The 2016 MW7.8 Kaikoura earthquake struck the northern part of south Island,New Zealand,within the active and complex Australia-Pacific plate boundary system.Firstly,we used the InSAR method to obtain coseismic LOS de...The 2016 MW7.8 Kaikoura earthquake struck the northern part of south Island,New Zealand,within the active and complex Australia-Pacific plate boundary system.Firstly,we used the InSAR method to obtain coseismic LOS deformation fields based on SAR images and applied offset tracking methods to obtain offset measurements based on optical satellite images.The maximum displacement of about 6 m is detected in the direction away from the satellite on the south-west side and also towards the satellite on the north-east side.The 3D deformation field is then resolved by the combination of these measurements with a least-square solve method,and comparisons with 3 components of GPS stations show good consistency.Despite complex features demonstrated in the 3D deformation field,there are still clear spatial correlations between surface deformation and faults distribution.It reveals that more than ten faults were ruptured during the earthquake,including some faults were previously understudies for their tectonic activities.The maximum horizontal deformation of about 10 m occurs along the Kekerengu fault with the vertical deformation up to 2 m.The 3D deformation shows that the mainshock is a multisegments faulting with a rupture process of strike-slip,compression,transpressional rupture and strike-slip in space along the NE direction.展开更多
Maintenance of aero-engine fleets is crucial for the efficiency,safety,and reliability of the aviation industry.With the increasing demand for air transportation,maintaining high-performing aero-engines has become sig...Maintenance of aero-engine fleets is crucial for the efficiency,safety,and reliability of the aviation industry.With the increasing demand for air transportation,maintaining high-performing aero-engines has become significant.Collaborative maintenance,specifically targeting aero-engine fleets,involves the coordination of multiple tasks and resources to enhance management efficiency and reduce costs.Digital Twin(DT)technology provides essential technical support for the intelligent operation and maintenance of aero-engine fleets.DT maps physical object properties to the virtual world,creating high-fidelity,dynamic models.However,DT-enhanced collaborative maintenance faces various challenges,including the construction of complex system-layer DT models,management of massive integrated DT data,and the development of fusion mechanisms and decision-making methods for DT data and models.Overcoming these challenges will allow the aviation industry to optimize aero-engine fleet maintenance,ensuring safety,efficiency,and cost-effectiveness while meeting the growing demand for air transportation.展开更多
Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA...Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan.展开更多
The mechanical behavior and progressive damage mechanism of novel aluminum matrix composites reinforced with 3D angle-interlock woven carbon fibers were investigated using a multiscale modeling approach.The mechanical...The mechanical behavior and progressive damage mechanism of novel aluminum matrix composites reinforced with 3D angle-interlock woven carbon fibers were investigated using a multiscale modeling approach.The mechanical properties and failure of yarns were evaluated using a microscale model under different loading scenarios.On this basis,a mesoscale model was developed to analyze the tensile behavior and failure mechanism of the composites.The interfacial decohesion,matrix damage,and failure of fibers and yarns were incorporated into the microscopic and mesoscopic models.The stress–strain curves and fracture modes from simulation show good agreement with the experimental curves and fracture morphology.Local interface and matrix damage initiate first under warp directional tension.Thereafter,interfacial failure,weft yarn cracking,and matrix failure occur successively.Axial fracture of warp yarn,which displays a quasi-ductile fracture characteristic,dominates the ultimate composites failure.Under weft directional tension,interfacial failure and warp yarn rupture occur at the early and middle stages.Matrix failure and weft yarn fracture emerge simultaneously at the final stage,leading to the cata-strophic failure of composites.The weft directional strength and fracture strain are lower than the warp directional ones because of the lower weft density and the more serious brittle fracture of weft yarns.展开更多
Objective To conduct a comparative study on the brain pharmacokinetics of seven ingredients(i.e.senkyunolide A,ferulic acid,formononetin,calycosin,ononin,calycosin-O-β-D-glucopyranoside,and paeoniflorin),which were t...Objective To conduct a comparative study on the brain pharmacokinetics of seven ingredients(i.e.senkyunolide A,ferulic acid,formononetin,calycosin,ononin,calycosin-O-β-D-glucopyranoside,and paeoniflorin),which were the compounds of Buyang Huanwu Decoction(BHD),in normal and cerebral ischemia rats administrated intragastrically with BHD.Methods The samples of normal and permanent middle cerebral artery occlusion(pMCAO)rats were collected by using brain microdialysis technique.The concentrations of seven ingredients were determined by the HPLC-MS/MS method.After the BHD were administrated intragastrically to the rats for seven consecutive days,brain microdialysis probes were inserted into the hippocampus of rats,and then the brain microdialysates were collected at 20 min time intervals for 5 h.The separation of the seven ingredients