Gas hydrate is regarded as a promising energy owing to the large carbon reserve and high energy density.However,due to the particularity of the formation and the complexity of exploitation process,the commercial explo...Gas hydrate is regarded as a promising energy owing to the large carbon reserve and high energy density.However,due to the particularity of the formation and the complexity of exploitation process,the commercial exploitation of gas hydrate has not been realized.This paper reviews the physical properties of gas hydratebearing sediments and focuses on the geomechanical response during the exploitation.The exploitation of gas hydrate is a strong thermal–hydrological–mechanical–chemical(THMC)coupling process:decomposition of hydrate into water and gas produces multi-physical processes including heat transfer,multi-fluid flow and deformation in the reservoir.These physical processes lead to a potential of geomechanical issues during the production process.Frequent occurrence of sand production is the major limitation of the commercial exploitation of gas hydrate.The potential landslide and subsidence will lead to the cessation of the production and even serious accidents.Preliminary researches have been conducted to investigate the geomechanical properties of gas hydrate-bearing sediments and to assess the wellbore integrity during the exploitation.The physical properties of hydrate have been fully studied,and some models have been established to describe the physical processes during the exploitation of gas hydrate.But the reproduction of actual conditions of hydrate reservoir in the laboratory is still a huge challenge,which will inevitably lead to a bias of experiment.In addition,because of the effect of microscopic mechanisms in porous media,the coupling mechanism of the existing models should be further investigated.Great efforts,however,are still required for a comprehensive understanding of this strong coupling process that is extremely different from the geomechanics involved in the conventional reservoirs.展开更多
In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal processing.While advancements in MEMS and ...In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal processing.While advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated adapters.This conventional approach adds considerable weight and volume to the package,especially for high channel count systems.To address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional packaging.This innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without implants.Furthermore,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action potentials.These findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.展开更多
The assembly of a protein complex is very important for its biological function,which can be investigated by determining the order of assembly/disassembly of its protein subunits.Although static structures of many pro...The assembly of a protein complex is very important for its biological function,which can be investigated by determining the order of assembly/disassembly of its protein subunits.Although static structures of many protein com-plexes are available in the protein data bank,their assembly/disassembly orders of subunits are largely unknown.In addi-tion to experimental techniques for studying subcomplexes in the assembly/disassembly of a protein complex,computa-tional methods can be used to predict the assembly/disassembly order.Since sampling is a nontrivial issue in simulating the assembly/disassembly process,coarse-grained simulations are more efficient than atomic simulations are.In this work,we developed computational protocols for predicting the assembly/disassembly orders of protein complexes via coarse-grained simulations.The protocols were illustrated via two protein complexes,and the predicted assembly/disassembly or-ders were consistent with the available experimental data.展开更多
基金Supported by the National Natural Science Foundation of China(51809275)the Science Foundation of China University of Petroleum,Beijing(2462018BJC002)
文摘Gas hydrate is regarded as a promising energy owing to the large carbon reserve and high energy density.However,due to the particularity of the formation and the complexity of exploitation process,the commercial exploitation of gas hydrate has not been realized.This paper reviews the physical properties of gas hydratebearing sediments and focuses on the geomechanical response during the exploitation.The exploitation of gas hydrate is a strong thermal–hydrological–mechanical–chemical(THMC)coupling process:decomposition of hydrate into water and gas produces multi-physical processes including heat transfer,multi-fluid flow and deformation in the reservoir.These physical processes lead to a potential of geomechanical issues during the production process.Frequent occurrence of sand production is the major limitation of the commercial exploitation of gas hydrate.The potential landslide and subsidence will lead to the cessation of the production and even serious accidents.Preliminary researches have been conducted to investigate the geomechanical properties of gas hydrate-bearing sediments and to assess the wellbore integrity during the exploitation.The physical properties of hydrate have been fully studied,and some models have been established to describe the physical processes during the exploitation of gas hydrate.But the reproduction of actual conditions of hydrate reservoir in the laboratory is still a huge challenge,which will inevitably lead to a bias of experiment.In addition,because of the effect of microscopic mechanisms in porous media,the coupling mechanism of the existing models should be further investigated.Great efforts,however,are still required for a comprehensive understanding of this strong coupling process that is extremely different from the geomechanics involved in the conventional reservoirs.
