Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve replacement.The present study explored the possible risk factors for anxiety and depressi...Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve replacement.The present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication safety.Methods Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient visits.Depression was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky scale.Results A total of 309 patients(aged 52.2±11.4 years)were included in the present study.The SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having depression.The SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having anxiety.Seven patients(2.3%)had both anxiety and depression.Logistic regression analysis revealed that only monthly income was an independent influencing factor for depression.Regarding anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater risk.More bleeding events and coagulation disorders could be observed in patients with anxiety,depression or both.When anxiety occurred,patients showed worse medication adherence.However,depression had no significant effect on medication adherence.Conclusion During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of warfarin.Analysis of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.展开更多
Efficient bifunction electrocatalyst is extremely interesting for electrochemical overall water splitting(OWS).Herein,a new RuO_(2)-Ru/MoO_(2)@CC(RRM/CC)bifunctional electrocatalyst was prepared via a solid phase reac...Efficient bifunction electrocatalyst is extremely interesting for electrochemical overall water splitting(OWS).Herein,a new RuO_(2)-Ru/MoO_(2)@CC(RRM/CC)bifunctional electrocatalyst was prepared via a solid phase reaction strategy.To obtain a suitable precursor for SPR,MoS_(2)nanosheets and RuO_(2)nanoparticles(NPs)were sequentially loaded onto carbon cloth conductive substrate.Subsequently,the prepared RuO_(2)/MoS_(2)/CC precursor was sealed in a furnace and annealed in Ar to trigger the redox SPR.After SPR,active RuO_(2)-Ru/MoO_(2)units containing metal–metal oxide interfaces were formed on CC substrate uniformly.The optimized RRM/CC sample annealed at 400℃exhibited a overpotential of 13 m V for hydrogen evolution reaction(HER)and 231 mV for oxygen evolution reaction(OER)at 10 mA·cm^(-2)under alkaline condition,respectively,which can be deduced to the modulated electronic structure and unique hierarchica structure.In addition,a low cell voltage of 1.48 V for OWS was required at 10 mA·cm^(-2)under alkaline condition Meanwhile,RRM/CC exhibited excellent pH-independent durability.展开更多
文摘Objective The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve replacement.The present study explored the possible risk factors for anxiety and depression during the coronavirus disease 2019(COVID-19)pandemic and analyzed the influence of psychological state on medication safety.Methods Eligible patients received a web-based questionnaire survey via the Wenjuanxing platform during outpatient visits.Depression was evaluated by the Self-Rating Depression Scale(SDS).Anxiety was evaluated by the Self-Rating Anxiety Scale(SAS).Medication adherence was evaluated by the Morisky scale.Results A total of 309 patients(aged 52.2±11.4 years)were included in the present study.The SDS score of all included patients was 36.9±9.4 points,of which 11(3.6%)patients were diagnosed as having depression.The SAS score of all included patients was 43.1±9.3 points,of which 71(23%)patients were diagnosed as having anxiety.Seven patients(2.3%)had both anxiety and depression.Logistic regression analysis revealed that only monthly income was an independent influencing factor for depression.Regarding anxiety,patients who underwent repeated operations had a 2.264-fold greater risk,and patients who received combination medication had a 2.140-fold greater risk.More bleeding events and coagulation disorders could be observed in patients with anxiety,depression or both.When anxiety occurred,patients showed worse medication adherence.However,depression had no significant effect on medication adherence.Conclusion During the COVID-19 pandemic,the detection rate of mental illnesses such as anxiety and depression was high,which seriously affected the medication safety of warfarin.Analysis of its influencing factors will provide a reference for further standardized regulation of warfarin anticoagulant therapy after valve replacement.
基金financially supported by Henan Provincial University Science and Technology Innovation Team(No.24IRTSTHN008)。
文摘Efficient bifunction electrocatalyst is extremely interesting for electrochemical overall water splitting(OWS).Herein,a new RuO_(2)-Ru/MoO_(2)@CC(RRM/CC)bifunctional electrocatalyst was prepared via a solid phase reaction strategy.To obtain a suitable precursor for SPR,MoS_(2)nanosheets and RuO_(2)nanoparticles(NPs)were sequentially loaded onto carbon cloth conductive substrate.Subsequently,the prepared RuO_(2)/MoS_(2)/CC precursor was sealed in a furnace and annealed in Ar to trigger the redox SPR.After SPR,active RuO_(2)-Ru/MoO_(2)units containing metal–metal oxide interfaces were formed on CC substrate uniformly.The optimized RRM/CC sample annealed at 400℃exhibited a overpotential of 13 m V for hydrogen evolution reaction(HER)and 231 mV for oxygen evolution reaction(OER)at 10 mA·cm^(-2)under alkaline condition,respectively,which can be deduced to the modulated electronic structure and unique hierarchica structure.In addition,a low cell voltage of 1.48 V for OWS was required at 10 mA·cm^(-2)under alkaline condition Meanwhile,RRM/CC exhibited excellent pH-independent durability.
