Background:Melanocytic nevus is mainly treated by complete or partial removal.However,predicting the risk of malignant transformation of melanocytic nevi and which treatment patients should receive,surgical or nonsurg...Background:Melanocytic nevus is mainly treated by complete or partial removal.However,predicting the risk of malignant transformation of melanocytic nevi and which treatment patients should receive,surgical or nonsurgical management,to gain the best results and aesthetic outcomes is controversial.Methods:Global literature on melanocytic nevus treatment,published between 1997 and 2022,was scanned using the Web of Science Core Collection database.Microsoft Office Excel,CiteSpace V,VOSviewer,Scimago Graphica,Bibliometrix,and Biblioshiny packages in R were used for the bibliometric analysis to summarize the leading countries,institutions,professors,and research trends in this field.Results:This study included 1723 articles.Publications and citations exhibited positive trends over the past 20 years.The United States had the most productive organizations and publications in the comprehensive worldwide cooperation network,and China was recently one of the most active major participants.Professor Giovanni Pellacani,whose H-index,G-index,and M-index ranked first in this field,founded a virtual biopsy using reflectance confocal microscopy.In addition,Krengel and Kinsler contributed significantly to diagnosing and treating melanocytic nevi.The top 25 keywords in recent years were mostly about the mechanisms and risk factors for the malignant transformation of nevi.Conclusion:The future trend for melanocytic nevi treatment is to specify genotype-phenotype and genotypeoutcome correlations,choose proper therapy to reduce the risk of malignant transformation,and simultaneously achieve the best aesthetic outcomes.展开更多
Background:To investigate the common symptoms after Covid-19 infection,characteristics of adverse events after vaccination,changes in clinical manifestations related to Neurofibromatosis type 1(NF1),as well as the cur...Background:To investigate the common symptoms after Covid-19 infection,characteristics of adverse events after vaccination,changes in clinical manifestations related to Neurofibromatosis type 1(NF1),as well as the current vaccination status and factors related to vaccine hesitation among NF1 patients,in order to provide a basis for scientific protection and vaccine acceptance in NF1 individuals in the new phase of pandemic management.Methods:From December 29,2022,to January 10,2023,we conducted a self-assessment questionnaire survey among diagnosed NF1 patients.General data were provided including sex,age,main clinical presentations,and current treatment.This study mainly focused on the infection and vaccination status of Covid-19 among these patients with NF1.The data were statistically analyzed using SPSS26.0 software.Results:Of the 250 questionnaires distributed,226 were valid.Among the 164 patients(72.6%)with Covid-19 infection,the most common infection symptoms and incidence of patients were not significantly different from those in the normal population(P>0.05),but the incidence of symptoms such as nasal congestion,headache,myalgia,sore throat,abdominal pain,diarrhea,and eye discomfort was higher than that in the normal population(P<0.05),and no severe infection was observed;186 patients(82.3%)had completed the Covid-19 vaccination,and more than half of those who were not vaccinated had no plans for vaccination.Among the vaccinated patients,there was no significant difference in the incidence of adverse events,such as fever,pain,redness,and swelling at the injection site after vaccination,compared to the normal population(P>0.05),but the incidence of fatigue and headache was higher in NF1 patients(P<0.001).Most patients with NF1 believe that there is no significant progressive change in NF1-related clinical manifestations after Covid-19 infection and vaccination.Conclusion:Currently,some NF1 patients appear to be worried about the evolution of their disease after Covid-19 infection in the face of large fluctuations in the pandemic situation,and some patients hesitate to receive the vaccine due to their special disease condition.Thus,clinical trials should be conducted to develop a refined pandemic response and vaccination program for this special group.展开更多
Neurofibromatosis type 1(NF1)is an autosomal dominant inherited disease caused by mutations in the NF1 gene.It is characterized by cafe-au-lait macules(CALMs),cutaneous neurofibromas(CNF),plexiform neurofibromas(PNF),...Neurofibromatosis type 1(NF1)is an autosomal dominant inherited disease caused by mutations in the NF1 gene.It is characterized by cafe-au-lait macules(CALMs),cutaneous neurofibromas(CNF),plexiform neurofibromas(PNF),Lisch nodules,optic pathway gliomas(OPG),potential skeletal abnormalities,and other complications involving multiple organs and systems.[1]Additionally,approximately 10%of individuals with NF1 may progress to develop malignant peripheral nerve sheath tumors(MPNST).[1]The NF1 gene encodes neurofibromin,which regulates Ras and its downstream signaling pathways,such as the mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK)and phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathways.展开更多
Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation.However,few reviews have highlighted the significance of ma...Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation.However,few reviews have highlighted the significance of macrophages during the formation of abnormal scars.The purpose of this reviewwas to outline the polarization of macrophages from early to late stage of pathological scar formation,focusing on spatiotemporal diversity of M1 and M2 macrophages.In this review,the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail.First,an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis.Second,decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation.Third,M2 cells are highly expressed at both the margin and the superficial region,which is consistent with the invasive property of keloids.Finally,this review helps to characterize strategies for the prediction and prevention of pathological scar formation.展开更多
