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慢性睡眠剥夺对小鼠糖、脂代谢的影响及网络药理机制研究 被引量:4
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作者 朱丽敏 陈佩璐 +3 位作者 许光辉 易立涛 李明 罗友华 《脑与神经疾病杂志》 CAS 2022年第7期444-449,共6页
目的 本研究慢性睡眠剥夺(CSD)对小鼠糖脂代谢的影响及网络药理学机制。方法 实验中运用改良多平台水环境法建立CSD小鼠模型,通过监测小鼠空腹血糖(FBC),酶联免疫吸附试剂盒测定血清胰岛素、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)水水... 目的 本研究慢性睡眠剥夺(CSD)对小鼠糖脂代谢的影响及网络药理学机制。方法 实验中运用改良多平台水环境法建立CSD小鼠模型,通过监测小鼠空腹血糖(FBC),酶联免疫吸附试剂盒测定血清胰岛素、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)水水平反映慢性睡眠剥夺对小鼠糖、脂代谢的影响。同时,利用网络药理学技术预测CSD影响小鼠糖脂代谢的作用机制。结果 与正常小鼠相比,睡眠剥夺CSD小鼠的FBG降低,胰岛素含量升高,胰岛素抵抗指数显著增加,血清LDL和HDL含量明显下降,睡眠剥夺小鼠出现糖脂代谢障碍和胰岛素抵抗。网络药理学分析结果显示,CSD可能通过影响PI3K-Akt信号通路,Rap1信号通路,Toll样受体信号通路等途径导致糖脂代谢紊乱。结论 CSD可降低小鼠血糖,诱导胰岛素抵抗,通过多种途径参与、诱发小鼠糖、脂代谢紊乱。 展开更多
关键词 慢性睡眠剥夺 糖脂代谢 胰岛素抵抗 网络药理学
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Influence of fading on characteristics of thermal analysis curve of compacted graphite iron 被引量:2
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作者 Liu Jinhai yi litao +3 位作者 Li Guolu Liu Changqi Li yinguo Yang Zhaoyu 《China Foundry》 SCIE CAS 2011年第3期295-299,共5页
In general, during the production of compacted graphite iron (CGI), the active residual magnesium reduces and the effect of inoculation fades after magnesium treatment. In this paper, characteristics of the thermal an... In general, during the production of compacted graphite iron (CGI), the active residual magnesium reduces and the effect of inoculation fades after magnesium treatment. In this paper, characteristics of the thermal analysis curve of CGI are compared with those of ductile iron and grey cast iron. The fading effect on the compacted graphite percentage and thermal analysis curve were also studied. Results indicate that the undercooling of CGI is as low as that of ductile iron, but CGI shows evident recalescence. In fading process, the magnesium element acts with oxygen. For a decrease in magnesium content, both the compacted graphite percentage and the austenitic liquidus temperature increase. The temperature of eutectic undercooling (TEU) decreases before the flake graphite appears. After that, TEU increases quickly, up to as high as 20℃, and then gradually decreases. The evolution of recalescence degree is opposite to that of TEU. 展开更多
关键词 compacted graphite iron thermal analysis FADING compacted graphite percentage characteristicvalue
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