Objective:To study the safety,efficacy and mechanism of Wang Yulin self-made recipe Rexiao decoction in the treatment of acute bronchial asthma(BA).Methods:80 patients with acute attack BA were randomly divided into w...Objective:To study the safety,efficacy and mechanism of Wang Yulin self-made recipe Rexiao decoction in the treatment of acute bronchial asthma(BA).Methods:80 patients with acute attack BA were randomly divided into western medicine group(n=40)and traditional Chinese and western medicine group(n=40).The control group was treated with routine western medicine:salmeterol was inhaled twice a day,combined with oxygen therapy and inducement therapy.The Chinese and Western medical group was treated with Rexiao decoction in the western medical group.The course of treatment is 15 days.Their syndrome score,blood gas analysis(PaC02,Pa02)and induced sputum IL-5,EOS,IL-1 were observed.3.Pulmonary function(record of kidney,liver function,blood routine and adverse reactions in PEF%Pred,FEV1%Pred),group).Results:the total effective rate was 85%in western medicine group and 92.5%in traditional Chinese and western medicine group(P<0.01).After treatment,the score of TCM syndromes in the Chinese and western medicine group was better than that in the western medicine group(P<0.05).After treatment,the pulmonary function(FEV1%Pred)of the traditional Chinese and western medicine group was better than that of the western medicine group,and the PEF%Pred of the Chinese and western medicine group was better than that of the western medicine group.Analysis of Blood Gas in traditional Chinese and Western Medicine Group after treatment(PaO2)was significantly higher than that in the control group(P<0.05).There was no significant difference in the improvement of blood gas analysis(PaCO2)between the western medicine group and the traditional Chinese and western medicine group(P>0.05).The decrease of IL-13,EOS and IL-5 in sputum of traditional Chinese and western medicine group was more than that of western medicine group(P<0.01).There was no significant difference in liver function(AST,ALT),renal function(Cr,Urea),blood routine(WBC,RBC,PLT)before and after treatment in traditional Chinese and western medicine group(P>0.05),but no obvious adverse reactions were found.Conclusions:heat Asthma decoction is safe and effective in the treatment of hot asthma syndrome in acute attack.The target and inflammatory factors,eosinophils are likely to decrease,and the effect of airway inflammation and high reaction are decreased.展开更多
The biomimetic hydrofoils are frequently employed to enhance cavitation performance,although the underlying mechanisms remain to be fully elucidated.This study utilizes a cavitation visualization experimental system a...The biomimetic hydrofoils are frequently employed to enhance cavitation performance,although the underlying mechanisms remain to be fully elucidated.This study utilizes a cavitation visualization experimental system and mechanical characterization to experimentally investigate the transient cavitation features of a NACA0015 hydrofoil and its biomimetic counterparts with modified lending-edge.The findings demonstrate that,in comparison with the flat hydrofoil,the biomimetic hydrofoil experiences a cavitation morphology transition at a lower cavitation number,with a reduction of up to 0.38.Moreover,the maximum cavity length and the maximum cavitation area are reduced by 17.11%,17.32%,signifying a reduction in cavitation intensity.Proper orthogonal decomposition(POD)analysis revealed that the primary mechanism for the enhanced cavitation performance of the leading-edge wave structured biomimetic hydrofoil is the suppression of cloud cavitation shedding.At an attack angle of 6°,the biomimetic hydrofoil exhibited the highest lift coefficient increase of 18.56%,corresponding to a lift-to-drag ratio improvement of 9.56%.By analyzing the cavitation patterns of the two hydrofoils,it is evident that the rate of change in the maximum cavity length isolines for the biomimetic hydrofoil is lower than that of the flat hydrofoil.For an equivalent level of cavitation intensity,the biomimetic hydrofoil exhibits a lower cavitation number compared with the flat hydrofoil.These demonstrate that the wavy leading-edge design of the biomimetic hydrofoil effectively reduces the severity of cavitation,thereby confirming the efficacy of the biomimetic hydrofoil in enhancing cavitation performance.展开更多
基金Science and technology cooperation project of guizhou province(No.7134).
