Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) S...Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) SmSb_(2) through electrical transport and synchrotron x-ray diffraction measurements.At P_(C)~2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition.In the pristine AFM phase below P_(C),the AFM transition temperature of SmSb_(2) is insensitive to pressure;in the emergent magnetic phase above P_(C),however,the magnetic critical temperature increases rapidly with increasing pressure.In addition,at ambient pressure,the magnetoresistivity(MR) of SmSb_(2) increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K.With increasing pressure above P_(C),the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent MR.This leads us to argue an AFM-like state for SmSb_(2) above P_(C).Within the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb_(2).展开更多
Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum rep...Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum representation ofits analytical solution. we find that the pure coherent states evolve into the new mixed thermal superposed states in thediffusion channel. Also, we investigate the statistical properties of the initial coherent states and their entropy evolutions inthe diffusion channel, and find that the entropy evolutions are only related to the decay time and without the amplitudes ofthe initial coherent states.展开更多
Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in...Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be elucidated.In this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were obtained.It was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and SeMDPGQQ.The protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative PCR.The results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.展开更多
The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 tempe...The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 temperature-programmed reduction （TPR）, and Mǒssbauer spectroscopy. The FTS performances of the catalysts were tested in a slurry phase reactor. The characterization results indicated that Mn increased the surface area of the catalyst, and improved the dispersion of （α-Fe2O3 and reduced its crystallite size as a result of the high dispersion effect of Mn and the Fe-Mn interaction. The Fe-Mn interaction also suppressed the reduction of （α-Fe2O3 to Fe3O4, stabilized the FeO phase, and （or） decreased the carburization degree of the catalysts in the H2 and syngas reduction processes. In addition, incorporated Mn decreased the initial catalyst activity, but improved the catalyst stability because Mn restrained the reoxidation of iron carbides to Fe3O4, and improved further carburization of the catalysts. Manganese suppressed the formation of CH4 and increased the selectivity to light olefins （C2-4^=）, but it had little effect on the selectivities to heavy （C5＋） hydrocarbons. All these results indicated that the strong Fe-Mn interaction suppressed the chemisorptive effect of the Mn as an electronic promoter, to some extent, in the precipitated iron-manganese catalyst system.展开更多
Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate comb...Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM. Methods： A retrospective review of data from 386 intramucosaL gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed. Results： LNM was detected in 40 （10.4%） of the 386 patients. Histological typeand vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection （ESD） indication also revealed that the undifferential type was the only significant factor for LNM. Conclusions： It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients.展开更多
Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regress...Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within3 mo and nearly all of the masses completely resolved within 1 year. We conclude that the clinical characteristics of inflammatory myofibroblastic tumors are variable and, accordingly, the disease needs to be subdivided and treated on an individual basis. Surgery is always the first-line treatment; however, for those masses assessed as unresectable, conservative therapy with in-tense follow-up should be considered.展开更多
The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground...The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground, causing displacement or stress to adjacent spread foundations. Based on the similarity theory, a laboratory model test of shield tunnel driving was carried out to study the influence of shield tunnel excavation on the displace ment of adjacent spread foundation. The results show that foundation closer to the tunnel has greater displacement or settlement than that further away. The horizontal dis placement is small and is influenced greatly by the cutting face. The displacement along the machine driving direction is bigger and is significantly affected by the thrust force. Settlement occurs primarily when shield machine passes close to the foundation and is the greatest at that time. Uneven settlement at the bottom of the spread foundation reaches a maximum after the excavation ends. In a numerical simulation, a particle flow model was con structed to study the impact of shield tunnel excavation on the stresses in the ground. The model showed stress con centration at the bottom of the spread foundation. With the increasing ground loss ratio, a loose area appears in the tunnel dome where the contact force dropped. Above the loose area, the contact force increases, forming an arch shaped soil area which prevents the loose area from expanding to the ground surface. The excavation also changed the pressure distribution around spread foundation.展开更多
Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of...Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Hehai University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes.展开更多
To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is ...To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in geomaterials.Considering the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated Mohr-Coulomb,and brittle Hoek-Brown media.Compared with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large deformation.The ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel walls.The stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening face.This study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.展开更多
Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was desig...Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was designed to evaluate the efficacy and clinical outcomes of atezolizumab plus etoposide/platinum(EP).Methods:Data obtained in this retrospective study were captured from six oncology units of five medical facilities from January 2019 to April 2022.For first-line treatments,atezolizumab combined with EP vs.EP alone,we primarily evaluated progression-free survival(PFS);other efficacy indicators,including overall survival(OS),objective response rate(ORR),and patterns of SCLC progression and adverse events(AEs)were assessed.Results:The primary analysis included data from 225 patients,of whom 133 received EP along with atezolizumab(atezolizumab group)and 92 received EP alone(EP group).The PFS duration of the atezolizumab group[7.10 months;95%confidence interval(95%CI),6.53-9.00]exceeded that of the EP group(6.50 months;95%CI,4.83-7.53).Overall,the hazard ratio(HR)was 0.69(95%CI,0.49-0.97)(P=0.029);particularly,the HR was 0.54(95%CI,0.36-0.80)among patients undergoing≥4 chemotherapy cycles and 0.33(95%CI,0.20-0.56)among individuals with atezolizumab maintenance.The ORR and disease-control rate(DCR)were similar between the two groups.Because of incomplete OS data,the median OS was not determined for either group.Bone marrow suppression was the most common AE detected(58.6%)in the atezolizumab group.Immune-related AEs occurred in 19 patients in the atezolizumab group(14.3%),with only one case of grade 3 encephalitis.Conclusions:This RW study in China demonstrated improved clinical outcomes of atezolizumab along with EP for ES-SCLC,particularly in the chemosensitive population.These results align with the results of the IMpower133 study,although the impact of this treatment modality on OS warrants additional follow-up studies.展开更多
In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s ...In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and fermentation.The change in the bacterial phase distribution after the fermentation was also analysed.The results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated digestion.Meanwhile,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated fermentation.In addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the CR.Therefore,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food.展开更多
A compressed sensing（CS） based channel estimation algorithm is proposed by using the delay-Doppler sparsity of the fast fading channel.A compressive basis expansion channel model with sparsity in both time and frequ...A compressed sensing（CS） based channel estimation algorithm is proposed by using the delay-Doppler sparsity of the fast fading channel.A compressive basis expansion channel model with sparsity in both time and frequency domains is given.The pilots in accordance with a novel random pilot matrix in both time and frequency domains are sent to measure the delay-Doppler sparsity channel.The relatively nonzero channel coefficients are tracked by random pilots at a sampling rate significantly below the Nyquist rate.The sparsity channels are estimated from a very limited number of channel measurements by the basis pursuit algorithm.The proposed algorithm can effectively improve the channel estimation performance when the number of pilot symbols is reduced with improvement of throughput efficiency.展开更多
In recent years,the rapid development of e-commerce exposes great vulnerabilities in online transactions for fraudsters to exploit.Credit card transactions take a salient role in nowadays’online transactions for its ...In recent years,the rapid development of e-commerce exposes great vulnerabilities in online transactions for fraudsters to exploit.Credit card transactions take a salient role in nowadays’online transactions for its obvious advantages including discounts and earning credit card points.So credit card fraudulence has become a target of concern.In order to deal with the situation,credit card fraud detection based on machine learning is been studied recently.Yet,it is difficult to detect fraudulent transactions due to data imbalance(normal and fraudulent transactions),for which Smote algorithm is proposed in order to resolve data imbalance.The assessment of Light Gradient Boosting Machine model which proposed in the paper depends much on datasets collected from clients’daily transactions.Besides,to prove the new model’s superiority in detecting credit card fraudulence,Light Gradient Boosting Machine model is compared with Random Forest and Gradient Boosting Machine algorithm in the experiment.The results indicate that Light Gradient Boosting Machine model has a good performance.The experiment in credit card fraud detection based on Light Gradient Boosting Machine model achieved a total recall rate of 99%in real dataset and fast feedback,which proves the new model’s efficiency in detecting credit card fraudulence.展开更多
