Background:Observational studies have shown that inflammatory bowel disease(IBD),such as ulcerative colitis(UC)and Crohn disease(CD),is associated with gingivitis and periodontal disease(GP).This study aims to investi...Background:Observational studies have shown that inflammatory bowel disease(IBD),such as ulcerative colitis(UC)and Crohn disease(CD),is associated with gingivitis and periodontal disease(GP).This study aims to investigate whether there is a causal relationship between IBD and GP.Methods:This study assessed the causal relationship between IBD and GP through a two-sample Mendelian randomization(MR)study.The required data were obtained through the IEU OpenGWAS project.Instrumental variable screening and the MR and sensitivity analyses were performed using the“TwoSampleMR”R package.Results:IBD,UC,and CD may have a causal effect on GP(IBD,inverse variance weighting[IVW]OR=1.05,95%CI=1.00–1.10,P=0.03;UC,IVWOR=1.05,95%CI=1.00–1.11,P=0.03;CD,weighted median OR=1.06,95%CI=1.00–1.13,P=0.04;simple mode OR=1.15,95%CI=1.02–1.31,P=0.03).Scatterplots,forest plots,and funnel plots showed a significant relationship between IBD and GP and confirmed the robustness of the model.In sensitivity testing,no horizontal pleiotropy or heterogeneity was found in this study.Conclusions:This study found a possible causal relationship between IBD(UC and CD)and GP,which deserves to be considered in clinical practice.展开更多
With its significant morbidity and mortality,anastomotic leaking is a serious concern in the field of colorectal surgical treatments.A number of strategies and actions have been introduced in the last few years with t...With its significant morbidity and mortality,anastomotic leaking is a serious concern in the field of colorectal surgical treatments.A number of strategies and actions have been introduced in the last few years with the goal of reducing the incidence of this surgical complication and the clinical consequences that follow.Based on the most recent academic research,this article aims to provide a comprehensive assessment of the current approaches for the prevention and management of anastomotic leakage in the context of colorectal cancer surgeries.In addition to encouraging more study and innovation in this crucial field,the aim is to provide useful insights and references for clinical practices in the prevention and treatment of anastomotic leakage.展开更多
基金the Training Project of Key Talents of Youth Medicine in Jiangsu Province of China(No.QNRC2016330)the Graduate Research-Innovation Project in Jiangsu Province(No.SJCX21_1644)+5 种基金the Academic Science and Technology Innovation Fund for College Students(No.202011117056Y)the Social Development-Health Care Project of Yangzhou,Jiangsu Province(No.YZ2018087)the Social Development-Health Care Project of Yangzhou,Jiangsu Province(No.YZ2021075)the High-Level Talent“Six One Projects”Top Talent Scientific Research Project of Jiangsu Province(No.LGY2019034)the Graduate Research-Innovation Project in Jiangsu Province(No.SJCX22_1816)the Social development project of the key R&D plan of Jiangsu Provincial Department of Science and Technology(No.BE2022773).
文摘Background:Observational studies have shown that inflammatory bowel disease(IBD),such as ulcerative colitis(UC)and Crohn disease(CD),is associated with gingivitis and periodontal disease(GP).This study aims to investigate whether there is a causal relationship between IBD and GP.Methods:This study assessed the causal relationship between IBD and GP through a two-sample Mendelian randomization(MR)study.The required data were obtained through the IEU OpenGWAS project.Instrumental variable screening and the MR and sensitivity analyses were performed using the“TwoSampleMR”R package.Results:IBD,UC,and CD may have a causal effect on GP(IBD,inverse variance weighting[IVW]OR=1.05,95%CI=1.00–1.10,P=0.03;UC,IVWOR=1.05,95%CI=1.00–1.11,P=0.03;CD,weighted median OR=1.06,95%CI=1.00–1.13,P=0.04;simple mode OR=1.15,95%CI=1.02–1.31,P=0.03).Scatterplots,forest plots,and funnel plots showed a significant relationship between IBD and GP and confirmed the robustness of the model.In sensitivity testing,no horizontal pleiotropy or heterogeneity was found in this study.Conclusions:This study found a possible causal relationship between IBD(UC and CD)and GP,which deserves to be considered in clinical practice.
基金supported by grants from the Graduate Research-Innovation Project in Jiangsu province(No.SJCX22_1816)the Graduate Research and Practice Innovation Plan of Graduate Education Innovation Project in Jiangsu Province(No.SJCX211644)+2 种基金Social Development Project of Key R&D Plan of Jiangsu Provincial Department of Science and Technology(No.BE2022773)Hospital Project of Subei People’s Hospital(No.YYGL202228)the Social Development-Health Care Project of Yangzhou,Jiangsu Province(No.YZ2021075).
文摘With its significant morbidity and mortality,anastomotic leaking is a serious concern in the field of colorectal surgical treatments.A number of strategies and actions have been introduced in the last few years with the goal of reducing the incidence of this surgical complication and the clinical consequences that follow.Based on the most recent academic research,this article aims to provide a comprehensive assessment of the current approaches for the prevention and management of anastomotic leakage in the context of colorectal cancer surgeries.In addition to encouraging more study and innovation in this crucial field,the aim is to provide useful insights and references for clinical practices in the prevention and treatment of anastomotic leakage.