The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing.However,the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxici...The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing.However,the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity.Herein,a controlled/sustained release polyvinyl alco-hol/chitosan/sulfonated lignin hydrogel(PVA-CS-L)integrated mechanical strengthening and bioactivities of lignin was developed.The lignin-induced non-covalent bond network(van der Waals force,hydrogen and electrostatic interactions)promoted energy dissipation when the hy-drogel was subjected to stretching and compression.This endowed the PVA-CS-L hydrogel with improved tensile(∼36 kPa)and compressive strength(∼900 kPa),as well as compressive tough-ness(∼9.0 MJ/m^(3)),which were superior to the polyvinyl alcohol/chitosan hydrogel(PVA-CS)(31 kPa,680 kPa,and 7.5 MJ/m^(3),respectively).The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin.Also,the developed hydrogel had good biocom-patibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus.Finally,preliminary evaluation of drug delivery reveals that the presence of lignin enabled the hydrogel to exhibit longer-lasting controlled/sustained epigallocatechin gallate release properties.Such lignin-based controlled/sustained release hydro-gel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective,easy-to-operate manufacturing of load-bearing and bioactive materials.展开更多
基金the National Natural Science Foundation of China(grant nos.82202470,82102344,and 82172228)Shanghai Rising Star Program supported by the Science and Technology Commission of Shanghai Municipality(grant no.20QA1405600)+3 种基金Natural Science Foundation of Shanghai(grant no.22ZR1422300)Innovative Research Team of High-Level Local Universities in Shanghai(grant no.SHSMU-ZDCX20210400)Clinical Research Plan of SHDC(grant no.SHDC2020CR1019B)Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by(grant no.22MC1940300).
文摘Background:Melanocytic nevus is mainly treated by complete or partial removal.However,predicting the risk of malignant transformation of melanocytic nevi and which treatment patients should receive,surgical or nonsurgical management,to gain the best results and aesthetic outcomes is controversial.Methods:Global literature on melanocytic nevus treatment,published between 1997 and 2022,was scanned using the Web of Science Core Collection database.Microsoft Office Excel,CiteSpace V,VOSviewer,Scimago Graphica,Bibliometrix,and Biblioshiny packages in R were used for the bibliometric analysis to summarize the leading countries,institutions,professors,and research trends in this field.Results:This study included 1723 articles.Publications and citations exhibited positive trends over the past 20 years.The United States had the most productive organizations and publications in the comprehensive worldwide cooperation network,and China was recently one of the most active major participants.Professor Giovanni Pellacani,whose H-index,G-index,and M-index ranked first in this field,founded a virtual biopsy using reflectance confocal microscopy.In addition,Krengel and Kinsler contributed significantly to diagnosing and treating melanocytic nevi.The top 25 keywords in recent years were mostly about the mechanisms and risk factors for the malignant transformation of nevi.Conclusion:The future trend for melanocytic nevi treatment is to specify genotype-phenotype and genotypeoutcome correlations,choose proper therapy to reduce the risk of malignant transformation,and simultaneously achieve the best aesthetic outcomes.
基金supported by the National Natural Science Foundation of China (grant nos. 82102344 and 82172228)Shanghai Rising Star Program supported by Science and Technology Commission of Shanghai Municipality (grant no. 20QA1405600)+4 种基金Science and Technology Commission of Shanghai Municipality (grant no. 19JC1413)Natural Science Foundation of Shanghai (grant no. 22ZR1422300)“Chenguang Program” supported by Shanghai Education Development Foundation (grant no. 19CG18)Shanghai Municipal Key Clinical Specialty (grant no.shslczdzk00901)Innovative Research Team of High-level Local Universities in Shanghai (grant no. SSMUZDCX20180700)
文摘Background:To investigate the common symptoms after Covid-19 infection,characteristics of adverse events after vaccination,changes in clinical manifestations related to Neurofibromatosis type 1(NF1),as well as the current vaccination status and factors related to vaccine hesitation among NF1 patients,in order to provide a basis for scientific protection and vaccine acceptance in NF1 individuals in the new phase of pandemic management.Methods:From December 29,2022,to January 10,2023,we conducted a self-assessment questionnaire survey among diagnosed NF1 patients.General data were provided including sex,age,main clinical presentations,and current treatment.This study mainly focused on the infection and vaccination status of Covid-19 among these patients with NF1.The data were statistically analyzed using SPSS26.0 software.Results:Of the 250 questionnaires distributed,226 were valid.Among the 164 patients(72.6%)with Covid-19 infection,the most common infection symptoms and incidence of patients were not significantly different from those in the normal population(P>0.05),but the incidence of symptoms such as nasal congestion,headache,myalgia,sore throat,abdominal pain,diarrhea,and eye discomfort was higher than that in the normal population(P<0.05),and no severe infection was observed;186 patients(82.3%)had completed the Covid-19 vaccination,and more than half of those who were not vaccinated had no plans for vaccination.Among the vaccinated patients,there was no significant difference in the incidence of adverse events,such as fever,pain,redness,and swelling at the injection site after vaccination,compared to the normal population(P>0.05),but the incidence of fatigue and headache was higher in NF1 patients(P<0.001).Most patients with NF1 believe that there is no significant progressive change in NF1-related clinical manifestations after Covid-19 infection and vaccination.Conclusion:Currently,some NF1 patients appear to be worried about the evolution of their disease after Covid-19 infection in the face of large fluctuations in the pandemic situation,and some patients hesitate to receive the vaccine due to their special disease condition.Thus,clinical trials should be conducted to develop a refined pandemic response and vaccination program for this special group.