System logs are essential for detecting anomalies,querying faults,and tracing attacks.Because of the time-consuming and labor-intensive nature of manual system troubleshooting and anomaly detection,it cannot meet the ...System logs are essential for detecting anomalies,querying faults,and tracing attacks.Because of the time-consuming and labor-intensive nature of manual system troubleshooting and anomaly detection,it cannot meet the actual needs.The implementation of automated log anomaly detection is a topic that demands urgent research.However,the prior work on processing log data is mainly one-dimensional and cannot profoundly learn the complex associations in log data.Meanwhile,there is a lack of attention to the utilization of log labels and usually relies on a large number of labels for detection.This paper proposes a novel and practical detection model named LCC-HGLog,the core of which is the conversion of log anomaly detection into a graph classification problem.Semantic temporal graphs(STG)are constructed by extracting the raw logs’execution sequences and template semantics.Then a unique graph classifier is used to better comprehend each STG’s semantic,sequential,and structural features.The classification model is trained jointly by graph classification loss and label contrastive loss.While achieving discriminability at the class-level,it increases the fine-grained identification at the instance-level,thus achieving detection performance even with a small amount of labeled data.We have conducted numerous experiments on real log datasets,showing that the proposed model outperforms the baseline methods and obtains the best all-around performance.Moreover,the detection performance degrades to less than 1%when only 10%of the labeled data is used.With 200 labeled samples,we can achieve the same or better detection results than the baseline methods.展开更多
BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two ca...BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two cases of which are unilateral scrotal agenesis and not accompanied by cryptorchidism.This is the first reported case of unilateral scrotal agenesis with cryptorchidism and scrotoplasty.CASE SUMMARY A 2-year-old boy was admitted to our hospital with left cryptorchidism and ipsilateral CSA.An innovative method was used in the patient where a scrotal skin pedicle from the right part of scrotal skin was transplanted to the left side.At the same time,descent orchiopexy was performed.At the 4-mo follow-up,the left testicle was located in the scrotum and the size and shape were normal.CONCLUSION For unilateral CSA with ipsilateral cryptorchidism,contralateral scrotal pedicle transplantation and descent orchiopexy appear to be a successful surgical option.展开更多
基金Project supported by the National Key Research and Development Program of China (Grant Nos. 2023YFA1406102 and 2022YFA1602603)the National Natural Science Foundation of China (Grant Nos. 12374049 and 12174395)+2 种基金the China Postdoctoral Science Foundation (Grant No. 2023M743542)Hefei Institutes of Physical Science,Chinese Academy of Sciences the Director’s Fundation of (Grant No. YZJJ2024QN41)the Basic Research Program of the Chinese Academy of Sciences Based on Major Scientific Infrastructures (Grant No. JZHKYPT-2021-08)。
文摘Motivated by the recent discovery of unconventional superconductivity around a magnetic quantum critical point in pressurized CeSb_(2),here we present a high-pressure study of an isostructural antiferromagnetic(AFM) SmSb_(2) through electrical transport and synchrotron x-ray diffraction measurements.At P_(C)~2.5 GPa,we found a pressure-induced magnetic phase transition accompanied by a Cmca→P4/nmm structural phase transition.In the pristine AFM phase below P_(C),the AFM transition temperature of SmSb_(2) is insensitive to pressure;in the emergent magnetic phase above P_(C),however,the magnetic critical temperature increases rapidly with increasing pressure.In addition,at ambient pressure,the magnetoresistivity(MR) of SmSb_(2) increases suddenly upon cooling below the AFM transition temperature and presents linear nonsaturating behavior under high field at 2 K.With increasing pressure above P_(C),the MR behavior remains similar to that observed at ambient pressure,both in terms of temperature-and field-dependent MR.This leads us to argue an AFM-like state for SmSb_(2) above P_(C).Within the investigated pressure of up to 45.3 GPa and the temperature of down to 1.8 K,we found no signature of superconductivity in SmSb_(2).
基金Collaborative Innovation Project of University,Anhui Province(Grant No.GXXT-2022-088).
文摘Using the operator correspondence of the real and fictious modes in the thermo entangled state representation, wesolve the quantum master equation describing the diffusion channel and obtain the Kraus operator-sum representation ofits analytical solution. we find that the pure coherent states evolve into the new mixed thermal superposed states in thediffusion channel. Also, we investigate the statistical properties of the initial coherent states and their entropy evolutions inthe diffusion channel, and find that the entropy evolutions are only related to the decay time and without the amplitudes ofthe initial coherent states.