and internal standard(IS)was carried out on an ACQUITY UPLC BEH C18(2.1 mm×100 mm,1.7μm)chromatographic column,using a mobile phase consisting of acetonitrile(containing 0.1%formic acid)and water(containing 0.1%formic acid)for gradient elution within 13 min.The ionization was conducted using an ESI source in positive ion mode.Multiple reaction monitoring mode was used for quantification of ingredients in BHD.Results Linearity,accuracy,precision,matrix effect and stability of LC-MS/MS method were all satisfactory,successfully applied to compare the pharmacokinetics of the analytes between normal and model rats after intragastric administration of BHD.Compared with the normal group,the model group after the administration of the BHD showed that T1/2 of formononetin and ononin were longer,and except for calycosin-O-β-D-glucopyranoside(P<0.01),there was no significant difference between the normal group and the model group.The C_(max) of senkyunolide A and calycosin of model group were increased,while the T_(max) of senkyunolide A was decreased,and except for the T_(max) of PF,the differences between the two groups were statistically significant(P<0.01).Conclusion The LC-MS/MS method combined with microdialysis was successfully applied to the comparative study of brain pharmacokinetics of seven ingredients in BHD.After intragastric administration of BHD,there were differences in the pharmacokinetics of seven ingredients in the brain hippocampus between normal rats and model rats,probably related to the characteristics of the ingredients and the effects of cerebral ischemia on the absorption and distribution of the ingredients.展开更多
Trends toward the globalization of the manufacturing industry and the increasing demands for small-batch,short-cycle,and highly customized products result in complexities and fluctuations in both external and internal...Trends toward the globalization of the manufacturing industry and the increasing demands for small-batch,short-cycle,and highly customized products result in complexities and fluctuations in both external and internal manufacturing environments,which poses great challenges to manufacturing enterprises.Fortunately,recent advances in the Industrial Internet of Things(IIoT)and the widespread use of embedded processors and sensors in factories enable collecting real-time manufacturing status data and building cyber–physical systems for smart,flexible,and resilient manufacturing systems.In this context,this paper investigates the mechanisms and methodology of self-organization and self-adaption to tackle exceptions and disturbances in discrete manufacturing processes.Specifically,a general model of smart manufacturing complex networks is constructed using scale-free networks to interconnect heterogeneous manufacturing resources represented by network vertices at multiple levels.Moreover,the capabilities of physical manufacturing resources are encapsulated into virtual manufacturing services using cloud technology,which can be added to or removed from the networks in a plug-and-play manner.Materials,information,and financial assets are passed through interactive links across the networks.Subsequently,analytical target cascading is used to formulate the processes of self-organizing optimal configuration and self-adaptive collaborative control for multilevel key manufacturing resources while particle swarm optimization is used to solve local problems on network vertices.Consequently,an industrial case based on a Chinese engine factory demonstrates the feasibility and efficiency of the proposed model and method in handling typical exceptions.The simulation results show that the proposed mechanism and method outperform the event-triggered rescheduling method,reducing manufacturing cost,manufacturing time,waiting time,and energy consumption,with reasonable computational time.This work potentially enables managers and practitioners to implement active perception,active response,self-organization,and self-adaption solutions in discrete manufacturing enterprises.展开更多
基金co-supported by the National Key Research and Development Program of China(Grant No.2019YFC1509204)the National Nonprofit Fundamental Research Grant of China,Institute of Geology,China Earthquake Administration(Grant No.IGCEA2005 and No.IGCEA2014)the National Science Foundation of China(Grant No.41631073)
文摘The 2016 MW7.8 Kaikoura earthquake struck the northern part of south Island,New Zealand,within the active and complex Australia-Pacific plate boundary system.Firstly,we used the InSAR method to obtain coseismic LOS deformation fields based on SAR images and applied offset tracking methods to obtain offset measurements based on optical satellite images.The maximum displacement of about 6 m is detected in the direction away from the satellite on the south-west side and also towards the satellite on the north-east side.The 3D deformation field is then resolved by the combination of these measurements with a least-square solve method,and comparisons with 3 components of GPS stations show good consistency.Despite complex features demonstrated in the 3D deformation field,there are still clear spatial correlations between surface deformation and faults distribution.It reveals that more than ten faults were ruptured during the earthquake,including some faults were previously understudies for their tectonic activities.The maximum horizontal deformation of about 10 m occurs along the Kekerengu fault with the vertical deformation up to 2 m.The 3D deformation shows that the mainshock is a multisegments faulting with a rupture process of strike-slip,compression,transpressional rupture and strike-slip in space along the NE direction.
