and dendrites formation of the Li metal anode.As a result,the symmetrical cell under the double-layered artificial SEI protection shows excellent cycling stability of 300 h at 5.0 mA·cm^(−2)for 1 mAh·cm^(−2).Notably,the Li||LiFePO_(4)full cell also exhibits enhanced capacity retention of 150.1 mAh·g^(−1)after 600 cycles at 1.0 C.Additionally,the protected Li foil can effectively resist the air and water corrosion,signifying the safe operation of Li metal in practical applications.This present finding proposed a different tactic to achieve safe and dendrite-free Li metal anodes with excellent cycling stability.
基金Funding was provided by the National Key R&D Program of China(2018YFC2000600).
文摘A Chinese Compilation of Physical Activities was compiled to estimate the energy costs of physical activities(PAs)using data on adults aged 18–64.Data were obtained from published articles and laboratory measurements.Databases,including PubMed,Embase,Scopus,Ebsco,Web of Science,Chinese National Knowledge Infrastructure,Wan Fang Data,National Science and Technology Report Service,Public Health Scientific Data were searched to collect data from inception to January 2022,on energy expenditure associated with PA in the healthy Chinese population.Two reviewers independently screened the literature and extracted,classified,and summarized data.Data were measured for 36 PAs using indirect calorimetry.Detailed descriptions of specific activities and metabolic equivalent values were provided by summarizing 241 physical activities in 13 categories.The first edition of the Chinese Compilation of PAs in Healthy Adults Aged 18–64(CCPA)was created.It provides valuable resources for people who regularly engage in physical exercise,researchers,educators,fitness professionals,and health or commercial sectors to quickly obtain various PA MET intensities.In the future,the energy expenditure of various PAs of different ages within the Chinese population can be measured based on the CCPA.
基金supported by Singapore Ministry of Education Academic Research Fund Tier 1(No.04MNP000567C120)Startup Grant of Hehai University(No.JIH 1829010Y).
文摘The biochemical consequences induced by xenobiotic stress are featured in dose-response and timeresolved landscapes.Understanding the dynamic process of cellular adaptations is crucial in conducting the risk assessment for chemical exposure.As one of the most phenotype-related omics,metabolome in response to environmental stress can vary from seconds to days.Up to now,very few dynamic metabolomics studies have been conducted to provide time-dependent mechanistic interpretations in understanding xenobiotics-induced cellular adaptations.This study aims to explore the time-resolved metabolite dysregulation manner and dynamically perturbed biological functions in MCF-7 cells exposed to bisphenol A(BPA),a well-known endocrine-disrupting chemical.By sampling at 11 time points from several minutes to hours,thirty seven significantly dysregulated metabolites were identified,ranging from amino acids,fatty acids,carboxylic acids and nucleoside phosphate compounds.The metabolites in different pathways basically showed distinct time-resolved changing patterns,while those within the common class or same pathways showed similar and synchronized dysregulation behaviors.The pathway enrichment analysis suggested that purine metabolism,pyrimidine metabolism,aminoacyl-tRNA biosynthesis as well as glutamine/glutamate(GABA)metabolism pathways were heavily disturbed.As exposure event continued,MCF-7 cells went through multiple sequential metabolic adaptations from cell proliferation to energy metabolism,which indicated an enhancing cellular requirement for elevated energy homeostasis,oxidative stress response and ER-αmediated cell growth.We further focused on the time-dependent metabolite dysregulation behavior in purine and pyrimidine metabolism,and identified the impaired glycolysis and oxidative phosphorylation by redox imbalance.Lastly,we established a restricted cubic splinebased model to fit and predict metabolite’s full range dysregulation cartography,with metabolite’sensitivity comparisons retrieved and novel biomarkers suggested.Overall,the results indicated that 8 h BPA exposure leaded to global dynamic metabolome adaptions including amino acid,nucleoside and sugar metabolism disorders,and the dysregulated metabolites with interfered pathways at different stages are of significant temporal distinctions.