基金supported by the National Natural Science Foundation of China(32272319,31972020,32202032)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be elucidated.In this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were obtained.It was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and SeMDPGQQ.The protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative PCR.The results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.
基金Foundation item:the National Outstanding Young Scientists Foundation of China(20625620)the National Key Basic Research Program of China(973 Program,2007CB216401)+1 种基金the National Natural Science Foundation of China(20590360)the Natural Science Foundation of Shanxi Province(2006021014).
文摘The effects of Manganese （Mn） incorporation on a precipitated iron-based Fischer-Tropsch synthesis （FTS） catalyst were investigated using N2 physical adsorption, air differential thermal analysis （DTA）, H2 temperature-programmed reduction （TPR）, and Mǒssbauer spectroscopy. The FTS performances of the catalysts were tested in a slurry phase reactor. The characterization results indicated that Mn increased the surface area of the catalyst, and improved the dispersion of （α-Fe2O3 and reduced its crystallite size as a result of the high dispersion effect of Mn and the Fe-Mn interaction. The Fe-Mn interaction also suppressed the reduction of （α-Fe2O3 to Fe3O4, stabilized the FeO phase, and （or） decreased the carburization degree of the catalysts in the H2 and syngas reduction processes. In addition, incorporated Mn decreased the initial catalyst activity, but improved the catalyst stability because Mn restrained the reoxidation of iron carbides to Fe3O4, and improved further carburization of the catalysts. Manganese suppressed the formation of CH4 and increased the selectivity to light olefins （C2-4^=）, but it had little effect on the selectivities to heavy （C5＋） hydrocarbons. All these results indicated that the strong Fe-Mn interaction suppressed the chemisorptive effect of the Mn as an electronic promoter, to some extent, in the precipitated iron-manganese catalyst system.
文摘Objective： Accurate estimation of lymph node metastasis （LNM） in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM. Methods： A retrospective review of data from 386 intramucosaL gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed. Results： LNM was detected in 40 （10.4%） of the 386 patients. Histological typeand vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection （ESD） indication also revealed that the undifferential type was the only significant factor for LNM. Conclusions： It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients.
文摘Inflammatory myofibroblastic tumors are usually treated by surgical resection. We herein report two cases of intra-abdominal inflammatory myofibroblastic tumors that were unresectable and underwent spontaneous regression without any treatment. Our case report and literature review show that regression is more common in the middle-aged and older male populations. Abdominal discomfort and fever were the most common symptoms, but the majority of patients had no obvious physical signs. There was no specific indicator for diagnosis. The majority of the lesions regressed within3 mo and nearly all of the masses completely resolved within 1 year. We conclude that the clinical characteristics of inflammatory myofibroblastic tumors are variable and, accordingly, the disease needs to be subdivided and treated on an individual basis. Surgery is always the first-line treatment; however, for those masses assessed as unresectable, conservative therapy with in-tense follow-up should be considered.
基金funded by the National Natural Science Foundation of China (Nos. 51278422 and 50925830)the National 973 Plan Topics of China (No. 2010CB732105)+1 种基金the National Science and Technology Pillar Program of China (No. 2012BAG05B03)the Sichuan Youth Science and Technology Foundation, China (No. 2012JQ0021)
文摘The section of shield tunnel of the Chengdu Metro line passes primarily through sandy cobble strata. There are many buildings with spread foundations along the lines. Shield tunnel construction will disturb the ground, causing displacement or stress to adjacent spread foundations. Based on the similarity theory, a laboratory model test of shield tunnel driving was carried out to study the influence of shield tunnel excavation on the displace ment of adjacent spread foundation. The results show that foundation closer to the tunnel has greater displacement or settlement than that further away. The horizontal dis placement is small and is influenced greatly by the cutting face. The displacement along the machine driving direction is bigger and is significantly affected by the thrust force. Settlement occurs primarily when shield machine passes close to the foundation and is the greatest at that time. Uneven settlement at the bottom of the spread foundation reaches a maximum after the excavation ends. In a numerical simulation, a particle flow model was con structed to study the impact of shield tunnel excavation on the stresses in the ground. The model showed stress con centration at the bottom of the spread foundation. With the increasing ground loss ratio, a loose area appears in the tunnel dome where the contact force dropped. Above the loose area, the contact force increases, forming an arch shaped soil area which prevents the loose area from expanding to the ground surface. The excavation also changed the pressure distribution around spread foundation.