基金sponsored by the National Natural Science Foundation of China(Grant Nos.52275471 and 52175448)Beijing Nova Program No.20220484015the New Cornerstone Science Foundation through the XPLORERPRIZE.
文摘Maintenance of aero-engine fleets is crucial for the efficiency,safety,and reliability of the aviation industry.With the increasing demand for air transportation,maintaining high-performing aero-engines has become significant.Collaborative maintenance,specifically targeting aero-engine fleets,involves the coordination of multiple tasks and resources to enhance management efficiency and reduce costs.Digital Twin(DT)technology provides essential technical support for the intelligent operation and maintenance of aero-engine fleets.DT maps physical object properties to the virtual world,creating high-fidelity,dynamic models.However,DT-enhanced collaborative maintenance faces various challenges,including the construction of complex system-layer DT models,management of massive integrated DT data,and the development of fusion mechanisms and decision-making methods for DT data and models.Overcoming these challenges will allow the aviation industry to optimize aero-engine fleet maintenance,ensuring safety,efficiency,and cost-effectiveness while meeting the growing demand for air transportation.
基金we appreciate Shanbi Zhou for providing the way about how to prepare the fresh amnion.And the study was funded by the Medical Research Project of Chongqing(NO.20141014)the Medical Characteristic Professional Subjects Construction Project of Chongqing(NO.2013-46).
文摘Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan.
基金co-supported by the National Natural Science Foundation of China(Nos.51765045 and 51365043)the Aeronautical Science Foundation of China(No.2019ZF056013)the Jiangxi Provincial Natural Science Foundation(No.20202ACBL204010)。
文摘The mechanical behavior and progressive damage mechanism of novel aluminum matrix composites reinforced with 3D angle-interlock woven carbon fibers were investigated using a multiscale modeling approach.The mechanical properties and failure of yarns were evaluated using a microscale model under different loading scenarios.On this basis,a mesoscale model was developed to analyze the tensile behavior and failure mechanism of the composites.The interfacial decohesion,matrix damage,and failure of fibers and yarns were incorporated into the microscopic and mesoscopic models.The stress–strain curves and fracture modes from simulation show good agreement with the experimental curves and fracture morphology.Local interface and matrix damage initiate first under warp directional tension.Thereafter,interfacial failure,weft yarn cracking,and matrix failure occur successively.Axial fracture of warp yarn,which displays a quasi-ductile fracture characteristic,dominates the ultimate composites failure.Under weft directional tension,interfacial failure and warp yarn rupture occur at the early and middle stages.Matrix failure and weft yarn fracture emerge simultaneously at the final stage,leading to the cata-strophic failure of composites.The weft directional strength and fracture strain are lower than the warp directional ones because of the lower weft density and the more serious brittle fracture of weft yarns.
