BACKGROUND Peripheral regional block combined with general anesthesia might be a preferable anesthetic regimen for elderly patients undergoing total hip arthroplasty.AIM To investigate whether ultrasound-guided,direct...BACKGROUND Peripheral regional block combined with general anesthesia might be a preferable anesthetic regimen for elderly patients undergoing total hip arthroplasty.AIM To investigate whether ultrasound-guided,direct suprainguinal injection for fascia iliaca block accelerated recovery after general anesthesia and relieved postoperative pain after total hip arthroplasty.METHODS Patients who underwent total hip arthroplasty under general anesthesia in 2015 or 2019 at The Second Affiliated Hospital of Xuzhou Medical University were retrospectively analyzed.The patients were grouped based on whether preoperative suprainguinal fascia iliaca block was performed or not.The time to tracheal extubation and time spent in the post-anesthesia care unit(PACU),intraoperative remifentanil dosage,fentanyl consumption in the PACU,postoperative cumulative fentanyl consumption within 48 h after operation,visual analogue scale at rest and during movement on the first and second days after surgery,and adverse reactions were compared.RESULTS Thirty-one elderly patients who underwent total hip arthroplasty were included in the study(block group,n=16;no-block group,n=15).The visual analog scale scores at rest and during movement on the first and second days were significantly lower in the block group than in the no-block group(all P<0.05).Compared with the no-block group,the intraoperative remifentanil dosage was lower,the time to tracheal extubation and the time spent in the PACU were shorter in the block group(all P<0.01).Fentanyl consumption in the PACU and postoperative cumulative fentanyl consumption in 48 h after operation were lower in the block group(all P<0.01).The incidence of dizziness was higher in the no-block group than in the block group(P=0.037).CONCLUSION Ultrasound-guided,direct suprainguinal injection for fascia iliaca block led to faster recovery after general anesthesia and early postoperative pain relief in elderly patients undergoing total hip arthroplasty.展开更多
The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost c...The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.展开更多
This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logisti...This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logistic regression is proposed to adaptively identify the important genes in groups. Furthermore, by improving the pathwise coordinate descent algorithm, a fast solving algorithm is developed for computing the regularized paths of the adaptive logistic regression. The results from the experiments performed on the microarray data of rat liver regeneration are provided to illustrate the effectiveness of the proposed method and verify the biological rationality of the selected biomarkers.展开更多
The objective of this paper is to investigate the dynamic behavior of cloud cavitating flow around a flexible hydrofoil with experimental and numerical methods.The tightly coupled fluid-structure interaction(FSI)model...The objective of this paper is to investigate the dynamic behavior of cloud cavitating flow around a flexible hydrofoil with experimental and numerical methods.The tightly coupled fluid-structure interaction(FSI)modeling is applied and validated with the experimental data.The Q-criterion andω-criterion are applied to illustrate the interaction between the vortex structures and cavities.The flexibility is seen to result in nose-up twist deformation,causing a reduction of the shedding frequency from an increase in the attached cavity length.Due to the flexibility,the fluctuation of load coefficients of the flexible hydrofoil is larger than that of the rigid hydrofoil.Moreover,the re-entrant jet propagation speed of the flexible hydrofoil is greater than that of the rigid hydrofoil.The shed cloud cavity is observed to be uniform along the flexible hydrofoil span under the combined influence of the strong vibration and the gap flow.展开更多
The safe use of intraoperative blood salvage （IBS） in cancer surgery remains controversial. Here, we investigated the kil ing effect of cisplatin combined with hyperthermia on human hepatocarcinoma （HepG2） cel s a...The safe use of intraoperative blood salvage （IBS） in cancer surgery remains controversial. Here, we investigated the kil ing effect of cisplatin combined with hyperthermia on human hepatocarcinoma （HepG2） cel s and erythrocytes from IBS in vitro. HepG2 cel s were mixed with concentrated erythrocytes and pretreated with cisplatin （50, 100, and 200μg/ml） alone at 37 °C for 60 min and cisplatin （25, 50, 100, and 200μg/ml） combined with hyperthermia at 42 °C for 60 min. After pretreatment, the cel viability, colony formation and DNA metabolism in HepG2 and the Na＋-K＋-ATPase activity, 2,3-diphosphoglycerate （2,3-DPG） concentration, free hemoglobin （Hb） level, osmotic fragility, membrane phosphatidylserine externalization, and blood gas variables in erythrocytes were determined. Pretreatment with cisplatin （50, 100, and 200μg/ml） combined with hyperthermia （42 °C） for 60 min significantly decreased HepG2 cel viability, and completely inhibited colony formation and DNA metabolism when the HepG2 cel concentration was 5×104 ml？1 in the erythrocyte （P0.05）. In conclusion, pre-treatment with cisplatin （50μg/ml） combined with hyperthermia （42 °C） for 60 min effectively eliminated HepG2 cel s from IBS but did not significantly affect erythrocytes in vitro.展开更多
