Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work r...Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.展开更多
PM_(2.5)pollution variations in different microenvironments would result in PM_(2.5)exposure inequity between rural and urban residents.In this study,the real-time PM_(2.5)exposure of urban and rural residents in Chin...PM_(2.5)pollution variations in different microenvironments would result in PM_(2.5)exposure inequity between rural and urban residents.In this study,the real-time PM_(2.5)exposure of urban and rural residents in China was examined based on portable PM_(2.5)sensors together with activity patterns derived from questionnaire surveys,with a focus on students and senior citizens who are sensitive to air pollution.The results showed that PM_(2.5)exposure varied significantly among different resident groups,with higher PM_(2.5)exposure of rural residents than those of urban residents.PM_(2.5)exposure peaks mostly occurred during(Accompanied)cooking activities owing to strong emissions.Sleeping and resting were the main activities that affected PM_(2.5)exposures of different resident groups,accounting for 60.7%-94.5%of total daily exposures.Furthermore,the long duration of sleeping makes it the predominant activity contributing to PM 25 exposure inequity.It is necessary to obtain point-to-point respiratory volume(respiratory rate)data when measuring real-time PM_(2.5)exposure data and incorporate respiratory volume(respiratory rate)into the analysis of PM_(2.5)exposure.For the first time,this study quantified the PM_(2.5)exposure inequality based on a novel method and can provide useful information for further studies on the exposure inequity.展开更多
基金the National Natural Science Foundation of China(Nos.62003023,32071407,52073138,52003018 and 52003019)Beijing Natural Science Foundation(No.7212204)Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University.
文摘Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.
基金supported by Yunnan Provincial Science and Technology Project at Southwest United Graduate School(Grant No.202302AO370001)NHC Key Laboratory of Nuclear Technology Medical Transformation(MIANYANG CENTRAL HOSPITAL)(Grant No.2021HYX030 and 2021HYX006).
文摘PM_(2.5)pollution variations in different microenvironments would result in PM_(2.5)exposure inequity between rural and urban residents.In this study,the real-time PM_(2.5)exposure of urban and rural residents in China was examined based on portable PM_(2.5)sensors together with activity patterns derived from questionnaire surveys,with a focus on students and senior citizens who are sensitive to air pollution.The results showed that PM_(2.5)exposure varied significantly among different resident groups,with higher PM_(2.5)exposure of rural residents than those of urban residents.PM_(2.5)exposure peaks mostly occurred during(Accompanied)cooking activities owing to strong emissions.Sleeping and resting were the main activities that affected PM_(2.5)exposures of different resident groups,accounting for 60.7%-94.5%of total daily exposures.Furthermore,the long duration of sleeping makes it the predominant activity contributing to PM 25 exposure inequity.It is necessary to obtain point-to-point respiratory volume(respiratory rate)data when measuring real-time PM_(2.5)exposure data and incorporate respiratory volume(respiratory rate)into the analysis of PM_(2.5)exposure.For the first time,this study quantified the PM_(2.5)exposure inequality based on a novel method and can provide useful information for further studies on the exposure inequity.