基金supported by grants from the National Natural Science Foundation of China(Nos.82102344 and 82172228)Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by the Science and Technology Commission of Shanghai Municipality(No.22MC1940300)+3 种基金Innovative research team of high-level local universities in Shanghai(No.SHSMU-ZDCX20210400)Natural Science Foundation of Shanghai(No.22ZR1422300)Shanghai Municipal Key Clinical Specialty(No.shslczdzk00901)the Project of Biobank(No.YBKA202204)from Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine.
文摘Neurofibromatosis type 1(NF1)is an autosomal dominant inherited disease caused by mutations in the NF1 gene.It is characterized by cafe-au-lait macules(CALMs),cutaneous neurofibromas(CNF),plexiform neurofibromas(PNF),Lisch nodules,optic pathway gliomas(OPG),potential skeletal abnormalities,and other complications involving multiple organs and systems.[1]Additionally,approximately 10%of individuals with NF1 may progress to develop malignant peripheral nerve sheath tumors(MPNST).[1]The NF1 gene encodes neurofibromin,which regulates Ras and its downstream signaling pathways,such as the mitogen-activated protein kinase(MEK)/extracellular signal-regulated kinase(ERK)and phosphatidylinositol-3-kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR)pathways.
文摘Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar formation.However,few reviews have highlighted the significance of macrophages during the formation of abnormal scars.The purpose of this reviewwas to outline the polarization of macrophages from early to late stage of pathological scar formation,focusing on spatiotemporal diversity of M1 and M2 macrophages.In this review,the role of macrophages in the formation of hypertrophic scars and keloids is summarized in detail.First,an increased number of M2 cells observed before injuries are significantly associated with susceptibility to abnormal scar pathogenesis.Second,decreased expression of M1 at the early stage and delayed expression of M2 at the late stage results in pathological scar formation.Third,M2 cells are highly expressed at both the margin and the superficial region,which is consistent with the invasive property of keloids.Finally,this review helps to characterize strategies for the prediction and prevention of pathological scar formation.
基金financial support from National Natural Science Foundation of China(No.32201500No.32271811)+2 种基金Natural Science Foundation of Jiangsu Province(No.BK20220431)Jiangsu Provincial Key Research and Development Program(No.BE2021368)the China Postdoctoral Science Foundation(No.2023M731708).
文摘The favorable antioxidant and antimicrobial activities of lignin have been shown to promote wound healing.However,the accumulation of lignin in high concentrations in the body brings about varying degrees of biotoxicity.Herein,a controlled/sustained release polyvinyl alco-hol/chitosan/sulfonated lignin hydrogel(PVA-CS-L)integrated mechanical strengthening and bioactivities of lignin was developed.The lignin-induced non-covalent bond network(van der Waals force,hydrogen and electrostatic interactions)promoted energy dissipation when the hy-drogel was subjected to stretching and compression.This endowed the PVA-CS-L hydrogel with improved tensile(∼36 kPa)and compressive strength(∼900 kPa),as well as compressive tough-ness(∼9.0 MJ/m^(3)),which were superior to the polyvinyl alcohol/chitosan hydrogel(PVA-CS)(31 kPa,680 kPa,and 7.5 MJ/m^(3),respectively).The construction of electrostatic interaction could not only slow down the sudden release of lignin but also make the hydrogel exhibit a good pH-sensitive behavior of controlled-release lignin.Also,the developed hydrogel had good biocom-patibility and the released lignin had reactive oxygen species scavenging as well as inhibitory activity against Staphylococcus aureus.Finally,preliminary evaluation of drug delivery reveals that the presence of lignin enabled the hydrogel to exhibit longer-lasting controlled/sustained epigallocatechin gallate release properties.Such lignin-based controlled/sustained release hydro-gel that integrates the molecular structure and biological difunctional features of lignin gives new insight into cost-effective,easy-to-operate manufacturing of load-bearing and bioactive materials.