文摘Objective:To study the safety,efficacy and mechanism of Wang Yulin self-made recipe Rexiao decoction in the treatment of acute bronchial asthma(BA).Methods:80 patients with acute attack BA were randomly divided into western medicine group(n=40)and traditional Chinese and western medicine group(n=40).The control group was treated with routine western medicine:salmeterol was inhaled twice a day,combined with oxygen therapy and inducement therapy.The Chinese and Western medical group was treated with Rexiao decoction in the western medical group.The course of treatment is 15 days.Their syndrome score,blood gas analysis(PaC02,Pa02)and induced sputum IL-5,EOS,IL-1 were observed.3.Pulmonary function(record of kidney,liver function,blood routine and adverse reactions in PEF%Pred,FEV1%Pred),group).Results:the total effective rate was 85%in western medicine group and 92.5%in traditional Chinese and western medicine group(P<0.01).After treatment,the score of TCM syndromes in the Chinese and western medicine group was better than that in the western medicine group(P<0.05).After treatment,the pulmonary function(FEV1%Pred)of the traditional Chinese and western medicine group was better than that of the western medicine group,and the PEF%Pred of the Chinese and western medicine group was better than that of the western medicine group.Analysis of Blood Gas in traditional Chinese and Western Medicine Group after treatment(PaO2)was significantly higher than that in the control group(P<0.05).There was no significant difference in the improvement of blood gas analysis(PaCO2)between the western medicine group and the traditional Chinese and western medicine group(P>0.05).The decrease of IL-13,EOS and IL-5 in sputum of traditional Chinese and western medicine group was more than that of western medicine group(P<0.01).There was no significant difference in liver function(AST,ALT),renal function(Cr,Urea),blood routine(WBC,RBC,PLT)before and after treatment in traditional Chinese and western medicine group(P>0.05),but no obvious adverse reactions were found.Conclusions:heat Asthma decoction is safe and effective in the treatment of hot asthma syndrome in acute attack.The target and inflammatory factors,eosinophils are likely to decrease,and the effect of airway inflammation and high reaction are decreased.
基金Project supported by the National Natural Science Foundation of China(Grant No.U24A20139)supported by the Key Research and Development Project of Zhejiang Province(Grant No.22024C01117)the KeyResearch and Development Project of Hangzhou(Grant No.2023SZD0041).
文摘The biomimetic hydrofoils are frequently employed to enhance cavitation performance,although the underlying mechanisms remain to be fully elucidated.This study utilizes a cavitation visualization experimental system and mechanical characterization to experimentally investigate the transient cavitation features of a NACA0015 hydrofoil and its biomimetic counterparts with modified lending-edge.The findings demonstrate that,in comparison with the flat hydrofoil,the biomimetic hydrofoil experiences a cavitation morphology transition at a lower cavitation number,with a reduction of up to 0.38.Moreover,the maximum cavity length and the maximum cavitation area are reduced by 17.11%,17.32%,signifying a reduction in cavitation intensity.Proper orthogonal decomposition(POD)analysis revealed that the primary mechanism for the enhanced cavitation performance of the leading-edge wave structured biomimetic hydrofoil is the suppression of cloud cavitation shedding.At an attack angle of 6°,the biomimetic hydrofoil exhibited the highest lift coefficient increase of 18.56%,corresponding to a lift-to-drag ratio improvement of 9.56%.By analyzing the cavitation patterns of the two hydrofoils,it is evident that the rate of change in the maximum cavity length isolines for the biomimetic hydrofoil is lower than that of the flat hydrofoil.For an equivalent level of cavitation intensity,the biomimetic hydrofoil exhibits a lower cavitation number compared with the flat hydrofoil.These demonstrate that the wavy leading-edge design of the biomimetic hydrofoil effectively reduces the severity of cavitation,thereby confirming the efficacy of the biomimetic hydrofoil in enhancing cavitation performance.