基金supported by National Natural Science Fund(No.31842033)。
文摘Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Hehai University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes.
基金financial supports from the Foundation of Key Laboratory of Transportation Tunnel Engineering(Southwest Jiaotong University)Ministry of Education,China(Grant No.TTE2017-04)+1 种基金National Natural Science Foundation of China(Grant No.51908546)Natural Science Foundation of Jiangsu Province(Grant No.BK20170279)。
文摘To provide precise prediction of tunnelling-induced deformation of the surrounding geomaterials,a framework for derivation of rigorous large-strain solutions of unified spherical and cylindrical cavity contraction is presented for description of confinement-convergence responses for deep tunnels in geomaterials.Considering the tunnelling-induced large deformation,logarithmic strains are adopted for cavity contraction analyses in linearly elastic,non-associated Mohr-Coulomb,and brittle Hoek-Brown media.Compared with approximate solutions,the approximation error indicates the importance of release of small-strain restrictions for estimating tunnel convergence profiles,especially in terms of the scenarios with high stress condition and stiffness degradation under large deformation.The ground reaction curve is therefore predicted to describe the volume loss and stress relaxation around the tunnel walls.The stiffness of circular lining is calculated from the geometry and equivalent modulus of the supporting structure,and a lining installation factor is thus introduced to indicate the time of lining installation based on the prediction of spherical cavity contraction around the tunnel opening face.This study also provides a general approach for solutions using other sophisticated geomaterial models,and serves as benchmarks for analytical developments in consideration of nonlinear large-deformation behaviour and for numerical analyses of underground excavation.
基金supported by National Natural Science Foundation of China(No.82141117)the Capital Health Research and Development of Special Fund(No.2022-21023)+2 种基金Beijing Municipal Administration of Hospitals Incubating Program(No.PX2020045)Science Foundation of Peking University Cancer Hospital(No.2020-4)Wu Jieping Medical Foundation(No.320.6750.2021-16-19)。
文摘Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was designed to evaluate the efficacy and clinical outcomes of atezolizumab plus etoposide/platinum(EP).Methods:Data obtained in this retrospective study were captured from six oncology units of five medical facilities from January 2019 to April 2022.For first-line treatments,atezolizumab combined with EP vs.EP alone,we primarily evaluated progression-free survival(PFS);other efficacy indicators,including overall survival(OS),objective response rate(ORR),and patterns of SCLC progression and adverse events(AEs)were assessed.Results:The primary analysis included data from 225 patients,of whom 133 received EP along with atezolizumab(atezolizumab group)and 92 received EP alone(EP group).The PFS duration of the atezolizumab group[7.10 months;95%confidence interval(95%CI),6.53-9.00]exceeded that of the EP group(6.50 months;95%CI,4.83-7.53).Overall,the hazard ratio(HR)was 0.69(95%CI,0.49-0.97)(P=0.029);particularly,the HR was 0.54(95%CI,0.36-0.80)among patients undergoing≥4 chemotherapy cycles and 0.33(95%CI,0.20-0.56)among individuals with atezolizumab maintenance.The ORR and disease-control rate(DCR)were similar between the two groups.Because of incomplete OS data,the median OS was not determined for either group.Bone marrow suppression was the most common AE detected(58.6%)in the atezolizumab group.Immune-related AEs occurred in 19 patients in the atezolizumab group(14.3%),with only one case of grade 3 encephalitis.Conclusions:This RW study in China demonstrated improved clinical outcomes of atezolizumab along with EP for ES-SCLC,particularly in the chemosensitive population.These results align with the results of the IMpower133 study,although the impact of this treatment modality on OS warrants additional follow-up studies.
基金financial support from the National Key R&D Program of China(2018YFD0400500)the Key Research and Development Program of Jiangsu Province(BE2018323)Qing Lan Project of Jiangsu Province and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and fermentation.The change in the bacterial phase distribution after the fermentation was also analysed.The results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated digestion.Meanwhile,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated fermentation.In addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the CR.Therefore,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food.
