Due to overactive inflammation and hindered angiogenesis,self-healing of diabetic wounds(DW)remains challenging in the clinic.Platelet-derived exosomes(PLT-Exos),a novel exosome capable of anti-inflammation and pro-an...Due to overactive inflammation and hindered angiogenesis,self-healing of diabetic wounds(DW)remains challenging in the clinic.Platelet-derived exosomes(PLT-Exos),a novel exosome capable of anti-inflammation and pro-angiogenesis,show great potential in DW treatment.However,previous administration of exosomes into skin wounds is topical daub or intradermal injection,which cannot intradermally deliver PLT-Exos into the dermis layer,thus impeding its long-term efficacy in anti-inflammation and pro-angiogenesis.Herein,a dissolvable microneedle-based wound dressing(PLT-Exos@ADMMA-MN)was developed for transdermal and long-term delivery of PLT-Exos.Firstly,a photo-crosslinking methacrylated acellular dermal matrix-based hydrogel(ADMMA-GEL),showing physiochemical tailorability,fast-gelling performance,excellent biocompatibility,and pro-angiogenic capacities,was synthesized as a base material of our dressing.For endowing the dressing with anti-inflammation and pro-angiogenesis,PLT-Exos were encapsulated into ADMMA-GEL with a minimum effective concentration determined by our in-vitro experiments.Then,in-vitro results show that this dressing exhibits excellent properties in anti-inflammation and pro-angiogenesis.Lastly,in-vivo experiments showed that this dressing could continuously and transdermally deliver PLT-Exos into skin wounds to switch local macrophage into M2 phenotype while stimulating neovascularization,thus proving a low-inflammatory and pro-angiogenic microenvironment for DW healing.Collectively,this study provides a novel wound dressing capable of suppressing inflammation and stimulating vascularization for DW treatment.展开更多
Binders play a crucial role in enhancing the cycling stability of silicon anodes in next-generation Li-ion batteries.However,traditional linear polymer binders have difficulty withstanding the volume expansion of sili...Binders play a crucial role in enhancing the cycling stability of silicon anodes in next-generation Li-ion batteries.However,traditional linear polymer binders have difficulty withstanding the volume expansion of silicon during cycling.Herein,inspired by the fact that animals’claws can grasp objects firmly,a claw-like taurine-grafted-poly(acrylic acid)binder(Tau-g-PAA)is designed to improve the electrochemical performance of silicon anodes.The synergistic effects of different polar groups(sulfo and carboxyl)in Tau-g-PAA facilitate the formation of multidimensional interactions with silicon nanoparticles and the diffusion of Li ions,thereby greatly improving the stability and rate performance of silicon anodes,which aligns with results from density functional theory(DFT)simulations.As expected,a Tau-g-PAA/Si electrode exhibits excellent cycling performance with a high specific capacity of 1003mAhg−1at 1C(1C=4200mAhg−1)after 300 cycles,and a high rate performance.The design strategy of using polar small molecule-grafted polymers to create claw-like structures could inspire the development of better binders for silicon-based anodes.展开更多
Summary What is already known about this topic?Burkholderia pseudomallei(BP)infection leads to melioidosis,a tropical disease endemic to coastal provinces of southern China.Physicians in nonendemic areas,do not common...Summary What is already known about this topic?Burkholderia pseudomallei(BP)infection leads to melioidosis,a tropical disease endemic to coastal provinces of southern China.Physicians in nonendemic areas,do not commonly consider this disease as a primary differential diagnosis for febrile patients.What is added by this report?This article discusses a case of melioidosis in Northern China.The patient,who had recently visited a Southeast Asian region with high melioidosis prevalence,fell ill after exposure to contaminated water.The disease progressed quickly and with severity.What are the implications for public health practice?Healthcare workers need to remain vigilant regarding travel-related diseases for accurate differential diagnosis and to provide timely and effective treatment,especially for patients with recent travel history or symptoms during travel.展开更多
Developing new types of rechargeable metal-ion batteries beyond lithium-ions,including alkaline ion(such as Na+,K+)and multivalent ion(such as Mg 2+,Zn 2+,Ca 2+and Al 3+)batteries,is progressing quickly towards large-...Developing new types of rechargeable metal-ion batteries beyond lithium-ions,including alkaline ion(such as Na+,K+)and multivalent ion(such as Mg 2+,Zn 2+,Ca 2+and Al 3+)batteries,is progressing quickly towards large-scale energy storage systems.However,the major obstacle to their large-scale applications has been a lack of appropriate electrode materials with reversible metal ions insertion/extraction be-havior,resulting in inferior electrochemical performance.Here we develop a well-designed MoS_(2)/MoO_(2) hybrid nanosheets anchored on carbon cloth(MoS_(2)/MoO_(2)/CC)as electrode materials.This rational de-sign can effectively shorten ion diffusion distance,increase electric conductivity of the electrode,and buffer volume change.Benefiting from the synergistic effect of structural and compositional features,the MoS_(2)/MoO_(2)/CC electrode exhibits high initial reversible capacities(326 mA h g^(−1) at 0.1 A g^(−1) in magnesium-ion storage;1270 mA h g^(−1) at 0.1 A g^(−1) in sodium-ion storage),excellent rate capacities(57 mA h g^(−1) at 10 A g^(−1) in magnesium-ion storage;335 mA h g^(−1) at 5 A g^(−1) in sodium-ion storage)and long-term cycling stability(105 mA h g^(−1) after 600 cycle at 1 A g^(−1) in magnesium-ion storage;208 mA h g^(−1) after 600 cycles at 5 A g^(−1) in sodium-ion storage).We expect that the multi-engineering strategy will provide some valuable insights for the development of other advanced electrode materials for high-performance metal-ion batteries.展开更多
基金financially supported through grants from the National Natural Science Foundation of China(Grant No.82272497)Hunan Provincial Natural Science Foundation(Grant Nos.2021JJ20093,2022JJ30001,2023JJ40090)the Hunan Provincial Health Commission Scientific Research Projects(Grant No.202204075237).