基金supported by the National Key R&D Program of China(Grant Nos.2021ZD0201600,2022YFF0706504,2022ZD0209300,2019YFA0905200,2021YFC2501500,2021YFF1200700,2022ZD0212300)the National Natural Science Foundation of China(Grant No.61974154)+11 种基金the Key Research Program of Frontier Sciences,CAS(Grant No.ZDBS-LY-JSC024)the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,the Shanghai Branch(Grant No.JCYJ-SHFY-2022-01 and JCYJ-SHFY-2022-0xx)the Shanghai Municipal Science and Technology Major Project(Grant No.2021SHZDZX)the CAS Pioneer Hundred Talents Program,the Shanghai Pujiang Program(Grant Nos.21PJ1415100,19PJ1410900)the Science and Technology Commission Foundation of Shanghai(Nos.21JM0010200 and 21142200300)the Shanghai Rising-Star Program(Grant No.22QA1410900)Shanghai Sailing Program(No.22YF1454700)the Innovative Research Team of High-level Local Universities in Shanghai,the Jiangxi Province 03 Special Project and 5 G Project(Grant No.20212ABC03W07)Fund for Central Government in Guidance of Local Science and Technology Development(Grant No.20201ZDE04013)Special Fund for Science and Technology Innovation Strategy of Guangdong Province(Grant Nos.2021B0909060002,2021B0909050004)the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.62305368)the Youth Innovation Promotion Association for Excellent Members,CAS.
文摘In implantable electrophysiological recording systems,the headstage typically comprises neural probes that interface with brain tissue and integrated circuit chips for signal processing.While advancements in MEMS and CMOS technology have significantly improved these components,their interconnection still relies on conventional printed circuit boards and sophisticated adapters.This conventional approach adds considerable weight and volume to the package,especially for high channel count systems.To address this issue,we developed a through-polymer via(TPV)method inspired by the through-silicon via(TSV)technique in advanced three-dimensional packaging.This innovation enables the vertical integration of flexible probes,amplifier chips,and PCBs,realizing a flexible,lightweight,and integrated device(FLID).The total weight of the FLIDis only 25%that of its conventional counterparts relying on adapters,which significantly increased the activity levels of animals wearing the FLIDs to nearly match the levels of control animals without implants.Furthermore,by incorporating a platinum-iridium alloy as the top layer material for electrical contact,the FLID realizes exceptional electrical performance,enabling in vivo measurements of both local field potentials and individual neuron action potentials.These findings showcase the potential of FLIDs in scaling up implantable neural recording systems and mark a significant advancement in the field of neurotechnology.
基金This work was supported by the National Key Research and Development Program of China(2021YFA1301504)the Chinese Academy of Sciences Strategic Priority Research Program(XDB37040202)the National Natural Science Foundation of China(91953101).
文摘The assembly of a protein complex is very important for its biological function,which can be investigated by determining the order of assembly/disassembly of its protein subunits.Although static structures of many protein com-plexes are available in the protein data bank,their assembly/disassembly orders of subunits are largely unknown.In addi-tion to experimental techniques for studying subcomplexes in the assembly/disassembly of a protein complex,computa-tional methods can be used to predict the assembly/disassembly order.Since sampling is a nontrivial issue in simulating the assembly/disassembly process,coarse-grained simulations are more efficient than atomic simulations are.In this work,we developed computational protocols for predicting the assembly/disassembly orders of protein complexes via coarse-grained simulations.The protocols were illustrated via two protein complexes,and the predicted assembly/disassembly or-ders were consistent with the available experimental data.