The behaviors of unsteady flow structures and corresponding hydrodynamics for a pitching hydrofoil are investigated numerically and theoretically in the present paper.The aims are to derive the total lift by finite-do...The behaviors of unsteady flow structures and corresponding hydrodynamics for a pitching hydrofoil are investigated numerically and theoretically in the present paper.The aims are to derive the total lift by finite-domain impulse theory for subcavitating flow(σ=8.0)and cavitating flow(σ=3.0),and to quantify the distinct impact of individual vortex structures on the transient lift to appreciate the interplay among cavitation,flow structures,and vortex dynamics.The motion of the hydrofoil is set to pitch up clockwise with an almost constant rate from 0°to 15°and then back to 0°,for the Reynolds number,7.5×105,and the frequency,0.2 Hz,respectively.The results reveal that the presence of cavities delays the migration of the laminar separation bubble(LSB)from the trailing edge(TE)to the leading edge(LE),consequently postponing the hysteresis in the inflection of lift coefficients.The eventual stall under the sub-cavitation regime is the result of LSB bursting.While the instabilities within the leading-edge LSB induce the convection of cavitation-dominated vortices under the cavitation regime instead.Having validated the lift coefficients on the hydrofoil through the finite-domain impulse theory using the standard force expression,the Lamb vector integral emerges as the main contribution to the generation of unsteady lift.Moreover,the typical vortices’contributions to the transient lift during dynamic stall are accurately quantified.The analysis indicates that the clockwise leading-edge vortex(−LEV)contributes positively,while the counterclockwise trailing-edge vortex(+TEV)contributes negatively.The negative influence becomes particularly pronounced after reaching the peak of total lift,as the shedding of the concentrated wake vortex precipitates a sharp decline due to a predominant negative lift contribution from the TEV region.Generally,the vortices’contribution is relatively modest in sub-cavitating flow,but it is notably more significant in the context of incipient cavitating flow.展开更多
文摘BACKGROUND Peripheral regional block combined with general anesthesia might be a preferable anesthetic regimen for elderly patients undergoing total hip arthroplasty.AIM To investigate whether ultrasound-guided,direct suprainguinal injection for fascia iliaca block accelerated recovery after general anesthesia and relieved postoperative pain after total hip arthroplasty.METHODS Patients who underwent total hip arthroplasty under general anesthesia in 2015 or 2019 at The Second Affiliated Hospital of Xuzhou Medical University were retrospectively analyzed.The patients were grouped based on whether preoperative suprainguinal fascia iliaca block was performed or not.The time to tracheal extubation and time spent in the post-anesthesia care unit(PACU),intraoperative remifentanil dosage,fentanyl consumption in the PACU,postoperative cumulative fentanyl consumption within 48 h after operation,visual analogue scale at rest and during movement on the first and second days after surgery,and adverse reactions were compared.RESULTS Thirty-one elderly patients who underwent total hip arthroplasty were included in the study(block group,n=16;no-block group,n=15).The visual analog scale scores at rest and during movement on the first and second days were significantly lower in the block group than in the no-block group(all P<0.05).Compared with the no-block group,the intraoperative remifentanil dosage was lower,the time to tracheal extubation and the time spent in the PACU were shorter in the block group(all P<0.01).Fentanyl consumption in the PACU and postoperative cumulative fentanyl consumption in 48 h after operation were lower in the block group(all P<0.01).The incidence of dizziness was higher in the no-block group than in the block group(P=0.037).CONCLUSION Ultrasound-guided,direct suprainguinal injection for fascia iliaca block led to faster recovery after general anesthesia and early postoperative pain relief in elderly patients undergoing total hip arthroplasty.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.52279081,51839001)supported by the Beijing Natural Science Foundation (Grant No.3232033)the Fundamental Research Funds for the Central Universities (Grant No.2023CX01004).
文摘The objective is to study the vortical structural behaviors of a transient pitching hydrofoil and their effects on the hydrodynamic performance. The pitching motion of the hydrofoil is set to pitch up with an almost constant rate from 5° to 15° and then back to 5°, with the Reynolds number 4.4×10^(5) and the frequency 2 Hz. The results show that the main coherent structures around the pitching hydrofoil include small-scale laminar separation bubble (LSB), large-scale second vortex (SV) and trailing edge vortex (TEV) which are all vortical. The relationship between the vortical structure and the lift is investigated with the finite-domain impulse theory. It indicates that the major part of the lift is contributed by the LSB, whereas the shedding and the formation of the SV and TEV cause the fluctuation of the lift. The proper orthogonal decomposition (POD) method is applied to capture the most energetic modes, revealing that the LSB mode occupies a large amount of energy in the flow field. The dynamic mode decomposition (DMD) method accurately extracts the dominant frequency and modal characteristics, with the first mode corresponding to the mean flow, the second mode corresponding to the LSB structure and the third and fourth modes corresponding to the vortex shedding.
