Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of be...Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.展开更多
The Global Alliance of Disaster Research Institutes held its 3rd Global Summit of Research Institutes for Disaster Risk Reduction at the Disaster Prevention Research Institute,Kyoto University,Japan,19–21 March,2017....The Global Alliance of Disaster Research Institutes held its 3rd Global Summit of Research Institutes for Disaster Risk Reduction at the Disaster Prevention Research Institute,Kyoto University,Japan,19–21 March,2017.The Global Alliance seeks to contribute to enhancing disaster risk reduction(DRR) and disaster resilience through the collaboration of research organizations around the world.The summit aim was to expand the platform for bridging science and policy making by evaluating the evidence base needed to meet the expected outcomes and actions of the Sendai Framework for Disaster RiskReduction 2015–2030 and its Science and Technology Roadmap.The summit reflected the international nature of collaborative research and action.A pre-conference questionnaire filled out by Global Alliance members identified323 research projects that are indicative of current research.These were categorized to support seven parallel discussion sessions related to the Sendai Framework priorities for action.Four discussion sessions focused on research that aims to deepen the understanding of disaster risks.Three cross-cutting sessions focused on research that is aimed at the priorities for action on governance,resilience,and recovery.Discussion summaries were presentedin plenary sessions in support of outcomes for widely enhancing the science and policy of DRR.展开更多
文摘Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.
文摘The Global Alliance of Disaster Research Institutes held its 3rd Global Summit of Research Institutes for Disaster Risk Reduction at the Disaster Prevention Research Institute,Kyoto University,Japan,19–21 March,2017.The Global Alliance seeks to contribute to enhancing disaster risk reduction(DRR) and disaster resilience through the collaboration of research organizations around the world.The summit aim was to expand the platform for bridging science and policy making by evaluating the evidence base needed to meet the expected outcomes and actions of the Sendai Framework for Disaster RiskReduction 2015–2030 and its Science and Technology Roadmap.The summit reflected the international nature of collaborative research and action.A pre-conference questionnaire filled out by Global Alliance members identified323 research projects that are indicative of current research.These were categorized to support seven parallel discussion sessions related to the Sendai Framework priorities for action.Four discussion sessions focused on research that aims to deepen the understanding of disaster risks.Three cross-cutting sessions focused on research that is aimed at the priorities for action on governance,resilience,and recovery.Discussion summaries were presentedin plenary sessions in support of outcomes for widely enhancing the science and policy of DRR.
