Photoacoustic(PA) imaging has drawn tremendous research interest for various applications in biomedicine and experienced exponential growth over the past decade. Since the scattering effect of biological tissue on ult...Photoacoustic(PA) imaging has drawn tremendous research interest for various applications in biomedicine and experienced exponential growth over the past decade. Since the scattering effect of biological tissue on ultrasound is two-to three-orders magnitude weaker than that of light, photoacoustic imaging can effectively improve the imaging depth.However, as the depth of imaging further increases, the incident light is seriously affected by scattering that the generated photoacoustic signal is very weak and the signal-to-noise ratio(SNR) is quite low. Low SNR signals can reduce imaging quality and even cause imaging failure. In this paper, we proposed a new wavefront shaping and imaging method of low SNR photoacoustic signal using digital micromirror device(DMD) based superpixel method. We combined the superpixel method with DMD to modulate the phase and amplitude of the incident light, and the genetic algorithm(GA) was used as the wavefront shaping algorithm. The enhancement of the photoacoustic signal reached 10.46. Then we performed scanning imaging by moving the absorber with the translation stage. A clear image with contrast of 8.57 was obtained while imaging with original photoacoustic signals could not be achieved. The proposed method opens new perspectives for imaging with weak photoacoustic signals.展开更多
We have studied the high-pressure compression behavior of molybdenum up to 60 GPa by synchrotron radial x-ray diffraction(RXRD)in a diamond anvil cell(DAC).It is found that all diffraction peaks of molybdenum undergo ...We have studied the high-pressure compression behavior of molybdenum up to 60 GPa by synchrotron radial x-ray diffraction(RXRD)in a diamond anvil cell(DAC).It is found that all diffraction peaks of molybdenum undergo a split at around 27 GPa,and we believe that a phase transition from a body-centered cubic structure to a rhombohedral structure at room pressure has occurred.The slope of pressure–volume curve shows continuity before and after this phase transition,when fitting the pressure–volume curves of the body-centered cubic structure at low pressure and the rhombohedral structure at high pressure.A bulk modulus of 261.3(2.7)GPa and a first-order derivative of the bulk modulus of 4.15(0.14)are obtained by using the nonhydrostatic compression data at the angleψ=54.7°between the diffracting plane normal and stress axis.展开更多
This paper puts forward for the first time a combined transmission matrix （TM） method to measure the monochromatic TM of scattering media without a reference beam. This method can be named a sequential semi-definite...This paper puts forward for the first time a combined transmission matrix （TM） method to measure the monochromatic TM of scattering media without a reference beam. This method can be named a sequential semi-definite programming method which combines the sequential algorithm and the semi-definite programming method. Firstly, each part of the TM is calculated respectively in proper sequence. Then every part of TM is combined to form a complete TM in accordance with a certain rule. The phase modulation of the incident light is achieved by using a high speed digital mirror device with the superpixel method. We have experimentally demonstrated that the incident light field is focused at the target through scattering media using the measured TM to optimize the wavefront of the incident light. Compared with the semi- definite programming method, our method takes less computational time and occupies less memory space. The sequential semi-definite programming method shows potential applications in imaging through biological tissues.展开更多
We use feedback wavefront shaping technology to realize the multi-point uniform light focusing in three-dimensional(3D) space through scattering media only by loading the optimal mask once.General 3D spatial focusing ...We use feedback wavefront shaping technology to realize the multi-point uniform light focusing in three-dimensional(3D) space through scattering media only by loading the optimal mask once.General 3D spatial focusing needs to load the optimal mask multiple times to realize the spatial movement of the focal point and the uniformity of multi-point focusing cannot be guaranteed.First,we investigate the effects of speckle axial correlation and different axial distances on 3D spatial multi-point uniform focusing and propose possible solutions.Then we use our developed non-dominated sorting genetic algorithm suitable for 3D spatial focusing(S-NSGA) to verify the experiment of multi-point focusing in 3D space.This research is expected to have potential applications in the fields of optical manipulation and optogenetics.展开更多
