To obtain dynamic mechanical properties and failure rule of layered backfill under strain rates from10to80s-1,impactloading test on layered backfill specimens(LBS)was conducted by using split Hopkinson pressure bar sy...To obtain dynamic mechanical properties and failure rule of layered backfill under strain rates from10to80s-1,impactloading test on layered backfill specimens(LBS)was conducted by using split Hopkinson pressure bar system.The results indicatethat positive correlation can be found between dynamic compressive strength and strain rate,as well as between strength increasefactor and strain rate.Dynamic compressive strength of LBS gets higher as the arithmetic average cement-sand ratio increases.Compared with static compressive strength,dynamic compressive strength of LBS is enhanced by11%to163%.In addition,theenergy dissipating rate of LBS lies between that of corresponding single specimens,and it decreases as the average cement contentincreases.Deformation of LBS shows obvious discontinuity,deformation degree of lower strength part of LBS is generally higherthan that of higher strength part.A revised brittle fracture criterion based on the Stenerding-Lehnigk criterion is applied to analyzingthe fracture status of LBS,and the average relevant errors of the3groups between the test results and calculation results are4.80%,3.89%and4.66%,respectively.展开更多
Inositol requiring mutant 80(INO80)is a chromatin remodeler that regulates pluripotency maintenance of embryonic stem cells and reprogramming of somatic cells into pluripotent stem cells.However,the roles and mechanis...Inositol requiring mutant 80(INO80)is a chromatin remodeler that regulates pluripotency maintenance of embryonic stem cells and reprogramming of somatic cells into pluripotent stem cells.However,the roles and mechanisms of INO80 in porcine preimplantation embryonic development remain largely unknown.Here,we show that INO80 modulates trophectoderm epithelium permeability to promote porcine blastocyst development.The INO80 protein is highly expressed in the nuclei during morula-toblastocyst transition.Functional studies revealed that RNA interference(RNAi)-mediated knockdown of INO80 severely blocks blastocyst formation and disrupts lineage allocation between the inner cell mass and trophectoderm.Mechanistically,singleembryo RNA sequencing revealed that INO80 regulates multiple genes,which are important for lineage specification,tight junction assembly,and fluid accumulation.Consistent with the altered expression of key genes required for tight junction assembly,a permeability assay showed that paracellular sealing is defective in the trophectoderm epithelium of INO80 knockdown blastocysts.Importantly,aggregation of 8-cell embryos from the control and INO80 knockdown groups restores blastocyst development and lineage allocation via direct complementation of the defective trophectoderm epithelium.Taken together,these results demonstrate that INO80 promotes blastocyst development by regulating the expression of key genes required for lineage specification,tight junction assembly,and fluid accumulation.展开更多
BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent comp...BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent complication following PD.AIM To identify risk factors associated with DGE after the PD procedure.METHODS In this retrospective,cross-sectional study,clinical data were collected from 114 patients who underwent PD between January 2015 and June 2018.Demographic factors,pre-and perioperative characteristics,and surgical complications were assessed.Univariate and multivariate analyses were performed to identify risk factors for post-PD DGE.RESULTS The study included 66 males(57.9%)and 48 females(42.1%),aged 33-83 years(mean:62.5),with a male-to-female ratio of approximately 1.4:1.There were 63 cases(55.3%)of PD and 51 cases(44.7%)of pylorus-preserving pancreatoduodenectomy.Among the 114 patients who underwent PD,33(28.9%)developed postoperative DGE.Univariate analysis revealed significant differences in four of the 14 clinical indexes observed:pylorus preservation,retrocolonic anastomosis,postoperative abdominal complications,and early postoperative albumin(ALB).Logistic regression analysis further identified postoperative abdominal complic-ations[odds ratio(OR)=4.768,P=0.002],preoperative systemic diseases(OR=2.516,P=0.049),and early postoperative ALB(OR=1.195,P=0.003)as significant risk factors.CONCLUSION Postoperative severe abdominal complications,preoperative systemic diseases,and early postoperative ALB are identified as risk factors for post-PD DGE.展开更多
We investigate the photoconductivities of injection current and the shift current in transition metal dichalcogenide with warping term in the presence of sublattice potential and spin orbit coupling.The system shows t...We investigate the photoconductivities of injection current and the shift current in transition metal dichalcogenide with warping term in the presence of sublattice potential and spin orbit coupling.The system shows the valley photoconductivities of injection current and the photoconductivities of shift current.It is found that the warping term and the geometric tensor play a critical role in the system,which are responsible for the photoconductivities.Due to the interplay between the sublattice potential and the spin orbit coupling,the photoconductivities can be tuned.Furthermore,the effect of warping term on geometric tensor and the amplitude of the photoconductivities are also discussed.展开更多
基金Project(2012BAC09B02)supported by the 12th Five-Year Key Programs for Science and Technology Development of ChinaProject(2016zzts444)supported by the Financial Support from the Fundament Research Funds for the Central Universities of Central South University,China
文摘To obtain dynamic mechanical properties and failure rule of layered backfill under strain rates from10to80s-1,impactloading test on layered backfill specimens(LBS)was conducted by using split Hopkinson pressure bar system.The results indicatethat positive correlation can be found between dynamic compressive strength and strain rate,as well as between strength increasefactor and strain rate.Dynamic compressive strength of LBS gets higher as the arithmetic average cement-sand ratio increases.Compared with static compressive strength,dynamic compressive strength of LBS is enhanced by11%to163%.In addition,theenergy dissipating rate of LBS lies between that of corresponding single specimens,and it decreases as the average cement contentincreases.Deformation of LBS shows obvious discontinuity,deformation degree of lower strength part of LBS is generally higherthan that of higher strength part.A revised brittle fracture criterion based on the Stenerding-Lehnigk criterion is applied to analyzingthe fracture status of LBS,and the average relevant errors of the3groups between the test results and calculation results are4.80%,3.89%and4.66%,respectively.