文摘Due to overactive inflammation and hindered angiogenesis,self-healing of diabetic wounds(DW)remains challenging in the clinic.Platelet-derived exosomes(PLT-Exos),a novel exosome capable of anti-inflammation and pro-angiogenesis,show great potential in DW treatment.However,previous administration of exosomes into skin wounds is topical daub or intradermal injection,which cannot intradermally deliver PLT-Exos into the dermis layer,thus impeding its long-term efficacy in anti-inflammation and pro-angiogenesis.Herein,a dissolvable microneedle-based wound dressing(PLT-Exos@ADMMA-MN)was developed for transdermal and long-term delivery of PLT-Exos.Firstly,a photo-crosslinking methacrylated acellular dermal matrix-based hydrogel(ADMMA-GEL),showing physiochemical tailorability,fast-gelling performance,excellent biocompatibility,and pro-angiogenic capacities,was synthesized as a base material of our dressing.For endowing the dressing with anti-inflammation and pro-angiogenesis,PLT-Exos were encapsulated into ADMMA-GEL with a minimum effective concentration determined by our in-vitro experiments.Then,in-vitro results show that this dressing exhibits excellent properties in anti-inflammation and pro-angiogenesis.Lastly,in-vivo experiments showed that this dressing could continuously and transdermally deliver PLT-Exos into skin wounds to switch local macrophage into M2 phenotype while stimulating neovascularization,thus proving a low-inflammatory and pro-angiogenic microenvironment for DW healing.Collectively,this study provides a novel wound dressing capable of suppressing inflammation and stimulating vascularization for DW treatment.
基金This work was financially supported by the National Natural Science Foundation of China(No:22075173)the Science and Technology Commission of Shanghai Municipality(19DZ2271100 and 21010501100)the Australian Research Council(DE240100159)。
文摘Binders play a crucial role in enhancing the cycling stability of silicon anodes in next-generation Li-ion batteries.However,traditional linear polymer binders have difficulty withstanding the volume expansion of silicon during cycling.Herein,inspired by the fact that animals’claws can grasp objects firmly,a claw-like taurine-grafted-poly(acrylic acid)binder(Tau-g-PAA)is designed to improve the electrochemical performance of silicon anodes.The synergistic effects of different polar groups(sulfo and carboxyl)in Tau-g-PAA facilitate the formation of multidimensional interactions with silicon nanoparticles and the diffusion of Li ions,thereby greatly improving the stability and rate performance of silicon anodes,which aligns with results from density functional theory(DFT)simulations.As expected,a Tau-g-PAA/Si electrode exhibits excellent cycling performance with a high specific capacity of 1003mAhg−1at 1C(1C=4200mAhg−1)after 300 cycles,and a high rate performance.The design strategy of using polar small molecule-grafted polymers to create claw-like structures could inspire the development of better binders for silicon-based anodes.
文摘Summary What is already known about this topic?Burkholderia pseudomallei(BP)infection leads to melioidosis,a tropical disease endemic to coastal provinces of southern China.Physicians in nonendemic areas,do not commonly consider this disease as a primary differential diagnosis for febrile patients.What is added by this report?This article discusses a case of melioidosis in Northern China.The patient,who had recently visited a Southeast Asian region with high melioidosis prevalence,fell ill after exposure to contaminated water.The disease progressed quickly and with severity.What are the implications for public health practice?Healthcare workers need to remain vigilant regarding travel-related diseases for accurate differential diagnosis and to provide timely and effective treatment,especially for patients with recent travel history or symptoms during travel.
基金financially supported by in part the National Science Fund for Distinguished Young Scholars (No.51625102)the National Natural Science Foundation of China (Nos.51971065,22075173)+1 种基金the Innovation Program of Shanghai Municipal Educa-tion Commission (No.2019-01-07-00-07-E00028)the Science and Science and Technology Commission of Shanghai Municipality (Nos.19DZ2271100 and 21010501100).
文摘Developing new types of rechargeable metal-ion batteries beyond lithium-ions,including alkaline ion(such as Na+,K+)and multivalent ion(such as Mg 2+,Zn 2+,Ca 2+and Al 3+)batteries,is progressing quickly towards large-scale energy storage systems.However,the major obstacle to their large-scale applications has been a lack of appropriate electrode materials with reversible metal ions insertion/extraction be-havior,resulting in inferior electrochemical performance.Here we develop a well-designed MoS_(2)/MoO_(2) hybrid nanosheets anchored on carbon cloth(MoS_(2)/MoO_(2)/CC)as electrode materials.This rational de-sign can effectively shorten ion diffusion distance,increase electric conductivity of the electrode,and buffer volume change.Benefiting from the synergistic effect of structural and compositional features,the MoS_(2)/MoO_(2)/CC electrode exhibits high initial reversible capacities(326 mA h g^(−1) at 0.1 A g^(−1) in magnesium-ion storage;1270 mA h g^(−1) at 0.1 A g^(−1) in sodium-ion storage),excellent rate capacities(57 mA h g^(−1) at 10 A g^(−1) in magnesium-ion storage;335 mA h g^(−1) at 5 A g^(−1) in sodium-ion storage)and long-term cycling stability(105 mA h g^(−1) after 600 cycle at 1 A g^(−1) in magnesium-ion storage;208 mA h g^(−1) after 600 cycles at 5 A g^(−1) in sodium-ion storage).We expect that the multi-engineering strategy will provide some valuable insights for the development of other advanced electrode materials for high-performance metal-ion batteries.