When light travels in biological tissues,it undergoes multiple scattering and forms speckles,which seriously restricts the penetration depth of optical imaging in biological tissues.With wavefront shaping method,by mo...When light travels in biological tissues,it undergoes multiple scattering and forms speckles,which seriously restricts the penetration depth of optical imaging in biological tissues.With wavefront shaping method,by modulating the wavefront of incident light to compensate for the wavefront aberration,light focusing and scanning imaging through scattering media can be achieved.However,wavefront shaping must be accomplished within the speckle decorrelation time.Considering the short speckle decorrelation time of living tissues,the speed of wavefront shaping is rather essential.We propose a new iterative optimization wavefront shaping method to improve the speed of wavefront shaping in which the existing parallel optimization wavefront shaping method is improved and is combined with the superpixel method.Compared with the traditional multi-frequency parallel optimization method,the modulation rate of our method is doubled.Moreover,we combine the high frame rate amplitude modulator,i.e.,the digital micromirror device(DMD),with the superpixel method to replace the traditional phase modulator(i.e.,spatial light modulator),which further increases the optimization speed.In our experiment,when the number of the optical modes is 400,light focusing is achieved with only 1000 DMD superpixel masks and the enhancement factor reaches 223.Our approach provides a new path for fast light focusing through wavefront shaping.展开更多
Single atom catalysts(SACs)have been in the forefront of catalysts research because of their high efficiency and low cost and provide new ideas for development of renewable energy conversion and storage technologies.H...Single atom catalysts(SACs)have been in the forefront of catalysts research because of their high efficiency and low cost and provide new ideas for development of renewable energy conversion and storage technologies.However,the relationship between the intrinsic properties of materials such as lattice thermal conductivity and catalysis remains to be explored.In this work,the lattice thermal conductivity of BN and graphene was calculated by Sheng BTE.In addition,the adsorption properties of 3d-TM(TM=V,Cr,Mn,Fe,Co,Ni)on BN and graphene were investigated using first-principles methods,and it was found that Ni atom can form relatively stable SACs compared to other TMs.The molecular dynamics(MD)simulation and migration barrier of Ni loaded on BN and graphene were calculated.Our study found that graphene has higher thermal conductivity and is easier to form SACs than BN,but the SACs formed on BN surface have higher thermodynamic stability.展开更多
基金Project supported by the National Key Research and Development Program of China(Grant No.2017YFB1104500)the Beijing Natural Science Foundation,China(Grant No.7182091)+1 种基金the National Natural Science Foundation of China(Grant No.21627813)the Research Projects on Biomedical Transformation of China–Japan Friendship Hospital(Grant No.PYBZ1801)。
文摘Photoacoustic(PA) imaging has drawn tremendous research interest for various applications in biomedicine and experienced exponential growth over the past decade. Since the scattering effect of biological tissue on ultrasound is two-to three-orders magnitude weaker than that of light, photoacoustic imaging can effectively improve the imaging depth.However, as the depth of imaging further increases, the incident light is seriously affected by scattering that the generated photoacoustic signal is very weak and the signal-to-noise ratio(SNR) is quite low. Low SNR signals can reduce imaging quality and even cause imaging failure. In this paper, we proposed a new wavefront shaping and imaging method of low SNR photoacoustic signal using digital micromirror device(DMD) based superpixel method. We combined the superpixel method with DMD to modulate the phase and amplitude of the incident light, and the genetic algorithm(GA) was used as the wavefront shaping algorithm. The enhancement of the photoacoustic signal reached 10.46. Then we performed scanning imaging by moving the absorber with the translation stage. A clear image with contrast of 8.57 was obtained while imaging with original photoacoustic signals could not be achieved. The proposed method opens new perspectives for imaging with weak photoacoustic signals.
基金Project supported by the National Natural Science Foundation of China(Grant No.12075163)the Open fund project of Industrial Technology Institute of Sichuan University of Arts and Science,China(Grant No.ZNZZ2101)+1 种基金the Project of Ph.D special research of Sichuan University of Arts and Science,China(Grant No.2019BS006Z)supported by the Chinese Academy of Sciences(Grant Nos.KJCX2-SW-N03 and KJCX2-SW-N20)。
文摘We have studied the high-pressure compression behavior of molybdenum up to 60 GPa by synchrotron radial x-ray diffraction(RXRD)in a diamond anvil cell(DAC).It is found that all diffraction peaks of molybdenum undergo a split at around 27 GPa,and we believe that a phase transition from a body-centered cubic structure to a rhombohedral structure at room pressure has occurred.The slope of pressure–volume curve shows continuity before and after this phase transition,when fitting the pressure–volume curves of the body-centered cubic structure at low pressure and the rhombohedral structure at high pressure.A bulk modulus of 261.3(2.7)GPa and a first-order derivative of the bulk modulus of 4.15(0.14)are obtained by using the nonhydrostatic compression data at the angleψ=54.7°between the diffracting plane normal and stress axis.