基金supported by the Anhui Provincial Natural Science Foundation(1908085MC97,2008085MC85)National Natural Science Foundation of China(31802059,31902226)+1 种基金Hefei Innovation and Entrepreneurship Support Plan for Returnee Scholar(03082009)Anhui Provincial Innovation and Entrepreneurship Support Plan for Returnee Scholar(2020LCX015)。
文摘Inositol requiring mutant 80(INO80)is a chromatin remodeler that regulates pluripotency maintenance of embryonic stem cells and reprogramming of somatic cells into pluripotent stem cells.However,the roles and mechanisms of INO80 in porcine preimplantation embryonic development remain largely unknown.Here,we show that INO80 modulates trophectoderm epithelium permeability to promote porcine blastocyst development.The INO80 protein is highly expressed in the nuclei during morula-toblastocyst transition.Functional studies revealed that RNA interference(RNAi)-mediated knockdown of INO80 severely blocks blastocyst formation and disrupts lineage allocation between the inner cell mass and trophectoderm.Mechanistically,singleembryo RNA sequencing revealed that INO80 regulates multiple genes,which are important for lineage specification,tight junction assembly,and fluid accumulation.Consistent with the altered expression of key genes required for tight junction assembly,a permeability assay showed that paracellular sealing is defective in the trophectoderm epithelium of INO80 knockdown blastocysts.Importantly,aggregation of 8-cell embryos from the control and INO80 knockdown groups restores blastocyst development and lineage allocation via direct complementation of the defective trophectoderm epithelium.Taken together,these results demonstrate that INO80 promotes blastocyst development by regulating the expression of key genes required for lineage specification,tight junction assembly,and fluid accumulation.
文摘BACKGROUND Mortality rates after pancreaticoduodenectomy(PD)have significantly decreased in specialized centers.However,postoperative morbidity,particularly delayed gastric emptying(DGE),remains the most frequent complication following PD.AIM To identify risk factors associated with DGE after the PD procedure.METHODS In this retrospective,cross-sectional study,clinical data were collected from 114 patients who underwent PD between January 2015 and June 2018.Demographic factors,pre-and perioperative characteristics,and surgical complications were assessed.Univariate and multivariate analyses were performed to identify risk factors for post-PD DGE.RESULTS The study included 66 males(57.9%)and 48 females(42.1%),aged 33-83 years(mean:62.5),with a male-to-female ratio of approximately 1.4:1.There were 63 cases(55.3%)of PD and 51 cases(44.7%)of pylorus-preserving pancreatoduodenectomy.Among the 114 patients who underwent PD,33(28.9%)developed postoperative DGE.Univariate analysis revealed significant differences in four of the 14 clinical indexes observed:pylorus preservation,retrocolonic anastomosis,postoperative abdominal complications,and early postoperative albumin(ALB).Logistic regression analysis further identified postoperative abdominal complic-ations[odds ratio(OR)=4.768,P=0.002],preoperative systemic diseases(OR=2.516,P=0.049),and early postoperative ALB(OR=1.195,P=0.003)as significant risk factors.CONCLUSION Postoperative severe abdominal complications,preoperative systemic diseases,and early postoperative ALB are identified as risk factors for post-PD DGE.
基金Project supported by the National Natural Science Foundation of China(Grant No.11504095)the Science and Technology Program for Institutions of Higher Learning in Shandong Province,China(Grant No.J18KA224).
文摘We investigate the photoconductivities of injection current and the shift current in transition metal dichalcogenide with warping term in the presence of sublattice potential and spin orbit coupling.The system shows the valley photoconductivities of injection current and the photoconductivities of shift current.It is found that the warping term and the geometric tensor play a critical role in the system,which are responsible for the photoconductivities.Due to the interplay between the sublattice potential and the spin orbit coupling,the photoconductivities can be tuned.Furthermore,the effect of warping term on geometric tensor and the amplitude of the photoconductivities are also discussed.