基金supported by the National Natural Science Foundation of China(60972056)the Innovation Foundation of Shanghai Education Committee(09ZZ89)Shanghai Leading Academic Discipline Project and STCSM(S30108and08DZ2231100)
文摘A compressed sensing（CS） based channel estimation algorithm is proposed by using the delay-Doppler sparsity of the fast fading channel.A compressive basis expansion channel model with sparsity in both time and frequency domains is given.The pilots in accordance with a novel random pilot matrix in both time and frequency domains are sent to measure the delay-Doppler sparsity channel.The relatively nonzero channel coefficients are tracked by random pilots at a sampling rate significantly below the Nyquist rate.The sparsity channels are estimated from a very limited number of channel measurements by the basis pursuit algorithm.The proposed algorithm can effectively improve the channel estimation performance when the number of pilot symbols is reduced with improvement of throughput efficiency.
文摘In recent years,the rapid development of e-commerce exposes great vulnerabilities in online transactions for fraudsters to exploit.Credit card transactions take a salient role in nowadays’online transactions for its obvious advantages including discounts and earning credit card points.So credit card fraudulence has become a target of concern.In order to deal with the situation,credit card fraud detection based on machine learning is been studied recently.Yet,it is difficult to detect fraudulent transactions due to data imbalance(normal and fraudulent transactions),for which Smote algorithm is proposed in order to resolve data imbalance.The assessment of Light Gradient Boosting Machine model which proposed in the paper depends much on datasets collected from clients’daily transactions.Besides,to prove the new model’s superiority in detecting credit card fraudulence,Light Gradient Boosting Machine model is compared with Random Forest and Gradient Boosting Machine algorithm in the experiment.The results indicate that Light Gradient Boosting Machine model has a good performance.The experiment in credit card fraud detection based on Light Gradient Boosting Machine model achieved a total recall rate of 99%in real dataset and fast feedback,which proves the new model’s efficiency in detecting credit card fraudulence.
基金the National Natural Science Foundation of China(U20B2045).
文摘System logs are essential for detecting anomalies,querying faults,and tracing attacks.Because of the time-consuming and labor-intensive nature of manual system troubleshooting and anomaly detection,it cannot meet the actual needs.The implementation of automated log anomaly detection is a topic that demands urgent research.However,the prior work on processing log data is mainly one-dimensional and cannot profoundly learn the complex associations in log data.Meanwhile,there is a lack of attention to the utilization of log labels and usually relies on a large number of labels for detection.This paper proposes a novel and practical detection model named LCC-HGLog,the core of which is the conversion of log anomaly detection into a graph classification problem.Semantic temporal graphs(STG)are constructed by extracting the raw logs’execution sequences and template semantics.Then a unique graph classifier is used to better comprehend each STG’s semantic,sequential,and structural features.The classification model is trained jointly by graph classification loss and label contrastive loss.While achieving discriminability at the class-level,it increases the fine-grained identification at the instance-level,thus achieving detection performance even with a small amount of labeled data.We have conducted numerous experiments on real log datasets,showing that the proposed model outperforms the baseline methods and obtains the best all-around performance.Moreover,the detection performance degrades to less than 1%when only 10%of the labeled data is used.With 200 labeled samples,we can achieve the same or better detection results than the baseline methods.
基金Supported by the National Natural Science Foundation of China,No.81602219
文摘BACKGROUND Congenital scrotal agenesis(CSA)is very rare.There are 11 cases of congenital scrotal agenesis or absence reported in the literature,most of which are bilateral and accompanied by cryptorchidism.Only two cases of which are unilateral scrotal agenesis and not accompanied by cryptorchidism.This is the first reported case of unilateral scrotal agenesis with cryptorchidism and scrotoplasty.CASE SUMMARY A 2-year-old boy was admitted to our hospital with left cryptorchidism and ipsilateral CSA.An innovative method was used in the patient where a scrotal skin pedicle from the right part of scrotal skin was transplanted to the left side.At the same time,descent orchiopexy was performed.At the 4-mo follow-up,the left testicle was located in the scrotum and the size and shape were normal.CONCLUSION For unilateral CSA with ipsilateral cryptorchidism,contralateral scrotal pedicle transplantation and descent orchiopexy appear to be a successful surgical option.