基金Project supported by the National Key Research and Development Program of China(Grant No.2017YFB1104500)the Natural Science Foundation of Beijing(Grant No.7182091)the National Natural Science Foundation of China(Grant No.21627813)
文摘This paper puts forward for the first time a combined transmission matrix （TM） method to measure the monochromatic TM of scattering media without a reference beam. This method can be named a sequential semi-definite programming method which combines the sequential algorithm and the semi-definite programming method. Firstly, each part of the TM is calculated respectively in proper sequence. Then every part of TM is combined to form a complete TM in accordance with a certain rule. The phase modulation of the incident light is achieved by using a high speed digital mirror device with the superpixel method. We have experimentally demonstrated that the incident light field is focused at the target through scattering media using the measured TM to optimize the wavefront of the incident light. Compared with the semi- definite programming method, our method takes less computational time and occupies less memory space. The sequential semi-definite programming method shows potential applications in imaging through biological tissues.
基金Project supported by the Natural Science Foundation of Beijing Municipality,China(Grant No.7182091)。
文摘We use feedback wavefront shaping technology to realize the multi-point uniform light focusing in three-dimensional(3D) space through scattering media only by loading the optimal mask once.General 3D spatial focusing needs to load the optimal mask multiple times to realize the spatial movement of the focal point and the uniformity of multi-point focusing cannot be guaranteed.First,we investigate the effects of speckle axial correlation and different axial distances on 3D spatial multi-point uniform focusing and propose possible solutions.Then we use our developed non-dominated sorting genetic algorithm suitable for 3D spatial focusing(S-NSGA) to verify the experiment of multi-point focusing in 3D space.This research is expected to have potential applications in the fields of optical manipulation and optogenetics.
基金the National Key Research and Development Program of China(Grant No.2017YFB1104500)the Beijing Natural Science Foundation(Grant No.7182091)+1 种基金the National Natural Science Foundation of China(Grant No.21627813)the Research Projects on Biomedical Transformation of China-Japan Friendship Hospital(PYBZ1801).
文摘When light travels in biological tissues,it undergoes multiple scattering and forms speckles,which seriously restricts the penetration depth of optical imaging in biological tissues.With wavefront shaping method,by modulating the wavefront of incident light to compensate for the wavefront aberration,light focusing and scanning imaging through scattering media can be achieved.However,wavefront shaping must be accomplished within the speckle decorrelation time.Considering the short speckle decorrelation time of living tissues,the speed of wavefront shaping is rather essential.We propose a new iterative optimization wavefront shaping method to improve the speed of wavefront shaping in which the existing parallel optimization wavefront shaping method is improved and is combined with the superpixel method.Compared with the traditional multi-frequency parallel optimization method,the modulation rate of our method is doubled.Moreover,we combine the high frame rate amplitude modulator,i.e.,the digital micromirror device(DMD),with the superpixel method to replace the traditional phase modulator(i.e.,spatial light modulator),which further increases the optimization speed.In our experiment,when the number of the optical modes is 400,light focusing is achieved with only 1000 DMD superpixel masks and the enhancement factor reaches 223.Our approach provides a new path for fast light focusing through wavefront shaping.
基金supported by the Key Projects of NSFC-Henan Joint Fund(Nos.U1404216 and U2004209)the Natural Science Foundation of China(No.21603109)+2 种基金the Scientific Research Program Funded by Shaanxi Provincial Education Department(No.20JK0676)the Fundamental Research Funds for the University of Henan Province(No.200303)Dalian High-level Talent Innovation Support Program(No.2019RQ075)。
文摘Single atom catalysts(SACs)have been in the forefront of catalysts research because of their high efficiency and low cost and provide new ideas for development of renewable energy conversion and storage technologies.However,the relationship between the intrinsic properties of materials such as lattice thermal conductivity and catalysis remains to be explored.In this work,the lattice thermal conductivity of BN and graphene was calculated by Sheng BTE.In addition,the adsorption properties of 3d-TM(TM=V,Cr,Mn,Fe,Co,Ni)on BN and graphene were investigated using first-principles methods,and it was found that Ni atom can form relatively stable SACs compared to other TMs.The molecular dynamics(MD)simulation and migration barrier of Ni loaded on BN and graphene were calculated.Our study found that graphene has higher thermal conductivity and is easier to form SACs than BN,but the SACs formed on BN surface have higher thermodynamic stability.