基金supported by the National Natural Science Foundation of China(No.81873227)。
文摘Objective To conduct a comparative study on the brain pharmacokinetics of seven ingredients(i.e.senkyunolide A,ferulic acid,formononetin,calycosin,ononin,calycosin-O-β-D-glucopyranoside,and paeoniflorin),which were the compounds of Buyang Huanwu Decoction(BHD),in normal and cerebral ischemia rats administrated intragastrically with BHD.Methods The samples of normal and permanent middle cerebral artery occlusion(pMCAO)rats were collected by using brain microdialysis technique.The concentrations of seven ingredients were determined by the HPLC-MS/MS method.After the BHD were administrated intragastrically to the rats for seven consecutive days,brain microdialysis probes were inserted into the hippocampus of rats,and then the brain microdialysates were collected at 20 min time intervals for 5 h.The separation of the seven ingredients and internal standard(IS)was carried out on an ACQUITY UPLC BEH C18(2.1 mm×100 mm,1.7μm)chromatographic column,using a mobile phase consisting of acetonitrile(containing 0.1%formic acid)and water(containing 0.1%formic acid)for gradient elution within 13 min.The ionization was conducted using an ESI source in positive ion mode.Multiple reaction monitoring mode was used for quantification of ingredients in BHD.Results Linearity,accuracy,precision,matrix effect and stability of LC-MS/MS method were all satisfactory,successfully applied to compare the pharmacokinetics of the analytes between normal and model rats after intragastric administration of BHD.Compared with the normal group,the model group after the administration of the BHD showed that T1/2 of formononetin and ononin were longer,and except for calycosin-O-β-D-glucopyranoside(P<0.01),there was no significant difference between the normal group and the model group.The C_(max) of senkyunolide A and calycosin of model group were increased,while the T_(max) of senkyunolide A was decreased,and except for the T_(max) of PF,the differences between the two groups were statistically significant(P<0.01).Conclusion The LC-MS/MS method combined with microdialysis was successfully applied to the comparative study of brain pharmacokinetics of seven ingredients in BHD.After intragastric administration of BHD,there were differences in the pharmacokinetics of seven ingredients in the brain hippocampus between normal rats and model rats,probably related to the characteristics of the ingredients and the effects of cerebral ischemia on the absorption and distribution of the ingredients.
基金This paper was funded by the Key Program of the National Natural Science Foundation of China(Grant No.U2001201)the Project funded by China Postdoctoral Science Foundation(Grant No.2022M712591)the Fundamental Research Funds for the Central Universities.
文摘Trends toward the globalization of the manufacturing industry and the increasing demands for small-batch,short-cycle,and highly customized products result in complexities and fluctuations in both external and internal manufacturing environments,which poses great challenges to manufacturing enterprises.Fortunately,recent advances in the Industrial Internet of Things(IIoT)and the widespread use of embedded processors and sensors in factories enable collecting real-time manufacturing status data and building cyber–physical systems for smart,flexible,and resilient manufacturing systems.In this context,this paper investigates the mechanisms and methodology of self-organization and self-adaption to tackle exceptions and disturbances in discrete manufacturing processes.Specifically,a general model of smart manufacturing complex networks is constructed using scale-free networks to interconnect heterogeneous manufacturing resources represented by network vertices at multiple levels.Moreover,the capabilities of physical manufacturing resources are encapsulated into virtual manufacturing services using cloud technology,which can be added to or removed from the networks in a plug-and-play manner.Materials,information,and financial assets are passed through interactive links across the networks.Subsequently,analytical target cascading is used to formulate the processes of self-organizing optimal configuration and self-adaptive collaborative control for multilevel key manufacturing resources while particle swarm optimization is used to solve local problems on network vertices.Consequently,an industrial case based on a Chinese engine factory demonstrates the feasibility and efficiency of the proposed model and method in handling typical exceptions.The simulation results show that the proposed mechanism and method outperform the event-triggered rescheduling method,reducing manufacturing cost,manufacturing time,waiting time,and energy consumption,with reasonable computational time.This work potentially enables managers and practitioners to implement active perception,active response,self-organization,and self-adaption solutions in discrete manufacturing enterprises.