基金supported by National Nature Science Foundation of China(No.61203293)Key Scientific and Technological Project of Henan Province(No.122102210131)+3 种基金Program for Science and Technology Innovation Talents in Universities of Henan Province(No.13HASTIT040)Foundation of Henan Educational Committee(No.13A120524)Henan Normal University Doctoral Topics(No.qd14156)Henan Higher School Funding Scheme for Young Teachers(No.2012GGJS-063)
文摘This paper is devoted to identifying the biomarkers of rat liver regeneration via the adaptive logistic regression. By combining the adaptive elastic net penalty with the logistic regression loss, the adaptive logistic regression is proposed to adaptively identify the important genes in groups. Furthermore, by improving the pathwise coordinate descent algorithm, a fast solving algorithm is developed for computing the regularized paths of the adaptive logistic regression. The results from the experiments performed on the microarray data of rat liver regeneration are provided to illustrate the effectiveness of the proposed method and verify the biological rationality of the selected biomarkers.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52279081,51839001)supported by the Natural Science Foundation of Beijing Municipality(Grant No.3232033)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.2023CX01004)the BIT Research and Innovation Promoting Project(Grant No.2022YCXY014).
文摘The objective of this paper is to investigate the dynamic behavior of cloud cavitating flow around a flexible hydrofoil with experimental and numerical methods.The tightly coupled fluid-structure interaction(FSI)modeling is applied and validated with the experimental data.The Q-criterion andω-criterion are applied to illustrate the interaction between the vortex structures and cavities.The flexibility is seen to result in nose-up twist deformation,causing a reduction of the shedding frequency from an increase in the attached cavity length.Due to the flexibility,the fluctuation of load coefficients of the flexible hydrofoil is larger than that of the rigid hydrofoil.Moreover,the re-entrant jet propagation speed of the flexible hydrofoil is greater than that of the rigid hydrofoil.The shed cloud cavity is observed to be uniform along the flexible hydrofoil span under the combined influence of the strong vibration and the gap flow.
基金Project supported by the Scientific Research from Chinese Ministryof Health-Zhejiang Health Department,China(Nos.WKJ2008-2-021and WKJ2013-2-019)
文摘The safe use of intraoperative blood salvage （IBS） in cancer surgery remains controversial. Here, we investigated the kil ing effect of cisplatin combined with hyperthermia on human hepatocarcinoma （HepG2） cel s and erythrocytes from IBS in vitro. HepG2 cel s were mixed with concentrated erythrocytes and pretreated with cisplatin （50, 100, and 200μg/ml） alone at 37 °C for 60 min and cisplatin （25, 50, 100, and 200μg/ml） combined with hyperthermia at 42 °C for 60 min. After pretreatment, the cel viability, colony formation and DNA metabolism in HepG2 and the Na＋-K＋-ATPase activity, 2,3-diphosphoglycerate （2,3-DPG） concentration, free hemoglobin （Hb） level, osmotic fragility, membrane phosphatidylserine externalization, and blood gas variables in erythrocytes were determined. Pretreatment with cisplatin （50, 100, and 200μg/ml） combined with hyperthermia （42 °C） for 60 min significantly decreased HepG2 cel viability, and completely inhibited colony formation and DNA metabolism when the HepG2 cel concentration was 5×104 ml？1 in the erythrocyte （P0.05）. In conclusion, pre-treatment with cisplatin （50μg/ml） combined with hyperthermia （42 °C） for 60 min effectively eliminated HepG2 cel s from IBS but did not significantly affect erythrocytes in vitro.
基金supported by the National Science Foundation of China (Grant Nos.52279081,and 51839001).
文摘The behaviors of unsteady flow structures and corresponding hydrodynamics for a pitching hydrofoil are investigated numerically and theoretically in the present paper.The aims are to derive the total lift by finite-domain impulse theory for subcavitating flow(σ=8.0)and cavitating flow(σ=3.0),and to quantify the distinct impact of individual vortex structures on the transient lift to appreciate the interplay among cavitation,flow structures,and vortex dynamics.The motion of the hydrofoil is set to pitch up clockwise with an almost constant rate from 0°to 15°and then back to 0°,for the Reynolds number,7.5×105,and the frequency,0.2 Hz,respectively.The results reveal that the presence of cavities delays the migration of the laminar separation bubble(LSB)from the trailing edge(TE)to the leading edge(LE),consequently postponing the hysteresis in the inflection of lift coefficients.The eventual stall under the sub-cavitation regime is the result of LSB bursting.While the instabilities within the leading-edge LSB induce the convection of cavitation-dominated vortices under the cavitation regime instead.Having validated the lift coefficients on the hydrofoil through the finite-domain impulse theory using the standard force expression,the Lamb vector integral emerges as the main contribution to the generation of unsteady lift.Moreover,the typical vortices’contributions to the transient lift during dynamic stall are accurately quantified.The analysis indicates that the clockwise leading-edge vortex(−LEV)contributes positively,while the counterclockwise trailing-edge vortex(+TEV)contributes negatively.The negative influence becomes particularly pronounced after reaching the peak of total lift,as the shedding of the concentrated wake vortex precipitates a sharp decline due to a predominant negative lift contribution from the TEV region.Generally,the vortices’contribution is relatively modest in sub-cavitating flow,but it is notably more significant in the context of incipient cavitating flow.
